Publications

Vilalta, M., Hughes, N. P., Von Eyben, R., Giaccia, A. J., & Graves, E. E. (2016). Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location. Molecular Imaging and Biology, 1-10.

Bazan, J. G., Duan, F., Snyder, B. S., Horng, D., Graves, E. E., Siegel, B. A., . . . Loo, B. W. (2016). Metabolic tumor volume predicts overall survival and local control in patients with stage III non-small cell lung cancer treated in ACRIN 6668/RTOG 0235. European Journal of Nuclear Medicine and Molecular Imaging, 1-8.

Yang, J., Yamamoto, T., Pollock, S., Berger, J., Diehn, M., Graves, E. E., . . . Keall, P. J. (2016). The impact of audiovisual biofeedback on 4D functional and anatomic imaging: Results of a lung cancer pilot study. Radiotherapy and Oncology, 120(2), 267-272.

Vilalta, M., Rafat, M., & Graves, E. E. (2016). Effects of radiation on metastasis and tumor cell migration. Cellular and Molecular Life Sciences, 73(16), 2999-3007. doi:10.1007/s00018-016-2210-5

Graves, E. E., Hicks, R. J., Binns, D., Bressel, M., Le, Q.-T., Peters, L., . . . Rischin, D. (2016). Quantitative and qualitative analysis of [18F]FDG and [18F]FAZA positron emission tomography of head and neck cancers and associations with HPV status and treatment outcome. European Journal of Nuclear Medicine and Molecular Imaging, 43(4), 617-625.

Shuhendler, A. J., Ye, D., Brewer, K. D., Bazalova-Carter, M., Lee, K.-H., Kempen, P., … Rao, J. (2015). Molecular Magnetic Resonance Imaging of Tumor Response to Therapy. Scientific Reports, 5, 14759. http://doi.org/10.1038/srep14759

Ali, R., Apte, S., Vilalta, M., Subbarayan, M., Miao, Z., Chin, F. T., & Graves, E. E. (2015). 18F-EF5 PET Is Predictive of Response to Fractionated Radiotherapy in Preclinical Tumor Models. PLoS ONE, 10(10), e0139425.

Rafat, M., Ali, R., & Graves, E. E. (2015). Imaging radiation response in tumor and normal tissue. American Journal of Nuclear Medicine and Molecular Imaging, 5(4), 317–332.

Zhou, H., Hallac, R. R., Lopez, R., Denney, R., MacDonough, M. T., Li, L., Graves, E. E., … Mason, R. P. (2015). Evaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and 19F MRI. American Journal of Nuclear Medicine and Molecular Imaging, 5(2), 143–153.

Harris, J. P., Chang-Halpenny, C. N., Maxim, P. G., Quon, A., Graves, E. E., Diehn, M., & Loo Jr, B. W. (2015). Outcomes of Modestly Hypofractionated Radiation for Lung Tumors: Pre- and Mid-Treatment Positron Emission Tomography-Computed Tomography Metrics as Prognostic Factors. Clinical Lung Cancer, 16(6), 475-485.

Vilalta M, Rafat M, Giaccia AJ, Graves EE. Recruitment of circulating breast cancer cells is stimulated by radiotherapy. Cell Reports 2014; Volume 8 , Issue 2 , 402 - 409
Lartey FM, Ahn GO, Shen B, Cord KT, Smith T, Chua JY, Rosenblum S, Liu H, James ML, Chernikova S, Lee SW, Pisani LJ, Tirouvanziam R, Chen JW, Palmer TD, Chin FT, Guzman R, Graves EE, Loo BW Jr. PET Imaging of Stroke-Induced Neuroinflammation in Mice Using [18F]PBR06. Molecular Imaging and Biology 2014; 16(1):109-17
Bazalova M, Nelson G, Noll JM, Graves EE. Modality comparison for small animal radiotherapy: a simulation study. Medical Physics 2014; 41(1):011710
Wallner PE, Anscher MS, Barker CA, Bassetti M, Bristow RG, Cha YI, Dicker AP, Formenti SC, Graves EE, Hahn SM, Hei TK, Kimmelman AC, Kirsch DG, Kozak KR, Lawrence TS, Marples B, McBride WH, Mikkelsen RB, Park CC, Weidhaas JB, Zietman AL, Steinberg M. Current Status and Recommendations for the Future of Research, Teaching, and Testing in the Biological Sciences of Radiation Oncology: Report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, Executive Summary. International Journal of Radiation Oncology Biology Physics 2014; 88(1):11-7

