Showing 11-20 of 37 Results
Donald Kennedy Chair in the School of Humanities and Sciences and Professor of Genetics
Current Research and Scholarly Interests The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
Dr. Morris Herzstein Professor of Biology
Current Research and Scholarly Interests We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.
Philip C. Hanawalt
Dr. Morris Herzstein Professor in Biology, Emeritus
Current Research and Scholarly Interests Our current research focuses in two principal areas:
1. The molecular basis for diseases in which the pathway of transcription-coupled DNA repair is defective, including Cockyne syndrome (CS) and UV-sensitive syndrome (UVSS). Patients are severely sensitive to sunlight but get no cancers. See Hanawalt & Spivak, 2008, for review.
2. Transcription arrest by guanine-rich DNA sequences and non-canonical secondary structures. Transcription collisions with replication forks.
H Craig Heller
Lorry I. Lokey/Business Wire Professor
Current Research and Scholarly Interests Neurobiology of sleep, circadian rhythms, regulation of body temperature, mammalian hibernation, and human exercise physiology. Currently applying background in sleep and circadian neurobiology the understanding and correcting the learning disability of Down Syndrome.
Joseph (Joe) Lipsick
Professor of Pathology, of Genetics and, by courtesy, of Biology
Current Research and Scholarly Interests Function and evolution of the Myb oncogene family; function and evolution of E2F transcriptional regulators and RB tumor suppressors; epigenetic regulation of chromatin and chromosomes; cancer genetics.
Sharon R. Long
William C. Steere, Jr. - Pfizer Inc. Professor in Biological Sciences and Professor, by courtesy, of Biochemistry
Current Research and Scholarly Interests Biochemistry, genetics and cell biology of plant-bacterial symbiosis
Ann and Bill Swindells Professor in the School of Humanities and Sciences and Professor, by courtesy, of Neurobiology
Current Research and Scholarly Interests We are studying how neural circuits are assembled during development, and how they contribute to sensory perception. We are addressing these questions at different levels from molecular, cellular, circuit to animal behavior. We are primarily using Drosophila as a model organism for our studies. Most recently, we are also developing novel genetic tools in the mouse to extend our studies to the mammalian brain.
Assistant Professor of Biology
Current Research and Scholarly Interests Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity.
Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine and Professor of Molecular and Cellular Physiology
Current Research and Scholarly Interests Our research objectives are to understand the cellular mechanisms involved in the development and maintenance of epithelial cell polarity. Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs.