2019

Oh Y, Park Y, Cho JH, Wu H, Paulk NK, Liu LX, Kim N, Kay MA, Wu JC, Lin MZ. An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging. Nature Chemical Biology 2019;15(5):433-436. PMID: 30936501. PMCID: 6563924

Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. A premature termination codon mutation in MYBPC3 causes hypertrophic cardiomyopathy via chronic activation of nonsense-mediated decay. Circulation 2019;139(6):799-811. PMID: 30586709.  PMCID: 1512906

Tada Y, Heidary S, Tachibana A, Zaman J, Neofytou E, Dash R, Wu JC, Yang PC. Myocardial viability of the peri-infarct region measured by T1 mapping post manganese-enhanced MRI correlates with LV dysfunction. International Journal of Cardiology 2019;281:8-14. PMCID: 30739802. PMCID: 64334939

Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC. A human iPSC double-reporter system enables purification of cardiac lineage subpopulations with distinct function and drug response profiles. Cell Stem Cell 2019;24(5):802-811. PMID: 30880024. PMCID: 6499654

Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC. Human induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in breast cancer patients. Circulation 2019;139(21):2451-2465. PMID: 30866650. PMCID: 6528817

Guo H, Tian L, Zhang JZ, Kitani T, Paik DT, Lee WH, Wu JC. Single-cell RNA sequencing of human embryonic stem cell differentiation delineates adverse effects of nicotine on embryonic development. Stem Cell Reports 2019;12(4):772-786. PMID: 30827876. PMCID: 6449785

Blinova K, Schocken D, Patel D, Daluwatte C, Vicente J, Wu JC, Strauss DG. Clinical trial in a dish: personalized stem cell derived cardiomyocyte assay compared to clinical trial results for two QT prolonging drugs. Clinical Translational Science 2019;12(6):687-697. PMID: 31328865. PMCID: 6853144

Zhang H, Tian L, Shen M, Tu C, Wu H, Gu M, Paik DT, Wu JC. Generation of quiescent cardiac fibroblasts from human induced pluripotent stem cells for in vitro modeling of cardiac fibrosis. Circulation Research 2019;125(5):552-566. PMID: 31288631. PMCID: 6768436

Goodyer WR, Beyersdorf BM, Paik DT, Tian L, Li G, Buikema JW, Chirikian O, Choi S, Venkatraman S, Adams EL, Tessier-Lavigne M, Wu JC, Wu SM. Transcriptomic profiling of the developing cardiac conduction system at single-cell resolution. Circulation Research 2019;125(4):379-397. PMID: 31284824. PMCID: 6675655

Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. Journal of Physiology 2019;597(17):4533-4564. PMID: 31278749. PMCID: 6767694

Sass G, Madigan RT, Joubert LM, Bozzi A, Sayed N, Wu JC, Stevens DA. A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruzi infection of human stem cell-derived cardiomyocytes. American Journal of Tropical Medicine and Hygiene 2019;101(2):383-391. PMID: 31219005. PMCID: 6685576

Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC. Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. European Heart Journal 2019; 40(45):3685-3695. PMID: 31219556.

Belbachir N, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo H, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S, Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Baró I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S. RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome. European Heart Journal 2019; 40(37):3081-3094. PMID: 31114854

Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko J, Chaudhary R, Yi SA, Nam KH, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature 2019;572(7769):335-340. PMID: 31316208. PMCID: 6779479

266) Li G, Tian L, Goodyer W, Kort EJ, Buikema JW, Xu A, Wu JC, Jovinge S, Wu SM. Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development. Development 2019;146(12). pii: dev173476. PMID: 31142541. PMCID: 6602356

Bozzi A, Sayed N, Matsa E, Sass G, Neofytou E, Clemons KV, Correa-Oliveira R, Stevens DA, Wu JC. Using human induced pluripotent stem cell-derived cardiomyocytes as a model to study Trypanosoma cruzi infection. Stem Cell Reports 2019;12(6):1232-1241. PMID: 31105048. PMCID: 6565757

Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. Modeling cardiovascular risks of E-cigarettes with human-induced pluripotent stem cell-derived endothelial cells. Journal American College Cardiology 2019;73(21):2722-2737. PMID: 31146818. PMCID: 6637948 (*Covered by Yahoo, CNN, Fox Business, The Sun, CBS New York, CBS Bay Area, San Francisco Chronicle, and other major news outlet) (Editor-in-Chief’s Top Picks From 2019)

Ebert A, Joshi AU, Andorf S, Dai Y, Sampathkumar S, Chen H, Li Y, Garg P, Toischer K, Hasenfuss G, Mochly-Rosen D, Wu JC. Proteasome-dependent regulation of distinct metabolic states during long-term culture of human iPSC-derived cardiomyocytes. Circulation Research 2019;125(1):90-103. PMID: 31104567. PMCID: 6613799

Lam CK, Tian L, Belbachir N, Wnorowski A, Shrestha R, Ma N, Kitani T, Rhee JW, Wu JC. Identifying the transcriptome signatures of calcium channel blockers in human induced pluripotent stem cell-derived cardiomyocytes. Circulation Research 2019;125(2):212-222. PMID: 31079550. PMCID: 6610656

Sass G, Tsamo AT, Chounda GAM, Nangmo PK, Sayed N, Bozzi A, Wu JC, Nkengfack AE, Stevens DA. Vismione B interferes with Trypanosoma cruzi infection of Vero cells and human stem cell-derived cardiomyocytes. American Journal of Tropical Medicine and Hygiene 2019; 101(6):1359-1368. PMID: 31571568. PMCID: 6896885

Lau E, Han Y, Williams DR, Thomas CT, Shrestha R, Wu JC, Lam MPY. Splice-junction-based mapping of alternative isoforms in the human proteome. Cell Reports 2019;29(11):3751-3576. PMID: 31825849. PMCID: 6961840

Rohani L, Machiraju P, Sabouny R, Meng G, Liu S, Zhao T, Iqbal F, Ravandi A, Wu JC, Khan A, Shutt T, Rancourt D, Greenway SC. Reversible mitochondrial fragmentation in iPSC-derived cardiomyocytes from children with DCMA, a mitochondrial cardiomyopathy. Canadian Journal of Cardiology 2019;S0828-282X(19):31286-3.

Wnorowski A, Sharma A, Chen H, Wu H, Shao NY, Sayed N, Liu C, Countryman S, Stodieck LS, Rubins KH, Wu SM, Lee PHU, Wu JC. Effects of spaceflight on human induced pluripotent stem cell-derived cardiomyocyte structure and function. Stem Cell Reports 2019;13(6):960-969. PMID: 31708475. PMCID: 6915842 (*Covered by CNN, BBC, Yahoo News, and other major news outlet. Featured on journal cover)

Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T. Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. Nature Medicine 2019;25(8):1280-1289. PMID: 31359001.

Lau E, Paik DT, Wu JC. Systems-wide approaches in induced pluripotent stem cell models. Annual Review Pathology 2019;14:395-419. PMID: 30379619. PMCID: 1012802

Stack JP, Moslehi J, Sayed N, Wu JC. Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it? European Hear Journal 2019;40(22):1764-1770. PMID: 29377985. PMCID: 1012807

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of life sciences and engineering in understanding and treating heart failure. Circulation Research 2019;124(1):161-169. PMID: 30605412. PMCID: 6350935

Sayed N, Ameen M, Wu JC. Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell. Cardiovascular Research 2019;115(5):949-959. PMID: 30768178. PMCID: 6933506

Abi-Gerges N, McMahon C, Vargas H, Sager P, Chui R, Stevens D, Davila J, Schaub JR, Wu JC, Del Rio C, Mathes C, Miller PE, Burns-Naas LA, Ghetti A. The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment. Journal Pharmacological Toxicology Methods 2019;98:106582. PMID: 31077805

Wu JC, Woo YJ, Mayerle M, Harrington RA, Quertermous T. Stanford Cardiovascular Institute. Circulation Research 2019;124(10):1420-1424. PMID: 31070998.

Williams IM, Wu JC. Generation of endothelial cells from human pluripotent stem cells. Arteriosclerosis Thrombosis Vascular Biology 2019;39(7):1317-1329. PMID: 31242035. PMCID: 6597190

Ouyang X, Telli ML, Wu JC. Induced pluripotent stem cell-based cancer vaccines. Frontiers Immunology 2019;10:1510. PMID: 31338094. PMCID: 6628907.

Wang L, Pegram MD, Wu JC. Induced pluripotent stem cells as a novel cancer vaccine. Expert Opinion Biological Therapy 2019:1-7. PMID: 31364894.

Pang L, Sager P, Yang X, Shi H, Sannajust F, Brock M, Wu JC, Abi-Gerges N, Lyn-Cook B, Berridge BR, Stockbridge N. Workshop Report: FDA Workshop on improving cardiotoxicity assessment with human-relevant platforms. Circulation Research 2019;125(9):855-867. PMID: 31600125. PMCID: 6788760

Wu JC, Garg P, Yoshida Y, Yamanaka S, Gepstein L, Hulot JS, Knollmann BC, Schwartz PJ. Towards precision medicine with human iPSCs for cardiac channelopathies. Circulation Research 2019;125(6):653-658. PMID: 31465267.

Qin X, Han D, Wu JC. Molecular imaging of cardiac regenerative medicine. Current Opinion in Biomedical Engineering 2019, 9:66–73.

Hajipour MJ, Mehrani M, Abbasi SH, Amin A, Kassaian SE, Garbern JC, Caracciolo G, Zanganeh S, Chitsazan M, Aghaverdi H, Kamali Shahri SM, Ashkarran A, Raoufi M, Bauser-Heaton H, Zhang J, Muehlschlegel JD, Moore A, Lee RT, Wu JC, Serpooshan V, Mahmoudi M. Nanoscale technologies for prevention and treatment of heart failure: challenges and opportunities. Chemical Reviews 2019;119(21):11352-11390. PMID: 31490059

2018

Rhee S, Chung JI, King DA, D'amato G, Paik DT, Duan A, Chang A, Nagelberg D, Sharma B, Jeong Y, Diehn M, Wu JC, Morrison AJ, Red-Horse K. Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart diseaseNature Communication 2018;9(1):368. PMID: 29371594. PMCID: 5785521

Lee AS, Inayathullah M, Lijkwan MA, Zhao X, Sun W, Parekh MB, Kooreman N, Malkovskiy AV, Lau E, Qin X, Pothineni VR, Park S, Hong WX, Sanchez-Freire V, Zhang WY, Ebert AD, Chan CK, Nguyen PK, Rajadas J, Wu JC. A novel slow release collagen matrix cross-linked with pro-survival factor analogs promotes stem cell survival for treatment of ischemic cardiovascular diseaseNature Biomedical Engineering 2018;2:104-113. PMID: 29721363

Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yu H, Dey D, Nelakanti R, Brouwer T, Paik DT, Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC. iPSC-based cancer vaccination: an autologous stem cell vaccine against cancerCell Stem Cell 2018;22(4):501-513. PMID: 29456158 PMCID: 6134179  

Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC. SETD7 drives cardiac lineage commitment through stage-specific transcriptional activationCell Stem Cell 2018;22(3):428-444. PMID: 29499155. PMCID: 5785460

Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, Kuhl E, Bernstein D, Couture LA, Gold JD, Zimmermann WH, Wu JC. Passive stretch induces structural and functional maturation of engineered heart muscle as predicted by computational modelingStem Cells 2018;36(2):265-277. PMID: 29086457. PMCID: 5785460

Moneghetti KJ, Giraldeau G, Wheeler MT, Kobayashi Y, Vrtovec B, Boulate D, Kuznetsova T, Schnittger I, Wu JC, Myers J, Ashley E, Haddad F. Incremental value of right heart metrics and exercise performance to well-validated risk scores in dilated cardiomyopathyEuropean Heart Journal Cardiovascular Imaging2018;19(8):916-025. PMID: 28977353.

Zhao X, Chen H, Xiao D, Yang H, Itzhaki I, Qin X, Chour T, Aguirre A, Lehmann K, Kim Y, Shukla P, Holmstrom A, Zhang JZ, Zhuge Y, Ndoye BC, Zhao M, Neofytou E, Zimmermann WH, Jain M, Wu JC. Comparison of non-human primate vs. human induced pluripotent stem cell-derived cardiomyocytes for treatment of myocardial infarctionStem Cell Report 2018;10(2):422-435. PMID: 29398480. PMCID: 5830958

Qin X, Chen H, Yang H, Wu H, Zhao X, Wang H, Chour T, Neofytou E, Ding D, Daldrup-Link H, Heilshorn SC, Li K, Wu JC. Photoacoustic imaging of embryonic stem cell-derived cardiomyocytes in living hearts with ultrasensitive semiconducting polymer nanoparticlesAdvanced Functional Materials 2018; 28(1): 1704939. PMID: 30473658

Argenziano M, Lambers E, Hong L, Sridhar A, Zhang M, Chalazan B, Menon A, Savio-Galimberti E, Wu JC, Rehman J, Darbar D. Electrophysiologic characterization of calcium handling in human induced pluripotent stem cell-derived atrial cardiomyocytesStem Cell Reports 2018;1867-1878. PMID: 29731429.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM,Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G. Cross-site reliability of human induced pluripotent stem-cell derived cardiomyocyte based safety assays using microelectrode arrays: results from a blinded CiPA pilot studyToxicological Sciences 2018;8(1):6618. PMID: 29718449.

Sharma A, Zhang Y, Buikema JW, Serpooshan V, Chirikian O, Kosaric N, Churko JM, Dzilic E, Shieh A, Burridge PW, Wu JC, Wu SM. Stage-specific effects of bioactive lipids on human iPSC cardiac differentiation and cardiomyocyte proliferationScientific Report 2018;8(1):6618. PMID: 29700394.

Cheng H, Dharmadhikari AV, xx, Wu JC, Lupski JR, Arnesen T, Cooper GM, Chung WK, Gecz J, Stessman HAF, Meng L, Lyon GJ. Truncating variants in NAA15 are associated with variable levels of intellectual disability, autism spectrum disorder, and congenital anomaliesAmerican Journal Human Genetics2018;102(5):985-994. PMID: 29656860.

Adam M, Kooreman N, Jagger A, Wagenhaeuser MU, Mehrkens D, Wang Y, Kayama Y, Toyama K, Raaz U, Schellinger IN, Maegdefessel L, Spin JM, Hamming JF, Quax PHA, Baldus S, Wu JC, Tsao PS.Systemic upregulation of IL-10 (Interleukin-10) using a nonimmunogenic vector reduces growth and rate of dissecting abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 2018; 38(8):1796-1805.  PMID: 29880489.

Ma N, Zhang J, Itzhaki I, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JCDetermining the pathogenicity of a genomic variant of uncertain significance using CRISPR/Cas9 and human-induced pluripotent stem cells. Circulation 2018; Epub ahead of print. PMID: 29914921.

Vrtovec B, Poglajen G, Sever M, Zemljic G, Frljak S, Cerar A, Cukjati M, Jaklic M, Cernelc P, Haddad F,Wu JCEffects of Repetitive Transendocardial CD34+ cell transplantation in patients with non-ischemic dilated cardiomyopathy. Circulation Research 2018;123(3):389-396. PMID: 9880546. PMCID: pending

Paik DT, Tian L, Lee J, Sayed N, Chen IY, Rhee S, Rhee JW, Kim Y, Wirka RC, Buikema JW, Wu SM, Red-Horse K, Quertermous T, Wu JC. Large-scale single-cell RNA-seq reveals molecular signatures of heterogeneous populations of human induced pluripotent stem cell-derived endothelial cellsCirculation Research2018;123:443-450. PMID: 29986945.

