Current Research and Scholarly Interests
Mammalian metabolic homeostasis is a tightly regulated process that affects nearly all aspects of organismal physiology. A key aspect of metabolic homeostasis is the coordinated response of multiple tissues to changes in energy supply or energy demand. We are interested in understanding the biochemical signaling pathways that orchestrate these responses. We focus on chemical messengers, a fundamental class of endogenous molecules that mediate intercellular and inter-organ communication. Our studies have applications to diseases associated with dysfunctional metabolic homeostasis, including obesity, diabetes, cardiovascular disease, neurodegeneration, and certain cancers.