Publications

Preprint

Bo Zhou, Steve S. Ho, Louis C. Leung, Thomas R. Ward, Marcus Ho, Melanie J. Plastini, Scott C. Vermilyea, Marina E. Emborg, Thaddeus G. Golos, Megan A. Albertelli, Philippe Mourrain, Dimitri Perrin, Karen J. Parker, Alexander E. Urban. Haplotype-phased Callithrix jacchus embryonic stem cell line for genome editing using CRISPR/Cas9. BioRxiv 6036333 [preprint].

2024

Catherine F. Talbot, Ozge Oztan, Sierra M. V. Simmons, Callum Trainor, Lesly C. Ceniceros, Duyen K. K. Nguyen, Laura A. Del Rosso, Joseph P. Garner, John P. Capitanio, and Karen J. Parker. Nebulized vasopressin penetrates CSF and improves social cognition without inducing aggression in a rhesus monkey model of autism. Proceedings of the National Academy of Sciences, 2024
Kendall M. Coden, Duyen K. K. Nguyen, Roberta Moorhead, Beatriz E. Stix-Brunell, Joanna N. Baker, Karen J. Parker, and Joseph P. Garner. Making bloodwork work: the impact of sample collection, processing, and storage on plasma glutathione measurement, and implications for translation. Translational Psychiatry, 2024
Michele A. Basso, Aaron P. Batista, Steve W. C. Chang, Katalin M. Gothard, Cory T. Miller, Karen J. Parker, and Jan Zimmermann. The Future of Nonhuman Primate Neuroscience: Peril or Possibilities? The Journal of Neuroscience, 2024
Lauren Clarke, Neil Gesundheit, Elliott H. Sherr, Antonio Y. Hardan and Karen J. Parker. Vasopressin deficiency: a hypothesized driver of both social impairment and fluid imbalance in autism spectrum disorder. Molecular Psychiatry, 2024
Ozge Oztan, Laura A. Del Rosso, Sierra M. Simmons, Duyen K. K. Nguyen, Catherine F. Talbot, John P. Capitanio, Joseph P. Garner and Karen J. Parker. Naturally occurring low sociality in female rhesus monkeys: A tractable model for autism or not? Molecular Autism, 2024

2023

Karen J. Parker. Tales from the life and lab of a female social neuroscientist. Comprehensive Psychoneuroendocrinology, 2023
Joseph P. Garner, Catherine F. Talbot, Laura A. Del Rosso, Brenda McCowan, Sreetharan Kanthaswamy, David Haig, John P. Capitanio and Karen J. Parker. Rhesus macaque social functioning is paternally, but not maternally, inherited by sons: potential implications for autism. Molecular Autism, 2023
Benjamin A. Tabak, Gareth Leng, Angela Szeto, Karen J. Parker, Joseph G. Verbalis, Toni E. Ziegler, Mary R. Lee, Inga D. Neumann and Armando J. Mendez. Advances in human oxytocin measurement: challenges and proposed solutions. Molecular Psychiatry, 2023
Camille Noufi, Jonathan Berger, Karen J. Parker, Daniel L. Bowling. Acoustically-driven phoneme removal that preserves vocal affect cues. International Conference on Acoustics, Speech and Signal Processing, 2023