Chang ACY, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, Ashley E, Wu JC, Blau HM. Telomere shortening is a hallmark of genetic cardiomyopathiesProceedings National Academy of Science 2018;115(37):9276-9281. PMID: 30150400.

Liu Q, Van Bortle K, Zhang Y, Zhao MT, Zhang JZ, Geller BS, Gruber JJ, Jiang C, Wu JC, Snyder MP. Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acidScientific Report 2018;8(1):12960. PMID: 30154523.

Kim JB, Kobayashi Y, Kuznetsova T, Moneghetti KJ, Brenner DA, O'Malley R, Dao C, Wu JC, Fischbein M, Craig Miller D, Yeung AC, Liang D, Haddad F, Fearon WF. Cytokines profile of reverse cardiac remodeling following transcatheter aortic valve replacement. International Journal Cardiology 2018;270:83-88. PMID: 30219541.

Garg P, Oikonomopoulos A, Chen H, Li Y, Lam CK, Sallam K, Perez M, Lux RL, Sanguinetti MC, Wu JCGenome editing of induced pluripotent stem cells to decipher cardiac channelopathy variant. Journal American College Cardiology 2018;72(1):62-75. PMID: 29957233

Lau E, Venkatraman V, Thomas CT, Wu JC, Van Eyk JE, Lam MPY. Identifying high-priority proteins across the human diseasome using semantic similarityJournal Proteome Research 2018; Epub ahead of print. PMID: 3025117.

Churko JM, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, Wessells QN, Chen SY, Chen WY, Chetal K, Mantalas G, Neff N, Jabart E, Sharma A, Nolan GP, Salomonis N, Wu JC. Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysisNature Communication2018;9(1):4906. PMID: 30464173.

Cao Y, Chen H, Qiu R, Hanna M, Ma E, Hjort M, Zhang A, Lewis RS, Wu JC, Melosh NA. Universal intracellular biomolecule delivery with precise dosage controlScience Advance 2018;4(10):eaat8131. PMID: 30402539.

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JCCirculation 2018: Epub ahead of print. PMID: 30586709.

Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W. Myocardial perfusion imaging: Lessons learned and work to be done-updateJournal Nuclear Cardiology 2018;25(1):39-52. PMID: 29110288.

Ong SG, Lee WH, Zhou Y, Wu JC. Mining exosomal microRNAs from human-induced pluripotent stem cells-derived cardiomyocytes for cardiac regenerationMethods Molecular Biology 2018;1733:127-136. PMID: 29435928

Stack JP, Moslehi J, Sayed N, Wu JC. Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it? European Hear Journal 2018; Epub ahead of print. PMID: 29377985.

Magdy T, Schuldt AJT, Wu JC, Bernstein D, Burridge PW. Human induced pluripotent stem cell (hiPSC)-derived cells to assess drug cardiotoxicity: opportunities and problemsAnnual Review Pharmacology Toxicology 2018;58:83-103. PMID: 28992430

Zhang JZ, Guo H, Wu JC. Applications of genetically engineered human pluripotent stem cell reporters in cardiac stem cell biologyCurrent Opinion Biotechnology 2018;52:66-73. PMID: 29579626.

Liu C, Oikonomopoulos A, Sayed N, Wu JC. Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyondDevelopment 2018;145(5). Pii:dev156166. PMID: 29519889.

Oikonomopoulos A, Kitani T, Wu JCPluripotent stem cell-derived cardiomyocytes as a platform for cell therapy applications: progress and hurdles for clinical translation. Molecular Therapy 2018; Epub ahead. PMID: 29699941.

Wnorowski A, Yang H, Wu JCProgress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models. Advance Drug Delivery Review 2018;S0169-409x. PMID: 29885330.

Garg P, Garg V, Shrestha R, Sanguinetti MC, Kamp TJ, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes as models for cardiac channelopathies: a primer for non-electrophysiologists.Circulation Research 2018;123(2):224-243. PMID: 29976690.

Lau E, Paik DT, Wu JC. Systems-wide approaches in induced pluripotent stem cell modelsAnnual Review Pathology 2018; Epub ahead of print. PMID: 30379619.

Huang NF, Serpooshan V, Morris VB, Sayed N, Pardon G, Abilez OJ, Nakayama KH, Pruitt BL, Wu SM, Yoon YS, Zhang J, Wu JC. Big bottlenecks in cardiovascular tissue engineeringCommun Biol 2018;1:199. PMID: 30480100.

Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicityNature Protocol2018;13(12):3018-3041. PMID: 30413796.

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of life sciences and engineering in understanding and treating heart failure.Circulation Research 2019;124(1):161-169. PMID: 30605412.

Fernández-Avilés F, Sanz-Ruiz R, Climent AM, Badimon L, Bolli R, Charron D, Fuster V, Janssens S, Kastrup J, Kim HS, Lüscher TF, Martin JF, Menasché P, Pinto FJ, Simari RD, Stone GW, Terzic A, Willerson JT, Wu JC; TACTICS Writing Group. Global overview of the Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes (TACTICS) recommendations: a comprehensive series of challenges and priorities of cardiovascular regenerative medicineCirculation Research 2018;122(2):199-201. PMID: 29348246.

Rhee JW, Wu JCCardiac cell cycle activation as a strategy to improve iPSC-derived cardiomyocyte therapyCirculation Research 2018;122(1):14-16. PMID: 29301838. PMCID: 5773069

Wu JC, Qin X, Neofytou E. Radiolabeled duramycin: promising translational imaging of myocardial apoptosisJACC Cardiovascular Imaging 2018; Epub ahead of print. PMID: 29454760.

Nishiga M, Guo H, Wu JC. Induced pluripotent stem cells as a biopharmaceutical factory for extracellular vesiclesEuropean Heart Journal 2018;39(20):1848-1850. PMID: 29547885.

Rhee JW, Wu JC. Dyslipidaemia: In vivo genome editing of ANGPTL3: a therapy for atherosclerosis?Nature Review Cardiology 2018;15(5):259-260. PMID: 29618844.

Lau E, Wu JC. Omics, big data, and precision medicine in cardiovascular sciences. Circulation Research2018;122(9):1165-1168. PMID: 29700063.

Lam CK, Wu JCDisease modelling and drug discovery for hypertrophic cardiomyopathy using pluripotent stem cells: how far have we come? European Heart Journal 2018; 39(43):3893-3895. PMID: 30010924.

Tu C, Chao BS, Wu JC. Strategies for improving the maturity of human induced pluripotent stem cell-derived cardiomyocytesCirculation Research 2018;123(5):512-514. PMID: 30355143.

Wu JC. From the BCVS chair. Circulation Research 2018;23(8):942-943. PMID: 30355039.

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction.
Zhao X, Chen H, Xiao D, Yang H, Itzhaki I, Qin X, Chour T, Aguirre A, Lehmann K, Kim Y, Shukla P, Holmström A, Zhang JZ, Zhuge Y, Ndoye BC, Zhao M, Neofytou E, Zimmermann WH, Jain M, Wu JC.
Stem Cell Reports. 2018 Jan 26. pii: S2213-6711(18)30028-6. doi: 10.1016/j.stemcr.2018.01.002. [Epub ahead of print]

Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?
Stack JP, Moslehi J, Sayed N, Wu JC.
Eur Heart J. 2018 Jan 25. doi: 10.1093/eurheartj/ehx811. [Epub ahead of print]

Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.
Rhee S, Chung JI, King DA, D'amato G, Paik DT, Duan A, Chang A, Nagelberg D, Sharma B, Jeong Y, Diehn M, Wu JC, Morrison AJ, Red-Horse K.
Nat Commun. 2018 Jan 25;9(1):368. doi: 10.1038/s41467-017-02796-3.

Global Overview of the Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes (TACTICS) Recommendations: A Comprehensive Series of Challenges and Priorities of Cardiovascular Regenerative Medicine.
Fernández-Avilés F, Sanz-Ruiz R, Climent AM, Badimon L, Bolli R, Charron D, Fuster V, Janssens S, Kastrup J, Kim HS, Lüscher TF, Martin JF, Menasché P, Pinto FJ, Simari RD, Stone GW, Terzic A, Willerson JT, Wu JC; TACTICS Writing Group.
Circ Res. 2018 Jan 19;122(2):199-201. doi: 10.1161/CIRCRESAHA.117.312099. No abstract available.

Cardiac Cell Cycle Activation as a Strategy to Improve iPSC-Derived Cardiomyocyte Therapy.
Rhee JW, Wu JC.
Circ Res. 2018 Jan 5;122(1):14-16. doi: 10.1161/CIRCRESAHA.117.312287. No abstract available.

2017

Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu JC, Snyder MP, Rabinovitch M. Patient-specific iPSC-derived endothelial cells uncover pathways that protect against pulmonary hypertension in BMPR2 mutation carriers. Cell Stem Cell 2017;20(4):490-504.

Tiburcy M, Hudson JE, Balfanz P, Schlick SF, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake L, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. Defined engineered human myocardium with advanced maturation for applications in heart failure modelling and repair. Circulation 2017;135(19):1832-1847.

Kobayashi Y, Moneghetti KJ, Boralkar K, Amsallem M, Tuzovic M, Liang D, Yang PC, Narayan S, Kuznetsova T, Wu JC, Schnittger I, Haddad F. Challenging the complementarity of different metrics of left atrial function: insight from a cardiomyopathy-based study. European Heart Journal: Cardiovascular Imaging 2017;18(10):1153-1162.  

Lin ZC, McGuire AF, Burridge PW, Matsa E, Lou HY, Wu JC. Cui B. Accurate nanoelectrode recordings of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease. Microsystems & Nanoengineering 2017;3:16080.

Sa S, Gu M, Chappell J, Shao NY, Ameen M, Elliott KA, Li D, Grubert F, Li CG, Taylor S, Cao A, Ma Y, Fong R, Nguyen L, Wu JC, Snyder MP, Rabinovitch M. iPSC Model of pulmonary arterial hypertension reveals novel gene expression and patient specificity.  American Journal of Respiratory Care and Critical Care Medicine 2017;195(5):930-941.

Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Human AML-iPSCs reacquire leukemic properties after differentiation and model clonal variation of disease. Cell Stem Cell 2017;20(3):329-344.

Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo NA, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC. A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases. Circulation Research 2017;120(10):1561-1571.

Cao Y, Hjort M, Chen H, Birey F, Leal-Ortiz SA, Han CM, Santiago JG, Paşca SP, Wu JC, Melosh NA. Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring. Proceedings National Academy of Science 2017;114(10):E1866-E1874.

Serpooshan V, Chen P, Wu H, Lee S, Sharma A, Hu DA, Venkatraman S, Ganesan AV, Usta OB, Yarmush M, Yang F, Wu JC, Demirci U, Wu SM. Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue. Biomaterials 2017;131:47-57.

Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N,  Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Science Translational Medicine 2017;9(377):eaaf2584.

Lee S, Serpooshan V, Tong X, Venkatraman S, Lee M, Lee J, Chirikian O, Wu JC, Wu SM, Yang F. Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness. Biomaterials 2017;131:111-120.

Chuang W, Sharma A, Shukla P, Li G, Mall M, Rajarajan K, Abilez OJ, Hamaguchi R, Wu JC, Wernig M, Wu SM. Partial reprogramming of pluripotent stem cell-derived cardiomyocytes into neurons. Scientific Report 2017;7:44840

Lee AS, Tang C, Hong WX, Park S, Bazalova-Carter M, Nelson G Sanchez-Freire V, Bakerman I, Zhang W, Neofytou E, Connolly AJ, Chan CK, Graves EE, Weissman IL, Nguyen PK, Wu JC. External beam radiation therapy for the treatment of human pluripotent stem cell-derived teratomas. Stem Cells 2017;35(8):1994-2000.

Liu Q, Jiang C, Xu J, Zhao M, Van Bortle K, Cheng X, Wang G, Chang HY, Wu JC, Snyder MP. Genome-wide temporal profiling of transcriptome and open-chromatin of early cardiomyocyte differentiation derived from hiPSCs and hESCs. Circulation Research 2017;121(4):376-391.

Li X, Kuznetsova T, Cauwenberghs N, Wheeler M, Maecker H, Wu JC, Haddad F, Dai H. Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease. Proceedings National Academy of Science 2017;114(27):7089-7094.

Lee WH, Chen WY, Shao NY, Xiao D, Qin X, Baker N, Bae HR, Wei TT, Wang Y, Shukla P, Wu H, Kodo K, Ong SG, Wu JC. Comparison of non-coding RNAs in exosomes and functional efficacy of human embryonic stem cell- versus induced pluripotent stem cell-derived cardiomyocytes. Stem Cells 2017;35(10):2138-2149.

Wanjare M, Hou L, Nakayama KH, Kim JJ, Mezak NP, Abilez OJ, Tzatzalos E, Wu JC, Huang NF. Anisotropic microfibrous scaffolds enhance the organization and function of cardiomyocytes derived from induced pluripotent stem cells. Biomaterials Sciences 2017;5(8):1567-1578. PMID: 28715029.

Gowrishankar G, Hardy J, Wardak M, Namavari M, Reeves RE, Neofytou E, Srinivasan A, Wu JC, Contag CH, Gambhir SS. Specific imaging of bacterial infection using 6″-18F-Fluoromaltotriose: a second-generation PET tracer targeting the maltodextrin transporter in bacteria. Journal Nuclear Medicine 2017;58(10):1679-1684.

Chamberland S, Yang HH, Pan MM, Evans SW, Guan S, Chavarha M, Yang Y, Salesse C, Wu H, Wu JC, Clandinin TR, Toth K, Lin MZ, St-Pierre F. Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators. eLife 2017;6.pii:e25690.

Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC. Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics. Cell Report 2017;20(8):1978-1990.

Moneghetti KJ, Giraldeau G, Wheeler MT, Kobayashi Y, Vrtovec B, Boulate D, Kuznetsova T, Schnittger I, Wu JC, Myers J, Ashley E, Haddad F. Incremental value of right heart metrics and exercise performance to well-validated risk scores in dilated cardiomyopathy. European Heart Journal Cardiovascular Imaging 2017;

Churko JM, Lee J, Ameen M, Gu M, Venkatasubramanian M, Diecke S, Sallam K, Im H, Wang G, Gold JD, Salomonis N, Snyder MP, Wu JCTranscriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods. Nature Biomedical Engineering 2017;1:826-837.

Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, Kuhl E, Bernstein D, Couture LA, Gold JD, Zimmermann WH, Wu JC. Passive stretch induces structural and functional maturation of engineered heart muscle as predicted by computational modeling. Stem Cells 2017

Zhao M, Shao NY, Hu S, Ma N, Srinivasan R, Jahanbani F, Lee J, Zhang SL, Snyder MP, Wu JC. Cell Type-specific chromatin signatures underline regulatory DNA elements in human induced pluripotent stem cells and somatic cells. Circulation Research 2017;121:1237-1250.

