Current Research and Scholarly Interests
My laboratory studies how oncogenes such as MYC initiate and maintain cancer. In particular we have shown that shutting down oncogenes even for a brief time can reverse cancer or elicit "Oncogene Addiction"
For a recent review of our work please see: The MYC oncogene - the grand orchestrator of cancer growth and immune evasion Nature Reviews Clinical Oncology, 2022
Examples of project in my laboraory:
We are studying basic mechanisms of Oncogene Addiction: the role of Self-renewal/Stemness, Metabolism, Host Immune System, Protein
Biogenesis, Microbiome, Extracellular Vesicles.
We are developing novel therapeutics using small molecules, nanoparticles, proteins/peptides that can be used to target oncogenes and/or restore the immune response against cancer.
We are developing new diagnostic and imaging methods such as PET, Mass Spec, Nanoproteomics.