Monje Lab Selected Publications
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis.
Savchuk S, Gentry KM, Wang W, Carleton E, Biagi-Junior CAO, Luthria K, Yalçın B, Ni L, Farnsworth HC, Davis RA, Drexler R, Melms JC, Liu Y, Acosta-Alvarez L, Hartmann GG, Pavarino EC, LaBelle J, Woo PJ, Toland AM, Qu F, Kim YS, Filbin MG, Krasnow MA, Ligon KL, Izar B, Sage J, Sabatini BL, Monje M*, Venkatesh HS*. (2025) Nature Oct;646(8087):1232-1242. doi: 10.1038/s41586-025-09492-z
*co-corresponding
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
Drexler, R., Drinnenberg, A., Gavish, A., Yalcin, B., Shamardani, K., Rogers, A.E., Mancusi, R., Trivedi, V., Taylor, K.R., Kim, Y.S….Deisseroth K*, Monje M*. (2025) Cell 188(17):4640-4657. doi: 10.1016/j.cell.2025.05.031
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice.
Geraghty AC, Acosta-Alvarez L, Rotiroti MC, Dutton S, O'Dea MR, Kim W, Trivedi V, Mancusi R, Shamardani K, Malacon K, Woo PJ, Martinez-Velez N, Pham T, Reche-Ley NN, Otubu G, Castenada EH, Nwangwu K, Xu H, Mulinyawe SB, Zamler DB, Ni L, Cross K, Rustenhoven J, Kipnis J, Liddelow SA, Mackall CL, Majzner RG, Monje M. (2025) Cell 188(12):3238-3258. doi: 10.1016/j.cell.2025.03.041
GABAergic neuron-to-glioma synapses in diffuse midline gliomas
Barron, T., Yalcin, B., Su, M., Byun, Y.G., Gavish, A., Shamardani, K., Xu, H., Ni, L., Soni, N., Mehta, V., Maleki Jahan, S., Kim, Y.S., Taylor, K.R., Keough, M.B., Quezada, M.A., Geraghty, A.C., Mancusi, R., Vo, L.T., Castaneda, E.H., Woo, P.J., Petritsch, C.K., Vogel, H., Kaila, K., and Monje, M. (2025) Nature 639(8056):1060-1068. doi:10.1038/s41586-024-08579-3
Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
Monje, M*., Mahdi, J., Majzner, R., Yeom, K.W., Schultz, L.M., Richards, R.M., Barsan, V., Song, K.-W., Kamens, J., Baggott, C., et al.... Ramakrishna S*., Mackall C*. (2024) Nature 637(8046), 708–715. doi: 10.1038/s41586-024-08171-9
Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice
Pan, Y*., Hysinger, J.D., Yalcin, B., Lennon, J.J., Byun, Y.G., Raghavan, P., Schindler, N.F., Anastasaki, C., Chatterjee, J., Ni, L., Xu H., Malacon K, Jahan SM., Ivec AE., Aghoghovwia BE., Mount CW, Nagaraja S., Scheaffer S., Attardi LD., Gutmann DH*., Monje M.* (2024) Nat Neurosci 27, 1555-1564. doi: 10.1038/s41593-024-01654-y
*co-corresponding
Myelin plasticity in the ventral tegmental area is required for opioid reward
Yalçın B, Pomrenze MB, Malacon K, Drexler R, Rogers AE, Shamardani K, Chau IJ, Taylor KR, Ni L, Contreras-Esquivel D, Malenka RC, Monje M. (2024) Nature Jun;630(8017):677-685. doi: 10.1038/s41586-024-07525-7
Glioma synapses recruit mechanisms of adaptive plasticity
Taylor, KR, Barron T, Hui A, Spitzer A, Yalcin B, Ivec AE, Geraghty AC, Hartmann, Arzt M, Gillespie S, Ni L, Zhang H, Venkatesh HS, Du P, Mancusi R, Chau IJ, Ponnuswami A, Aziz-Bose R, Tirosh I, Suva ML, Monje M (2023) Nature 623, 366–374 doi: 10.1038/s41586-023-06678-1
The neuroscience of cancer
Mancusi R, Monje M. The neuroscience of cancer. Nature. 2023 Jun;618(7965):467-479. doi: 10.1038/s41586-023-05968-y. Epub 2023 Jun 14. PMID: 37316719.
Cancer neuroscience: State of the field, emerging directions.
