FEATURED PUBLICATIONS
2024
Albert M. Li and Jiangbin Ye. Deciphering the Warburg effect: Metabolic Reprogramming, Epigenetic Remodeling, and Cell Dedifferentiation. Annual Review of Cancer Biology 2024.
Bo He, Lauren Stoffel, Clifford He, Kumsun Cho, Albert Li, Haowen Jiang, Brittany Flowers, Kha The Nguyen, Kelly Wen Wang, Audrey Yixin Zhao, Meng-Ning Zhou, Sofia Ferreira, Laura Attardi, Jiangbin Ye. Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state. Cell Death & Dis. 2024 Jan 26;15(1), 89. PMCID: PMC10810848
Haowen Jiang, Mohamed Jedoui and Jiangbin Ye. The Warburg effect drives dedifferentiation through epigenetic reprogramming. Cancer Biology & Medicine. 2024 (Editorial)
2022-2023
Dimitris Karagiannis, Warren Wu, Albert Li, Makiko Hayashi, Xiao Chen, Michaela Yip, Vaibhav Mangipudy, Xinjing Xu, Francisco J Sánchez-Rivera, Yadira M Soto-Feliciano, Jiangbin Ye, Thales Papagiannakopoulos, Chao Lu. Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors. Cell Rep. 2024 Jan 23;43(1):113629. PMCID: 38165806
Albert M. Li*, Bo He*, Dimitris Karagiannis, Yang Li, Haowen Jiang, Preethi Srinivasan, Yaniel Ramirez, Meng-Ning Zhou, Christina Curtis, Joshua J. Gruber, Chao Lu, Erinn B. Rankin, Jiangbin Ye. Serine starvation silences estrogen receptor signaling through histone hypoacetylation. PNAS 2023 Sep 19;120(38):e2302489120. PMID: 37695911 *Equal contribution.
Haowen Jiang, Clifford Jiajun He, Albert M. Li, Bo He, Yang Li, Meng-Ning Zhou, Jiangbin Ye. Mitochondrial uncoupling inhibits reductive carboxylation in cancer cells. Mol Cancer Res. 2023 Jun 26;MCR-23-0049. PMID: 37358566.
Duo Zhang, Albert Li, Menggui Huang, Lin Zhang, Kathryn Wellen, Xiaowei Xu, Crystal Conn, Wei Zou, Mark Kahn, Seth Rhoades, Aalim Weljie, Nduka Amankulor, Daniel Yoshor, Jiangbin Ye, Constantinos Koumenis, Yanqing Gong, Yi Fan. PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. Cell Metabolism. 2023 Mar 7;35(3):517-534.e8. PMID: 36804058.
Pingting Liu, Wei Chen, Haowen Jiang*, Haoliang Huang, Liping Liu, Fang Fang, Liang Li, Xue Feng, Dong Liu, Roopa Dalal, Yang Sun, Paymaan Jafar-Nejad, Karen Ling, Frank Rigo, Jiangbin Ye, Yang Hu. Differential Effects of SARM1 Inhibition in Traumatic Glaucoma and EAE Optic Neuropathies. Molecular Therapy-Nucleic Acids. 2023 Feb 27;32:13-27. PMID 36950280. *co-first author.
Fan Yang, Duo Zhang, Haowen Jiang, Jiangbin Ye, Lin Zhang, Stephen J Bagley, Jeffery Winkler, Yanqing Gong, Yi Fan. Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Science Translational Medicine 2023 Feb 15;15(683):eabq3558. PMID: 36791206.
Haowen Jiang, Rachel Greathouse, Sarah J. Tiche, Man Zhao, Bo He, Yang Li, Albert M. Li, Balint Forgo, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos, Meng-Ning Zhou, Joshua J. Gruber, Erinn B. Rankin, Zhen Hu, Hiroyuki Shimada, Bill Chiu, Jiangbin Ye. Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma. Cancer Research. 2023 Jan 18;83(2):346. PMID: 36651077.
