Agenda
Drug-induced Pulmonary Hypertension Symposium:
Applying Lessons Learned from The Aminorex Epidemic
2nd Meeting of the International Collaborative
April 13-14, 2023 • Hoover Institution - David & Joan Traitel Building, Stanford, CA
Day 1
8:00 – 8:30
Opening and Welcome
Roham Zamanian (Stanford)
Marc Humbert (Paris-Saclay)
8:30 – 9:00
Keynote Remarks
Lloyd B. Minor (Dean, Stanford School of Medicine)
Marissa Mayer (Sunshine)
Session 1: Epidemiology of drug and toxin-induced pulmonary hypertension
(Chairs: Marc Humbert, Harm Bogaard)
9:00 – 9:30
WSPH and ESC/ERS guidelines:
New classification of PH risk factor
Gérald Simonneau (Paris-Saclay)
9:30 – 10:00
Pharmacovigilance: Capturing a rare-disease signal
Qun-Ying Yue (Uppsala Monitoring Centre, UMC)
10:00 – 10:30
Identifying new drugs associated with PAH
Charles Khouri (Grenoble)
10:30 - 11:00
Coffee break
Session 2: Anorexigen-induced pulmonary hypertension
(Chairs: Hiroshi Watanabe, Andrew Sweatt, Meinhard Kneussl)
11:00 – 11:20
PAH associated by aminorex fumarate
Meinhard Kneussl (Vienna)
11:20 – 11:50
From fenfluramine to benfluorex
Laurent Savale (Paris-Saclay)
11:50 – 12:10
Clinical Similarities and differences with IPAH
Raquel Lyn (Stanford)
12:30 – 13:00
Discussion
13:00 - 14:00
Lunch break
Session 3: Mechanisms of anorexigen-induced pulmonary hypertension
(Chairs: Anna Hemnes, Christophe Guignabert, Marlene Rabinovitch)
14:00 – 14:30
Genetic and molecular mechanisms of Meth-APAH
Vinicio DJ Perez (Stanford)
14:30 – 15:00
Genetics of PAH and drug-associated PAH
David Montani (Paris-Saclay)
15:00 - 15:30
Anorexigen associated Pulmonary vascular pathology
Peter Dorfmüller (Geissen)
15:30 – 16:00
Channelopathies and Pulmonary Vascular Disease
Anna Hemnes (Vanderbilt)
16:00 - 16:30
Coffee break
Session 4: Amphetamine-induced cardiopulmonary disease
(Chairs: Paul Corris, Deborah Levine, Yon Sung)
16:30 – 17:00
Global Epidemic of amphetamine abuse
Steve Shoptaw (UCLA)
17:00 – 17:30
From methamphetamines to prescription stimulants
Roham Zamanian (Stanford)
17:30 - 18:00
Discussion and Summary of the day
Marlene Rabinovitch (Stanford)
18:00 - 19:00
Reception
Day 2
Session 1: Drug & toxin-induced PH – toxic oil and chemotherapeutic substances
(Chairs: Peter Dorfmüller, Irene Lang, Edda Spiekerkoetter)
8:00 – 8:30
Cardio-Oncology – A Review
Irene Lang (Vienna)
8:30 – 9:00
Toxic oil and pathomechanisms
Pilar Escribano-Subias (Madrid)
9:00 – 9:30
Dasatinib-induced PAH and possible roles of other TKI
Olivier Sitbon (Paris-Saclay)
9:30 – 10:00
TKI’s & PAH: data from the bench (benefits and risks)
Christophe Guignabert (Paris-Saclay)
10:00 – 10:30
Predicting Safer TKI’s Through Transcriptomics
Adam Andruska (Stanford)
10:30 - 11:00
Agents inducing PVOD: alkylating agents and solvents
Marc Humbert (Paris-Saclay)
11:00 – 11:15
Discussion
11:15 - 11:30
Coffee break
Session 2: Drug and toxin-induced pulmonary hypertension – new observations
(Chairs: Gérald Simonneau, Roham Zamanian, Norbert Voelkel)
11:30 – 11:50
Pediatrics - Diazoxide and PAH
Rachel Hopper (Stanford)
11:50 – 12:10
Could leflunomide and teriflunomide induce PAH?
Jason Weatherald (Edmonton)
12:10 - 12:30
Chinese herbs & PAH: The Qing Dai / Indirubin data
Yuichi Tamura (Tokyo)
12:30 – 12:50
Interferon and direct-acting antivirals
Harm Bogaard (Netherlands)
12:50 – 13:15
Round Table Discussion
Faculty / UMC / FDA / EMA
13:15 – 13:30
Summary of the meeting, Adjourn
Roham Zamanian (Stanford)