Bazan JG, Koong AC, Kapp DS, Quon A, Graves EE, Loo BW, Chang DT. Metabolic tumor volume predicts for disease progression and survival in patients with squamous cell carcinoma of the anal canal. Journal of Nuclear Medicine 2013; 54 (1): 27-32.
Sasportas LS, Hosford DN, Sodini MA, Waters DJ, Zambricki EA, Barral JK, Graves EE, Brinton TJ, Yock PG, Le QT, Sirjani D. Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 2013; S2212-4403(13)00096-5.
Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT. A Novel Aldehyde Dehydrogenase-3 Activator (Alda-89) Protects Submandibular Gland Function from Irradiation without Accelerating Tumor Growth. Clinical Cancer Research 2013; 19(16):4455-4464.
Fan Q, Nanduri A, Yang J, Yamamoto T, Loo B, Graves E, Zhu L, Mazin S. Toward a planning scheme for emission guided radiation therapy (EGRT): FDG based tumor tracking in a metastatic breast cancer patient. Medical Physics 2013; 40(8):081708.
Ali R, Gunduz-Demir C, Szilágyi T, Durkee B, Graves EE. Semi-automatic segmentation of subcutaneous tumours from micro-computed tomography images. Physics in Medicine and Biology2013; 58(22):8007-8019.
Yang J, Yamamoto T, Mazin S, Graves EE, Keall P. The potential of positron emission tomography (PET) for intra-treatment dynamic lung tumor tracking: A phantom study. Medical Physics 2013. [In press]

Chennupati S, Quon A, Kamaya A, Pai RK, La T, Krakow TE, Graves E, Koong A, Chang DT. Positron Emission Tomography for Predicting Pathologic Response Following Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer. American Journal of Clinical Oncology 2012; 35:334-339.
Lee P, Bazan JG, Lavori PW, Weerasuriya DK, Quon A, Le QT, Wakelee HA, Graves EE, Loo BW. Metabolic Tumor Volume is an Independent Prognostic Factor in Patients Treated Definitively for Non-Small Cell Lung Cancer. Clinical Lung Cancer 2012; 13:52-58.
Chu KP, Murphy JD, La TH, Krakow TE, Graves E, Hsu A, Maxim PG, Loo B, Chang DT, Le QT. Prognostic Value of Metabolic Tumor Volume and Velocity in Predicting Head and Neck Cancer Outcomes. International Journal of Radiation Oncology Biology Physics 2012; 83:1521-1527.
Tang C, Murphy JD, Khong B, La TH, Kong C, Fischbein NJ, Colevas AD, Iagaru AH, Graves EE, Le QT. Validation that Metabolic Tumor Volume Predicts Outcome in Head and Neck Cancer. International Journal of Radiation Oncology Biology Physics 2012; 83:1514-1520.
Jayachandran P, Pai RK, Quon A, Graves E, Krakow TE, La T, Loo BW; Koong AC, Chang DT. Postchemoradiotherapy Positron Emission Tomography Predicts Pathologic Response and Survival in Patients with Esophageal Cancer. International Journal of Radiation Oncology Biology Physics 2012; 84:471-477.
Le QT, Fisher R, Oliner KS, Young RJ, Cao H, Kong C, Graves E, Hicks RJ, McArthur GA, Peters L, O'Sullivan B, Giaccia A, Rischin D. Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer. Clinical Cancer Research 2012; 18:1798-1807.
Nair VS, Gevaert O, Davidzon G, Napel S, Graves EE, Hoang CD, Shrager JB, Quon A, Rubin DL, Plevritis SK. Prognostic PET 18F-FDG uptake imaging features are associated with major oncogenomic alterations in patients with resected non-small cell lung cancer. Cancer Research 2012; 72:3725-3734.
Abelson JA, Murphy JD, Trakul N, Bazan JG, Maxim PG, Graves EE, Quon A, Le QT, Diehn M, Loo BW Jr. Metabolic imaging metrics correlate with survival in early stage lung cancer treated with stereotactic ablative radiotherapy. Lung Cancer 2012; 78:219-224.
Bazalova M, Weil MD, Wilfley B, Graves EE. Monte Carlo model of the scanning beam digital x-ray (SBDX) source. Physics in Medicine and Biology 2012; 57:7381-7394.
Tseng D, Rachakonda LP, Su Z, Advani R, Horning S, Hoppe RT, Quon A, Graves EE, Loo BW Jr, Tran PT. Interim-treatment quantitative PET parameters predict progression and death among patients with Hodgkin's disease. Radiation Oncology2012; 7:5.
Ackerman N, Graves E. The Potential for Cerenkov Luminescence Imaging of Alpha Emitting Isotopes. Physics in Medicine and Biology 2012; 57:771-783.

