Current Research and Scholarly Interests
My research is focused on clinical trials for stroke, spanning the full breadth of stroke care, including acute intervention, prevention, and recovery trials. The majority of my NIH funded research has centered on the use of imaging biomarkers (specifically multiomadal CT and MRI) to select patients for acute stroke interventions. I have served as the principal investigator of CRISP, a prospective cohort study to assess the utility of CT perfusion for patient selection and the Protocol Director of DEFUSE 3, a Phase 3 randomized controlled trial of endovascular therapy for acute stroke in the 6-16 hour time-window. DEFUSE 3 was conducted at 38 US sites and was the first trial to be funded and executed through StrokeNet, the NINDS clinical stroke trial network.