Clinical Focus

  • Pathology
  • Anatomic and Clinical Pathology

Academic Appointments

Professional Education

  • Residency:Stanford University School of Medicine Registrar (1997) CA
  • Fellowship:Stanford University School of Medicine Registrar (1995) CA
  • Board Certification: Anatomic and Clinical Pathology, American Board of Pathology (1997)
  • Medical Education:Columbia University College of Physicians and Surgeons (1992) NY


All Publications

  • Double Rarities, Double Challenges: Extra-Mammary Paget's Disease and Anal Adenocarcinoma. Digestive diseases and sciences Gholami, S., Wood, L. S., Bingham, D., Kin, C. 2016; 61 (4): 996-999

    View details for DOI 10.1007/s10620-015-3819-1

    View details for PubMedID 26233548

  • Double Rarities, Double Challenges: Extra-Mammary Paget's Disease and Anal Adenocarcinoma DIGESTIVE DISEASES AND SCIENCES Gholami, S., Wood, L. S., Bingham, D., Kin, C. 2016; 61 (4): 996-999
  • Gastric Outlet Obstruction Caused by Heterotopic Pancreas in an Adolescent DIGESTIVE DISEASES AND SCIENCES Rodriguez, A. A., Berquist, W., Bingham, D. 2015; 60 (4): 835-837

    View details for DOI 10.1007/s10620-014-3314-0

    View details for Web of Science ID 000354464900010

    View details for PubMedID 25107445

  • Molecular assessment of surgical-resection margins of gastric cancer by mass-spectrometric imaging. Proceedings of the National Academy of Sciences of the United States of America Eberlin, L. S., Tibshirani, R. J., Zhang, J., Longacre, T. A., Berry, G. J., Bingham, D. B., Norton, J. A., Zare, R. N., Poultsides, G. A. 2014; 111 (7): 2436-2441


    Surgical resection is the main curative option for gastrointestinal cancers. The extent of cancer resection is commonly assessed during surgery by pathologic evaluation of (frozen sections of) the tissue at the resected specimen margin(s) to verify whether cancer is present. We compare this method to an alternative procedure, desorption electrospray ionization mass spectrometric imaging (DESI-MSI), for 62 banked human cancerous and normal gastric-tissue samples. In DESI-MSI, microdroplets strike the tissue sample, the resulting splash enters a mass spectrometer, and a statistical analysis, here, the Lasso method (which stands for least absolute shrinkage and selection operator and which is a multiclass logistic regression with L1 penalty), is applied to classify tissues based on the molecular information obtained directly from DESI-MSI. The methodology developed with 28 frozen training samples of clear histopathologic diagnosis showed an overall accuracy value of 98% for the 12,480 pixels evaluated in cross-validation (CV), and 97% when a completely independent set of samples was tested. By applying an additional spatial smoothing technique, the accuracy for both CV and the independent set of samples was 99% compared with histological diagnoses. To test our method for clinical use, we applied it to a total of 21 tissue-margin samples prospectively obtained from nine gastric-cancer patients. The results obtained suggest that DESI-MSI/Lasso may be valuable for routine intraoperative assessment of the specimen margins during gastric-cancer surgery.

    View details for DOI 10.1073/pnas.1400274111

    View details for PubMedID 24550265

    View details for PubMedCentralID PMC3932851

  • Inherited pancreatic endocrine tumor syndromes: Advances in molecular pathogenesis, diagnosis, management, and controversies CANCER Jensen, R. I., Berna, M. J., Bingham, D. B., Norton, J. A. 2008; 113 (7): 1807-1843


    Pancreatic endocrine tumors (PETs) can occur as part of 4 inherited disorders, including Multiple Endocrine Neoplasia type 1 (MEN1), von Hippel-Lindau disease (VHL), neurofibromatosis 1 (NF-1) (von Recklinghausen disease), and the tuberous sclerosis complex (TSC). The relative frequency with which patients who have these disorders develop PETs is MEN1>VHL>NF-1>TSC. Over the last few years, there have been major advances in the understanding of the genetics and molecular pathogenesis of these disorders as well in the localization and the medical and surgical treatment of PETs in such patients. The study of PETs in these disorders not only has provided insights into the possible pathogenesis of sporadic PETs but also has presented several unique management and treatment issues, some of which are applicable to patients with sporadic PETs. Therefore, the study of PETs in these uncommon disorders has provided valuable insights that, in many cases, are applicable to the general group of patients with sporadic PETs. In this article, these areas are reviewed briefly along with the current state of knowledge of the PETs in these disorders, and the controversies that exist in their management are summarized briefly and discussed.

    View details for DOI 10.1002/cncr.23648

    View details for Web of Science ID 000259661800011

    View details for PubMedID 18798544

  • Splenic diffuse large B-cell lymphoma in a patient with type 1 Gaucher disease: diagnostic and therapeutic challenges ANNALS OF HEMATOLOGY Brody, J. D., Advani, R., Shin, L. K., Bingham, D. B., Rosenberg, S. A. 2006; 85 (11): 817-820

    View details for DOI 10.1007/s00277-006-0176-3

    View details for Web of Science ID 000240520100011

    View details for PubMedID 16937096