Current Research and Scholarly Interests
My laboratory seeks to discover new bioactive metabolite signaling pathways that control mammalian metabolism and physiology. Our unique and multidisciplinary approach combines synthetic chemistry, biochemistry, mass spectrometry, and genetics to chart functionally relevant regions of unannotated biochemical space. In recent years, we have mapped entire branches of previously unknown bioactive metabolites and identified their functions. These discoveries include a circulating PM20D1/N-acyl amino acid pathway in blood and a MAGL-controlled lipid signaling pathway in the brain. Ultimately, we hope to translate these findings into pharmacologically tractable opportunities (e.g., enzyme inhibitors, transporter antagonists, or receptor modulators) for therapeutic intervention in cardiometabolic disease.