Monje Lab Selected Publications

Electrical and synaptic integration of glioma into neural circuits
Venkatesh HS, Morishita W, Geraghty AC, Silverbush D, Gillespie SM, Arzt M, Tam LT, Espenel C, Ponnuswami A, Ni L, Woo PJ, Taylor KR, Agarwal A, Regev A, Brang D, Vogel H, Hervey-Jumper S, Bergles DE, Suvà ML, Malenka RC, Monje M. Nature. 2019 Sep;573(7775):539-545. doi: 10.1038/s41586-019-1563-y. Epub 2019 Sep 18. PMID: 31534222

Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State
Nagaraja S, Quezada MA, Gillespie SM, Arzt M, Lennon JJ, Woo PJ, Hovestadt V, Kambhampati M, Filbin MG, Suva ML, Nazarian J, Monje M. Mol Cell. 2019 Sep 28. pii: S1097-2765(19)30685-9. doi: 10.1016/j.molcel.2019.08.030. [Epub ahead of print] PMID: 31588023

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment
Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T, Marton RM, Paşca SP, Greenberg ME, Longo FM, Monje M. Neuron.2019 Jul 17;103(2):250-265.e8. pii: S0896-6273(19)30389-7. doi: 10.1016/j.neuron.2019.04.032.  Epub 2019 May 20

Developmental origins and emerging therapeutic opportunities for childhood cancer
Filbin M, Monje M. Nat Med 2019 Mar;25(3):367-376. doi: 10.1038/s41591-019-0383-9. Epub 2019 Mar 6.

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment
Gibson EM, Nagaraja S, Ocampo A, Tam LT, Wood LS, Pallegar PN, Greene JJ, Geraghty AC, Goldstein AK, Ni L, Woo PJ, Barres BA, Liddelow S, Vogel H, Monje M. Cell. 2019 Jan 10;176(1-2):43-55.e13. doi: 10.1016/j.cell.2018.10.049. Epub 2018 Dec 6.

Myelin Plasticity and Nervous System Function
Monje M.  Annu Rev Neurosci. 2018 Jul 8;41:61-76. Annu Rev Neurosci. Jul 8;41:61-76. doi: 10.1146/annurev-neuro-080317-061853.

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas
Mount CW, Majzner RG, Sundaresh S, Arnold EP, Kadapakkam M, Haile S, Labanieh L, Hulleman E, Woo PJ, Rietberg SP, Vogel H, Monje M, Mackall CL. Nat Med. 2018 Apr 16. doi: 10.1038/s41591-018-0006-x

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma
Venkatesh HS, Tam LT, Woo PJ, Lennon J, Nagaraja S, Gillespie SM, Ni J, Duveau DY, Morris PJ, Zhao JJ, Thomas CJ, Monje M. Nature. 2017 Sep 28;549(7673):533-537. doi: 10.1038/nature24014. Epub 2017 Sep 20.

Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma
Qin EY, Cooper DD, Abbott KL, Lennon J, Nagaraja S, Mackay A, Jones C, Vogel H, Jackson PK, Monje M. Cell. 2017 Aug 24;170(5):845-859.e19. doi: 10.1016/j.cell.2017.07.016. Epub 2017 Aug 1

Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma
Nagaraja S, Vitanza NA, Woo PJ, Taylor KR, Liu F, Zhang L, Li M, Meng W, Ponnuswami A, Sun W, Ma J, Hulleman E, Swigut T, Wysocka J, Tang Y, Monje M. (2017) Cancer Cell, Apr 11. pii: S1535-6108(17)30107-1

Neuronal Activity in Ontogeny and Oncology
Venkatesh H, Monje M (2017) Trends in Cancer, 3(2):89-112

Neuronal activity promotes glioma growth through neuroligin-3 secretion
Venkatesh HS, Johung T, Caretti V, Noll A, Tang Y, Nagaraja S, Gibson EM, Mount CW, Pollepalli J, Mitra SS, Woo PJ, Malenka RM, Vogel H, Bredel M, Mallick P, Monje M (2015) Cell, 161(4):803-16

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
C. S. Grasso, Y. Tang, N. Truffaux, N. E. Berlow, L. Liu, M. A. Debily, M. J. Quist, L. E. Davis, E. C. Huang, P. J. Woo, A. Ponnuswami, S. Chen, T. B. Johung, W. Sun, M. Kogiso, Y. Du, L. Qi, Y. Huang, M. Hutt-Cabezas, K. E. Warren, L. Le Dret, P. S. Meltzer, H. Mao, M. Quezado, D. G. van Vuurden, J. Abraham, M. Fouladi, M. N. Svalina, N. Wang, C. Hawkins, J. Nazarian, M. M. Alonso, E. H. Raabe, E. Hulleman, P. T. Spellman, X. N. Li, C. Keller, R. Pal, J. Grill, M. Monje (2015) Nat Med 21, 555-559    

Subventricular Spread of Diffuse Intrinsic Pontine Glioma
Caretti V, Bugiani M, Freret ME, Schellen P, Jansen M, van Vuurden D, Kaspers G, Fisher PG, Hulleman E, Wesseling P, Vogel H, Monje M (2014) Acta Neuropathologica, 128(4):605-7.

Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain.
Gibson EM, Purger D, Mount CW, Goldstein AK, Lin GL, Wood LS, Inema I, Miller SE, Bieri G, Zuchero JB, Barres BA, Woo PJ, Vogel H, Monje M (2014). Science 344 (6183):1252304. [abstract] [reprint] [full text]
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Effect of cancer therapy on neural stem cells: implications for cognitive function.
Gibson E, Monje M. (2012) Curr Opin Oncol. 24(6):672-8