Social Neurosciences Research Program
The principal goal of the Parker Lab Social Neurosciences Research Program at Stanford University is to better understand the biology of social functioning using an integrative, translational approach. Our behavioral research spans studies of individual differences in rhesus monkey social development to studies of social cognition impairments in various clinical populations (e.g., in children with autism; in survivors of pediatric hypothalamic-pituitary tumors; in adults with posttraumatic stress disorder). We are also developing several innovative monkey models of social impairments, including studies of rhesus monkeys that naturally exhibit social cognition deficits and common marmoset monkeys which are engineered to do so. Our biological studies employ epigenetic, gene expression, and neurotransmitter-based approaches to identify biomarkers of impaired social functioning, and we also conduct treatment trials to test the efficacy of novel pharmacotherapies to improve social abilities in low-social monkeys and in children with autism. Our lab is particularly interested in testing whether “social” neuropeptide (e.g., oxytocin and arginine vasopressin) signaling pathways are implicated in human and non-human primate social behavior, and whether these neuropeptide pathways are robust biomarkers of, and treatment targets for, social impairments in clinical populations.
Please visit our “research studies” page to learn more about the specific projects our team is currently conducting, and ways in which YOU can help move research forward, either by joining our research team, participating in one of our research studies, or by donating to our research program.
Our journal article reported that intranasal oxytocin treatment improves social abilities in children with autism, and that individuals with the lowest pretreatment blood oxytocin concentrations showed the greatest social improvement. These findings reveal a personalized component to oxytocin treatment which may have important implications for identifying patients that stand to benefit most from oxytocin administration.