Selected Publications


Kapiloff, M.S., Farkash, Y., Wegner, M., and Rosenfeld, M.G. Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements. Science, 253: 786-789, 1991

Kapiloff, M.S., Shillace, R.V., Westphal, A.M., and Scott, J.D. mAKAP: An A-Kinase Anchoring Protein Targeted to the Nuclear Membrane of Differentiated Myocytes. Journal of Cell Science, 112: 2725-2736, 1999

Pare, G.C., Easlick, J.L., Mislow, J.M., McNally, E.M., and Kapiloff, M.S. Nesprin-1α Contributes to the Targeting of mAKAP to the Cardiac Myocyte Nuclear Envelope. Experimental Cell Research, 303: 388-399, 2005

Dodge-Kafka, K.L., Soughayer, J., Pare, G.C., Michel, J.J.C., Langeberg, L.K., Kapiloff, M.S., and Scott, J.D. The Protein Kinase A Anchoring Protein mAKAP Coordinates Two Integrated cAMP Effector Pathways. Nature, 437: 574-578, 2005. PMC1636584

Pare, G.C., Bauman, A.L., McHenry, M., Michel, J.J.C., Dodge-Kafka, K.L., and Kapiloff, M.S. The mAKAP Complex Participates in the Induction of Cardiac Myocyte Hypertrophy by Adrenergic Receptor Signaling. Journal of Cell Science, 118: 5637-5646, 2005

Kapiloff, M.S., Piggott, L.A., Sadana, R., Li, J., Heredia, L., Henson, E., Efendiav, R. and Dessauer, C.W.  An Adenylyl Cyclase-mAKAPβ Signaling Complex Regulates cAMP Levels in Cardiac Myocytes. Journal of Biological Chemistry, 284 (35): 23540-23546, 2009, PMC2749128.

Li, J., Negro, A., Lopez, J., Bauman, A.L., Henson, E., Dodge-Kafka, K.L., and Kapiloff, M.S. The mAKAPβ Scaffold Regulates Cardiac Myocyte Hypertrophy via Recruitment of Activated Calcineurin, Journal of Molecular and Cellular Cardiology, 48: 387–394, 2010. PMC2813376

Dodge-Kafka, K.L., Bauman, A., Mayer, N., Henson, E., Heredia, L., Ahn, J., McAvoy, T., Nairn, A. C., and Kapiloff, M.S. cAMP-Stimulated Protein Phosphatase 2A Activity Associated with mAKAP Signaling Complexes Inhibits the Phosphorylation and Activity of the cAMP-Specific Phosphodiesterase PDE4D3, Journal of Biological Chemistry, 285 (15): 11078-11086, 2010. PMC2856983

Li, J., Kritzer, M.D., Michel, J.J., Le, A., Thakur, H., Gayanilo, M., Passariello, C.L., Negro, A., Danial, J.B., Oskouei, B., Sanders, M., Hare, J.M., Hanauer, A., Dodge-Kafka, K.L., and Kapiloff, M.S. Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy. Circulation Research, 112: 128-139, 2013. PMC3537852

Kritzer, M.D., Li, J., Passariello, C.L., Gayanilo, M., Thakur, H., Dayan, J., Dodge-Kafka, K.L., and Kapiloff, M.S. The Scaffold Protein Muscle A-Kinase Anchoring Protein β Orchestrates Cardiac Myocyte Hypertrophic Signaling Required for the Development of Heart Failure. Circulation: Heart Failure, 7 (4):663-672, 2014. PMC4277867

Passariello, C.L., Martinez, E.C., Thakur, H., Cesareo, M., Li, J., and Kapiloff, M.S. RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome, Journal of Molecular and Cellular Cardiology, 93: 98–105, 2016. PMC4846495

Dodge-Kafka, K.L., Gildart, M., Li, J., Thakur, H., and Kapiloff, M.S. Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes, Journal of Molecular and Cellular Cardiology, 118: 13-25, 2018

Boczek, T., Cameron, E.G., Yu, W., Xia, X., Shah, S.H., Chabeco, B.C., Galvao, J., Nahmou, M., Li, J., Thakur, H., Goldberg, J.L., and Kapiloff, M.S. Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment. Journal of Neuroscience,   39(28):5466-5480, 2019. PMC6616289

Li, X., Li, J., Martinez, E.C., Froese, A., Passariello, C.L., Henshaw, K., Rusconi, F., Li, Y., Yu, Q., Thakur, H., Nikolaev, V.O. and Kapiloff, M.S. Calcineurin Aβ-specific anchoring confers isoform-specific compartmentation and function in pathological cardiac myocyte hypertrophy. Circulation, 142 (10):948-962, 2020. PMC7484230 Discussed in editorial by Woulfe, et al., Circulation, 142 (10):963–966, 2020. 

Li, J., Tan, Y., Passariello, C.L., Martinez, E.C., Kritzer, M.D., Li, X., Li, X., Li, Y., Yu, Q., Ohgi, K., Thakur, H., MacArthur, Jr., J.W., Ivey, J.R., Woo, Y.J., Emter, C.A., Dodge-Kafka, K.L., Rosenfeld, M.G., and Kapiloff, M.S. Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width versus Length As a Therapeutic Target For Heart Failure. Circulation, 142 (22):2138-2154, 2020. PMC7704863

Boczek, T., Yu, Q., Zhu, Y., Dodge-Kafka, K.L., Goldberg, J.L., and Kapiloff, M.S. cAMP At Perinuclear mAKAPα Signalosomes Is Regulated By Local Ca2+ Signaling In Primary Hippocampal Neurons. eNeuro. 8(1) ENEURO.0298-20.20212021. PMC7920539

Martinez, E.C., Li, J., Ataam, J.A., Tokarski, K., Thakur, H., Karakikes, I., Dodge-Kafka, K.L. and Kapiloff, M.S. Targeting mAKAPβ Expression as a Therapeutic Approach for Ischemic Cardiomyopathy. Gene Therapy, 30(7-8):543-551, 2023. PMC9339585

Cameron, E.G., Nahmou, M., Toth, A.B., Heo, L., Dalal, R., Yan, W., Nallagatla, P., Xia, X., Hay, S., Knasel, C., Stiles, T.L., Douglas, C., Atkins, M., Tanasa, B., Sun, C. Ashouri, M., Bian, M., Chang, K-C., Russano, K., Shah, S., Woodworth, M.B., Galvao, J., Nair, R.V., Kapiloff, M.S., and Goldberg., J.L. A Molecular Switch for Neuroprotective Reactive Astrocytes, Nature, 626(7999):574-582, 2024.


Passariello, C.L., Li, J., Dodge-Kafka, K.L., and Kapiloff, M.S. mAKAP - A Master Scaffold for Cardiac Remodeling. Journal of Cardiovascular Pharmacology, 65(3):218-25, 2015. PMC4355281

Cameron, E.G. and Kapiloff M.S. Intracellular Compartmentation of cAMP Promotes Neuroprotection and Regeneration of CNS Neurons, Neural Regeneration Research, 12(2):201-202, 2017, PMC5361496

Dodge-Kafka, K., Gildart, M., Tokarski, K., and Kapiloff, M.S. mAKAPβ signalosomes – a nodal regulator of gene transcription associated with pathological cardiac remodeling. Cellular Signaling, 63: 109357, 2019.

Boczek, T., and Kapiloff, M.S. Compartmentalization of local cAMP signaling in neuronal growth and survival. Neural Regeneration Research, 15(3):453-454, 2020.


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