School of Medicine
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Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Neurobiology
Current Research and Scholarly Interests We study how our brains generate social interactions that differ between the sexes. Such gender differences in behavior are regulated by sex hormones, experience, and social cues. Accordingly, we are characterizing how these internal and external factors control gene expression and neuronal physiology in the two sexes to generate behavior. We are also interested in understanding how such sex differences in the healthy brain translate to sex differences in many neuro-psychiatric illnesses.
Sapp Family Provostial Professor, David Starr Jordan Director, Stanford Bio-X and Professor of Biology and of Neurobiology
Current Research and Scholarly Interests The goal of research in the Shatz Laboratory is to discover how brain circuits are tuned up by experience during critical periods of development both before and after birth by elucidating cellular and molecular mechanisms that transform early fetal and neonatal brain circuits into mature connections. To discover mechanistic underpinnings of circuit tuning, the lab has conducted functional screens for genes regulated by neural activity and studied their function for vision, learning and memory.
Hong Seh and Vivian W. M. Lim Professor in the School of Engineering and Professor, by courtesy, of Neurobiology and of Bioengineering
Bio Our group (Neural Prosthetic Systems Laboratory, NPSL; directed by Prof. Shenoy) conducts neuroscience, neuroengineering, and translational research to better understand how the brain controls movement, and to design medical systems to assist people with movement disabilities. Our neuroscience research investigates the neural basis of movement preparation and generation using a combination of electro-/opto-physiological, behavioral, computational and theoretical techniques. Our neuroengineering research investigates the design of high-performance and robust neural prostheses. Neural prostheses are also known as brain-computer interfaces (BCIs) and brain-machine interfaces (BMIs). These systems translate neural activity from the brain into control signals for prosthetic devices, which can assist people with paralysis by restoring lost motor functions. Our translational research, including an FDA pilot clinical trial termed BrainGate2, are conducted as part of the our Neural Prosthetic Translational Laboratory (NPTL; co-directed by Profs. Shenoy & Henderson).
Professor of Neurobiology, Emeritus
Current Research and Scholarly Interests The biochemistry and molecular genetics of growth and differentiation of nerve cells. The structure, biosynthesis and mechanism of action of nerve growth factor and other neurotrophins. Gene regulation in target organs and glial cells during nerve regeneration. The role of apolipoproteins and of the myelin protein PMP-22 during nerve degeneration and regeneration and in peripheral neuropathies.