Latest information on COVID-19
Support teaching, research, and patient care.
Wah Chiu is a pioneer in methodology development for cryogenic electron microscopy (cryo-EM). His work has made multiple transformational contributions in developing single particle cryo-EM as a tool for the structural determination of molecular machines at atomic resolution in the last three decades. His lab has solved many cryo-EM structures including viruses, chaperonins, membrane proteins, ion channels, antigen-antibody complexes, protein-RNA complexes and RNA in collaboration with many scientists around the world. He continues to establish high standard testing and characterization protocols for cryo-EM instrumentation and to develop new image processing and modeling algorithms for cryo-EM structure determination. His current research focuses on developing cryogenic electron tomography (cryo-ET) to determine near atomic resolution structures of molecular complexes in situ.
Use cryo-EM to determine atomic structures of RNA, channels, pumps, transporters, chaperonins, protein degradation machines, and viruses in different functional states in conjunction with biochemical and physiological characterizations.
Unified Data Resource for 3DEM
Our interests span across DNA and RNA viruses infecting from bacteria, archaea and mammals.
We are developing experimental and computational tools to visualize molecular components in situ
My research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.