2022

Catherine F. Talbot, Jesus E. Madrid, Laura A. Del Rosso, John P. Capitanio, Joseph P. Garner, Karen J. Parker. Rhesus monkey sociality is stable across time and linked to variation in the initiation but not receipt of prosocial behavior. American Journal of Primatology, 2022
Steven H. Woodward, Andrea L. Jamison, Christina Khan, Sasha Gala, Chloe Bhowmick, Diana Villasenor, Gisselle Tamayoa Melissa Puckett, Karen J. Parker. Reading the mind in the eyes in PTSD: Limited Moderation by the presence of a service dog. Journal of Psychiatric Research, 2022
Ozge Oztan, Olena Zyga, Diane E.J. Stafford, Karen J. Parker. Linking oxytocin and arginine vasopressin signaling abnormalities to social behavior impairments in Prader-Willi syndrome. Neuroscience and Biobehavioral Reviews, 2022
Lauren Clarke, Olena Zyga, Psalm L. Pineo-Cavanaugh, Michael Jeng, Nancy J. Fischbein, Sonia Partap, Laurence Katznelson, Karen J. Parker. Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits. Neuroscience and Biobehavioral Reviews, 2022
Karen J. Parker. Leveraging a translational research approach to drive diagnostic and treatment advances for autism. Molecular Psychiatry, 2022
Elena Itskovich, Daniel L. Bowling, Joseph P. Garner and Karen J. Parker. Oxytocin and the social facilitation of placebo effects. Molecular Psychiatry, 2022
Mirko Uljarevic, Nicholas T. Bott, Robin A. Libove, Jennifer M. Phillips, Karen J. Parker and Antonio Y. Hardan. Characterizing emotion recognition and theory of mind performance profiles in unaffected siblings of autistic children. Frontiers in Psychology, 2022

2021

Ozge Oztan, Catherine F. Talbot, Emanuela Argilli, Alyssa C. Maness, Sierra M. Simmons, Noreen Mohsin, Laura A. Del Rosso, Joseph P. Garner, Elliott H. Sherr, John P. Capitanio and Karen J. Parker. Autism-associated biomarkers: test–retest reliability and relationship to quantitative social trait variation in rhesus monkeys. Molecular Autism, 2021
Adam K. Myers, Catherine F. Talbot, Laura A. Del Rosso, Alyssa C. Maness, Sierra M. V. Simmons, Joseph P. Garner, John P. Capitanio, Karen J. Parker. Assessment of medical morbidities in a rhesus monkey model of naturally occurring low sociality. Autism Research, 2021
Elena Itskovich, Olena Zyga, Robin A. Libove, Jennifer M. Phillips, Joseph P. Garner, and Karen J. Parker. Complex interplay between cognitive ability and social motivation in predicting social skill: A unique role for social motivation in children with autism. Autism Research, 2021.
Catherine F. Talbot, Alyssa C. Maness, John P. Capitanio, Karen J. Parker. The factor structure of the macaque social responsiveness scale‐revised predicts social behavior and personality dimensions. American Journal of Primatology, 2021
Rui Yuan, Jordan M. Nechvatal, Christine L. Buckmaster, Sarah Ayash, Karen J. Parker, Alan F. Schatzberg, David M. Lyons & Vinod Menon. Long-term effects of intermittent early life stress on primate prefrontal–subcortical functional connectivity. Neuropsychopharmacology, 2021.

2020

Ozge Oztan, Joseph P. Garner, John N. Constantino, Karen J. Parker. Neonatal CSF vasopressin concentration predicts later medical record diagnoses of autism spectrum disorder. Proceedings of the National Academy of Sciences, 2020.
Catherine F. Talbot, Joseph P. Garner, Alyssa C. Maness, Brenda McCowan, John P. Capitanio, and Karen J. Parker. A psychometrically robust screening tool to rapidly identify socially impaired monkeys in the general population. Autism Research, 2020.
Jesus E. Madrid, Karen J. Parker, Alexander G. Ophir. Variation, plasticity, and alternative mating tactics: Revisiting what we know about the socially monogamous prairie vole. Advances in the Study of Behavior, 2020.

