Current Research and Scholarly Interests
My laboratory is interested in understanding the metabolic pathways and bioactive small molecules that control mammalian energy homeostasis. Our research program spans three main areas: 1) discovery of new metabolic pathways, 2) identification of genetically-encoded factors that control metabolite signaling, and 3) development of animal models for characterizing the role of metabolic pathways in physiology and disease. To achieve these goals, we use a multidisciplinary approach that combines classical biochemistry, mass spectrometry, organic chemistry, and mouse genetics. While our main disease interests include obesity and type 2 diabetes, our research has applications to other disorders associated with metabolic dysfunction such as neurodegeneration and certain cancers.