The Lu Chen Lab Select Publications
Publications 2003-present
Thapliyal, S., Arendt, K.L., Lau, A.G. and Chen, L. (2023). Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity. eLife, 11:e79863.
Cao, B., Scherrer, G., and Chen, L. (2022). Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain. Neuron, 110(24): 4108 – 24.
Chen, L., Li, X., Tjia, M., and Thapliyal, S. (2022). Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly. Curr Opin Neurobiol 75, 102553.
Lu, J., Tjia, M., Mullen, B., Cao, B., Lukasiewicz, K., Shah-Morales, S., Weiser, S., Cameron, L.P., Olsen, D.E., Chen, L., and Zuo, Y. (2021). An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress. Molecular Psychiatry, 26(11): 6237-6252.
Raj, N., McEachin, Z.T., Harousseau, W., Zhou, Y., Zhang, F., Merritt-Garza, M.E., Taliaferro, J.M., Kalinowska, M., Marro, S.G., Hales, C.M., Berry-Kravis, E., Wolf-Ochoa, M.W., Martinez-Cerdeño, V., Wernig, M., Chen, L., Klann, E., Warren, S.T., Jin, P., Wen, Z., Bassell, G.J. (2021). Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis. Cell Rep. 2021 Apr 13;35(2):108991. PubMed PMID: 33852833.
Park, E., Lau, A.G., Arendt, K.L. and Chen, L. (2021). FMRP interacts with RARα in synaptic retinoic acid signaling and homeostatic synaptic plasticity. International Journal of Molecular Sciences, 22(12): 6579.
Miry, O., Li, J. and Chen, L. (2020). The quest for the hippocampal memory engram: from theories to experimental evidence. Frontiers in Behavioral Neuroscience 14, 632019.
Li, J., Jiang, R.Y., Arendt, K.L., Hsu, Y., Zhai, S.R. and Chen, L. (2020). Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome. eLife (in press).
Yang, Y., Geng, Y., Jiang, D., Ning, L., Kim, H.J., Jeon, N.L., Lau, A.G., Chen, L., and Lin, M.Z. (2019). Kinase pathway inhibition restores PSD95 induction in neurons lacking fragile X mental retardation protein. Proceedings of the National Academy of Sciences of the United States of America, 116 (24): 12007-12012.
Hsu, Y., Li, J., Wu, D., Südhof, T.C., and Chen, L. (2019). Synaptic retinoic acid receptor mediates mTOR-dependent metaplasticity that controls hippocampal learning. Proceedings of the National Academy of Sciences of the United States of America, 116 (14): 7113-7122.
Li, J., Park, E., Zhong, L., and Chen, L. (2019). Homeostatic synaptic plasticity as a metaplasticity mechanism – a molecular and cellular perspective. Current Opinion in Neurobiology, 54: 44-53.
Zhong, L., Chen, X, Südhof, T.C., and Chen, L. (2018). Retinoic acid receptor RARα-dependent synaptic signaling mediates homeostatic synaptic plasticity at the inhibitory synapses of mouse visual cortex. The Journal of Neuroscience, 38:10454-10466.
Zhang, Z., Marro, S.G., Zhang, Y.S., Arendt, K.L., Zhou, B., Fair, T., Nan, Y., Südhof, T.C., Wernig, M. and Chen, L. (2018). Fragile-X Mutation Impairs Homeostatic Plasticity in Human Neurons by Blocking Synaptic Retinoic-Acid Signaling. Science Translational Medicine, 10 (452) eaar4338.
Park, E., Tjia, M., Zuo, Y., Chen, L. (2018). Postnatal ablation of synaptic retinoic acid signaling impairs cortical information processing and sensory discrimination in mice. The Journal of Neuroscience, 38(23): 5277-88.
Wu, D., Bacaj, T., Morishita, W., Goswami, D., Arendt, K. L., Xu, W., Chen, L., Malenka, R. C., Südhof, T. C. (2017). Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP. Nature, 544: 316-321.
Temkin, P., Morishita, W., Goswami, D., Arendt, K.L., Chen, L., and Malenka, R.C. (2017). The retromer supports AMPA receptor trafficking during LTP. Neuron, 94(1): 74-82.
