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The Effect of Exercise on Muscle Dysfunction in Cystinosis
Recruiting
I'm InterestedTrial ID: NCT04071548
Purpose
Classification of activity tolerance is of importance in chronic progressive myopathies, not
only to better understand functional implications of the disease state itself, but also for
purposes of exercise prescription for health maintenance. Maximal exercise testing has been
considered as the gold standard of assessing maximal aerobic capacity, however testing in
individuals with neuromuscular disease is often limited due to pain, activity intolerance,
musculoskeletal impairments, fatigue and other such related variables. Often, submaximal
exercise testing can overcome some of these obstacles, and as such, is used frequently in the
clinical environment. Non-ambulatory exercise testing utilizing an arm ergometer specifically
has not been studied as heavily, especially in those with progressive myopathies. For this
study, we will use maximal aerobic capacity testing for individuals with Cystinosis Myopathy
utilizing a bike ergometer to allow testing of individuals regardless of their ambulatory
status.
Official Title
The Effect of Exercise on Muscle Dysfunction in Cystinosis
Stanford Investigator(s)
Richard J. Reimer, MD
Associate Professor of Neurology (Adult Neurology) and, by courtesy, of Molecular and Cellular Physiology
Eligibility
Inclusion Criteria:
>=18 years -<= 60 years male or female with documented diagnosis of Cystinosis
Exclusion Criteria:
All Cystinosis participants:
- female subject who is known or suspected to be pregnant
- excluded for other illnesses or medications that may impact growth, nutritional
status, development, or bone health unrelated to cystinosis
Exercise intervention:
- exercise limitation due to pre-existing heart disease
- individuals on medications that limit heart rate (beta adrenergic blockers)
- unable to plantar flex or dorsiflex ankle against resistance
- unable to use pedal ergometer
Intervention(s):
other: HIIT Exercise
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Tina Duong, MPT, PHDc
703-855-9677