2019

Karen J. Parker, Ozge Oztan, Robin A. Libove, Noreen Mohsin, Debra S. Karhson, Raena D. Sumiyoshi, Jacqueline E. Summers, Kyle E. Hinman, Kara S. Motonaga, Jennifer M. Phillips, Dean S. Carson, Lawrence K. Fung, Joseph P. Garner, Antonio Y. Hardan. A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism. Science Translational Medicine, 2019.
Michael G. Mariscal, Ozge Oztan, Sophie M. Rose, Robin A. Libove, Lisa P. Jackson, Raena D. Sumiyoshi, Tara H. Trujillo, Dean S. Carson, Jennifer M. Phillips, Joseph P. Garner, Antonio Y. Hardan, Karen J. Parker. Blood oxytocin concentration positively predicts contagious yawning behavior in children with autism spectrum disorder. Autism Research, 2019.
Karen J. Parker, Christine L. Buckmaster, Shellie A. Hyde, Alan F. Schatzberg, David M. Lyons. Nonlinear relationship between early life stress exposure and subsequent resilience in monkeys. Scientific Reports, 2019.

2018

Ozge Oztan, Joseph P. Garner, Sonia Partap, Elliott H. Sherr, Antonio Hardan, Cristan Farmer, Audrey Thurm, Susan Swedo, Karen J. Parker. Cerebrospinal fluid vasopressin and symptom severity in children with autism. Annals of Neurology, 2018.
Jesus E. Madrid, Tara M. Mandalaywala, Sean P. Coyne, Jamie Ahloy-Dallaire, Joseph P. Garner, Christina S. Barr, Dario Maestripieri, and Karen J. Parker. Adaptive developmental plasticity in rhesus macaques: The serotonin transporter gene interacts with maternal care to affect juvenile social behaviour. Proceedings of the Royal Society B, 2018.
Karen J. Parker, Joseph P. Garner, Ozge Oztan, Erna R. Tarara, Jiang Li, Valentina Sclafani, Laura A. Del Rosso, Katie Chun, Sean W. Berquist, Michael G. Chez, Sonia Partap, Antonio Y. Hardan, Elliott H. Sherr, and John P. Capitanio. Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates. Science Translational Medicine, 2018.
Debra S. Karhson, Karolina M. Krasinska, Jamie Ahloy Dallaire, Robin A. Libove, Jennifer M. Phillips, Allis S. Chien, Joseph P. Garner, Antonio Y. Hardan and Karen J. Parker. Plasma anandamide concentrations are lower in children with autism spectrum disorder. Molecular Autism, 2018.
Ozge Oztan, Lisa P. Jackson, Robin A. Libove, Raena D. Sumiyoshi, Jennifer M. Phillips, Joseph P. Garner, Antonio Y. Hardan, and Karen J. Parker. Biomarker discovery for disease status and symptom severity in children with autism. Psychoneuroendocrinology, 2018.

2017

Jesus E. Madrid, Ozge Oztan, Valentina Sclafani, Laura A. Del Rosso, Laura A. Calonder, Katie Chun, John P. Capitanio, Joseph P. Garner & Karen J. Parker. Preference for novel faces in male infant monkeys predicts cerebrospinal fluid oxytocin concentrations later in life. Scientific Reports, 2017.
Karen J. Parker, Ozge Oztan, Robin A. Libove, Raena D. Sumiyoshi, Lisa P. Jackson, Debra S. Karhson, Jacqueline E. Summers, Kyle E. Hinman, Kara S. Motonaga, Jennifer M. Phillips, Dean S. Carson, Joseph P. Garner, and Antonio Y. Hardan. Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism. Proceedings of the National Academy of Sciences, 2017.
Tara M. Mandalaywala, Lauren A. Petrullo, Karen J. Parker, Dario Maestripieri, and James P. Higham. Vigilance for threat accounts for inter-individual variation in physiological responses to adversity in rhesus macaques: A cognition × environment approach. Developmental Psychobiology, 2017.