Keck, T., Toyoizumi, T., Chen, L., Doiron, B., Feldman, D. E., Fox, K., Gerstner, W., Haydon, P. G., Hübener, M., Lee, H. K., Lisman, J. E., Rose, T., Sengpiel, F., Stellwagen, D., Stryker, M. P., Turrigiano, G. G., van Rossum, M. C. (2017). Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2017; 372 (1715).
Yee, A., Hsu, Y.T. and Chen, L. (2017). A metaplasticity view of the interaction between Hebbian and homeostatic plasticity. Philosophical Transactions of the Royal Society B 372: 20160155.
Yee, A and Chen, L. (2016). Differential regulation of spontaneous and evoked inhibitory synaptic transmission in somatosensory cortex by retinoic acid. Synapse 70 (11): 445-52 (cover story).
Arendt, K.L., Zhang, Z., Ganesan, S., Hintze, M., Shin, M., Tang, Y., Cho, A, Graef, I., and Chen, L. (2015). Calcineurin Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis. Proceedings of the National Academy of Sciences of the United States of America, 112:E5744-52.
Kim, J., Ganesan, S., Luo, S.X., Wu, Y.W., Huang, E.J., Chen, L., and Ding, J.B. Aldehyde Dehydrogenase 1a1 (ALDH1a1) mediates a GABA synthesis pathway in midbrain dopaminergic neurons. Science, 350: 102-6.
Anderson, G.R., Aoto, J., Tabuchi, K., Foldy, C., Covy, J., Yee, A.X., Wu, D., Chen, L., Malenka, R.C., and Südhof, T.C. (2015). beta-Neurexins control neural circuit dynamics by regulating endocannbinoid signaling at excitatory synapses. Cell, 162(3): 593-606.
Arendt, K.L., Zhang, Y., Jurado, S., Malenka, R.C., Südhof, T.C., and Chen, L. (2015). Retinoic acid and LTP recruit postsynaptic AMPA-receptor using distinct SNARE-dependent mechanisms. Neuron, 86, 442-456.
Liang, J., Xu, W., Hsu, Y.T., Yee, A.X., Chen, L., and Südhof, T.C. (2015). Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibnition to cognitive impairements. Molecular Psychiatry, 20(7): 850-9.
Chen, L., Lau, A. G., and Sarti, F. (2014). Synaptic retinoic acid signaling and homeostatic synaptic plasticity. Neuropharmacology, 78: 3-12.
Yu, X., Wang, G., Gilmore, A., Yee, A.Y., Li, X., Xu, T., Smith, S.J., Chen, L.,and Zuo, Y. (2013). Accelerated Experience-dependent Pruning of Cortical Synapses in Ephrin-A2 Knockout Mice. Neuron 80(1): 64-71.
Sarti, F., Zhang, Z.J., Schroeder, J., and Chen, L. (2013). Rapid suppression of inhibitory synaptic transmission by retinoic acid. Journal of Neuroscience 33(28): 11440-50.
Zhang, Y.S., Pak, C.H., Han, Y., Ahlenius, H., Zhang, Z.J., Chandra, S., Marro, S., Patzke, C., Acuna, C., Covy, J., Xu, W., Yang, N.,Danko, T., Chen, L., Wernig, M. and Sudhof, T.C. (2013).Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron 78(5):785-98.
Hastie, P., Ulrich, M., Wang, H., Arant, R.J., Lau, A.G., Zhang, Z., Isacoff, E.Y. and Chen, L. (2013). AMPA Receptor/TARP stoichiometry visualized by single molecule subunit counting. Proceedings of the National Academy of Sciences of the United States of America, 110, 5163-8.
Arendt, K. L., and Chen, L. (2013).Chronic inactivation of a neural circuit enhances LTP by inducing silent synapse formation. Journal of Neuroscience 33(5): 2087-96.
Chen, L., Lau, A. G., and Sarti, F. (2013). Synaptic retinoic acid signaling and homeostatic synaptic plasticity. Neuropharmacology (in press).
