Our laboratory is interested in developing and applying chemical tools to dissect the functional roles of hydrolases in a number of human health conditions. Our research group is made up of a mix of synthetic organic chemists, biologists, biochemists, and cell biologists. We are currently using synthetic chemistry to build new reagents that allow enzyme activity to be monitored in complex biological samples including cells, tissues and whole organisms. We are applying these tools to
- Functional studies of the proteasome and serine hydrolases in the human parasites Toxoplasma gondii and Plasmodium falciparum
- Identification of novel serine hydrolase targets in the pathogenic bacteria Staphylococcus aureus and Mycobacterium tuberculosis
- Development of fluorescent enzyme sensors for applications in image guided surgery.
Bogyo Lab Values Statement:
In the Bogyo Lab, we believe that scientific research, and those involved, is improved by an open, diverse, and inclusive environment. We welcome researchers of all races, ethnicities, gender identities, sexual orientations, religions, educational backgrounds, and abilities. Our lab is committed to challenging systemic inequities in science and fostering a collaborative space in which we can all learn from each other.