Winkler F, Venkatesha HS, Amit M, Batchelor T, Demir IJ, Deneen B, Gutmann DH, Hervey-Jumper S, Kuner T, Mabbot D, Platten M, Rolls A, Soan EK, Want TC, Wich W, Venkataramani V, Monje M. (2023) Cell 186(8) 1689-1707. doi.org/10.1016/j.cell.2023.02.002
GD2-CAR T-cell therapy for H3K27M-mutated diffuse midline gliomas
Majzner, R. G., Ramakrishna, S., Yeom, K. W., Patel, S., Chinnasamy, H., Schultz, L. M., Richards, R. M., Jiang, L., Barsan, V., Mancusi, R., Geraghty, A. C., Good, Z., Mochizuki, A. Y., Gillespie, S. M., Toland, A. M. S., Mahdi, J., Reschke, A., Nie, E., Chau, I. J., Rotiroti, M. C., Mount, C. W., Baggott, C., Mavroukakis, S., Egeler, E., Moon, J., Erickson, C., Green, S., Kunicki, M., Fujimoto, M., Ehlinger, Z., Reynolds, W., Kurra, S., Warren, K. E., Prabhu, S., Vogel, H., Rasmussen, L., Cornell, T. T., Partap, S., Fisher, P. G., Campen, C. J., Filbin, M. G., Grant, G., Sahaf, B., Davis, K. L., Feldman, S. A., Mackall CL*, Monje M* (2022) Nature 603:934-941 doi: 10.1038/s41586-022-04489-4
Maladaptive myelination promotes generalized epilepsy progression
Knowles JK*, Soane C, Frost E, Tam LT, Fraga D, Xu H, Batra A, Ni L, Villar K, Saucedo T, John Huguenard J*, Monje M* (2022) Nature Neuroscience 25(5):596-606. doi: 10.1038/s41593-022-01052-2
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
Fernandez-Castaneda, A., Lu, P., Geraghty, A.C., Song, E., Lee, M.H., Wood, J., O'Dea, M.R., Dutton, S., Shamardani, K., Nwangwu, K., Mancusi R, Yalçın B, Taylor KR, Acosta-Alvarez L, Malacon K, Keough MB, Ni L, Woo PJ, Contreras-Esquivel D, Toland AMS, Gehlhausen JR, Klein J, Takahashi T, Silva J, Israelow B, Lucas C, Mao T, Peña-Hernández MA, Tabachnikova A, Homer RJ, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Vogel H, Hefti MM, Perl DP, Liddelow S, Folkerth R, Putrino D, Nath A., Iwasaki A.*, Monje M.* (2022). Cell. 10.1016/j.cell.2022.06.008.
NF1 mutation drives neuronal activity-dependent initiation of optic glioma
Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR, Liau LM, Goldberg JL, Monje M, Gutmann DH. Nature. 2021 May 26. doi: 10.1038/s41586-021-03580-6. PMID: 34040258
Microglia in Cancer Therapy-Related Cognitive Impairment
Gibson EM, Monje M. Trends Neurosci. 2021 Jun;44(6):441-451. doi: 10.1016/j.tins.2021.02.003. Epub 2021 Mar 2. Review. PMID: 33674135.
Roadmap for the Emerging Field of Cancer Neuroscience
Monje M, Borniger JC, D'Silva NJ, Deneen B, Dirks PB, Fattahi F, Frenette PS, Garzia L, Gutmann DH, Hanahan D, Hervey-Jumper SL, Hondermarck H, Hurov JB, Kepecs A, Knox SM, Lloyd AC, Magnon C, Saloman JL, Segal RA, Sloan EK, Sun X, Taylor MD, Tracey KJ, Trotman LC, Tuveson DA, Wang TC, White RA, Winkler F. Cell. 2020 Apr 16;181(2):219-222. doi: 10.1016/j.cell.2020.03.034. PMID: 32302564
Electrical and synaptic integration of glioma into neural circuits
Venkatesh HS, Morishita W, Geraghty AC, Silverbush D, Gillespie SM, Arzt M, Tam LT, Espenel C, Ponnuswami A, Ni L, Woo PJ, Taylor KR, Agarwal A, Regev A, Brang D, Vogel H, Hervey-Jumper S, Bergles DE, Suvà ML, Malenka RC, Monje M. Nature. 2019 Sep;573(7775):539-545. doi: 10.1038/s41586-019-1563-y. Epub 2019 Sep 18. PMID: 31534222
Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State
Nagaraja S, Quezada MA, Gillespie SM, Arzt M, Lennon JJ, Woo PJ, Hovestadt V, Kambhampati M, Filbin MG, Suva ML, Nazarian J, Monje M. Mol Cell. 2019 Sep 28. pii: S1097-2765(19)30685-9. doi: 10.1016/j.molcel.2019.08.030. [Epub ahead of print] PMID: 31588023
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment
Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T, Marton RM, Paşca SP, Greenberg ME, Longo FM, Monje M. Neuron.2019 Jul 17;103(2):250-265.e8. pii: S0896-6273(19)30389-7. doi: 10.1016/j.neuron.2019.04.032. Epub 2019 May 20
Developmental origins and emerging therapeutic opportunities for childhood cancer
Filbin M, Monje M. Nat Med 2019 Mar;25(3):367-376. doi: 10.1038/s41591-019-0383-9. Epub 2019 Mar 6.