Chen, L., Südhof, T.C. and Reiss, A.L. (2012). Trailing targeted therapies for autism. Nature Medicine, 18(12), 1746-7.
Sarti, F., Schroeder, J., Aoto, J. and Chen, L. (2012). Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity. Frontiers in Molecular Neuroscience, 5:16. doi:10.3389/fnmol.2012.00016.
Wang, H., Zhang, Z., Hintze, M. and Chen, L. (2011). Calcium regulates neuronal retinoic acid synthesis during homeostatic synaptic plasticity. Journal of Neuroscience, 31(49): 17764-71.
Tracy, T.E., Yan, J.J. and Chen, L. (2011). Acute knockdown of AMPA receptors reveals a trans-synaptic signaling pathway for presynaptic maturation. EMBO Journal, 30(8):1577-92.
Soden, M. and Chen, L. (2010). Fragile-X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid. Journal of Neuroscience, 30:16910-21.
Little, D. and Chen, L. (2009). Identification of coevolving residues and coevolution potentials emphasizing structure, bond formation and catalytic coordination in protein evolution. PLoS ONE 4(3): e4762. doi:10.1371/journal.pone.0004762.
Poon, M. and Chen, L. (2008). Retinoic acid-gated sequence-dependent translational control by RARα. Proceedings of the National Academy of Sciences of the United States of America, 105, 20303-20308.
Maghsoodi, B., Poon, M., Nam, C.I., Aoto J., Ting, P. and Chen, L. (2008). Retinoic acid regulates RARα-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 105, 16015-20.
Aoto J., Maghsoodi, B., Nam, C.I., Poon, M., Ting, P. and Chen, L. Aoto, J., Nam, C.I., Poon, M., Ting, P. and Chen, L. (2008). Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron, 60, 308-320. [PDF][ supplemental information]
Hastie, P. and Chen, L. (2007). Synaptic trapping of AMPA receptors. Cell Science Reviews.
Chen, L., Tracy, T., and Nam, C.I. (2007). Dynamics of postsynaptic glutamate receptor targeting. Current Opinion in Neurobiology 17 (1), 53-58.
Aoto, J. and Chen, L. (2007). Bidirectional ephrin/Eph signaling in synaptic function. Brain Research Reviews 1184, 72-80.
Aoto, J., Ting, P., Maghsoodi, B., Xu, N., Henkemeyer, M. and Chen, L. (2007). Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. Journal of Neuroscience, 27, 7508-19.
Chen, L., and Maghsoodi, B., (2006). Synaptic trafficking of AMPA receptors. [.In Protein Trafficking in the Neuron (Ed. Bean, A. J.). Elsevier Academic Press, Oxford, UK].
Nam, C. I. and Chen, L. (2005). Postsynaptic Assembly Induced by Presynaptic Neurexin and Neurotransmitter. Proceedings of the National Academy of Sciences of the United States of America, 102, 6137-42.
Chen, L., El-Husseini, A., Tomita, A., Bredt, D. S., and Nicoll, R. A. (2003). Stargazin differentially controls the trafficking of AMPA and kainate receptors. Molecular Pharmacology, 64, 703-706.
Tomita, S., Chen, L., Kawasaki, Y., Petralia, R. S., Wenthold, R. J., Nicoll, R. A., and Bredt, D. S. (2003). Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. Journal of Cell Biology, 161, 805-816.
Older Publications
Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., and Nicoll, R. A. (2002). Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proceedings of the National Academy of Sciences of the United States of America, 99, 13902-7.
Chetkovich, D. M*., Chen, L.*, Stocker, T. J., Nicoll, R.A., and Bredt, D. S. (2002). Phosphorylation of the PDZ Binding Site of Stargazin Regulates Binding to PSD-95 and Synaptic Targeting of AMPA Receptors. Journal of Neuroscience, 22, 5791-6. (*, equal contribution).
Bao, S. and Chen., L (2002). Genetic substrates of memory: cerebellum [.In Encyclopedia of Learning and Memory, 2nd edition (Ed. Byrne, J. H.). MacMillan Publishers, Farmington Hills].