Haowen Jiang, Albert M. Li, Jiangbin Ye. The magic bullet: Niclosamide. (Review) Frontiers Onology. 2022 Nov 21;12:1004978. PMID: 36479072
Sooyeon Lee, Haixia Xu, Aidan Van Vleck, Alex M. Mawla, Albert Mao Li, Jiangbin Ye, Mark O. Huising, Justin P. Annes. β-cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes. Diabetes. 2022 Jul1;71(7):1439-1453. PMID: 35472723.
Ioannis I Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V Karagounis, Brett I Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S Wu, Yang Li, Jiangbin Ye, David A Scott, Andrei L Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W Tobias, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G Hatzigeorgiou, Sandra Ryeom, J Alan Diehl, Serge Y Fuchs, Ellen Puré, Constantinos Koumenis. A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression. Nature Cell Biology. 2022 Jun;24(6):940-953. PMID: 35654839.
Vignesh Viswanathan, Hongbin Cao, Julie Saiki, Dadi Jiang, Aaron Mattingly, Dhanya Nambiar, Joshua Bloomstein, Yang Li, Sizun Jiang, Manish Chamoli, Davud Sirjani, Michael Kaplan, F Christopher Holsinger, Rachel Liang, Rie Von Eyben, Haowen Jiang, Li Guan, Edward Lagory, Zhiping Feng, Garry Nolan, Jiangbin Ye, Nicholas Denko, Sarah Knox, Daria-Mochly Rosen, Quynh-Thu Le. Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype. PNAS nexus. 2022 Jun9;1(2):pgac056 PMID: 35707206.
Fang F, Zhuang P, Feng X, Liu P, Liu D, Huang H, Li L, Chen W, Liu L, Sun Y, Jiang H, Ye J, Hu Y. NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function. Mol Ther. 2022 Apr 6;30(4):1421-1431. PMID: 35114390
2020-2021
Albert M. Li, Yang Li, Bo He, Haowen Jiang, Yaniel Ramirez, Meng-Ning Zhou, Chao Lu, Joshua J. Gruber, Erinn B. Rankin, Jiangbin Ye. Serine starvation silences estrogen receptor signaling through histone hypoacetylation. bioRxiv 2021.09.05. doi: https://doi.org/10.1101/2021.09.05.459037
Gentaro Ikeda, Michelle R. Santoso, Yuko Tada, Albert M. Li, Evgeniya Vaskova, Ji-Hye Jung, Connor O’Brien, Elizabeth Egan, Jiangbin Ye, and Phillip C. Yang. Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium. Journal of American College of Cardiology. 2021 Mar 2;77(8) 1073-1088. PMID: 33632482.
Dhanir Tailor, Catherine C. Going, Angel Resendez, Vineet Kumar, Dhanya K. Nambiar, Yang Li, Edward Lewis LaGory, Ali Ghoochani, Alisha M. Birk, Tanya Stoyanova, Jiangbin Ye*, Amato J. Giaccia, Quynh-Thu Le, Rana P. Singh, George W. Sledge, Sharon J. Pitteri, Sanjay V. Malhotra. Novel Aza-podophyllotoxin Derivative Induces Oxidative Phosphorylation and Cell Death via Direct AMPK Activation in Triple Negative Breast Cancer. British Journal of Cancer. 2021 Feb;124(3):604-615. PMID: 33139797.
Liz J. Valente, Amy Tarangelo, Albert Mao Li, Marwan Naciri, Nitin Raj, Anthony M Boutelle, Yang Li, Stephano Spano Mello, Kathryn Bieging-Rolett, Ralph J. DeBerardinis, Jiangbin Ye*, Scott J. Dixon, and Laura D. Attardi. p53 Deficiency Drives Pleiotropic Changes in Cell Behavior. Journal of Cell Biology. 2020 Nov 2;219(11):e201908212. PMID: 32886745.
Albert M. Li and Jiangbin Ye. Reprogramming of serine, glycine and one-carbon metabolism in cancer. Biochim Biophys Acta Mol Basis Dis. (Review). 2020 Oct 1;1866(10):165841. PMID: 32439610.