2016

Valentina Sclafani, Laura A. Del Rosso, Shannon K. Seil, Laura A. Calonder, Jesus E. Madrid, Kyle J. Bone, Elliott H. Sherr, Joseph P. Garner, John P. Capitanio, and Karen J. Parker. Early predictors of impaired social functioning in male rhesus macaques (Macaca mulatta). PLoS One, 2016.
Deborah S. Karhson, Antonio Y. Hardan, and Karen J. Parker. Endocannabinoid signaling in social functioning: an RDoC perspective. Translational Psychiatry, 2016.
Lauren A. Petrullo, Tara M. Mandalaywala, Karen J. Parker, Dario Maestripieri, and James P. Higham. Effects of early life adversity on cortisol/salivary alpha-amylase symmetry in free-ranging juvenile rhesus macaques. Hormones and Behavior, 2016.

2015

Sean P. Coyne, Stephen G. Lindell, Jessica Clemente, Christina S. Barr, Karen J. Parker, Dario Maestripieri. Dopamine D4 receptor genotype variation in free-ranging rhesus macaques and its association with juvenile behavior. Behavioural Brain Research, 2015.
Dean S. Carson, Joseph P. Garner, Shellie A. Hyde, Robin A. Libove, Sean W. Berquist, Kirsten B. Hornbeak, Lisa P. Jackson, Raena D. Sumiyoshi, Christopher L. Howerton, Sadie L. Hannah, Sonia Partap, Jennifer M. Phillips, Antonio Y. Hardan, and Karen J. Parker. Arginine vasopressin is a blood-based biomarker of social functioning in children with autism. PLoS One, 2015.
Dean S. Carson, Sean W. Berquist, Tara H. Trujillo, Joseph P. Garner, Sadie L. Hannah, Shellie A. Hyde, Raena D. Sumiyoshi, Lisa P. Jackson, Jacob K. Moss, Matthew C. Strehlow, Samuel H. Cheshier, Sonia Partap, Antonio Y. Hardan, and Karen J. Parker. Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children. Molecular Psychiatry, 2015.
Christine L. Buckmaster, Shellie A. Hyde, Karen J. Parker, and David M. Lyons. Cup tool use by squirrel monkeys. American Journal of Primatology, 2015.

2014

Karen J. Parker, Joseph P. Garner, Robin A. Libove, Shellie A. Hyde, Kirsten B. Hornbeak, Dean S. Carson, Chun-Ping Liao, Jennifer M. Phillips, Joachim F. Hallmayer, and Antonio Y. Hardan. Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. Proceedings of the National Academy of Sciences, 2014.
Dean S. Carson, Christopher L. Howerton, Joseph P. Garner, Shellie A. Hyde, Catherine L. Clark, Antonio Y. Hardan, Anna A. Penn, and Karen J. Parker. Plasma vasopressin concentrations positively predict cerebrospinal fluid vasopressin concentrations in human neonates. Peptides, 2014.
Andrea C. Samson, Jennifer M. Phillips, Karen J. Parker, Shweta Shah, James J. Gross, and Antonio Y. Hardan. Emotion dysregulation and the core features of autism spectrum disorder. Journal of Autism and Developmental Disorders, 2014.
Kaeli W. Yuen, Joseph P. Garner, Dean S. Carson, Jennifer Keller, Anna Lembke, Shellie A. Hyde, Heather A. Kenna, Lakshika Tennakoon, Alan F. Schatzberg, and Karen J. Parker. Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol. Journal of Psychiatric Research, 2014.
Tara M. Mandalaywala, James P. Higham, Michael Heistermann, Karen J. Parker, and Dario Maestripieri. Physiological and behavioural responses to weaning conflict in free-ranging primate infants. Animal Behaviour, 2014.
Tara M. Mandalaywala, Karen J. Parker, and Dario Maestripieri. Early experience affects the strength of vigilance for threat in rhesus monkey infants. Psychological Science, 2014.

2013

Catherine L. Clark, Nicholas St John, Anca M. Pasca, Shellie A. Hyde, Kirsten Hornbeak, Marina Abramova, Heidi Feldman, Karen J. Parker, and Anna A. Penn. Neonatal CSF oxytocin levels are associated with parent report of infant soothability and sociability. Psychoneuroendocrinology, 2013.
Nikolaos P. Daskalakis, Rosemary C. Bagot, Karen J. Parker, Christiaan H. Vinkers, and E. Ronald de Kloet. The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology, 2013.