Kim JB, Kobayashi Y, Moneghetti KJ, Brenner DA, O’Malley R, Schnittger I, Wu JC, Murtagh G, Beshiri A, Fischbein M, Miller DC, Liang D, Yeung AC, Haddad F, Fearon WC. GDF-15 (growth differentiation factor 15) is associated with lack of ventricular recovery and mortality after transcatheter aortic valve replacement. Circulation: Cardiovascular Interventions 2017

Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, Mitalipov S, Snyder MP, Wu JC. Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proceedings National Academy of Science 2017;114(52):E11111-E11120.

Termglinchan V, Seeger T, Chen C, Wu JC, Karakikes I. Efficient genome editing in induced pluripotent stem cells with engineered nucleases in vitro. Methods Molecular Biology 2017;1521:55-68.

Shi Y, Inoue H, Wu JC, Yamanaka S. Induced pluripotent stem cell technology: a decade of progress. Nature Review Drug Discovery 2017;16(2):115-130.

Seeger T, Porteus M, Wu JC. Genome editing in cardiovascular biology. Circulation Research 2017;120(5):778-780.

Wnorowski A, Wu JC. 3-dimensionally printed, native-like scaffolds for myocardial tissue engineering. Circulation Research 2017;120(8):1224-1226.

Povsic TJ, Scott R, Mahaffey KW, Blaustein R, Edelberg JM, Lefkowitz MP, Solomon SD, Fox JC, Healy KE, Khakoo AY, Losordo DW, Malik FI, Monia BP, Montgomery RL, Riesmeyer J, Schwartz GG, Zelenkofske SL, Wu JC, Wasserman SM, Roe MT. Navigating the future of cardiovascular drug development-leveraging novel approaches to drive innovation and drug discovery: summary of findings from the Novel Cardiovascular Therapeutics Conference. Cardiovascular Drugs and Therapy 2017;31(4):445-458.

Fernández-Avilés F, Sanz-Ruiz R, Climent AM, Badimon L, Bolli R, Charron D, Fuster V, Janssens S, Kastrup J, Kim HS, Lüscher TF, Martin JF, Menasché P, Simari RD, Stone GW, Terzic A, Willerson JT, Wu JC; TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) Writing Group. Global position paper on cardiovascular regenerative medicine: Scientific statement of the transnational alliance for regenerative therapies in cardiovascular syndromes (TACTICS) international group for the comprehensive cardiovascular application of regenerative medicinal products. European Heart Journal 2017;38(33):2532-2546.  

Zhang J, Li H, Trounson A, Wu JC, Niol P. Combining hiPSCs and human genetics: major applications in drug development. Cell Stem Cell 2017;21(2):161-165.

Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyopathy. Nature Nanotechnology 2017;12(9):845-855.

Magdy T, Schuldt AJT, Wu JC, Bernstein D, Burridge PW. Human induced pluripotent stem cell (hiPSC)-derived cells to assess drug cardiotoxicity: opportunities and problems. Annual Review Pharmacology Toxicology 2017

Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W. Myocardial perfusion imaging: Lessons learned and work to be done-update. Journal Nuclear Cardiology 2017

2016

Riegler J, Ebert A, Qin X, Shen Q, Wang M, Ameen M, Kodo K, Ong SG, Lee WH, Lee G, Neofytou E, Gold JD, Connolly AJ, Wu JC. Comparison of magnetic resonance imaging and serum biomarkers for detection of human pluripotent stem cell-derived teratomas. Stem Cell Reports 2016;6(2):176-87.

Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmstrom A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Human induced pluripotent stem-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nature Medicine 2016;22(5):547-56.

Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D. Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation. FASEB J 2016;30(4):1464-79.

Calderon D, Prot M, You S, Marquet C, Bellamy V, Bruneval P, Valette F, de Almeida P, Wu JC, Pucéat M, Menasché P, Chatenoud L. Control of immune response to allogeneic embryonic stem cells by CD3 antibody-mediated operational tolerance induction. American Journal Transplantation 2016;16(2):454-67.

He C, Hu H, Wilson KD, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC. Systematic characterization of long non-coding RNAs reveals the contrasting coordination of cis- and trans- molecular regulation in human fetal and adult heart. Circulation Cardiovascular Genetics 2016;9(2):110-118.

Yuan K, Shao NY, Hennigs JK, Discipulo M, Orcholski ME, Shamskhou E, Richter A, Hu X, Wu JC, de Jesus Perez V. Increased pyruvate dehydrogenase kinase 4 expression in lung pericytes is associated with reduced endothelial-pericyte interactions and small vessel loss in pulmonary arterial hypertension. American Journal Pathology 2016;186(9):2500-14.

Hu S, Zhao MT, Jahanbani F, Shao NY, Lee WH, Chen H, Snyder MP, Wu JC. Effects of cellular origin on differentiation of human induced pluripotent stem cell-derived endothelial cells. JCI Insight 2016;1(8). pii: e85558.

Mizutani M, Wu JC, Nusse R. Fibrosis of the neonatal mouse heart after cryoinjury is accompanied by Wnt signaling activation and epicardial-to-mesenchymal transition. Journal American Heart Association 2016;4(3):e002457.

Hnatiuk AP, Ong SG, Olea FD, Locatelli P, Riegler J, Lee WH, Jen CH, De Lorenzi A, Giménez CS, Laguens R, Wu JC, Crottogini A. Allogeneic mesenchymal stromal cells overexpressing mutant human hypoxia-inducible factor 1-α (HIF1-α) in an ovine model of acute myocardial infarction. Journal American Heart Association 2016;5(7):e003714.

Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Proceedings National Academy of Science 2016;113(46):13120-13125.

Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, Molkentin JD. A tension-based model distinguishes hypertrophic versus dilated cardiomyopathy. Cell 2016;165(5):1147-59.

Kuznetsova T, Haddad F, Tikhonoff V, Kloch-Badelek M, Ryabikov A, Knez J, Malyutina S, Stolarz-Skrzypek K, Thijs L, Schnittger I, Wu JC, Casiglia E, Narkiewicz K, Kawecka-Jaszcz K, Staessen JA; European Project On Genes in Hypertension (EPOGH) Investigators. Impact and pitfalls of scaling of left ventricular and atrial structure in population-based studies. Journal Hypertension 2016;34(6):1186-1194.

Vrtovec B, Sever M, Jensterle M, Poglajen G, Janez A, Kravos N, Zemljic G, Cukjati M, Cernelc P, Haddad F, Wu JC, Jorde UP. Efficacy of CD34+ stem cell therapy in nonischemic dilated cardiomyopathy is absent in patients with diabetes but preserved in patients with insulin resistance. Stem Cells Translational Medicine 2016;5(5):632-638.

Paik KJ, Maan ZN, Zielins ER, Duscher D, Whittam AJ, Morrison SD, Brett EA, Ransom RC, Hu MS, Wu JC, Gurtner GC, Longaker MT, Wan DC. Short Hairpin RNA silencing of PHD-2 improves neovascularization and functional outcomes in diabetic wounds and ischemic limbs. PLoS One 2016;11(3):e0150927.

Liang P, Sallam K*, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Termglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Scheinman MM, Bers DM, Wu JC. Patient-specific and genome-edited induced pluripotent stem cell-derived cardiomyocytes elucidate single cell phenotype of Brugada Syndrome. Journal American College of Cardiology 2016;68(19):2086-2096.

Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC. iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Nature Cell Biology 2016;18(10):1031-42.

Shen-Orr SS, Furman D, Kidd BA, Haddad F, Lovelace P, Huang YW, Rosenberg-Hasson Y, Mackey S, Grisar FA, Pickman Y, Maecker HT, Chien YH, Dekker CL, Wu JC, Butte AJ, Davis MM. Defective signaling in the JAK-STAT pathway tracks with chronic inflammation and cardiovascular risk in aging humans. Cell Systems 2016;3(4):374-384.e4.

Qin X, Riegler J, Tiburcy M, Zhao X, Chour T, Ndoye B, Nguyen M, Adams J, Ameen M, Denney TS Jr, Yang PC, Nguyen P, Zimmermann WH, Wu JC. Magnetic resonance imaging of cardiac strain pattern following transplantation of human tissue engineered heart muscles. Circulation Cardiovascular Imaging 2016;9:e004731.

Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC. Transcriptome profiling of patient-specific human iPSC-cardiomyocytes predicts individual drug safety and efficacy responses in vitro. Cell Stem Cell 2016;19(3):311-325.

Golpanian S, Schulman IH, Ebert RF, Heldman AW, DiFede DL, Yang PC, Wu JC, Bolli R, Perin EC, Moyé L, Simari RD, Wolf A, Hare JM; Cardiovascular Cell Therapy Research Network. Concise review: review and perspective of cell dosage and routes of administration from preclinical and clinical studies of stem cell therapy for heart disease. Stem Cells Translational Medicine 2016;5(2):186-91.

Burridge PW, Diecke S, Matsa E, Sharma A, Wu H, Wu JC. Modeling cardiovascular diseases with patient-specific human pluripotent stem cell-derived cardiomyocytes. Methods Molecular Biology 2016;1353:119-30.

Tzatzalos E, Abilez OJ, Shukla P, Wu JC. Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies. Advanced Drug Delivery Review 2016;96:234-44.

Sayed N, Liu C, Wu JC. Translation of human iPSCs: From clinical trial in a dish to precision medicine. Journal American College of Cardiology 2016;67(18):2161-76.

Lee WH, Nguyen PK, Fleischmann D, Wu JC. DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging. European Heart Journal 2016;37(40):3075-3080.

Chanana AM, Rhee JW, Wu JC. Human induced pluripotent stem cell approaches to model inborn and acquired metabolic heart diseases. Current Opinion Cardiology 2016;31(3):266-74.

Chen IY, Matsa E, Wu JC. Induced pluripotent stem cells: at the heart of cardiovascular precision medicine. Nature Review Cardiology 2016;13(6):333-49.

Gurvitz M, Burns KM, Brindis R, Broberg CS, Daniels CJ, Fuller SM, Honein MA, Khairy P, Kuehl KS, Landzberg MJ, Mahle WT, Mann DL, Marelli A, Newburger JW, Pearson GD, Starling RC, Tringali GR, Valente AM, Wu JC, Califf RM. Emerging research directions in adult congenital heart disease: a report from an NHLBI/ACHA working group. Journal American College Cardiology 2016;67(16):1956-64.

Ogle BM, Bursac N, Domian I, Huang NF, Menasché P, Murry CE, Pruitt B, Radisic M, Wu JC, Wu SM, Zhang J, Zimmermann WH, Vunjak-Novakovic G. Distilling complexity to advance cardiac tissue engineering. Science Translational Medicine 2016;8(342):342ps13.

Matsa E, Ahrens JH, Wu JC. Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine. Physiological Reviews 2016;96(3):1093-126.

Nguyen PK, Rhee JW, Wu JC. Adult stem cell therapy and heart failure, 2000 to 2016: a systematic review.  JAMA Cardiology 2016;1(7):831-841.

Nguyen PK, Neofytou E, Rhee JW, Wu JC. Potential strategies for addressing the major clinical hurdles facing stem cell therapy. JAMA Cardiology 2016;1(8):953-962.

Sheng CC, Amiri-Kordestani L, Palmby T, Force T, Hong CC, Wu JC, Croce K, Kim G, Moslehi J. 21st century cardio-oncology : identifying cardiac safety signals in the era of personalized medicine. JACC: Basic to Translational Science 2016;1(5):386-398.

2015

Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories.
Hwang HS, Kryshtal DO, Feaster TK, Sánchez-Freire V, Zhang J, Kamp TJ, Hong CC, Wu JC, Knollmann BC.
J Mol Cell Cardiol. 2015 Aug;85:79-88. doi: 10.1016/j.yjmcc.2015.05.003. Epub 2015 May 14.
PMID: 25982839
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Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension.
Haddad F, Spruijt OA, Denault AY, Mercier O, Brunner N, Furman D, Fadel E, Bogaard HJ, Schnittger I, Vrtovec B, Wu JC, de Jesus Perez V, Vonk-Noordegraaf A, Zamanian RT.
JACC Cardiovasc Imaging. 2015 Jun;8(6):627-38. doi: 10.1016/j.jcmg.2014.12.029. Epub 2015 May 14.
PMID: 25981508
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Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Feaster TK, Cadar AG, Wang L, Williams CH, Chun YW, Hempel JE, Bloodworth N, Merryman WD, Lim CC, Wu JC, Knollmann BC, Hong CC.
Circ Res. 2015 Dec 4;117(12):995-1000. doi: 10.1161/CIRCRESAHA.115.307580. Epub 2015 Oct 1.
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Modeling Cardiovascular Diseases with Patient-Specific Human Pluripotent Stem Cell-Derived Cardiomyocytes.
Burridge PW, Diecke S, Matsa E, Sharma A, Wu H, Wu JC.
Methods Mol Biol. 2016;1353:119-30. doi: 10.1007/7651_2015_196.
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Genetic and Epigenetic Regulation of Human Cardiac Reprogramming and Differentiation in Regenerative Medicine.
Burridge PW, Sharma A, Wu JC.
Annu Rev Genet. 2015 Nov 23;49:461-84. doi: 10.1146/annurev-genet-112414-054911.
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Lift NIH restrictions on chimera research.
Sharma A, Sebastiano V, Scott CT, Magnus D, Koyano-Nakagawa N, Garry DJ, Witte ON, Nakauchi H, Wu JC, Weissman IL, Wu SM.
Science. 2015 Nov 6;350(6261):640. doi: 10.1126/science.350.6261.640-a. Epub 2015 Nov 5. No abstract available.
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Cytokines profile in hypertensive patients with left ventricular remodeling and dysfunction.
Kuznetsova T, Haddad F, Knez J, Rosenberg-Hasson Y, Sung J, Cauwenberghs N, Thijs L, Karakikes I, Maecker H, Mahaffey KW, Wu JC, Staessen JA.
J Am Soc Hypertens. 2015 Oct 17. pii: S1933-1711(15)00740-8. doi: 10.1016/j.jash.2015.10.003. [Epub ahead of print]
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Control of Immune Response to Allogeneic Embryonic Stem Cells by CD3 Antibody-Mediated Operational Tolerance Induction.
Calderon D, Prot M, You S, Marquet C, Bellamy V, Bruneval P, Valette F, de Almeida P, Wu JC, Pucéat M, Menasché P, Chatenoud L.
Am J Transplant. 2015 Oct 22. doi: 10.1111/ajt.13477. [Epub ahead of print]
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Chemically Defined Culture and Cardiomyocyte Differentiation of Human Pluripotent Stem Cells.
Burridge PW, Holmström A, Wu JC.
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Human Engineered Heart Muscles Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model.
Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC.
Circ Res. 2015 Aug 19. pii: CIRCRESAHA.115.306985. [Epub ahead of print]
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Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells.
Yang W, Liu Y, Slovik KJ, Wu JC, Duncan SA, Rader DJ, Morrisey EE.
PLoS One. 2015 Aug 17;10(8):e0134995. doi: 10.1371/journal.pone.0134995. eCollection 2015.
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A Rapid, High-Quality, Cost-Effective, Comprehensive, and Expandable Targeted Next-Generation Sequencing Assay for Inherited Heart Diseases.
Wilson KD, Shen P, Fung E, Karakikes I, Zhang A, InanlooRahatloo K, Odegaard J, Sallam K, Davis RW, Lui G, Ashley E, Scharfe C, Wu JC.
Circ Res. 2015 Aug 11. pii: CIRCRESAHA.115.306723. [Epub ahead of print]
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Manganese-Enhanced Magnetic Resonance Imaging Enables In Vivo Confirmation of Peri-Infarct Restoration Following Stem Cell Therapy in a Porcine Ischemia-Reperfusion Model.
Dash R, Kim PJ, Matsuura Y, Ikeno F, Metzler S, Huang NF, Lyons JK, Nguyen PK, Ge X, Wong Po Foo C, McConnell MV, Wu JC, Yeung AC, Harnish P, Yang PC.
J Am Heart Assoc. 2015 Jul 27;4(7). pii: e002044. doi: 10.1161/JAHA.115.002044.
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Assessment of the Radiation Effects of Cardiac CT Angiography Using Protein and Genetic Biomarkers.
Nguyen PK, Lee WH, Li YF, Hong WX, Hu S, Chan C, Liang G, Nguyen I, Ong SG, Churko J, Wang J, Altman RB, Fleischmann D, Wu JC.
JACC Cardiovasc Imaging. 2015 Aug;8(8):873-84. doi: 10.1016/j.jcmg.2015.04.016. Epub 2015 Jul 22.
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Tumor promoting effects of myeloid derived suppressor cells are potentiated by hypoxia-induced expression of miR-210.
Noman MZ, Janji B, Hu S, Wu JC, Martelli F, Bronte V, Chouaib S.
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Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand?
Ebert AD, Diecke S, Chen IY, Wu JC.
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Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JCCell Stem Cell. 2015 Jun 16. pii: S1934-5909(15)00178-2.