Murphy JD, La TH, Chu K, Quon A, Fischbein NJ, Maxim PG, Graves EE, Loo BW, Le QT. Post-Radiation Metabolic Tumor Volume Predicts Outcome in Head-and-Neck Cancer.International Journal of Radiation Oncology Biology Physics 2011; 80:514-521.
Apte SD, Chin FT, Graves EE. Molecular Imaging of Hypoxia: Strategies for Probe Design and Application. Current Organic Synthesis 2011; 8:593-603.
Kozak M, Murphy J, Schipper ML, Donington JS, Zhou L, Whyte, RI, Shrager JB, Hoang, C, Bazan J, Maxim PG, Graves EE, Diehn M, Hara W, Quon A, Le QT, Wakelee HA, Loo BW. Tumor Volume as a Potential Imaging-Based Risk-Stratification Factor in Trimodality Therapy for Locally Advanced Non-small Cell Lung Cancer. Journal of Thoracic Oncology 2011; 6:920-926.
Bazalova M, Nelson G, Noll JM, Graves EE. The Importance of Tissue Segmentation for Dose Calculations for Kilovoltage Radiation Therapy. Medical Physics 2011; 38:3039-3049.
Murphy JD, Chisholm KM, Daly ME, Wiegner EA, Truong D, Iagaru A, Maxim PG, Loo BW, Graves EE, Kaplan MJ, Kong C, Le QT. Correlation between metabolic tumor volume and pathologic tumor volume in squamous cell carcinoma of the oral cavity. Radiotherapy and Oncology 2011; 80:514-521.
Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan J, Bouley DM,Graves EE, Denny WA, Hay MP, Giaccia AJ. Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality. Science Translational Medicine 2011; 3:94ra70.
Nelson GS, Perez J, Vilalta M, Graves E. Facilitating multimodal preclinical imaging studies in mice by using an immobilization bed. Comparative Medicine 2011; 61:499-504.

