FEATURED PUBLICATIONS

Recent Publications (2018-present)

  1. Liz J. Valente, Amy Tarangelo, Albert Mao Li, Marwan Naciri, Nitin Raj, Anthony M. Boutelle, Yang Li, Stephano Spano Mello, Kathryn Bieging-Rolett, Ralph J. DeBerardinis, Jiangbin Ye, Scott J. Dixon, Laura D. Attardi. p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen. J Cell Biol (2020) 219 (11): e201908212.DOI: 10.1083.
  2. Yiren Xiao, Kaushik N Thakkar, Hongjuan Zhao, James Broughton, Yang Li, Jose A Seoane, Anh N Diep, Thomas J Metzner, Rie von Eyben, David L Dill, James D Brooks, Christina Curtis, John T Leppert, Jiangbin Ye, Donna M Peehl, Amato J Giaccia, Subarna Sinha, Erinn B Rankin. The m 6 A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. PNAS 2020 Aug 19 DOI: 10.1073/pnas.200516117. PMID: 32817424
  3. Albert M. Li and Jiangbin Ye. Reprogramming of serine, glycine and one-carbon metabolism in cancer. Biochimica et biophysica acta. Molecular basis of disease. 2020 May DOI: 10.1016/j.bbadis.2020.1655841
  4. Albert M. Li and Jiangbin Ye. The PHGDH enigma: do cancer cells only need serine or also a redox modulator? Cancer Letters 2020 Feb 4 DOI: 10.1016/j.canlet2020.01.036. PMID: 32032680.
  5. Yang Li, Joshua J. Gruber, Ulrike M. LitzenburgerYiren Zhou, Yu Rebecca Miao, Edward L. LaGory, Albert M. Li, Zhen Hu, Lori S. Hart, John M. Maris, Howard Y. Chang, Amato J. Giaccia, Jiangbin Ye. Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia.  Cell Death & Disease 2020 Feb 6;11(2):102 DOI: 10.1038/s41419-020-2303-9 PMCID: PMC7005271.
  6. Albert M. Li, Gregory S. Ducker, Yang Li, Jose A. Seoane, Yiren Xiao, Stavros Melemenidis, Yiren Zhou, Ling Liu, Sakari Vanharanta, Edward E. Graves, Erinn B. Rankin, Christina Curtis, Joan Massagué, Joshua D. Rabinowitz, Craig B. Thompson*, Jiangbin Ye*.  Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Molecular Cancer Research 2020 Jan 15 DOI: 10.1158/1541-7786.MCR-19-0606. PMID: 31941752 *Co-corresponding author.
  7. Feven Tameire, Ioannis I. Verginadis, Nektaria Maria Leli, Christine Polte, Crystal S. Conn , Rani Ojha, Carlo Salas Salinas, Frank Chinga, Alexandra. M. Monroy, Weixuan Fu , Paul Wang , Andrew Kossenkov, Jiangbin Ye, Ravi K. Amaravadi, Zoya Ignatova, Serge Y. Fuchs, J. Alan Diehl , Davide Ruggero and Constantinos Koumenis . ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature Cell Biology. volume 21, pages 889–899 (2019) PMCID: PMC6608727.
  8. Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D. Attardi, and Scott J. Dixon. P53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. Cell Reports. 2018 January 16;22(3):569-575.

Previous Publications   

  1. Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis and Craig B. Thompson. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes & Development 2015. 29:2331-2336.
  2. Jiangbin Ye, Jing Fan, Sriram Venneti, Ying-Wooi Wan, Bruce R. Pawel, Ji Zhang, Lydia W.S. Finley, Chao Lu, Tullia Lindsten, Justin Cross, Guoliang Qing, Zhandong Liu, M. Celeste Simon, Joshua D. Rabinowitz, and Craig B. Thompson. Serine catabolism regulates mitochondrial redox control during hypoxia.  Cancer Discovery. 2014 Sep 3. pii: CD-14-0250. 
  3. Jing Fan, Jiangbin Ye, Jurre J. Kamphorst, Tomer Shlomi, Craig B. Thompson, and Joshua D. Rabinowitz.  Quantitative flux analysis reveals folate-dependent NADPH production. Nature 2014 Jun 12;510(7504):298-302.
  4. Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Patrick S. Ward, Jing Fan, Joshua D. Rabinowitz and Craig B. Thompson. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. PNAS 2012 May 1;109(18):6904-9
  5.  Ye, J., Kumanova, M., Hart, L.S., Sloane, K., Zhang, H., De Panis, D.N., Bobrovnikova-Marjon, Diehl, J.A., Ron, D., Koumenis, C. The GCN2-ATF4 pathway is critical for tumor cell survival and proliferation in response to nutrient deprivation. EMBO Journal2010;29 (12):2082-2096