People

Group Lead

Matthew Bogyo
Professor

Bio

Curriculum Vitae

Dr. Bogyo received a B.Sc. degree in Chemistry from Bates College in 1993 and a Ph.D. in Biochemistry from the Massachusetts Institute of Technology in 1997. After completion of his degree he was appointed as a Faculty Fellow in the Department of Biochemistry and Biophysics at the University of California, San Francisco. Dr. Bogyo served as the Head of Chemical Proteomics at Celera Genomics from 2001 to 2003 while maintaining an Adjunct Faculty appointment at UCSF. In the Summer of 2003 Dr. Bogyo joined the Department of Pathology at Stanford Medical School and was appointed as a faculty member in the Department of Microbiology and Immunology in 2004. His interests are focused on the use of chemistry to study the role of proteases in human disease. In particular his laboratory is currently working on understanding the role of cysteine proteases in tumorgenesis and also in the life cycle of human parasites and bacterial pathogens. Dr. Bogyo currently serves on the Editorial Board of Biochemical Journal, Cell Chemical Biology, Molecular and Cellular Proteomics and is an Academic Editor at PLoS One. Dr. Bogyo is a consultant for several biotechnology and pharmaceutical companies in the Bay Area and is a founder and board member of Akrotome Imaging and Facile Therapeutics.

Postdoctoral Fellows

Maly Cosco
Postdoctoral Fellow

Bio

Maly earned her B.S. in Chemistry from Denison University in 2015. During her undergraduate studies, she conducted research in both organic chemistry, under the mentorship of Prof. Jordan Fantini, and radiology, with Dr. Eric Wall at Cincinnati Children’s Hospital Medical Center. She then began her Ph.D. in Chemistry at UCLA, in the laboratory of Prof. Ellen Sletten. Her graduate work centered around the development of polymethine dyes and nanomaterials for shortwave infrared imaging. In these pursuits, she was co-mentored by Dr. Oliver Bruns at the Helmholtz Pioneer Campus in Munich, Germany, where she established methods for real-time, multicolor optical imaging in vivo. After completion of her Ph.D. in 2020, Maly joined the Bogyo lab in 2021 and is pursuing covalently targeted imaging agents for serine hydrolases in pathogenic bacteria.

Marta Barniol-Xicota
Postdoctoral Fellow

Bio

Marta received her B.Sc. in Pharmacy from the University of Barcelona in 2011 and a MSc in Experimental Organic Chemistry in 2013. She then joined the lab of Prof. Santiago Vázquez where she focused on the synthesis of small molecules targeting ion channels. As a graduate student, Marta also worked in the labs of Dr. Steven Hilton at UCL and Prof. Bill Degrado at UCSF. After earning her PhD in 2017, she received a Marie Curie fellowship to work with Prof. Steven Verhelst at KU Leuven, where she developed new chemical methods to study membrane proteases in their native environments. In October 2021 she joined the Bogyo lab where she works on identifying selective substrates and inhibitors for proteases involved in cancer using phage display approaches.  

Matteo Guerra
Postdoctoral Fellow

Bio

Matteo received his MSc in Biotechnology from Parma University (Italy) in 2016. Under the supervision of Prof. Simone Ottonello and Barbara Montanini, he worked on the development of an in vivo BRET-based platform for the identification of protein-protein interaction inhibitors. Matteo then moved to Heidelberg (Germany) to carry out his PhD at the European Molecular Biology Laboratory under the supervision of Prof. Carsten Schultz and Marcus Mall. During his doctoral studies, Matteo’s goal was to spatially resolve the complexity of the neutrophil serine protease (NSP) network in chronic airway diseases. To do so, he developed probes designed to quantify neutrophil elastase and cathepsin G activity specifically at the neutrophil surface and on eDNA within neutrophil extracellular traps (NETs). Matteo joined the Bogyo Lab in May 2021. He is currently interested in identifying molecular mechanisms that protect the respiratory tract from pathogen biofilm infections and in developing technologies for the in vivo imaging of solid tumors. 

Nichole Pedowitz
Postdoctoral Fellow

Bio

Nikki graduated from the University of Maryland in 2016 where she earned a B.S. (cum laude) in Chemistry and Biological Sciences. She performed undergraduate research in physical organic chemistry in Prof. Daniel Falvey's lab where she studied photo releasable protecting groups. She went on to earn a Ph.D. in Chemistry from the University of Southern California in 2021 under the mentorship of Prof. Matthew Pratt. Her graduate work centered around the posttranslational modification O-GlcNAcylation. During her time in the Pratt lab, Nikki developed selective inhibitors of O-GlcNAc modifications and investigated its role in fibroblast contraction. Nikki joined the Bogyo lab in October of 2021 and is interested in using covalent inhibitors to investigate the role of key enzymes in mammalian immune responses.

