FEATURED PUBLICATIONS

  1. Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis and Craig B. Thompson. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes & Development 2015. 29:2331-2336.
  2. Jiangbin Ye, Jing Fan, Sriram Venneti, Ying-Wooi Wan, Bruce R. Pawel, Ji Zhang, Lydia W.S. Finley, Chao Lu, Tullia Lindsten, Justin Cross, Guoliang Qing, Zhandong Liu, M. Celeste Simon, Joshua D. Rabinowitz, and Craig B. Thompson. Serine catabolism regulates mitochondrial redox control during hypoxia.  Cancer Discovery. 2014 Sep 3. pii: CD-14-0250. 
  3. Jing Fan, Jiangbin Ye, Jurre J. Kamphorst, Tomer Shlomi, Craig B. Thompson, and Joshua D. Rabinowitz.  Quantitative flux analysis reveals folate-dependent NADPH production. Nature 2014 Jun 12;510(7504):298-302.
  4. Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Patrick S. Ward, Jing Fan, Joshua D. Rabinowitz and Craig B. Thompson. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. PNAS 2012 May 1;109(18):6904-9
  5.  Ye, J., Kumanova, M., Hart, L.S., Sloane, K., Zhang, H., De Panis, D.N., Bobrovnikova-Marjon, Diehl, J.A., Ron, D., Koumenis, C. The GCN2-ATF4 pathway is critical for tumor cell survival and proliferation in response to nutrient deprivation. EMBO Journal2010;29 (12):2082-2096