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes. Karakikes I, Ameen M, Termglinchan V, Wu JCCirc Res. 2015 Jun 19;117(1):80-8.

Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Sallam K, Li Y, Sager PT, Houser SR, Wu JCCirc Res. 2015 Jun 5;116(12):1989-2004.

Schutt RC, Trachtenberg B, Cooke JP, Traverse JH, Henry TD, Pepine CJ, Willerson JT, Perin EC, Ellis SG, Zhao D, Bhatnagar A, Johnstone BH, Lai D, Resende M, Ebert RF, Wu JC, Sayre SL, Orozco A, Zierold C, Simari RD, Moyé L, Cogle CR, Taylor D. Bone marrow characteristics associated with changes in infarct size after STEMI: A biorepository evaluation from the CCTRN TIME TrialCirculation Research 2015;116(1):99-107. PMID: 25406300

Nejadnik H, Diecke S, Lenkov OD, Chapelin F, Donig J, Tong X, Derugin N, Chan RC, Gaur A, Yang F, Wu JC, Daldrup-Link HE Improved Approach for Chondrogenic Differentiation of Human Induced Pluripotent Stem Cells. Stem Cell Reviews and Reports 2015; Epub ahead of print. PMID: 25578634

Serpooshan V, Sivanesan S, Huang X, Mahmoudi M, Malkovskiy AV, Zhao M, Inayathullah M, Wagh D, Zhang XJ, Metzler S, Bernstein D, Wu JC, Ruiz-Lozano P, Rajadas J. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials 2015;37:289-98. PMID: 25443792

Pan Y, Leveson-Gower DB, de Almeida PE, Pierini A, Baker J, Florek M, Nishikii H, Kim BS, Ke R, Wu JC, Negrin RS. Engraftment of embryonic stem cells and differentiated progeny by host conditioning with total lymphoid irradiation and regulatory T cellsCell Report 2015;S2211-1247(15)00208-9. PMID: 25801020.

Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, Gho JM, Tsiapras D, Vink A, Wu JC, Asselbergs FW, Li RA, Hulot JS, Kranias EG, Hajjar RJ. Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nature Communication 2015;6:6955. PMID: 25923014

Lara-Pezz E, Menasché P, Trouvin JH, Badimón L, Ioannidis JP, Wu JC, Hill JA, Koch WJ, De Felice AF, de Waele P, Steenwinckel V, Hajjar RJ, Zeiher AM. Guidelines for translational research in heart failure. Journal Cardiovascular Translational Research 2015;8(1):3-22. PMID: 25604959

Ong SG, Lee WH, Kodo K, Wu JCMicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells. Advanced Drug Delivery Reviews 2015; Epub. PMID: 25887992

Narula JChandrashekhar YSDilsizian VGarcia MJKramer CMMalik SRyan TSen SWu JC. COCATS 4 Task Force 4: Training in Multimodality Imaging. Journal American College Cardiology2015;65(17):1788-85. PMID: 25777648

Wilson KD, Wu JCInduced pluripotent stem cells. Journal American Medical Association 2015;313(16):1613-4. PMID: 25919522.

Modeling Cardiovascular Diseases with Patient-Specific Human Pluripotent Stem Cell-Derived Cardiomyocytes.
Burridge PW, Diecke S, Matsa E, Sharma A, Wu H, Wu JC.
Methods Mol Biol. 2015 Feb 18. [Epub ahead of print]

Enabling Consistency in Pluripotent Stem Cell-Derived Products for Research and Development and Clinical Applications Through Material Standards.
French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD, Artzi N, Kim HW, Barker RW, Meissner A, Wu JC, Knowles JC, Williams D, García-Cardeña G, Sipp D, Oh S, Loring JF, Rao MS, Reeve B, Wall I, Carr AJ, Bure K, Stacey G, Karp JM, Snyder EY, Brindley DA.
Stem Cells Transl Med. 2015 Feb 3. pii: sctm.2014-0233. [Epub ahead of print]

Teratoma formation: a tool for monitoring pluripotency in stem cell research.
Nelakanti RV, Kooreman NG, Wu JC.
Curr Protoc Stem Cell Biol. 2015 Feb 2;32:4A.8.1-4A.8.17. doi: 10.1002/9780470151808.sc04a08s32.

Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes.
Burridge PW, Metzler SA, Nakayama KH, Abilez OJ, Simmons CS, Bruce MA, Matsuura Y, Kim P,Wu JC, Butte M, Huang NF, Yang PC.
Am J Transl Res. 2014 Nov 22;6(6):724-35. eCollection 2014.

Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency.
Diecke S, Lu J, Lee J, Termglinchan V, Kooreman NG, Burridge PW, Ebert AD, Churko JM, Sharma A, Kay MA, Wu JC.
Sci Rep. 2015 Jan 28;5:8081. doi: 10.1038/srep08081.

Variable activation of the DNA damage response pathways in patients undergoing single-photon emission computed tomography myocardial perfusion imaging.
Hee Lee W, Nguyen P, Hu S, Liang G, Ong SG, Han L, Sanchez-Freire V, Lee AS, Vasanawala M, Segall G, Wu JC.
Circ Cardiovasc Imaging. 2015 Feb;8(2). pii: e002851. doi: 10.1161/CIRCIMAGING.114.002851.

Improved Approach for Chondrogenic Differentiation of Human Induced Pluripotent Stem Cells.
Nejadnik H, Diecke S, Lenkov OD, Chapelin F, Donig J, Tong X, Derugin N, Chan RC, Gaur A, Yang F, Wu JC, Daldrup-Link HE.
Stem Cell Rev. 2015 Jan 13. [Epub ahead of print]

Intracoronary Transplantation of CD34(+) Cells Is Associated With Improved Myocardial Perfusion in Patients With Nonischemic Dilated Cardiomyopathy.
Lezaic L, Socan A, Poglajen G, Peitl PK, Sever M, Cukjati M, Cernelc P, Wu JC, Haddad F, Vrtovec B.
J Card Fail. 2015 Feb;21(2):145-52. doi: 10.1016/j.cardfail.2014.11.005. Epub 2014 Nov 18.

[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction.
Serpooshan V, Sivanesan S, Huang X, Mahmoudi M, Malkovskiy AV, Zhao M, Inayathullah M, Wagh D, Zhang XJ, Metzler S, Bernstein D, Wu JC, Ruiz-Lozano P, Rajadas J.
Biomaterials. 2015 Jan;37:289-98. doi: 10.1016/j.biomaterials.2014.08.045. Epub 2014 Oct 13.

Bone Marrow Characteristics Associated With Changes in Infarct Size After STEMI: A Biorepository Evaluation From the CCTRN TIME Trial.
Schutt RC, Trachtenberg BH, Cooke JP, Traverse JH, Henry TD, Pepine CJ, Willerson JT, Perin EC, Ellis SG, Zhao DX, Bhatnagar A, Johnstone BH, Lai D, Resende M, Ebert RF, Wu JC, Sayre SL, Orozco A, Zierold C, Simari RD, Moyé L, Cogle CR, Taylor DA; Cardiovascular Cell Therapy Research Network (CCTRN).
Circ Res. 2015 Jan 2;116(1):99-107. doi: 10.1161/CIRCRESAHA.116.304710. Epub 2014 Nov 18.

2014

Human Stem Cells for Modeling Heart Disease and for Drug Discovery.
Matsa E, Burridge PW, Wu JC.
Sci Transl Med. 2014 Jun 4;6(239):239ps6. Review.
PMID: 24898747 [PubMed - as supplied by publisher]
 
Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance.
de Almeida PE, Meyer EH, Kooreman NG, Diecke S, Dey D, Sanchez-Freire V, Hu S, Ebert A, Odegaard J, Mordwinkin NM, Brouwer TP, Lo D, Montoro DT, Longaker MT, Negrin RS, Wu JC.
Nat Commun. 2014 May 30;5:3903. doi: 10.1038/ncomms4903.
PMID: 24875164 [PubMed - in process]
 
Relationship between Echocardiographic and Magnetic Resonance Derived Measures of Right Ventricular Size and Function in Patients with Pulmonary Hypertension.
Shiran H, Zamanian RT, McConnell MV, Liang DH, Dash R, Heidary S, Sudini NL, Wu JC, Haddad F, Yang PC.
Am Soc Echocardiogr. 2014 Apr;27(4):405-12. doi: 10.1016/j.echo.2013.12.011. Epub 2014 Jan 18.
PMID: 24444659 [PubMed - in process]
 
The role of Hath6, a newly identified shear-stress-responsive transcription factor, in endothelial cell differentiation and function.
Fang F, Wasserman SM, Torres-Vazquez J, Weinstein B, Cao F, Li Z, Wilson KD, Yue W, Wu JC, Xie X, Pei X.
J Cell Sci. 2014 Apr 1;127(Pt 7):1428-40. doi: 10.1242/jcs.136358. Epub 2014 Jan 240
PMID: 24463812 [PubMed - in process]
 
Rapid and Efficient Conversion of Integration-Free Human Induced Pluripotent Stem Cells to GMP-Grade Culture Conditions.
Durruthy-Durruthy J, Briggs SF, Awe J, Ramathal CY, Karumbayaram S, Lee PC, Heidmann JD, Clark A, Karakikes I, Loh KM, Wu JC, Hoffman AR, Byrne J, Reijo Pera RA, Sebastiano V.
PLoS One. 2014 Apr 9;9(4):e94231. doi: 10.1371/journal.pone.0094231. eCollection 2014.
PMID: 24718618 [PubMed - in process] Free Article
 
Stem Cell Imaging: From Bench to Bedside.
Nguyen PK, Riegler J, Wu JC.
Cell Stem Cell. 2014 Apr 3;14(4):431-444. doi: 10.1016/j.stem.2014.03.009. Review.
PMID: 24702995 [PubMed - as supplied by publisher]
 
Modeling Inherited Cardiac Disorders.
Sallam K, Kodo K, Wu JC.
Circ J. 2014 Mar 17. [Epub ahead of print]
PMID: 24632794 [PubMed - as supplied by publisher] Free Article
 
Stem cells and cardiovascular drug development--reply.
Mordwinkin NM, Lee AS, Wu JC.
JAMA. 2014 Mar 12;311(10):1070-1. doi: 10.1001/jama.2014.634. No abstract available.
PMID: 24618976 [PubMed - in process]
 
Construction and validation of nano gold tripods for molecular imaging of living subjects.
Cheng K, Kothapalli SR, Liu H, Koh AL, Jokerst JV, Jiang H, Yang M, Li J, Levi J, Wu JC, Gambhir SS, Cheng Z.
J Am Chem Soc. 2014 Mar 5;136(9):3560-71. doi: 10.1021/ja412001e. Epub 2014 Feb 11.
PMID: 24495038 [PubMed - in process]
 
Human-induced pluripotent stem cell models of inherited cardiomyopathies.
Karakikes I, Termglinchan V, Wu JC.
Curr Opin Cardiol. 2014 Feb 26. [Epub ahead of print]
PMID: 24576884 [PubMed - as supplied by publisher]
 
Tracking gene and cell fate for therapeutic gain.
Kooreman NG, Ransohoff JD, Wu JC.
Nat Mater. 2014 Feb;13(2):106-9. doi: 10.1038/nmat3868. Review. No abstract available.
PMID: 24452344 [PubMed - indexed for MEDLINE]
 
Relationship between Echocardiographic and Magnetic Resonance Derived Measures of Right Ventricular Size and Function in Patients with Pulmonary Hypertension.
Shiran H, Zamanian RT, McConnell MV, Liang DH, Dash R, Heidary S, Sudini NL, Wu JC, Haddad F, Yang PC.
J Am Soc Echocardiogr. 2014 Jan 17. pii: S0894-7317(13)00969-3. doi: 10.1016/j.echo.2013.12.011. [Epub ahead of print]
PMID: 24444659 [PubMed - as supplied by publisher]
 
Predicting the future with stem cells.
Mohsin S, Wu JC, Sussman MA.
Circulation. 2014 Jan 14;129(2):136-8. doi: 10.1161/CIRCULATIONAHA.113.007045. Epub 2013 Nov 18. No abstract available.
PMID: 24249719 [PubMed - in process] Free PMC Article
 
Cardiac stem cell biology: glimpse of the past, present, and future.
Matsa E, Sallam K, Wu JC.
Circ Res. 2014 Jan 3;114(1):21-7. doi: 10.1161/CIRCRESAHA.113.302895. Review.
PMID: 24385505 [PubMed - indexed for MEDLINE]
 
Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia.
Lijkwan MA, Hellingman AA, Bos EJ, van der Bogt KE, Huang M, Kooreman NG, de Vries MR, Peters HA, Robbins RC, Hamming JF, Quax PH, Wu JC.
Hum Gene Ther. 2014 Jan;25(1):41-9. doi: 10.1089/hum.2013.110. Epub 2014 Jan 7.
PMID: 24090375 [PubMed - in process]

2013

Patient-specific stem cells and cardiovascular drug discovery.
Mordwinkin NM, Lee AS, Wu JC.
JAMA. 2013 Nov 20;310(19):2039-40. doi: 10.1001/jama.2013.282409. No abstract available.
PMID: 24240927 [PubMed - indexed for MEDLINE]
 
Costimulation-adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation.
Huber BC, Ransohoff JD, Ransohoff KJ, Riegler J, Ebert A, Kodo K, Gong Y, Sanchez-Freire V, Dey D, Kooreman NG, Diecke S, Zhang WY, Odegaard J, Hu S, Gold JD, Robbins RC, Wu JC.
Stem Cells. 2013 Nov;31(11):2354-63. doi: 10.1002/stem.1501.
PMID: 24038578 [PubMed - in process]
 