Markus Lakemeyer
Postdoctoral Fellow

Bio

Markus Lakemeyer received his B.Sc. in Chemistry from RWTH Aachen University, Germany, in 2011. He moved to Philipps-University Marburg, Germany, and was awarded his M.Sc. in Medicinal Chemistry in 2014. Markus then started his PhD under the supervision of Prof. Stephan Sieber at Technical University of Munich (TUM). His graduate work was focused on the development and biochemical application of small molecule probes targeting the bacterial ClpXP protease. After receiving his Ph.D. in November 2018 and a short postdoc in the same group, Markus joined the Bogyo Lab in April 2019. His current project focusses on the identification and biological characterization of proteases produced by commensal bacteria.

Scott Lovell
Postdoctoral Fellow

Bio

Scott received his B.S. in Chemistry from the University of Sheffield in the summer of 2013. As part of his bachelor’s degree he worked for AstraZeneca from Sept 2011 – Aug 2012 as an organic synthetic chemist. In 2019 he earned his Ph.D. in Chemical Biology from Imperial College London where he worked with Prof. Edward Tate. His thesis focused on developing covalent inhibitors for KLK proteases to decipher their role in prostate cancer progression. Having joined the Bogyo lab in October 2019, Scott now works on developing selective inhibitors and substrates for serine hydrolases in cancer and pathogenic bacteria by using diverse chemical libraries and phage-display approaches.

Ryan Muir
Postdoctoral Fellow

Bio

Ryan received his B.S. in Biochemistry/Chemistry from the University of California San Diego in 2014. He then earned his Ph.D. in Chemistry and Chemical Biology from the University of California, San Francisco in 2019 where he worked in the lab of Dr. Adam Renslo. His thesis focused on the synthesis and biological evaluation of chemical probes to interrogate aberrant iron metabolism observed in cancer. This approach was used to develop several Fe(II)-activated prodrugs that showed a high selectivity in several KRAS-driven cancer models. Additionally, he developed an Fe(II)-sensing PET reporter that could detect spontaneous KRAS-driven tumors in several murine models. Ryan joined the Bogyo lab in Feb 2020. His current focus is on targeting proteases in P. falciparum parasites for new detection and treatment strategies.   

PhD Students

Laura Keller
Graduate Student, Chemical and Systems Biology

Bio

Laura graduated from Bowdoin College in 2015 with a Bachelor of Arts (magna cum laude) in Biochemistry and Neuroscience. Her undergraduate research with Dr. Patsy Dickinson focused on the permeability of connective tissue sheaths in the American lobster to endogenous hormone neuropeptides. After graduation, she worked for two years as a research technician in Dr. Oksana Berezovska's lab at the MassGeneral Institute for Neurodegenerative Disease, studying the interaction between Presenilin 1 and Synaptotagmin 1 in Alzheimer's disease. Before coming to Stanford, she was a ChEM-H summer intern at Novartis Institutes for Biomedical Research (NIBR) working in the Ophthalmology Department. In the Bogyo lab, Laura is interested in understanding the function of serine hydrolases in commensal microbiomes.

Franco Faucher
Ph.D. Student Department of Chemistry

Bio

Franco graduated from the University of California Berkeley with a B.S. in Chemistry and a minor in Biological Engineering in 2019. At Berkeley, he worked under the guidance of Dr. Gabor Somorjai working in the field of surface science while developing supported metal nanoparticle based heterogeneous catalysts. Franco also spent time researching in the Vision Science Program studying lipid circuits and immune response with Dr. Karsten Gronert. While at UC Berkeley, he completed a summer internship at Genentech synthesizing antibacterial small molecules and improving synthetic routes. In the Bogyo lab, Franco is interested in developing covalent cyclic peptide inhibitors for future use as therapeutics, imaging agents, and biological tools. Franco is a National Science Foundation Graduate Research Fellowship Program scholar and is also ChEM-H Chemical Biology Interface fellowship trainee.

John Bennett
PhD. Student Department of Chemistry

Bio

John graduated from Colgate University in 2019 with a Bachelors of Arts (Summa Cum Laude) in Biochemistry and Classical Studies. His undergraduate research with Dr. Ernie Nolen focused on the chemistry of oxazolidinones as intermediates in unnatural amino acid synthesis to develop C-linked peptidoglycans. During his time at Colgate, he also had the opportunity to work with Dr. Kenneth Jacobson at the NIDDK where he synthesized a library of antagonists for the P2Y14 receptor. In the Bogyo Lab, John is interested in using chemical probes to study how environmental factors alter serine hydrolase activity in pathogenic bacteria.

Undergraduates

Philip Ipock
Undergraduate Researcher

Our Team