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment
Gibson EM, Nagaraja S, Ocampo A, Tam LT, Wood LS, Pallegar PN, Greene JJ, Geraghty AC, Goldstein AK, Ni L, Woo PJ, Barres BA, Liddelow S, Vogel H, Monje M. Cell. 2019 Jan 10;176(1-2):43-55.e13. doi: 10.1016/j.cell.2018.10.049. Epub 2018 Dec 6.
Myelin Plasticity and Nervous System Function
Monje M. Annu Rev Neurosci. 2018 Jul 8;41:61-76. Annu Rev Neurosci. Jul 8;41:61-76. doi: 10.1146/annurev-neuro-080317-061853.
Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas
Mount CW, Majzner RG, Sundaresh S, Arnold EP, Kadapakkam M, Haile S, Labanieh L, Hulleman E, Woo PJ, Rietberg SP, Vogel H, Monje M, Mackall CL. Nat Med. 2018 Apr 16. doi: 10.1038/s41591-018-0006-x
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma
Venkatesh HS, Tam LT, Woo PJ, Lennon J, Nagaraja S, Gillespie SM, Ni J, Duveau DY, Morris PJ, Zhao JJ, Thomas CJ, Monje M. Nature. 2017 Sep 28;549(7673):533-537. doi: 10.1038/nature24014. Epub 2017 Sep 20.
Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma
Qin EY, Cooper DD, Abbott KL, Lennon J, Nagaraja S, Mackay A, Jones C, Vogel H, Jackson PK, Monje M. Cell. 2017 Aug 24;170(5):845-859.e19. doi: 10.1016/j.cell.2017.07.016. Epub 2017 Aug 1
Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma
Nagaraja S, Vitanza NA, Woo PJ, Taylor KR, Liu F, Zhang L, Li M, Meng W, Ponnuswami A, Sun W, Ma J, Hulleman E, Swigut T, Wysocka J, Tang Y, Monje M. (2017) Cancer Cell, Apr 11. pii: S1535-6108(17)30107-1
Neuronal Activity in Ontogeny and Oncology
Venkatesh H, Monje M (2017) Trends in Cancer, 3(2):89-112
Neuronal activity promotes glioma growth through neuroligin-3 secretion
Venkatesh HS, Johung T, Caretti V, Noll A, Tang Y, Nagaraja S, Gibson EM, Mount CW, Pollepalli J, Mitra SS, Woo PJ, Malenka RM, Vogel H, Bredel M, Mallick P, Monje M (2015) Cell, 161(4):803-16
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
C. S. Grasso, Y. Tang, N. Truffaux, N. E. Berlow, L. Liu, M. A. Debily, M. J. Quist, L. E. Davis, E. C. Huang, P. J. Woo, A. Ponnuswami, S. Chen, T. B. Johung, W. Sun, M. Kogiso, Y. Du, L. Qi, Y. Huang, M. Hutt-Cabezas, K. E. Warren, L. Le Dret, P. S. Meltzer, H. Mao, M. Quezado, D. G. van Vuurden, J. Abraham, M. Fouladi, M. N. Svalina, N. Wang, C. Hawkins, J. Nazarian, M. M. Alonso, E. H. Raabe, E. Hulleman, P. T. Spellman, X. N. Li, C. Keller, R. Pal, J. Grill, M. Monje (2015) Nat Med 21, 555-559
Subventricular Spread of Diffuse Intrinsic Pontine Glioma
Caretti V, Bugiani M, Freret ME, Schellen P, Jansen M, van Vuurden D, Kaspers G, Fisher PG, Hulleman E, Wesseling P, Vogel H, Monje M (2014) Acta Neuropathologica, 128(4):605-7.
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain.
Gibson EM, Purger D, Mount CW, Goldstein AK, Lin GL, Wood LS, Inema I, Miller SE, Bieri G, Zuchero JB, Barres BA, Woo PJ, Vogel H, Monje M (2014). Science 344 (6183):1252304. [abstract] [reprint] [full text]
Effect of cancer therapy on neural stem cells: implications for cognitive function.
Gibson E, Monje M. (2012) Curr Opin Oncol. 24(6):672-8