CD34+ stem cell therapy in nonischemic dilated cardiomyopathy patients.
Vrtovec B, Poglajen G, Sever M, Lezaic L, Socan A, Haddad F, Wu JC.
Clin Pharmacol Ther. 2013 Oct;94(4):452-8. doi: 10.1038/clpt.2013.134. Epub 2013 Jul 31. Review.
PMID: 23903668 [PubMed - indexed for MEDLINE]
 
Noninvasive imaging of hypoxia-inducible factor-1α gene therapy for myocardial ischemia.
Chen IY, Gheysens O, Li Z, Rasooly JA, Wang Q, Paulmurugan R, Rosenberg J, Rodriguez-Porcel M, Willmann JK, Wang DS, Contag CH, Robbins RC, Wu JC, Gambhir SS.
Hum Gene Ther Methods. 2013 Oct;24(5):279-88. doi: 10.1089/hgtb.2013.028.
PMID: 23937265 [PubMed - indexed for MEDLINE]
 
Comparison of transendocardial and intracoronary CD34+ cell transplantation in patients with nonischemic dilated cardiomyopathy.
Vrtovec B, Poglajen G, Lezaic L, Sever M, Socan A, Domanovic D, Cernelc P, Torre-Amione G, Haddad F, Wu JC.
Circulation. 2013 Sep 10;128(11 Suppl 1):S42-9. doi: 10.1161/CIRCULATIONAHA.112.000230.
PMID: 24030420 [PubMed - indexed for MEDLINE]
 
Screening drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays.
Navarrete EG, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Wu H, Beygui RE, Wu SM, Robbins RC, Bers DM, Wu JC.
Circulation. 2013 Sep 10;128(11 Suppl 1):S3-13. doi: 10.1161/CIRCULATIONAHA.112.000570.
PMID: 24030418 [PubMed - indexed for MEDLINE]
 
Global epigenomic reconfiguration during mammalian brain development.
Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, Rao A, Esteller M, He C, Haghighi FG, Sejnowski TJ, Behrens MM, Ecker JR.
Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4.
PMID: 23828890 [PubMed - indexed for MEDLINE] Free PMC Article
 
Development of poly(β-amino ester)-based biodegradable nanoparticles for nonviral delivery of minicircle DNA.
Keeney M, Ong SG, Padilla A, Yao Z, Goodman S, Wu JC, Yang F.
ACS Nano. 2013 Aug 27;7(8):7241-50. doi: 10.1021/nn402657d. Epub 2013 Jul 16.
PMID: 23837668 [PubMed - in process]
 
Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies.
Lee AS, Tang C, Rao MS, Weissman IL, Wu JC.
Nat Med. 2013 Aug;19(8):998-1004. doi: 10.1038/nm.3267. Epub 2013 Aug 6. Review.
PMID: 23921754 [PubMed - indexed for MEDLINE]
 
Molecular imaging: the key to advancing cardiac stem cell therapy.
Chen IY, Wu JC.
Trends Cardiovasc Med. 2013 Aug;23(6):201-10. doi: 10.1016/j.tcm.2012.12.003. Epub 2013 Apr 3. Review.
PMID: 23561794 [PubMed - indexed for MEDLINE]
 
Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells.
Chan CK, Lindau P, Jiang W, Chen JY, Zhang LF, Chen CC, Seita J, Sahoo D, Kim JB, Lee A, Park S, Nag D, Gong Y, Kulkarni S, Luppen CA, Theologis AA, Wan DC, DeBoer A, Seo EY, Vincent-Tompkins JD, Loh K, Walmsley GG, Kraft DL, Wu JC, Longaker MT, Weissman IL.
Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12643-8. doi: 10.1073/pnas.1310212110. Epub 2013 Jul 15.
PMID: 23858471 [PubMed - indexed for MEDLINE] Free PMC Article
 
The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells.
Sharma A, Diecke S, Zhang WY, Lan F, He C, Mordwinkin NM, Chua KF, Wu JC.
J Biol Chem. 2013 Jun 21;288(25):18439-47. doi: 10.1074/jbc.M112.405928. Epub 2013 May 7.
PMID: 23653361 [PubMed - indexed for MEDLINE]
 
Overview of high throughput sequencing technologies to elucidate molecular pathways in cardiovascular diseases.
Churko JM, Mantalas GL, Snyder MP, Wu JC.
Circ Res. 2013 Jun 7;112(12):1613-23. doi: 10.1161/CIRCRESAHA.113.300939. Review.
PMID: 23743227 [PubMed - indexed for MEDLINE]
 
Induced pluripotency of human prostatic epithelial cells.
Zhao H, Sun N, Young SR, Nolley R, Santos J, Wu JC, Peehl DM.
PLoS One. 2013 May 22;8(5):e64503. doi: 10.1371/journal.pone.0064503. Print 2013.
PMID: 23717621 [PubMed - indexed for MEDLINE] Free PMC Article
 
Dissecting the molecular relationship among various cardiogenic progenitor cells.
Dey D, Han L, Bauer M, Sanada F, Oikonomopoulos A, Hosoda T, Unno K, De Almeida P, Leri A, Wu JC.
Circ Res. 2013 Apr 26;112(9):1253-62. doi: 10.1161/CIRCRESAHA.112.300779. Epub 2013 Mar 5.
PMID: 23463815 [PubMed - indexed for MEDLINE] Free PMC Article
 
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC, Wu JC.
Circulation. 2013 Apr 23;127(16):1677-91. doi: 10.1161/CIRCULATIONAHA.113.001883. Epub 2013 Mar 21.
PMID: 23519760 [PubMed - indexed for MEDLINE]
 
Effective delivery of stem cells using an extracellular matrix patch results in increased cell survival and proliferation and reduced scarring in skin wound healing.
Lam MT, Nauta A, Meyer NP, Wu JC, Longaker MT.
Tissue Eng Part A. 2013 Mar;19(5-6):738-47. doi: 10.1089/ten.TEA.2012.0480. Epub 2012 Nov 16.
PMID: 23072446 [PubMed - indexed for MEDLINE] Free PMC Article
 
Sacrificial layer technique for axial force post assay of immature cardiomyocytes.
Taylor RE, Kim K, Sun N, Park SJ, Sim JY, Fajardo G, Bernstein D, Wu JC, Pruitt BL.
Biomed Microdevices. 2013 Feb;15(1):171-81. doi: 10.1007/s10544-012-9710-3.
PMID: 23007494 [PubMed - indexed for MEDLINE] Free PMC Article
 
Immunogenicity of pluripotent stem cells and their derivatives.
de Almeida PE, Ransohoff JD, Nahid A, Wu JC.
Circ Res. 2013 Feb 1;112(3):549-61. doi: 10.1161/CIRCRESAHA.111.249243. Review.
PMID: 23371903 [PubMed - indexed for MEDLINE] Free PMC Article
 
A review of human pluripotent stem cell-derived cardiomyocytes for high-throughput drug discovery, cardiotoxicity screening, and publication standards.
Mordwinkin NM, Burridge PW, Wu JC.
J Cardiovasc Transl Res. 2013 Feb;6(1):22-30. doi: 10.1007/s12265-012-9423-2. Epub 2012 Nov 15. Review.
PMID: 23229562 [PubMed - indexed for MEDLINE] Free PMC Article
 
MicroRNA-302 increases reprogramming efficiency via repression of NR2F2.
Hu S, Wilson KD, Ghosh Z, Han L, Wang Y, Lan F, Ransohoff KJ, Burridge P, Wu JC.
Stem Cells. 2013 Feb;31(2):259-68. doi: 10.1002/stem.1278.
PMID: 23136034 [PubMed - indexed for MEDLINE] Free PMC Article
 
Advances in nanotechnology for the management of coronary artery disease.
Rhee JW, Wu JC.
Trends Cardiovasc Med. 2013 Feb;23(2):39-45. doi: 10.1016/j.tcm.2012.08.009. Epub 2012 Dec 13. Review.
PMID: 23245913 [PubMed - indexed for MEDLINE] Free PMC Article
 
Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up.
Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC.
Circ Res. 2013 Jan 4;112(1):165-73. doi: 10.1161/CIRCRESAHA.112.276519. Epub 2012 Oct 12.
PMID: 23065358 [PubMed - indexed for MEDLINE] Free Article
 
Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells.
Lan F, Lee AS, Liang P, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC.
Cell Stem Cell. 2013 Jan 3;12(1):101-13. doi: 10.1016/j.stem.2012.10.010.
PMID: 23290139 [PubMed - indexed for MEDLINE] Free PMC Article
 
American Journal of Nuclear Medicine and Molecular Imaging: Editorial Board (2014) e-Century Publishing Corporation.
Seto B, Jacobs PM, Mach RH, Bulte JW, Cai W, Alavi A, Divgi CR, Wu JC.
Am J Nucl Med Mol Imaging. 2013 Dec 15;4(1):89-95. eCollection 2013. No abstract available.
PMID: 24380049 [PubMed] Free PMC Article
 
Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.
Leeper NJ, Raiesdana A, Kojima Y, Kundu RK, Cheng H, Maegdefessel L, Toh R, Ahn GO, Ali ZA, Anderson DR, Miller CL, Roberts SC, Spin JM, de Almeida PE, Wu JC, Xu B, Cheng K, Quertermous M, Kundu S, Kortekaas KE, Berzin E, Downing KP, Dalman RL, Tsao PS, Schadt EE, Owens GK, Quertermous T.
Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):e1-e10. doi: 10.1161/ATVBAHA.112.300399. Epub 2012 Nov 15.
PMID: 23162013 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging neural stem cell graft-induced structural repair in stroke.
Daadi MM, Hu S, Klausner J, Li Z, Sofilos M, Sun G, Wu JC, Steinberg GK.
Cell Transplant. 2013;22(5):881-92.
PMID: 23044338 [PubMed - indexed for MEDLINE]
 
Generation of human iPSCs from human peripheral blood mononuclear cells using non-integrative Sendai virus in chemically defined conditions.
Churko JM, Burridge PW, Wu JC.
Methods Mol Biol. 2013;1036:81-8. doi: 10.1007/978-1-62703-511-8_7.
PMID: 23807788 [PubMed - indexed for MEDLINE]
 
MicroRNA expression profiling of human-induced pluripotent and embryonic stem cells.
Sharma A, Wu JC.
Methods Mol Biol. 2013;936:247-56. Review.
PMID: 23007513 [PubMed - indexed for MEDLINE] Free PMC Article
 
A transgenic tri-modality reporter mouse.
Yan X, Ray P, Paulmurugan R, Tong R, Gong Y, Sathirachinda A, Wu JC, Gambhir SS.
PLoS One. 2013 Aug 9;8(8):e73580. doi: 10.1371/journal.pone.0073580. eCollection 2013.
PMID: 23951359 [PubMed - indexed for MEDLINE] Free PMC Article
 
Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42).
Rajadas J, Sun W, Li H, Inayathullah M, Cereghetti D, Tan A, de Mello Coelho V, Chrest FJ, Kusiak JW, Smith WW, Taub D, Wu JC, Rifkind JM.
PLoS One. 2013;8(3):e58194. doi: 10.1371/journal.pone.0058194. Epub 2013 Mar 7.
PMID: 23505467 [PubMed - indexed for MEDLINE] Free PMC Article
 
Cardiovascular molecular imaging as a tool to study biology.
Rodriguez-Porcel M, Wu JC.
Theranostics. 2013 Dec 9;3(11):914-5. doi: 10.7150/thno.6333. eCollection 2013. No abstract available.
PMID: 24396501 [PubMed - in process] Free PMC Article

2012

Pluripotent stem cells: immune to the immune system?
Pearl JI, Kean LS, Davis MM, Wu JC.
Sci Transl Med. 2012 Dec 12;4(164):164ps25. doi: 10.1126/scitranslmed.3005090. Review.
PMID: 23241742 [PubMed - indexed for MEDLINE] Free PMC Article
 
In vivo directed differentiation of pluripotent stem cells for skeletal regeneration.
Levi B, Hyun JS, Montoro DT, Lo DD, Chan CK, Hu S, Sun N, Lee M, Grova M, Connolly AJ, Wu JC, Gurtner GC, Weissman IL, Wan DC, Longaker MT.
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20379-84. doi: 10.1073/pnas.1218052109. Epub 2012 Nov 20.
PMID: 23169671 [PubMed - indexed for MEDLINE] Free PMC Article
 
Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging.
Wang Y, Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC.
Circ Res. 2012 Dec 7;111(12):1494-503. doi: 10.1161/CIRCRESAHA.112.274969. Epub 2012 Sep 11.
PMID: 22967807 [PubMed - indexed for MEDLINE] Free PMC Article
 
Transient, inducible, placenta-specific gene expression in mice.
Fan X, Petitt M, Gamboa M, Huang M, Dhal S, Druzin ML, Wu JC, Chen-Tsai Y, Nayak NR.
Endocrinology. 2012 Nov;153(11):5637-44. doi: 10.1210/en.2012-1556. Epub 2012 Sep 25.
PMID: 23011919 [PubMed - indexed for MEDLINE] Free PMC Article
 
Induced pluripotent stem cells as a disease modeling and drug screening platform.
Ebert AD, Liang P, Wu JC.
J Cardiovasc Pharmacol. 2012 Oct;60(4):408-16. doi: 10.1097/FJC.0b013e318247f642. Review.
PMID: 22240913 [PubMed - indexed for MEDLINE] Free PMC Article
 
Pushing the reset button: chemical-induced conversion of amniotic fluid stem cells into a pluripotent state.
Diecke S, Wu JC.
Mol Ther. 2012 Oct;20(10):1839-41. doi: 10.1038/mt.2012.192. No abstract available.
PMID: 23023056 [PubMed - indexed for MEDLINE] Free PMC Article
 
In vivo, ex vivo, and in vitro studies on apelin's effect on myocardial glucose uptake.
Xu S, Han P, Huang M, Wu JC, Chang C, Tsao PS, Yue P.
Peptides. 2012 Oct;37(2):320-6. doi: 10.1016/j.peptides.2012.08.004. Epub 2012 Aug 10.
PMID: 22906703 [PubMed - in process]
 
Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation.
Gu M, Nguyen PK, Lee AS, Xu D, Hu S, Plews JR, Han L, Huber BC, Lee WH, Gong Y, de Almeida PE, Lyons J, Ikeno F, Pacharinsak C, Connolly AJ, Gambhir SS, Robbins RC, Longaker MT, Wu JC.
Circ Res. 2012 Sep 14;111(7):882-93. doi: 10.1161/CIRCRESAHA.112.269001. Epub 2012 Jul 19.
PMID: 22821929 [PubMed - indexed for MEDLINE] Free PMC Article
 
Safe genetic modification of cardiac stem cells using a site-specific integration technique.
Lan F, Liu J, Narsinh KH, Hu S, Han L, Lee AS, Karow M, Nguyen PK, Nag D, Calos MP, Robbins RC, Wu JC.
Circulation. 2012 Sep 11;126(11 Suppl 1):S20-8.
PMID: 22965984 [PubMed - indexed for MEDLINE] Free PMC Article
 