Motomura AR, Bazalova M, Zhou H, Keall PJ, Graves EE. Investigation of the effects of treatment planning variables in small animal radiotherapy dose distributions. Medical Physics 2010; 37:590-599.
Graves EE, Maity A, Le QT. The tumor microenvironment in NSCLC. Seminars in Radiation Oncology 2010; 20:156-163.
Schellenberg D, Quon A, Minn YA, Graves EE, Kunz P, Ford JM, Fisher GA, Goodman KA, Koong AC, Chang DT.18Fluorodoxyglucose-PET is prognostic of progression free and overall survival in locally advanced pancreas cancer treated with stereotactic radiotherapy. International Journal of Radiation Oncology Biology Physics 2010; 77:1420-1425.
Zhou H, Xu J, Rodriguez M, van den Haak F, Zhu X, Xian Y, Nelson G, Jogani R, Keall PJ, Graves EE. Development of a MicroCT-Based Image-Guided 3D Conformal Radiotherapy System for Small Animals. International Journal of Radiation Oncology Biology Physics 2010; 78:297-305.
Graves EE, Vilalta M, Cecic IK, Erler JT, Tran PT, Felsher D, Sayles L, Sweet-Cordero A, Le QT, Giaccia AJ. Hypoxia in Models of Lung Cancer: Implications for Radiotherapy and Targeted Therapeutics. Clinical Cancer Research 2010; 16:4843-4852.

Bennewith KL, Huang X, Ham CM, Graves EE, Erler JT, Kambham N, Feazell J, Yang GP, Koong A, Giaccia AJ. The Role of Tumor Cell-Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth. Cancer Research 2009; 69:775-784.
Zhou H, Keall PJ, Graves EE. A Bone Composition Model for Monte Carlo X-Ray Transport Simulations. Medical Physics2009; 36:1008-1018.
Rodriguez M, Zhou H, Keall P, Graves E. Commissioning of a Novel MicroCT/RT System for Small Animal Conformal Radiotherapy. Physics in Medicine and Biology 2009; 54:3727-3740.
Minn AY, Schellenberg D, Maxim P, Cox B, Dieterich S, Xing L, Graves E, Goodman K, Chang D, Koong AC. Pancreatic tumor motion on a single planning 4D-CT does not correlate with intrafraction tumor motion during treatment. American Journal of Clinical Oncology 2009; 32:364-368.
La TH, Filion EJ, Turnbull BB, Chu JN, Lee P, Nguyen K, Maxim P, Loo BW, Quon A, Graves EE, Le QT. Metabolic Tumor Volume Predicts for Recurrence and Death in Head and Neck Cancer. International Journal of Radiation Oncology Biology Physics 2009; 74:1335-1341.
Cairns R, Bennewith K, Graves E, Giaccia A, Chang D, Denko N. Pharmacologically increased tumor hypoxia can be measured by 18F FAZA PET and enhances tumor response to hypoxic cytotoxin PR-104. Clinical Cancer Research 2009; 15:7170-7174.
Bazalova M, Zhou H, Keall PJ, Graves EE. Kilovoltage beam Monte Carlo dose calculations in sub-millimeter voxels for small animal radiotherapy. Medical Physics 2009; 36:4991-4999.

Graves EE, Giaccia AJ. Imaging Tumoral Hypoxia: Oxygen Concentrations and Beyond. Oncology 2007, 21:368-378.
Graves EE, Quon A, Loo BW. RT_Image: An Open Source Tool for Investigating PET in Radiation Oncology. Technology in Cancer Research and Therapy 2007, 6:111-121.
Cecic I, Chan D, Sutphin P, Ray P, Gambhir SS, Giaccia A, Graves EE. Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia. Molecular Imaging 2007, 6: 219-228.
Cheng Z, Zhang L, Graves E, Xiong Z, Dandekar M, Chen X, Gambhir SS. Small-animal PET of melanocortin 1 receptor expression using a 18F-labeled alpha-melanocyte-stimulating hormone analog. Journal of Nuclear Medicine 2007, 48:987-994.
Lee P, Weerasuriya D, Le Q, Lavori PW, Quon A, Hara W, Wakelee H, Graves E, Loo BW. Metabolic Tumor Burden Predicts for Disease Progression in Lung Cancer. International Journal of Radiation Oncology Biology Physics 2007, 69: 328-333.
Graves EE, Zhou H, Chatterjee R, Keall PJ, Gambhir SS, Contag CH, Boyer AL. Design and Evaluation of a Variable Aperture Collimator for Conformal Radiotherapy of Small Animals Using a MicroCT Scanner. Medical Physics 2007, 34: 4359-4367.

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