Current Research and Scholarly Interests
Our laboratory is focused on identifying new secreted factors and hormones that can explain important aspects of metabolism regulation. We are specifically interested in studying orphan hormones as therapeutic targets or biomarkers in energy expenditure and obesity-related disorders such as diabetes and fatty liver. We are using a combination of genetic approaches, biochemistry, molecular biology and integrated proteomic techinques to identify and study new hormones and their function. We believe that the majority of blood proteins are uncharacterized and that we with new proteomic and genomic techniques, we can discover and uncover new functions of previously uncharacterized hormones.
In the past years, we have identified new pathways to increase energy expenditure and improve metabolic health, including the discovery of Slit2-C, a fragment of a secreted factor. Our long-term goal is to translate these biological findings into protein therapeutics or biomarkers of metabolic disease.