The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles.
Jang ES, Shin JH, Ren G, Park MJ, Cheng K, Chen X, Wu JC, Sunwoo JB, Cheng Z.
Biomaterials. 2012 Aug;33(22):5584-92. doi: 10.1016/j.biomaterials.2012.04.041. Epub 2012 May 8.
PMID: 22575830 [PubMed - indexed for MEDLINE] Free PMC Article
 
Biomaterial applications in cardiovascular tissue repair and regeneration.
Lam MT, Wu JC.
Expert Rev Cardiovasc Ther. 2012 Aug;10(8):1039-49. doi: 10.1586/erc.12.99. Review.
PMID: 23030293 [PubMed - indexed for MEDLINE] Free PMC Article
 
Early stem cell engraftment predicts late cardiac functional recovery: preclinical insights from molecular imaging.
Liu J, Narsinh KH, Lan F, Wang L, Nguyen PK, Hu S, Lee A, Han L, Gong Y, Huang M, Nag D, Rosenberg J, Chouldechova A, Robbins RC, Wu JC.
Circ Cardiovasc Imaging. 2012 Jul;5(4):481-90. doi: 10.1161/CIRCIMAGING.111.969329. Epub 2012 May 7.
PMID: 22565608 [PubMed - indexed for MEDLINE] Free PMC Article
 
Large animal induced pluripotent stem cells as pre-clinical models for studying human disease.
Plews JR, Gu M, Longaker MT, Wu JC.
J Cell Mol Med. 2012 Jun;16(6):1196-202. doi: 10.1111/j.1582-4934.2012.01521.x. Review.
PMID: 22212700 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging stem cell therapy for the treatment of peripheral arterial disease.
Ransohoff JD, Wu JC.
Curr Vasc Pharmacol. 2012 May;10(3):361-73. Review.
PMID: 22239638 [PubMed - indexed for MEDLINE] Free PMC Article
 
Dynamic microRNA expression during the transition from right ventricular hypertrophy to failure.
Reddy S, Zhao M, Hu DQ, Fajardo G, Hu S, Ghosh Z, Rajagopalan V, Wu JC, Bernstein D.
Physiol Genomics. 2012 May 1;44(10):562-75. doi: 10.1152/physiolgenomics.00163.2011. Epub 2012 Mar 27.
PMID: 22454450 [PubMed - indexed for MEDLINE] Free PMC Article
 
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.
Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC.
Sci Transl Med. 2012 Apr 18;4(130):130ra47. doi: 10.1126/scitranslmed.3003552.
PMID: 22517884 [PubMed - indexed for MEDLINE] Free PMC Article
 
Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns.
Sanchez-Freire V, Ebert AD, Kalisky T, Quake SR, Wu JC.
Nat Protoc. 2012 Apr 5;7(5):829-38. doi: 10.1038/nprot.2012.021.
PMID: 22481529 [PubMed - indexed for MEDLINE] Free PMC Article
 
Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.
Burridge PW, Keller G, Gold JD, Wu JC.
Cell Stem Cell. 2012 Jan 6;10(1):16-28. doi: 10.1016/j.stem.2011.12.013.
PMID: 22226352 [PubMed - indexed for MEDLINE] Free PMC Article
 
In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium.
Sheikh AY, Huber BC, Narsinh KH, Spin JM, van der Bogt K, de Almeida PE, Ransohoff KJ, Kraft DL, Fajardo G, Ardigo D, Ransohoff J, Bernstein D, Fischbein MP, Robbins RC, Wu JC.
Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):92-102. doi: 10.1161/ATVBAHA.111.238618. Epub 2011 Oct 27.
PMID: 22034515 [PubMed - indexed for MEDLINE] Free PMC Article
 
Epigenetic Modulations of Induced Pluripotent Stem Cells: Novel Therapies and Disease Models.
Huang C, Wu JC.
Drug Discov Today Dis Models. 2012;9(4):e153-e160.
PMID: 23646061 [PubMed] Free PMC Article
 
Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease.
van der Bogt KE, Hellingman AA, Lijkwan MA, Bos EJ, de Vries MR, van Rappard JR, Fischbein MP, Quax PH, Robbins RC, Hamming JF, Wu JC.
JACC Cardiovasc Imaging. 2012 Jan;5(1):46-55. doi: 10.1016/j.jcmg.2011.07.011.
PMID: 22239892 [PubMed - indexed for MEDLINE] Free PMC Article
 
Enhancement of human adipose-derived stromal cell angiogenesis through knockdown of a BMP-2 inhibitor.
Levi B, Nelson ER, Hyun JS, Glotzbach JP, Li S, Nauta A, Montoro DT, Lee M, Commons GC, Hu S, Wu JC, Gurtner GC, Longaker MT.
Plast Reconstr Surg. 2012 Jan;129(1):53-66. doi: 10.1097/PRS.0b013e3182361ff5.
PMID: 21915082 [PubMed - indexed for MEDLINE] Free PMC Article
 
Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes.
Liu J, Sun N, Bruce MA, Wu JC, Butte MJ.
PLoS One. 2012;7(5):e37559. doi: 10.1371/journal.pone.0037559. Epub 2012 May 18.
PMID: 22624048 [PubMed - indexed for MEDLINE] Free PMC Article

2011

Endothelial progenitor cells in cardiovascular disease and chronic inflammation: from biomarker to therapeutic agent.
Grisar JC, Haddad F, Gomari FA, Wu JC.
Biomark Med. 2011 Dec;5(6):731-44. doi: 10.2217/bmm.11.92. Review.
PMID: 22103609 [PubMed - indexed for MEDLINE] Free PMC Article
 
Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair.
Levi B, Hyun JS, Nelson ER, Li S, Montoro DT, Wan DC, Jia FJ, Glotzbach JC, James AW, Lee M, Huang M, Quarto N, Gurtner GC, Wu JC, Longaker MT.
Stem Cells. 2011 Dec;29(12):2018-29. doi: 10.1002/stem.757.
PMID: 21997852 [PubMed - indexed for MEDLINE] Free Article
 
Site-specific recombinase strategy to create induced pluripotent stem cells efficiently with plasmid DNA.
Karow M, Chavez CL, Farruggio AP, Geisinger JM, Keravala A, Jung WE, Lan F, Wu JC, Chen-Tsai Y, Calos MP.
Stem Cells. 2011 Nov;29(11):1696-704. doi: 10.1002/stem.730.
PMID: 21898697 [PubMed - indexed for MEDLINE] Free PMC Article
 
Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells.
Li Z, Hu S, Ghosh Z, Han Z, Wu JC.
Stem Cells Dev. 2011 Oct;20(10):1701-10. doi: 10.1089/scd.2010.0426. Epub 2011 Feb 28.
PMID: 21235328 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging: guiding the clinical translation of cardiac stem cell therapy.
Nguyen PK, Lan F, Wang Y, Wu JC.
Circ Res. 2011 Sep 30;109(8):962-79. doi: 10.1161/CIRCRESAHA.111.242909. Review.
PMID: 21960727 [PubMed - indexed for MEDLINE] Free PMC Article
 
Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells.
Lee AS, Xu D, Plews JR, Nguyen PK, Nag D, Lyons JK, Han L, Hu S, Lan F, Liu J, Huang M, Narsinh KH, Long CT, de Almeida PE, Levi B, Kooreman N, Bangs C, Pacharinsak C, Ikeno F, Yeung AC, Gambhir SS, Robbins RC, Longaker MT, Wu JC.
J Biol Chem. 2011 Sep 16;286(37):32697-704. doi: 10.1074/jbc.M111.235739. Epub 2011 Jun 30.
PMID: 21719696 [PubMed - indexed for MEDLINE] Free PMC Article
 
Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction.
Huang M, Nguyen P, Jia F, Hu S, Gong Y, de Almeida PE, Wang L, Nag D, Kay MA, Giaccia AJ, Robbins RC, Wu JC.
Circulation. 2011 Sep 13;124(11 Suppl):S46-54. doi: 10.1161/CIRCULATIONAHA.110.014019.
PMID: 21911818 [PubMed - indexed for MEDLINE] Free PMC Article
 
Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation.
Hu S, Huang M, Nguyen PK, Gong Y, Li Z, Jia F, Lan F, Liu J, Nag D, Robbins RC, Wu JC.
Circulation. 2011 Sep 13;124(11 Suppl):S27-34. doi: 10.1161/CIRCULATIONAHA.111.017954.
PMID: 21911815 [PubMed - indexed for MEDLINE] Free PMC Article
 
In vivo bioluminescence for tracking cell fate and function.
de Almeida PE, van Rappard JR, Wu JC.
Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H663-71. doi: 10.1152/ajpheart.00337.2011. Epub 2011 Jun 10. Review.
PMID: 21666118 [PubMed - indexed for MEDLINE] Free PMC Article
 
An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells.
Tang C, Lee AS, Volkmer JP, Sahoo D, Nag D, Mosley AR, Inlay MA, Ardehali R, Chavez SL, Pera RR, Behr B, Wu JC, Weissman IL, Drukker M.
Nat Biotechnol. 2011 Aug 14;29(9):829-34. doi: 10.1038/nbt.1947.
PMID: 21841799 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging cardiac stem cell therapy: translations to human clinical studies.
Zhang WY, Ebert AD, Narula J, Wu JC.
J Cardiovasc Transl Res. 2011 Aug;4(4):514-22. doi: 10.1007/s12265-011-9281-3. Epub 2011 May 3. Review.
PMID: 21538182 [PubMed - indexed for MEDLINE] Free PMC Article
 
Pretreatment with angiotensin-converting enzyme inhibitor improves doxorubicin-induced cardiomyopathy via preservation of mitochondrial function.
Hiona A, Lee AS, Nagendran J, Xie X, Connolly AJ, Robbins RC, Wu JC.
J Thorac Cardiovasc Surg. 2011 Aug;142(2):396-403.e3. doi: 10.1016/j.jtcvs.2010.07.097. Epub 2010 Nov 20.
PMID: 21094500 [PubMed - indexed for MEDLINE] Free PMC Article
 
Differences in osteogenic differentiation of adipose-derived stromal cells from murine, canine, and human sources in vitro and in vivo.
Levi B, Nelson ER, Brown K, James AW, Xu D, Dunlevie R, Wu JC, Lee M, Wu B, Commons GW, Vistnes D, Longaker MT.
Plast Reconstr Surg. 2011 Aug;128(2):373-86. doi: 10.1097/PRS.0b013e31821e6e49.
PMID: 21788829 [PubMed - indexed for MEDLINE]
 
Dissecting the oncogenic and tumorigenic potential of differentiated human induced pluripotent stem cells and human embryonic stem cells.
Ghosh Z, Huang M, Hu S, Wilson KD, Dey D, Wu JC.
Cancer Res. 2011 Jul 15;71(14):5030-9. doi: 10.1158/0008-5472.CAN-10-4402. Epub 2011 Jun 6.
PMID: 21646469 [PubMed - indexed for MEDLINE] Free PMC Article
 
Efficient gene delivery of primary human cells using peptide linked polyethylenimine polymer hybrid.
Dey D, Inayathullah M, Lee AS, LeMieux MC, Zhang X, Wu Y, Nag D, De Almeida PE, Han L, Rajadas J, Wu JC.
Biomaterials. 2011 Jul;32(20):4647-58. doi: 10.1016/j.biomaterials.2011.03.016. Epub 2011 Apr 8.
PMID: 21477858 [PubMed - indexed for MEDLINE] Free PMC Article
 
Derivation of human induced pluripotent stem cells for cardiovascular disease modeling.
Narsinh K, Narsinh KH, Wu JC.
Circ Res. 2011 Apr 29;108(9):1146-56. doi: 10.1161/CIRCRESAHA.111.240374. Review.
PMID: 21527744 [PubMed - indexed for MEDLINE] Free PMC Article
 
Comparison of human induced pluripotent and embryonic stem cells: fraternal or identical twins?
Narsinh KH, Plews J, Wu JC.
Mol Ther. 2011 Apr;19(4):635-8. doi: 10.1038/mt.2011.41. No abstract available.
PMID: 21455209 [PubMed - indexed for MEDLINE] Free PMC Article
 
Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells.
Pearl JI, Lee AS, Leveson-Gower DB, Sun N, Ghosh Z, Lan F, Ransohoff J, Negrin RS, Davis MM, Wu JC.
Cell Stem Cell. 2011 Mar 4;8(3):309-17. doi: 10.1016/j.stem.2011.01.012.
PMID: 21362570 [PubMed - indexed for MEDLINE] Free PMC Article
 
Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells.
Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Robbins RC, Wu JC.
J Clin Invest. 2011 Mar;121(3):1217-21. doi: 10.1172/JCI44635. Epub 2011 Feb 7.
PMID: 21317531 [PubMed - indexed for MEDLINE] Free PMC Article
 
Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells.
Panula S, Medrano JV, Kee K, Bergström R, Nguyen HN, Byers B, Wilson KD, Wu JC, Simon C, Hovatta O, Reijo Pera RA.
Hum Mol Genet. 2011 Feb 15;20(4):752-62. doi: 10.1093/hmg/ddq520. Epub 2010 Dec 3.
PMID: 21131292 [PubMed - indexed for MEDLINE] Free PMC Article
 
Cardiovascular molecular imaging: focus on clinical translation.
Chen IY, Wu JC.
Circulation. 2011 Feb 1;123(4):425-43. doi: 10.1161/CIRCULATIONAHA.109.916338. Review. No abstract available.
PMID: 21282520 [PubMed - indexed for MEDLINE] Free PMC Article
 
Radiation exposure from imaging tests: is there an increased cancer risk?
Nguyen PK, Wu JC.
Expert Rev Cardiovasc Ther. 2011 Feb;9(2):177-83. doi: 10.1586/erc.10.184. Review.
PMID: 21453214 [PubMed - indexed for MEDLINE] Free PMC Article
 
Sex differences in the diagnostic evaluation of coronary artery disease.
Nguyen PK, Nag D, Wu JC.
J Nucl Cardiol. 2011 Feb;18(1):144-52. doi: 10.1007/s12350-010-9315-2. Review. No abstract available.
PMID: 21136229 [PubMed - indexed for MEDLINE] Free PMC Article
 
Elastic properties of induced pluripotent stem cells.
Hammerick KE, Huang Z, Sun N, Lam MT, Prinz FB, Wu JC, Commons GW, Longaker MT.
Tissue Eng Part A. 2011 Feb;17(3-4):495-502. doi: 10.1089/ten.TEA.2010.0211. Epub 2010 Oct 25.
PMID: 20807017 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging of embryonic stem cell migration in vivo.
Lee AS, Wu JC.
Methods Mol Biol. 2011;750:101-14. doi: 10.1007/978-1-61779-145-1_7.
PMID: 21618086 [PubMed - indexed for MEDLINE] Free PMC Article
 
Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia.
Huang M, Wu JC.
Methods Mol Biol. 2011;709:211-21. doi: 10.1007/978-1-61737-982-6_13.
PMID: 21194030 [PubMed - indexed for MEDLINE] Free PMC Article
 
Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors.
Narsinh KH, Jia F, Robbins RC, Kay MA, Longaker MT, Wu JC.
Nat Protoc. 2011 Jan;6(1):78-88. doi: 10.1038/nprot.2010.173. Epub 2010 Dec 23.
PMID: 21212777 [PubMed - indexed for MEDLINE] Free PMC Article
 
