Bio
My research interests are focused on developing novel methods for detecting, monitoring, and treating hematologic malignancies; particularly non-Hodgkin lymphomas (NHLs). I aim to create tools to rapidly detect and quantify tumors and their response to chemotherapy and immunotherapy, thereby enabling personalized therapies. Toward this end, I utilize tools from a wide range of disciplines, including bioengineering, computational biology, and medical oncology. I previously implemented high-throughput sequencing of the immunoglobulin genes from plasma cell-free DNA for detection of diffuse large B cell and follicular lymphomas (DLBCL and FL), the two most common types of lymphoma. This work demonstrated the superior efficacy of this assay from cell-free DNA as compared to circulating white blood cells, and has led to its translation to the clinic. Recently, I have implemented targeted next-generation sequencing for ultra-sensitive detection of circulating tumor DNA utilizing Cancer Personalized Profiling by Deep Sequencing, or CAPP-Seq, for use in NHLs. This work has led to a number of important applications in the field, including early detection of disease relapse, non-invasive genotyping of tumors, and detection of transformation of follicular lymphoma into DLBCL.
Clinical Focus
- Medical Oncology
Honors & Awards
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Physician-Scientist Training Award, Damon Runyon Cancer Research Foundation (2016-2018)
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Åke Bertil Eriksson Endowed Young Investigator Award, ASCO Conquer Cancer Foundation (2016)
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Lymphoma Clinical Research Mentoring Program Scholar, Lymphoma Research Foundation (2014)
Professional Education
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PhD, Stanford University, Bioengineering (2018)
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Fellowship: Stanford University Hematology and Oncology Fellowship (2018) CA
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Fellowship: Stanford University Hematology and Oncology Fellowship (2017) CA
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Board Certification: American Board of Internal Medicine, Medical Oncology (2016)
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Board Certification: American Board of Internal Medicine, Internal Medicine (2012)
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Residency: Stanford University Internal Medicine Residency (2011) CA
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Medical Education: Mayo Clinic School of Medicine (2009) MN