Bao, S., Chen, L., Kim, J. J. and Thompson, R. F. (2002). Cerebellar cortical inhibition and classical eyeblink conditioning. Proceedings of the National Academy of Sciences of the United States of America, 99, 1592-97.
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N., Kawaski, Y., Wenthold R. J., Bredt, D. S., and Nicoll, R. A. (2000). Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature, 408, 936-943.
Bao, S., Chen, L., and Thompson, R. F. (2000). Learning- and cerebellum-dependent neuronal activity in the lateral pontine nucleus. Behavioral Neuroscience, 114, 254-61.
Bao, S., Chen, L., Qiao, X., and Thompson, R. F. (1999). Transgenic brain-derived neurotrophic factor modulates a developing cerebellar inhibitory synapse. Learning & Memory, 6, 276-283.
Chen, L., Bao, S., Qiao, X., and Thompson, R. F. (1999). Impaired cerebellar synapse maturation in waggler, a mutant mouse with a disrupted neuronal calcium channel gamma subunit. Proceedings of the National Academy of Sciences of the United States of America, 96, 12132-12137.
Chen, L., Bao, S., and Thompson R. F. (1999). Bilateral lesions of the interpositus nucleus completely prevent eyeblink conditioning in Purkinje cell degeneration mutant mice. Behavioral Neuroscience, 113, 204-210.
Bao, S., Chen, L., Qiao, X., and Thompson, R. F. (1998). Impaired classical eyeblink conditioning in waggler, a mutant mouse with localized BDNF deficit in the cerebellum. Learning and Memory, 5, 355-364.
Qiao, X., Chen, L., Gao, H., Bao, S, Hefti, H., Thompson, R. F., and Knusel, B. (1998). Cerebellar brain-derived neurotrophic factor-TrkB defect associated with impairment of eyeblink conditioning in stargazer mutant mice. Journal of Neuroscience, 18, 6990-6999.
Bao, S., Chen, L., and Thompson, R. F. (1998). Classical eyeblink conditioning in two strains of mice: conditioned responses, sensitization and spontaneous eyeblinks. Behavioral Neuroscience, 112, 714-718.
Kim, J. J., Shih, J. C., Chen, K., Chen, L., Bao, S., Maren, S., Anagnostaras, S. G., Fanselow, M. S., Maeyer, E. D., Seif, I., and Thompson, R. F. (1997). Selective enhancement of emotional, but not motor learning in monoamine oxidase A-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 94, 5929-5933.
Kim, J. J., Chen, L., Bao, S., Sun, W., and Thompson, R. F. (1996). Genetic dissection of the cerebellar circuitry involved in classical eyeblink conditioning. In: Gene Targeting and New Development in Neurobiology, 3-15. (Eds. S. Nakanishi et al.), Japan Scientific Societies Press, Tokyo.
Thompson, R. F., Bao, S., Chen, L., Cipriano, B., Grethe, J. S., Kim, J. J., Thompson, J. K., Tracy, J., Weninger, M. S., and Krupa, D. J. (1996). Associative learning. In: The Cerebellum and Cognition. 151-189. (Eds. J. D. Schmahmann), Academic Press, New York.
Shibuki, K., Gomi, H., Chen, L., Bao, S., Kim, J. J., Wakatsuki, H., Fujisaki, T., Fujimoto, K., Ikeda, T., Chen, C., Thompson, R. F., and Itohara, S. (1996) Deficient cerebellar long-term depression, impaired eyeblink conditioning and normal motor coordination in GFAP mutant mice. Neuron, 16, 587-599.
Chen, L., Bao, S., Kim, J. J., Lockard, J., and Thompson, R. F. (1996). Impaired classical eyeblink conditioning in cerebellar lesion and Purkinje cell degeneration mutant mice. Journal of Neuroscience, 16, 2829-2838.
Chen, C., Kano, M., Abeliovich, A., Chen, L., Bao, S., Kim, J. J., Hashimoto, K., Thompson, R. F., and Tonegawa, S. (1995). Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCg mutant mice. Cell, 83, 1233-1242.