Effects of long-term culture on human embryonic stem cell aging.
Xie X, Hiona A, Lee AS, Cao F, Huang M, Li Z, Cherry A, Pei X, Wu JC.
Stem Cells Dev. 2011 Jan;20(1):127-38. doi: 10.1089/scd.2009.0475. Epub 2010 Sep 9.
PMID: 20629482 [PubMed - indexed for MEDLINE] Free PMC Article

2010

Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging.
Kooreman NG, Wu JC.
J R Soc Interface. 2010 Dec 6;7 Suppl 6:S753-63. doi: 10.1098/rsif.2010.0353.focus. Epub 2010 Sep 29. Review.
PMID: 20880852 [PubMed - indexed for MEDLINE] Free PMC Article
 
Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499.
Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC.
Circ Cardiovasc Genet. 2010 Oct;3(5):426-35. doi: 10.1161/CIRCGENETICS.109.934281. Epub 2010 Aug 23.
PMID: 20733065 [PubMed - indexed for MEDLINE] Free PMC Article
 
Methods to assess stem cell lineage, fate and function.
Nguyen PK, Nag D, Wu JC.
Adv Drug Deliv Rev. 2010 Sep 30;62(12):1175-86. doi: 10.1016/j.addr.2010.08.008. Epub 2010 Sep 9. Review.
PMID: 20816906 [PubMed - indexed for MEDLINE] Free PMC Article
 
MicroRNA-210 as a novel therapy for treatment of ischemic heart disease.
Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, Sun N, Wang X, Martelli F, Robbins RC, Wu JC.
Circulation. 2010 Sep 14;122(11 Suppl):S124-31. doi: 10.1161/CIRCULATIONAHA.109.928424.
PMID: 20837903 [PubMed - indexed for MEDLINE] Free PMC Article
 
Role of molecular imaging in stem cell therapy for myocardial restoration.
Lijkwan MA, Bos EJ, Wu JC, Robbins RC.
Trends Cardiovasc Med. 2010 Aug;20(6):183-8. doi: 10.1016/j.tcm.2011.04.001. Review.
PMID: 22137639 [PubMed - indexed for MEDLINE] Free PMC Article
 
Effects of ionizing radiation on self-renewal and pluripotency of human embryonic stem cells.
Wilson KD, Sun N, Huang M, Zhang WY, Lee AS, Li Z, Wang SX, Wu JC.
Cancer Res. 2010 Jul 1;70(13):5539-48. doi: 10.1158/0008-5472.CAN-09-4238. Epub 2010 Jun 8.
PMID: 20530673 [PubMed - indexed for MEDLINE] Free PMC Article
 
Indirect imaging of cardiac-specific transgene expression using a bidirectional two-step transcriptional amplification strategy.
Chen IY, Gheysens O, Ray S, Wang Q, Padmanabhan P, Paulmurugan R, Loening AM, Rodriguez-Porcel M, Willmann JK, Sheikh AY, Nielsen CH, Hoyt G, Contag CH, Robbins RC, Biswal S, Wu JC, Gambhir SS.
Gene Ther. 2010 Jul;17(7):827-38. doi: 10.1038/gt.2010.30. Epub 2010 Mar 18.
PMID: 20237511 [PubMed - indexed for MEDLINE] Free PMC Article
 
Advances in cardiovascular molecular imaging for tracking stem cell therapy.
Ransohoff KJ, Wu JC.
Thromb Haemost. 2010 Jul;104(1):13-22. doi: 10.1160/TH09-08-0530. Epub 2010 May 10. Review.
PMID: 20458434 [PubMed - indexed for MEDLINE] Free PMC Article
 
Gene correction in human embryonic and induced pluripotent stem cells: promises and challenges ahead.
Narsinh KH, Wu JC.
Mol Ther. 2010 Jun;18(6):1061-3. doi: 10.1038/mt.2010.92. No abstract available.
PMID: 20514030 [PubMed - indexed for MEDLINE] Free PMC Article
 
Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion.
Huang NF, Niiyama H, Peter C, De A, Natkunam Y, Fleissner F, Li Z, Rollins MD, Wu JC, Gambhir SS, Cooke JP.
Arterioscler Thromb Vasc Biol. 2010 May;30(5):984-91. doi: 10.1161/ATVBAHA.110.202796. Epub 2010 Feb 18.
PMID: 20167654 [PubMed - indexed for MEDLINE] Free PMC Article
 
Current perspectives on imaging cardiac stem cell therapy.
Wu JC, Abraham MR, Kraitchman DL.
J Nucl Med. 2010 May 1;51 Suppl 1:128S-136S. doi: 10.2967/jnumed.109.068239. Epub 2010 Apr 15. Review.
PMID: 20395348 [PubMed - indexed for MEDLINE] Free PMC Article
 
Human iPS cell-based therapy: considerations before clinical applications.
Sun N, Longaker MT, Wu JC.
Cell Cycle. 2010 Mar 1;9(5):880-5. Epub 2010 Mar 2. Review.
PMID: 20160515 [PubMed - indexed for MEDLINE] Free PMC Article
 
A nonviral minicircle vector for deriving human iPS cells.
Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Panetta NJ, Chen ZY, Robbins RC, Kay MA, Longaker MT, Wu JC.
Nat Methods. 2010 Mar;7(3):197-9. doi: 10.1038/nmeth.1426. Epub 2010 Feb 7.
PMID: 20139967 [PubMed - indexed for MEDLINE] Free PMC Article
 
Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury.
Daadi MM, Davis AS, Arac A, Li Z, Maag AL, Bhatnagar R, Jiang K, Sun G, Wu JC, Steinberg GK.
Stroke. 2010 Mar;41(3):516-23. doi: 10.1161/STROKEAHA.109.573691. Epub 2010 Jan 14.
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Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells.
Ghosh Z, Wilson KD, Wu Y, Hu S, Quertermous T, Wu JC.
PLoS One. 2010 Feb 1;5(2):e8975. doi: 10.1371/journal.pone.0008975.
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Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction.
Swijnenburg RJ, Govaert JA, van der Bogt KE, Pearl JI, Huang M, Stein W, Hoyt G, Vogel H, Contag CH, Robbins RC, Wu JC.
Circ Cardiovasc Imaging. 2010 Jan;3(1):77-85. doi: 10.1161/CIRCIMAGING.109.872085. Epub 2009 Nov 17.
PMID: 19920031 [PubMed - indexed for MEDLINE] Free PMC Article
 
Embryonic stem cell biology: insights from molecular imaging.
Sallam K, Wu JC.
Methods Mol Biol. 2010;660:185-99. doi: 10.1007/978-1-60761-705-1_12.
PMID: 20680820 [PubMed - indexed for MEDLINE]
 
Comparison of gene-transfer efficiency in human embryonic stem cells.
Cao F, Xie X, Gollan T, Zhao L, Narsinh K, Lee RJ, Wu JC.
Mol Imaging Biol. 2010 Jan-Feb;12(1):15-24. doi: 10.1007/s11307-009-0236-x. Epub 2009 Jun 24.
PMID: 19551446 [PubMed - indexed for MEDLINE] Free PMC Article

2009

Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction.
Li Z, Wilson KD, Smith B, Kraft DL, Jia F, Huang M, Xie X, Robbins RC, Gambhir SS, Weissman IL, Wu JC.
PLoS One. 2009 Dec 31;4(12):e8443. doi: 10.1371/journal.pone.0008443.
PMID: 20046878 [PubMed - indexed for MEDLINE] Free PMC Article
 
Current-Controlled Electrical Point-Source Stimulation of Embryonic Stem Cells.
Chen MQ, Xie X, Wilson KD, Sun N, Wu JC, Giovangrandi L, Kovacs GT.
Cell Mol Bioeng. 2009 Dec;2(4):625-635.
PMID: 20652088 [PubMed] Free PMC Article
 
Poor functional recovery after transplantation of diabetic bone marrow stem cells in ischemic myocardium.
Govaert JA, Swijnenburg RJ, Schrepfer S, Xie X, van der Bogt KE, Hoyt G, Stein W, Ransohoff KJ, Robbins RC, Wu JC.
J Heart Lung Transplant. 2009 Nov;28(11):1158-1165.e1. doi: 10.1016/j.healun.2009.06.018. Epub 2009 Sep 26.
PMID: 19782602 [PubMed - indexed for MEDLINE] Free PMC Article
 
Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.
Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S.
Circulation. 2009 Sep 15;120(11 Suppl):S247-54. doi: 10.1161/CIRCULATIONAHA.108.843680.
PMID: 19752375 [PubMed - indexed for MEDLINE] Free Article
 
Novel minicircle vector for gene therapy in murine myocardial infarction.
Huang M, Chen Z, Hu S, Jia F, Li Z, Hoyt G, Robbins RC, Kay MA, Wu JC.
Circulation. 2009 Sep 15;120(11 Suppl):S230-7. doi: 10.1161/CIRCULATIONAHA.108.841155.
PMID: 19752373 [PubMed - indexed for MEDLINE] Free PMC Article
 
Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells.
Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, Hu S, Cherry AM, Robbins RC, Longaker MT, Wu JC.
Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15720-5. doi: 10.1073/pnas.0908450106. Epub 2009 Sep 8.
PMID: 19805220 [PubMed - indexed for MEDLINE] Free PMC Article
 
Effects of cell number on teratoma formation by human embryonic stem cells.
Lee AS, Tang C, Cao F, Xie X, van der Bogt K, Hwang A, Connolly AJ, Robbins RC, Wu JC.
Cell Cycle. 2009 Aug 15;8(16):2608-12. Epub 2009 Aug 24.
PMID: 19597339 [PubMed - indexed for MEDLINE] Free PMC Article
 
Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain.
Daadi MM, Li Z, Arac A, Grueter BA, Sofilos M, Malenka RC, Wu JC, Steinberg GK.
Mol Ther. 2009 Jul;17(7):1282-91. doi: 10.1038/mt.2009.104. Epub 2009 May 12.
PMID: 19436269 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging gene expression in human mesenchymal stem cells: from small to large animals.
Willmann JK, Paulmurugan R, Rodriguez-Porcel M, Stein W, Brinton TJ, Connolly AJ, Nielsen CH, Lutz AM, Lyons J, Ikeno F, Suzuki Y, Rosenberg J, Chen IY, Wu JC, Yeung AC, Yock P, Robbins RC, Gambhir SS.
Radiology. 2009 Jul;252(1):117-27. doi: 10.1148/radiol.2513081616. Epub 2009 Apr 14.
PMID: 19366903 [PubMed - indexed for MEDLINE] Free PMC Article
 
Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging.
Wang H, Cao F, De A, Cao Y, Contag C, Gambhir SS, Wu JC, Chen X.
Stem Cells. 2009 Jul;27(7):1548-58. doi: 10.1002/stem.81.
PMID: 19544460 [PubMed - indexed for MEDLINE] Free Article
 
MicroRNA profiling of human-induced pluripotent stem cells.
Wilson KD, Venkatasubrahmanyam S, Jia F, Sun N, Butte AJ, Wu JC.
Stem Cells Dev. 2009 Jun;18(5):749-58. doi: 10.1089/scd.2008.0247.
PMID: 19284351 [PubMed - indexed for MEDLINE] Free PMC Article
 
Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation.
Chen IY, Greve JM, Gheysens O, Willmann JK, Rodriguez-Porcel M, Chu P, Sheikh AY, Faranesh AZ, Paulmurugan R, Yang PC, Wu JC, Gambhir SS.
Mol Imaging Biol. 2009 May-Jun;11(3):178-87. doi: 10.1007/s11307-008-0182-z. Epub 2008 Nov 25.
PMID: 19034584 [PubMed - indexed for MEDLINE]
 
Imaging survival and function of transplanted cardiac resident stem cells.
Li Z, Lee A, Huang M, Chun H, Chung J, Chu P, Hoyt G, Yang P, Rosenberg J, Robbins RC, Wu JC.
J Am Coll Cardiol. 2009 Apr 7;53(14):1229-40. doi: 10.1016/j.jacc.2008.12.036.
PMID: 19341866 [PubMed - indexed for MEDLINE] Free PMC Article
 
Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.
van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC.
Transplantation. 2009 Mar 15;87(5):642-52. doi: 10.1097/TP.0b013e31819609d9.
PMID: 19295307 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging of STAT3 signaling pathway during mouse embryonic stem cell differentiation.
Xie X, Chan KS, Cao F, Huang M, Li Z, Lee A, Weissman IL, Wu JC.
Stem Cells Dev. 2009 Mar;18(2):205-14. doi: 10.1089/scd.2008.0152.
PMID: 18576943 [PubMed - indexed for MEDLINE] Free PMC Article
 
Transplantation of human embryonic stem cell-derived endothelial cells for vascular diseases.
Li Z, Han Z, Wu JC.
J Cell Biochem. 2009 Feb 1;106(2):194-9. doi: 10.1002/jcb.22003. Review.
PMID: 19097085 [PubMed - indexed for MEDLINE] Free PMC Article
 
Modeling conduction in host-graft interactions between stem cell grafts and cardiomyocytes.
Chen MQ, Yu J, Whittington RH, Wu JC, Kovacs GT, Giovangrandi L.
Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6014-7. doi: 10.1109/IEMBS.2009.5334024.
PMID: 19964687 [PubMed - indexed for MEDLINE]
 
Bioluminescence reporter gene imaging of human embryonic stem cell survival, proliferation, and fate.
Wilson KD, Huang M, Wu JC.
Methods Mol Biol. 2009;574:87-103. doi: 10.1007/978-1-60327-321-3_8.
PMID: 19685302 [PubMed - indexed for MEDLINE]
 
Long term non-invasive imaging of embryonic stem cells using reporter genes.
Sun N, Lee A, Wu JC.
Nat Protoc. 2009;4(8):1192-201. doi: 10.1038/nprot.2009.100. Epub 2009 Jul 23.
PMID: 19617890 [PubMed - indexed for MEDLINE] Free PMC Article

2008

In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation.
Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu JC.
Stem Cells Dev. 2008 Dec;17(6):1023-9. doi: 10.1089/scd.2008.0091.
PMID: 18491958 [PubMed - indexed for MEDLINE] Free PMC Article
 
Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells.
Hendry SL 2nd, van der Bogt KE, Sheikh AY, Arai T, Dylla SJ, Drukker M, McConnell MV, Kutschka I, Hoyt G, Cao F, Weissman IL, Connolly AJ, Pelletier MP, Wu JC, Robbins RC, Yang PC.
J Thorac Cardiovasc Surg. 2008 Oct;136(4):1028-1037.e1. doi: 10.1016/j.jtcvs.2007.12.053. Epub 2008 Jun 6.
PMID: 18954646 [PubMed - indexed for MEDLINE]
 
Short hairpin RNA interference therapy for ischemic heart disease.
Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC.
Circulation. 2008 Sep 30;118(14 Suppl):S226-33. doi: 10.1161/CIRCULATIONAHA.107.760785.
PMID: 18824759 [PubMed - indexed for MEDLINE] Free PMC Article
 
