Selected Publications


Kapiloff, M.S., Mathis, J.M., Nelson, C.A., Lin, C.R., and Rosenfeld, M.G. Calcium/Calmodulin-Dependent Protein Kinase Mediates a Pathway for Transcriptional Regulation. Proceedings of the National Academy of Science, USA, 88: 3710-3714, 1991

Kapiloff, M.S., Farkash, Y., Wegner, M., and Rosenfeld, M.G. Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements. Science, 253: 786-789, 1991

Kapiloff, M.S., Shillace, R.V., Westphal, A.M., and Scott, J.D. mAKAP: An A-Kinase Anchoring Protein Targeted to the Nuclear Membrane of Differentiated Myocytes. Journal of Cell Science, 112: 2725-2736, 1999

Kapiloff, M.S., Jackson, N., and Airhart, N. mAKAP and the Ryanodine Receptor Are Part of a Multi-Component Signaling Complex on the Cardiomyocyte Nuclear Membrane. Journal of Cell Science, 114: 3167-3176, 2001

Pare, G.C., Easlick, J.L., Mislow, J.M., McNally, E.M., and Kapiloff, M.S. Nesprin-1α Contributes to the Targeting of mAKAP to the Cardiac Myocyte Nuclear Envelope. Experimental Cell Research, 303: 388-399, 2005

Dodge-Kafka, K.L., Soughayer, J., Pare, G.C., Michel, J.J.C., Langeberg, L.K., Kapiloff, M.S., and Scott, J.D. The Protein Kinase A Anchoring Protein mAKAP Coordinates Two Integrated cAMP Effector Pathways. Nature, 437: 574-578, 2005. PMC1636584

Pare, G.C., Bauman, A.L., McHenry, M., Michel, J.J.C., Dodge-Kafka, K.L., and Kapiloff, M.S. The mAKAP Complex Participates in the Induction of Cardiac Myocyte Hypertrophy by Adrenergic Receptor Signaling. Journal of Cell Science, 118: 5637-5646, 2005

Kapiloff, M.S.*, Piggott, L.A., Sadana, R., Li, J., Heredia, L., Henson, E., Efendiav, R. and Dessauer, C.W.* An Adenylyl Cyclase-mAKAPβ Signaling Complex Regulates cAMP Levels in Cardiac Myocytes. Journal of Biological Chemistry, 284 (35): 23540-23546, 2009, PMC2749128. *co-corresponding authors

Li, J., Negro, A., Lopez, J., Bauman, A.L., Henson, E., Dodge-Kafka, K.L., and Kapiloff, M.S. The mAKAPβ Scaffold Regulates Cardiac Myocyte Hypertrophy via Recruitment of Activated Calcineurin, Journal of Molecular and Cellular Cardiology, 48: 387–394, 2010. PMC2813376

Dodge-Kafka, K.L., Bauman, A., Mayer, N., Henson, E., Heredia, L., Ahn, J., McAvoy, T., Nairn, A. C., and Kapiloff, M.S. cAMP-Stimulated Protein Phosphatase 2A Activity Associated with mAKAP Signaling Complexes Inhibits the Phosphorylation and Activity of the cAMP-Specific Phosphodiesterase PDE4D3, Journal of Biological Chemistry, 285 (15): 11078-11086, 2010. PMC2856983

Li, J., Kritzer, M.D., Michel, J.J., Le, A., Thakur, H., Gayanilo, M., Passariello, C.L., Negro, A., Danial, J.B., Oskouei, B., Sanders, M., Hare, J.M., Hanauer, A., Dodge-Kafka, K.L., and Kapiloff, M.S. Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy. Circulation Research, 112: 128-139, 2013. PMC3537852

Passariello, C.L., Gayanilo, M., Kritzer, M.D., Thakur, H., Cozacov, Z., Rusconi, F., Wieczorek, D., Sanders, M., Li, J., and Kapiloff, M.S. p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in α-tropomyosin Glu180Gly transgenic mice. American Journal of Physiology – Heart and Circulatory Physiology, 305 (7): H1010-H1019, 2013. PMC3798750. Featured in a podcast:

Kritzer, M.D., Li, J., Passariello, C.L., Gayanilo, M., Thakur, H., Dayan, J., Dodge-Kafka, K.L., and Kapiloff, M.S. The Scaffold Protein Muscle A-Kinase Anchoring Protein β Orchestrates Cardiac Myocyte Hypertrophic Signaling Required for the Development of Heart Failure. Circulation: Heart Failure, 7 (4):663-672, 2014. PMC4277867