Yiren Xiao, Kaushik N Thakkar, Hongjuan Zhao, James Broughton, Yang Li, Jose A Seoane, Anh N Diep, Thomas J Metzner, Rie von Eyben, David L Dill, James D Brooks, Christina Curtis, John T Leppert, Jiangbin Ye, Donna M Peehl, Amato J Giaccia, Subarna Sinha, Erinn B Rankin. The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21441-21449. PMID: 32817424.
Albert M. Li, Gregory S. Ducker, Yang Li, Jose A. Seoane, Yiren Xiao, Stavros Melemenidis, Yiren Zhou, Ling Liu, Sakari Vanharanta, Edward E. Graves, Erinn B. Rankin, Christina Curtis, Joan Massagué, Joshua D. Rabinowitz, Craig B. Thompson*, Jiangbin Ye*. Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Molecular Cancer Research. 2020 Apr;18(4):599-611. PMID: 31941752. *Equal Contribution.
Yang Li, Joshua J. Gruber, Ulrike M. Litzenburger, Yiren Zhou, Yu Rebecca Miao, Edward L. LaGory, Albert M. Li, Zhen Hu, Lori S. Hart, John M. Maris, Howard Y. Chang, Amato J. Giaccia, Jiangbin Ye. Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. Cell Death & Disease 2020 Feb 6;11(2):102 DOI: 10.1038/s41419-020-2303-9 PMCID: PMC7005271.
Albert M. Li and Jiangbin Ye. The PHGDH enigma: do cancer cells only need serine or also a redox modulator? Cancer Letters 2020 Feb 4 DOI: 10.1016/j.canlet2020.01.036. PMID: 32032680.
2018-2019
Feven Tameire, Ioannis I. Verginadis, Nektaria Maria Leli, Christine Polte, Crystal S. Conn , Rani Ojha, Carlo Salas Salinas, Frank Chinga, Alexandra. M. Monroy, Weixuan Fu , Paul Wang , Andrew Kossenkov, Jiangbin Ye*, Ravi K. Amaravadi, Zoya Ignatova, Serge Y. Fuchs, J. Alan Diehl , Davide Ruggero and Constantinos Koumenis . ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature Cell Biology. 2019 Aug;21(8):1052. PMID: 31316187
Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye*, Laura D. Attardi, Scott J. Dixon. p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. Cell Reports. 2018 Jan 16;22(3):569-575. PMID: 29346757
2010-2015
Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis and Craig B. Thompson. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes & Development 2015 Nov 15; 29(22):2331-6 PMID: 26543160.
Jiangbin Ye#, Jing Fan#, Sriram Venneti, Ying-Wooi Wan, Bruce R. Pawel, Ji Zhang, Lydia W.S. Finley, Chao Lu, Tullia Lindsten, Justin Cross, Guoliang Qing, Zhandong Liu, M. Celeste Simon, Joshua D. Rabinowitz, and Craig B. Thompson. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discovery. 2014 Dec;4(12):1406-17. PMID: 25186948. #Equal contribution.
Jing Fan#, Jiangbin Ye#, Jurre J. Kamphorst, Tomer Shlomi, Craig B. Thompson, and Joshua D. Rabinowitz. Quantitative flux analysis reveals folate-dependent NADPH production. Nature 2014 Jun 12;510(7504):298-302 PMID: 24805240. #Equal contribution.
Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Patrick S. Ward, Jing Fan, Joshua D. Rabinowitz and Craig B. Thompson. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. PNAS 2012 May 1;109(18):6904-9 PMID: 22509023.
Jiangbin Ye, Monika Kumanova, Lori S Hart, Kelly Sloane, Haiyan Zhang, Diego N. De Panis, Ekaterina Bobrovnikova-Marjon, Alan Diehl, David Ron and Constantinos Koumenis. The GCN2-ATF4 pathway is critical for tumor cell survival and proliferation in response to nutrient deprivation. EMBO J 2010 Jun 16;29(12):2082-96 PMID: 20473272.
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