Inclusion:

   - Patient resectable muscle-invasive bladder cancer with clinical stage T2-T4aN0/1M0
   with transitional and mixed transitional cell histology

   - Patients must be planning to undergo a radical cystectomy

   - Patients who have not received prior systemic chemotherapy or immunotherapy for
   treatment of MIBC

   - ECOG performance status of 0 or 1

   - Must have a life expectancy of at least 12 weeks at randomization

Exclusion:

   - Evidence of lymph node (N2-N3) or metastatic (M1) disease at time of screening.

   - Prior pelvic radiotherapy treatment within 2 years of randomization to study

   - Prior exposure to immune-mediated therapy (with exclusion of Bacillus-Calmette Guerin
   [BCG]), including but not limited to other anti-CTLA-4, anti-PD-1, anti PD-L1, or
   anti-PD-L2 antibodies.

   - Current or prior use of immunosuppressive medication within 14 days before the first
   dose of investigational product (IP). The following are exceptions to this criterion:
   Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra
   articular injection); Systemic corticosteroids at physiologic doses not to exceed 10
   mg/day of prednisone or its equivalent; Steroids as premedication for hypersensitivity
   reactions (eg, CT scan premedication)

   - Receipt of live attenuated vaccine within 30 days prior to the first dose of IP.

   - Uncontrolled intercurrent illness

   - Active infection including Tuberculosis, Hepatitis B, Hepatitis C, and Human
   Immunodeficiency