2012

Rabindra Tirouvanziam, Tetyana V. Obukhanych, Julie Laval, Pavel A. Aronov, Robin Libove, Arpita Goswami Banerjee, Karen J. Parker, Ruth O’Hara, Leonard A. Herzenberg, Leonore A. Herzenberg, and Antonio Y. Hardan. Distinct plasma profile of polar neutral amino acids, leucine, and glutamate in children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 2012.
Scott S. Hall, Amy A. Lightbody, Brigid E. McCarthy, Karen J. Parker, and Allan L. Reiss. Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome. Psychoneuroendocrinology, 2012.
Karen J. Parker, Christine L. Buckmaster, Steven E. Lindley, Alan F. Schatzberg, and David M. Lyons. Hypothalamic-pituitary-adrenal axis physiology and cognitive control of behavior in stress inoculated monkeys. International Journal of Behavioral Development, 2012.

2011

Alex G. Lee, David R. Cool, William C. Grunwald, Donald E. Neal, Christine L. Buckmaster, Michelle Y. Cheng, Shellie A. Hyde, David M. Lyons, and Karen J. Parker. A novel form of oxytocin in New World monkeys. Biology Letters, 2011.
Karen J. Parker, and Dario Maestripieri. Identifying key features of early stressful experiences that produce stress vulnerability and resilience in primates. Neuroscience & Biobehavioral Reviews, 2011.
James P. Higham, Christina S. Barr, Christy L. Hoffman, Tara M. Mandalaywala, Karen J. Parker, and Dario Maestripieri. Mu-opioid receptor (OPRM1) variation, oxytocin levels and maternal attachment in free-ranging rhesus macaques Macaca mulatta. Behavioral Neuroscience, 2011.
Renee J. Thompson, Karen J. Parker, Joachim F. Hallmayer, Christian E. Waugh, and Ian H. Gotlib. Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology, 2011.
Gregory E. Miller, Edith Chen, and Karen J. Parker. Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 2011.
Karen J. Parker, Shellie A. Hyde, Christine L. Buckmaster, Serena M. Tanaka, Katharine K. Brewster, Alan F. Schatzberg, David M. Lyons, and Steven H. Woodward. Somatic and neuroendocrine responses to standard and biologically salient acoustic startle stimuli in monkeys. Psychoneuroendocrinology, 2011.

2010

David M. Lyons, Karen J. Parker, and Alan F. Schatzberg. Animal models of early life stress: Implications for understanding resilience. Developmental Psychobiology, 2010.
Karen J. Parker, Christy L. Hoffman, Shellie A. Hyde, Carl S. Cummings, and Dario Maestripieri. Effects of age on cerebrospinal fluid oxytocin levels in free-ranging adult female and infant rhesus macaques. Behavioral Neuroscience, 2010.
Karen J. Parker, Heather A. Kenna, Jamie M. Zeitzer, Jennifer Keller, Christine M. Blasey, Janet A. Amico, and Alan F. Schatzberg. Preliminary evidence that plasma oxytocin levels are elevated in major depression. Psychiatry Research, 2010.

2009

David M. Lyons, Karen J. Parker, Maor Katz, and Alan F. Schatzberg. Developmental cascades linking stress inoculation, arousal regulation, and resilience. Frontiers in Behavioral Neuroscience, 2009.
Michael D. Edge, Wiveka Ramel, Emily M. Drabant, Janice R. Kuo, Karen J. Parker, and James J. Gross. For better or worse? Stress inoculation effects for implicit but not explicit anxiety. Depression and Anxiety, 2009.
Maor Katz, Chunlei Liu, Marie Schaer, Karen J. Parker, M-C. Ottet, Averi Epps, Christine L. Buckmaster, Roland Bammer, Michael E. Moseley, Alan F. Schatzberg, Stephan Eliez, David M. Lyons. Prefrontal plasticity and stress inoculation-induced resilience. Developmental Neuroscience, 2009.

