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Artery remodeling in pulmonary hypertension

Cellular and molecular control of neointimal lesion formation

Clonal analysis & lineage studies

Defining the cell types and subpopulations responsible for neointimal lesion formation at both the population and single cell level

Single cell RNA-seq & PH interactome

Mapping patterns of transcription and signaling among vascular cells over the course of artery remodeling in PH

Mouse models & drug discovery

Animal models allow a cellular understanding of lesion formation in PH and the search for drugs that block or reverse artery occlusion