Artery remodeling in pulmonary hypertension
Cellular and molecular control of neointimal lesion formation
Clonal analysis & lineage studies
Defining the cell types and subpopulations responsible for neointimal lesion formation at both the population and single cell level
Single cell RNA-seq & PH interactome
Mapping patterns of transcription and signaling among vascular cells over the course of artery remodeling in PH
Mouse models & drug discovery
Animal models allow a cellular understanding of lesion formation in PH and the search for drugs that block or reverse artery occlusion