Comparison of different adult stem cell types for treatment of myocardial ischemia.
van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, Swijnenburg RJ, Pearl J, Lee A, Fischbein M, Contag CH, Robbins RC, Wu JC.
Circulation. 2008 Sep 30;118(14 Suppl):S121-9. doi: 10.1161/CIRCULATIONAHA.107.759480.
PMID: 18824743 [PubMed - indexed for MEDLINE] Free PMC Article
 
Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.
Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Sheikh AY, Haddad M, Connolly AJ, Davis MM, Robbins RC, Wu JC.
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12991-6. doi: 10.1073/pnas.0805802105. Epub 2008 Aug 26.
PMID: 18728188 [PubMed - indexed for MEDLINE] Free PMC Article
 
Noninvasive radionuclide imaging of cardiac gene therapy: progress and potential.
Hiona A, Wu JC.
Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S87-95. doi: 10.1038/ncpcardio1113. Review.
PMID: 18641612 [PubMed - indexed for MEDLINE]
 
Intracellular and extracellular targets of molecular imaging in the myocardium.
Chun HJ, Narula J, Hofstra L, Wu JC.
Nat Clin Pract Cardiovasc Med. 2008 Aug;5 Suppl 2:S33-41. doi: 10.1038/ncpcardio1161. Review.
PMID: 18641605 [PubMed - indexed for MEDLINE]
 
Transcriptome alteration in the diabetic heart by rosiglitazone: implications for cardiovascular mortality.
Wilson KD, Li Z, Wagner R, Yue P, Tsao P, Nestorova G, Huang M, Hirschberg DL, Yock PG, Quertermous T, Wu JC.
PLoS One. 2008 Jul 9;3(7):e2609. doi: 10.1371/journal.pone.0002609.
PMID: 18648539 [PubMed - indexed for MEDLINE] Free PMC Article
 
Seeing is believing: tracking cells to determine the effects of cell transplantation.
Pearl J, Wu JC.
Semin Thorac Cardiovasc Surg. 2008 Summer;20(2):102-9. doi: 10.1053/j.semtcvs.2008.04.002. Review.
PMID: 18707641 [PubMed - indexed for MEDLINE]
 
In vitro and in vivo bioluminescence reporter gene imaging of human embryonic stem cells.
Wilson K, Yu J, Lee A, Wu JC.
J Vis Exp. 2008 May 2;(14). pii: 740. doi: 10.3791/740.
PMID: 19066577 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging of VEGF receptor in a rat myocardial infarction model using PET.
Rodriguez-Porcel M, Cai W, Gheysens O, Willmann JK, Chen K, Wang H, Chen IY, He L, Wu JC, Li ZB, Mohamedali KA, Kim S, Rosenblum MG, Chen X, Gambhir SS.
J Nucl Med. 2008 Apr;49(4):667-73. doi: 10.2967/jnumed.107.040576.
PMID: 18375924 [PubMed - indexed for MEDLINE] Free PMC Article
 
Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects.
Li Z, Suzuki Y, Huang M, Cao F, Xie X, Connolly AJ, Yang PC, Wu JC.
Stem Cells. 2008 Apr;26(4):864-73. doi: 10.1634/stemcells.2007-0843. Epub 2008 Jan 24.
PMID: 18218820 [PubMed - indexed for MEDLINE] Free PMC Article
 
Cardiac differentiation of embryonic stem cells with point-source electrical stimulation.
Chen MQ, Xie X, Hollis Whittington R, Kovacs GT, Wu JC, Giovangrandi L.
Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1729-32. doi: 10.1109/IEMBS.2008.4649510.
PMID: 19163013 [PubMed - indexed for MEDLINE]
 
Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes.
Cao F, Wagner RA, Wilson KD, Xie X, Fu JD, Drukker M, Lee A, Li RA, Gambhir SS, Weissman IL, Robbins RC, Wu JC.
PLoS One. 2008;3(10):e3474. doi: 10.1371/journal.pone.0003474. Epub 2008 Oct 22.
PMID: 18941512 [PubMed - indexed for MEDLINE] Free PMC Article
 

2007

Comparison of imaging techniques for tracking cardiac stem cell therapy.
Zhang SJ, Wu JC.
J Nucl Med. 2007 Dec;48(12):1916-9. No abstract available.
PMID: 18056330 [PubMed - indexed for MEDLINE] Free PMC Article
 
Spatial and temporal kinetics of teratoma formation from murine embryonic stem cell transplantation.
Cao F, van der Bogt KE, Sadrzadeh A, Xie X, Sheikh AY, Wang H, Connolly AJ, Robbins RC, Wu JC.
Stem Cells Dev. 2007 Dec;16(6):883-91.
PMID: 17896868 [PubMed - indexed for MEDLINE]
 
In vivo imaging and evaluation of different biomatrices for improvement of stem cell survival.
Cao F, Sadrzadeh Rafie AH, Abilez OJ, Wang H, Blundo JT, Pruitt B, Zarins C, Wu JC.
J Tissue Eng Regen Med. 2007 Nov-Dec;1(6):465-8. doi: 10.1002/term.55.
PMID: 18163533 [PubMed - indexed for MEDLINE] Free PMC Article
 
Quantum dot imaging for embryonic stem cells.
Lin S, Xie X, Patel MR, Yang YH, Li Z, Cao F, Gheysens O, Zhang Y, Gambhir SS, Rao JH, Wu JC.
BMC Biotechnol. 2007 Oct 9;7:67.
PMID: 17925032 [PubMed - indexed for MEDLINE] Free PMC Article
 
Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium.
Sheikh AY, Lin SA, Cao F, Cao Y, van der Bogt KE, Chu P, Chang CP, Contag CH, Robbins RC, Wu JC.
Stem Cells. 2007 Oct;25(10):2677-84. Epub 2007 Jul 12.
PMID: 17628019 [PubMed - indexed for MEDLINE] Free PMC Article
 
Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease.
Li Z, Wu JC, Sheikh AY, Kraft D, Cao F, Xie X, Patel M, Gambhir SS, Robbins RC, Cooke JP, Wu JC.
Circulation. 2007 Sep 11;116(11 Suppl):I46-54.
PMID: 17846325 [PubMed - indexed for MEDLINE] Free PMC Article
 
Cardiovascular molecular imaging.
Wu JC, Bengel FM, Gambhir SS.
Radiology. 2007 Aug;244(2):337-55. Epub 2007 Jun 25. Review.
PMID: 17592037 [PubMed - indexed for MEDLINE]
 
Positron emission tomography imaging of conditional gene activation in the heart.
Chang GY, Cao F, Krishnan M, Huang M, Li Z, Xie X, Sheikh AY, Hoyt G, Robbins RC, Hsiai T, Schneider MD, Wu JC.
J Mol Cell Cardiol. 2007 Jul;43(1):18-26. Epub 2007 Mar 24.
PMID: 17467733 [PubMed - indexed for MEDLINE] Free PMC Article
 
A novel platform device for rodent echocardiography.
Kutschka I, Sheikh AY, Sista R, Hendry SL, Chun HJ, Hoyt G, Kutschka W, Pelletier MP, Quertermous T, Wu JC, Robbins RC.
ILAR J. 2007 Jun 6;49:E1-7.
PMID: 18506056 [PubMed - indexed for MEDLINE] Free Article
 
Integration of genomics, proteomics, and imaging for cardiac stem cell therapy.
Chun HJ, Wilson KO, Huang M, Wu JC.
Eur J Nucl Med Mol Imaging. 2007 Jun;34 Suppl 1:S20-6. Review.
PMID: 17464506 [PubMed - indexed for MEDLINE]
 
An unusual cause of stroke from a left atrial mass.
Wu JC, Fishbein MC, Child JS.
J Am Soc Echocardiogr. 2007 May;20(5):537.e1-2.
PMID: 17484995 [PubMed - indexed for MEDLINE]
 
Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation.
Cao F, Drukker M, Lin S, Sheikh AY, Xie X, Li Z, Connolly AJ, Weissman IL, Wu JC.
Cloning Stem Cells. 2007 Spring;9(1):107-17.
PMID: 17386018 [PubMed - indexed for MEDLINE]
 
Clinical hurdles for the transplantation of cardiomyocytes derived from human embryonic stem cells: role of molecular imaging.
Swijnenburg RJ, van der Bogt KE, Sheikh AY, Cao F, Wu JC.
Curr Opin Biotechnol. 2007 Feb;18(1):38-45. Epub 2006 Dec 29. Review.
PMID: 17196814 [PubMed - indexed for MEDLINE]
 
Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function.
Xie X, Cao F, Sheikh AY, Li Z, Connolly AJ, Pei X, Li RK, Robbins RC, Wu JC.
Cloning Stem Cells. 2007 Winter;9(4):549-63.
PMID: 18154515 [PubMed - indexed for MEDLINE] Free PMC Article
 

2006

Molecular imaging of human embryonic stem cells: keeping an eye on differentiation, tumorigenicity and immunogenicity.
van der Bogt KE, Swijnenburg RJ, Cao F, Wu JC.
Cell Cycle. 2006 Dec;5(23):2748-52. Epub 2006 Dec 1.
PMID: 17172859 [PubMed - indexed for MEDLINE] Free Article
 
Proteomic analysis of reporter genes for molecular imaging of transplanted embryonic stem cells.
Wu JC, Cao F, Dutta S, Xie X, Kim E, Chungfat N, Gambhir S, Mathewson S, Connolly AJ, Brown M, Wang EW.
Proteomics. 2006 Dec;6(23):6234-49.
PMID: 17080479 [PubMed - indexed for MEDLINE] Free PMC Article
 
Right coronary cameral fistula resulting from surgery of double chamber right ventricle.
Leeper NJ, Gupta A, Murphy DJ, Wu JC.
J Am Soc Echocardiogr. 2006 Sep;19(9):1191.e9-11. No abstract available.
PMID: 16950481 [PubMed - indexed for MEDLINE]
 
Overview of stem cells and imaging modalities for cardiovascular diseases.
Chang GY, Xie X, Wu JC.
J Nucl Cardiol. 2006 Jul;13(4):554-69. Review.
PMID: 16919579 [PubMed - indexed for MEDLINE]
 
Noninvasive evaluation of immunosuppressive drug efficacy on acute donor cell survival.
Gheysens O, Lin S, Cao F, Wang D, Chen IY, Rodriguez-Porcel M, Min JJ, Gambhir SS, Wu JC.
Mol Imaging Biol. 2006 May-Jun;8(3):163-70.
PMID: 16555032 [PubMed - indexed for MEDLINE]
 
Transcriptional profiling of reporter genes used for molecular imaging of embryonic stem cell transplantation.
Wu JC, Spin JM, Cao F, Lin S, Xie X, Gheysens O, Chen IY, Sheikh AY, Robbins RC, Tsalenko A, Gambhir SS, Quertermous T.
Physiol Genomics. 2006 Mar 13;25(1):29-38. Epub 2006 Jan 3.
PMID: 16390873 [PubMed - indexed for MEDLINE] Free Article
 
Molecular imaging of cardiac stem cell transplantation.
Sheikh AY, Wu JC.
Curr Cardiol Rep. 2006 Mar;8(2):147-54. Review.
PMID: 16524542 [PubMed - indexed for MEDLINE]
 
18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer.
Zhang X, Cai W, Cao F, Schreibmann E, Wu Y, Wu JC, Xing L, Chen X.
J Nucl Med. 2006 Mar;47(3):492-501.
PMID: 16513619 [PubMed - indexed for MEDLINE] Free Article
 
In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.
Cao F, Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC.
Circulation. 2006 Feb 21;113(7):1005-14. Epub 2006 Feb 13.
PMID: 16476845 [PubMed - indexed for MEDLINE] Free Article
 
Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging.
Krishnan M, Park JM, Cao F, Wang D, Paulmurugan R, Tseng JR, Gonzalgo ML, Gambhir SS, Wu JC.
FASEB J. 2006 Jan;20(1):106-8. Epub 2005 Oct 24.
PMID: 16246867 [PubMed - indexed for MEDLINE] Free PMC Article
 
Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene.
Xiong Z, Cheng Z, Zhang X, Patel M, Wu JC, Gambhir SS, Chen X.
J Nucl Med. 2006 Jan;47(1):130-9.
PMID: 16391197 [PubMed - indexed for MEDLINE] Free Article
 

Before 2006

Human gene therapy and imaging: cardiology.
Wu JC, Yla-Herttuala S.
Eur J Nucl Med Mol Imaging. 2005 Dec;32 Suppl 2:S346-57. Review.
PMID: 16096829 [PubMed - indexed for MEDLINE]
 
Common congenital heart disorders in adults.
Wu JC, Child JS.
Curr Probl Cardiol. 2004 Nov;29(11):641-700. Review. No abstract available. Erratum in: Curr Probl Cardiol. 2005 Mar;30(3):4 p following 167.
PMID: 15536453 [PubMed - indexed for MEDLINE]
 
Molecular imaging of the kinetics of vascular endothelial growth factor gene expression in ischemic myocardium.
Wu JC, Chen IY, Wang Y, Tseng JR, Chhabra A, Salek M, Min JJ, Fishbein MC, Crystal R, Gambhir SS.
Circulation. 2004 Aug 10;110(6):685-91.
PMID: 15302807 [PubMed - indexed for MEDLINE] Free Article
 
Molecular imaging of cardiovascular gene products.
Wu JC, Tseng JR, Gambhir SS.
J Nucl Cardiol. 2004 Jul-Aug;11(4):491-505. Review. No abstract available.
PMID: 15295418 [PubMed - indexed for MEDLINE]
 
Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery.
Chen IY, Wu JC, Min JJ, Sundaresan G, Lewis X, Liang Q, Herschman HR, Gambhir SS.
Circulation. 2004 Mar 23;109(11):1415-20. Epub 2004 Mar 8.
PMID: 15007006 [PubMed - indexed for MEDLINE] Free Article
 
Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography.
Wu JC, Chen IY, Sundaresan G, Min JJ, De A, Qiao JH, Fishbein MC, Gambhir SS.
Circulation. 2003 Sep 16;108(11):1302-5. Epub 2003 Sep 8.
PMID: 12963637 [PubMed - indexed for MEDLINE] Free Article
 
Positron emission tomography imaging of cardiac reporter gene expression in living rats.
Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS.
Circulation. 2002 Jul 9;106(2):180-3.
PMID: 12105155 [PubMed - indexed for MEDLINE] Free Article
 
Optical imaging of cardiac reporter gene expression in living rats.
Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS.
Circulation. 2002 Apr 9;105(14):1631-4.
PMID: 11940538 [PubMed - indexed for MEDLINE] Free Article
 
Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice.
Wu JC, Sundaresan G, Iyer M, Gambhir SS.
Mol Ther. 2001 Oct;4(4):297-306.
PMID: 11592831 [PubMed - indexed for MEDLINE] Free Article
 
Severe regional ischemia alters coronary flow reserve in the remote perfusion area.
Wu JC, Yun JJ, Dione DP, Heller EN, Deckelbaum LI, Sinusas AJ.
J Nucl Cardiol. 2000 Jan-Feb;7(1):43-52.
PMID: 10698234 [PubMed - indexed for MEDLINE]
 
Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging.
Wu JC, Yun JJ, Heller EN, Dione DP, DeMan P, Liu YH, Zaret BL, Wackers FJ, Sinusas AJ.
J Nucl Med. 1998 Mar;39(3):417-25.
PMID: 9529285 [PubMed - indexed for MEDLINE] Free Article <