Onn Brandman

Associate Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology

Academic Appointments

Associate Professor, Biochemistry
Associate Professor (By courtesy), Chemical and Systems Biology
Member, Bio-X
Member, Stanford Cancer Institute

Professional Education

Ph.D., Stanford University, Chemical and Systems Biology (2008)
M.S., Stanford University, Computer Science (2000)
B.S., University of California, San Diego, Computer Science (1998)

Current Research and Scholarly Interests

The Brandman Lab studies how cells sense and respond to stress. We employ an integrated set of techniques including single cell analysis, mathematical modeling, genomics, structural studies, and in vitro assays.

Graduate and Fellowship Programs

All Publications

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Raymond Chen

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Martha S. Cyert

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The Cyert lab is identifying signaling networks for calcineurin, the conserved Ca2+/calmodulin-dependent phosphatase, and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin’s many physiological functions. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied.

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James Ferrell

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My lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.

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Hunter Fraser

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We study the evolution of complex traits by developing new experimental and computational methods.

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Judith Frydman

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Research Interests
The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.

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Michelle Hays

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Stephen M. Hinshaw

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Peter K. Jackson

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Research Interests
Cell cycle and cyclin control of DNA replication .

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Daniel Jarosz

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Research Interests
My laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.

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