Steven R. Alexander, MD
Clinical investigation has been a major component of my academic life for over 25 years. My research has focused on the epidemiology of ESRD and on clinical trials in acute and chronic kidney disease in children. As a pediatric nephrologist, I learned early the critical importance of collaborative research. I was the first pediatric nephrology representative to the NIH-NIDDK National CAPD Registry Advisory Committee in 1986 and served in a similar advisory role to the USRDS when it was established in 1988. I was a co-founder of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) in 1987 and continue to serve as Secretary of the NAPRTCS Board of Directors. The NAPRTCS is the largest and longest running multi-center study group in pediatric nephrology consisting of three registries (CKD, Dialysis, Transplant) that have enrolled over 17,000 patients from over 100 centers in four countries. My current participation in observational studies and clinical trials in pediatrics also includes the Prospective Pediatric CRRT Registry and the International Pediatric Peritonitis Registry. I now devote considerable time to mentoring junior faculty, fellows and other trainees. In 2006 I co-founded and continue to co-direct the Stanford Intensive Course in Clinical Research Study Design and Performance, a week-long immersion course for junior faculty and fellows that is given twice yearly. Since 2005 I have also been heavily involved in re-engineering the clinical and translational research enterprise at Stanford School of Medicine and now serve as Medical Director of Operations, Training and Compliance in Spectrum, Stanford’s Clinical and Translational Science Award.
Mary Leonard, MD, MSCE
Chairman of Pediatrics
Mary was named Pediatrics Department Chair in 2016 after joining the Division in 2014 as Associate Dean of Maternal and Child Health Research. Her multidisciplinary research program is focused primarily on the impact of chronic diseases on bone metabolism and nutrition, with an emphasis on changes in body composition and skeletal density and structure during growth, and in the context of chronic kidney disease and glucocorticoid therapy. She has maintained continuous NIH funding for nearly two decades.
She is the Founding Director of the new Stanford Assessment of Bone and Muscle across the Ages (SAMBA) Center. The Center houses state-of-the-art equipment for studies of bone microarchitecture, body composition, and muscle strength. As evidence of her success as a mentor, she recently renewed her NIDDK K24 award that supports these activities. She also served/serves as the primary mentor on multiple NIH and Foundation career development grants, including (3) F32, (1) K07, and (5) K23 awards. She is also Co-Director of the weekly clinical research in nephrology work-in-progress seminar that is attended by fellows, junior faculty and biostatisticians.
Paul C. Grimm, MD
Fellowship Program Director
Medical Director of Pediatric Kidney Transplantation
Fellows who join our training program have broad access to participate in a full range of research and scholarly activity. I have been involved in basic transplant research for 20 years. My work has been focused on the pathogenesis of subclinical rejection, and chronic allograft damage (chronic rejection). I have developed extensive expertise in computerized image analysis to quantitate chronic graft changes such as fibrosis. My lab has served as a core lab for multicenter trials on assessment of allograft pathology and is positioned to conduct vital research on the issue of diagnosis and quantitation of inflammation and rejection. Stanford has an long history of performing pediatric and adult transplants, a dedicated and productive pathologist and an extensive biopsy database and clinical follow-up data.