Wang, Y., Cameron, E.G., Li, J., Stiles, T.L., Kritzer, M.D., Lodhavia, R., Hertz, J., Nguyen, T., Kapiloff, M.S.,* and Goldberg, J.L.* Muscle A-Kinase Anchoring Protein-α is an injury- specific signaling scaffold required for neurotrophic- and cyclic adenosine monophosphate- mediated survival. EBioMedicine, 2 (12):1880-1887, 2015. PMC4703706 *co- corresponding authors

Passariello, C.L., Martinez, E.C., Thakur, H., Cesareo, M., Li, J., and Kapiloff, M.S. RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome, Journal of Molecular and Cellular Cardiology, 93: 98–105, 2016. PMC4846495

Shaw, P.X., Fang, J., Sang, A., Wang, Y., Kapiloff, M.S.,* and Goldberg, J.L.* Soluble adenylyl cyclase is required for retinal ganglion cell and photoreceptor differentiation. Investigative Ophthalmology and Visual Science, 57(11):5083-5092, 2016. PMC5053116 *co-corresponding authors

Dodge-Kafka, K.L., Gildart, M., Li, J., Thakur, H., and Kapiloff, M.S. Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes, Journal of Molecular and Cellular Cardiology, 118: 13-25, 2018

Boczek, T., Cameron, E.G., Yu, W., Xia, X., Shah, S.H., Chabeco, B.C., Galvao, J., Nahmou, M., Li, J., Thakur, H., Goldberg, J.L., and Kapiloff, M.S. Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment. Journal of Neuroscience,   39(28):5466-5480, 2019. PMC6616289

Li, X., Li, J., Martinez, E.C., Froese, A., Passariello, C.L., Henshaw, K., Rusconi, F., Li, Y., Yu, Q., Thakur, H., Nikolaev, V.O. and Kapiloff, M.S. Calcineurin Aβ-specific anchoring confers isoform-specific compartmentation and function in pathological cardiac myocyte hypertrophy. Circulation, 142 (10):948-962, 2020. PMC7484230 Discussed in editorial by Woulfe, et al., Circulation, 142 (10):963–966, 2020. 

Li, J., Tan, Y., Passariello, C.L., Martinez, E.C., Kritzer, M.D., Li, X., Li, X., Li, Y., Yu, Q., Ohgi, K., Thakur, H., MacArthur, Jr., J.W., Ivey, J.R., Woo, Y.J., Emter, C.A., Dodge-Kafka, K.L., Rosenfeld, M.G., and Kapiloff, M.S. Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width versus Length As a Therapeutic Target For Heart Failure. Circulation, 142 (22):2138-2154, 2020. PMC7704863

Boczek, T., Yu, Q., Zhu, Y., Dodge-Kafka, K.L., Goldberg, J.L., and Kapiloff, M.S. cAMP At Perinuclear mAKAPα Signalosomes Is Regulated By Local Ca2+ Signaling In Primary Hippocampal Neurons. eNeuro. 8(1) ENEURO.0298-20.20212021.


Kritzer, M.D., Li, J., Dodge-Kafka, K.L., and Kapiloff, M.S. AKAPs: The Architectural Underpinnings of Local cAMP signaling. Journal of Molecular and Cellular Cardiology, 52 (2): 351-358, 2012. PMC3168680

Passariello, C.L., Li, J., Dodge-Kafka, K.L., and Kapiloff, M.S. mAKAP - A Master Scaffold for Cardiac Remodeling. Journal of Cardiovascular Pharmacology, 65(3):218-25, 2015. PMC4355281

Martinez, E.C., Passariello, C.L., Li, J., Matheson, C.J, Dodge-Kafka, K.L., Reigan, P., and Kapiloff, M.S. RSK3 – A Regulator of Pathological Cardiac Remodeling, IUBMB Life, 67(5):331-7, 2015. PMC4449288

Kapiloff, M.S. and Emter, C. The Cardiac Enigma: Current Conundrums in Heart Failure
Research. F1000 Research, 5(F1000 Faculty Rev):72, 2016. Doi: 10.12688/f1000research.7278.1 PMC4754052

Cameron, E.G. and Kapiloff M.S. Intracellular Compartmentation of cAMP Promotes Neuroprotection and Regeneration of CNS Neurons, Neural Regeneration Research, 12(2):201-202, 2017, PMC5361496

Dodge-Kafka, K., Gildart, M., Tokarski, K., and Kapiloff, M.S. mAKAPβ signalosomes – a nodal regulator of gene transcription associated with pathological cardiac remodeling. Cellular Signaling, 63: 109357, 2019.

Boczek, T., and Kapiloff, M.S. Compartmentalization of local cAMP signaling in neuronal growth and survival. Neural Regeneration Research, 15(3):453-454, 2020.


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