We are interested in creating new molecular imaging tools to study biomolecules in living subjects. This entails the creation of new optical imaging instrumentation, synthesis of new molecular imaging agents, and the validation of these tools on diseased animal models.

Virtual Biopsy using OCT

We have developed a method to turn in-vivo OCT images into virtual H&E images using Machine Learning, enabling true non-invasive virtual biopsy.  In this method, OCT images of living tissues are co-registered with the corresponding H&E image of the same tissue to train a conditional generative adversarial network to convert one to the other.  This allows us to generate accurate three-dimensional high-resolution completely-virtual H&E images of living tissues.

Click to enlarge

Molecular Ocular Imaging

We pioneered a molecular imaging technique based on optical coherence tomography (OCT) where nanoparticles that scatter light produce a spectral OCT signal that can be mapped on a high-resolution anatomical OCT image of live tissues.  This allowed us to image molecular markers at a single cell resolution in living subjects, visualizing molecular cell-cell interactions and tissue heterogeneity.

Click to enlarge