2007

Karen J. Parker, Kimberly L. Rainwater, Christine L. Buckmaster, Alan F. Schatzberg, Steven E. Lindley, and David M. Lyons. Early life stress and novelty seeking behavior in adolescent monkeys. Psychoneuroendocrinology, 2007.
David M. Lyons, Karen J. Parker, Jamie M. Zeitzer, Christine L. Buckmaster, and Alan F. Schatzberg. Preliminary evidence that hippocampal volumes in monkeys predict stress levels of adrenocorticotropic hormone. Biological Psychiatry, 2007.
David M. Lyons, and Karen J. Parker. Stress inoculation‐induced indications of resilience in monkeys. Journal of Traumatic Stress, 2007.

2006

Karen J. Parker, Christine L. Buckmaster, Karan Sundlass, Alan F. Schatzberg, and David M. Lyons. Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates. Proceedings of the National Academy of Sciences, 2006.
Rupshi Mitra, Karan Sundlass, Karen J. Parker, Alan F. Schatzberg, and David M. Lyons. Social stress-related behavior affects hippocampal cell proliferation in mice. Physiology & Behavior, 2006.

2005

Karen J. Parker, Christine L. Buckmaster, Alan F. Schatzberg, and David M. Lyons. Intranasal oxytocin administration attenuates the ACTH stress response in monkeys. Psychoneuroendocrinology, 2005.
Karen J. Parker, Christine L. Buckmaster, Katharine R. Justus, Alan F. Schatzberg, and David M. Lyons. Mild early life stress enhances prefrontal-dependent response inhibition in monkeys. Biological Psychiatry, 2005.

2004

Karen J. Parker, Christine L. Buckmaster, Alan F. Schatzberg, and David M. Lyons. Prospective investigation of stress inoculation in young monkeys. Archives of General Psychiatry, 2004.

2003

Jamie M. Zeitzer, Christine L. Buckmaster, Karen J. Parker, Craig M. Hauck, David M. Lyons, and Emmanuel Mignot. Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness. Journal of Neuroscience, 2003.
Karen J. Parker, and Theresa M. Lee. Female meadow voles (Microtus pennsylvanicus) demonstrate same-sex partner preferences. Journal of Comparative Psychology, 2003.
Karen J. Parker, Alan F. Schatzberg, and David M. Lyons. Neuroendocrine aspects of hypercortisolism in major depression. Hormones and Behavior, 2003.

2002

Karen J. Parker, and Theresa M. Lee. Interaction of photoperiod and testes development is associated with paternal care in Microtus pennsylvanicus (meadow voles). Physiology & Behavior, 2002.

2001

Karen J. Parker, and Theresa M. Lee. Central vasopressin administration regulates the onset of facultative paternal behavior in Microtus pennsylvanicus (meadow voles). Hormones and Behavior, 2001.
Karen J. Parker, Katie M. Phillips, Lisa F. Kinney, and Theresa M. Lee. Day length and sociosexual cohabitation alter central oxytocin receptor binding in female meadow voles (Microtus pennsylvanicus). Behavioral neuroscience, 2001.
Karen J. Parker, Katie M. Phillips, and Theresa M. Lee. Development of selective partner preferences in captive male and female meadow voles, Microtus pennsylvanicus. Animal Behaviour, 2001.
Karen J. Parker, Lisa F. Kinney, Katie M. Phillips, and Theresa M. Lee. Paternal behavior is associated with central neurohormone receptor binding patterns in meadow voles (Microtus pennsylvanicus). Behavioral neuroscience, 2001.
Karen J. Parker, and Theresa M. Lee. Social and environmental factors influence the suppression of pup-directed aggression and development of paternal behavior in captive meadow voles (Microtus pennsylvanicus). Journal of Comparative Psychology, 2001.