Carol Conrad
Academic Appointments
- Associate Professor - Med Center Line, Pediatrics - Pulmonary Medicine
Contact Information
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Clinical Offices
Respiratory Specialties and ENT 730 Welch Rd 1st Floor Palo Alto, CA 94304 Tel Work (650) 497-8841 Fax (650) 497-8791Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 723-5191 Tel (650) 723-5223Not for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Pediatric Pulmonary
- Pulmonary Medicine/Cystic Fibrosis, Pediatric
- Lung Transplantation
- Heart-Lung Transplantation
- Lung Inflammation
Administrative Appointments
- Director, Pediatric Lung and Heart-Lung Transplant Program (2004 - present)
Professional Education
| Board Certification: | Pediatric Pulmonary, American Board of Pediatrics (1996) |
| Fellowship: | Johns Hopkins University, MD (1995) |
| Residency: | Children's Hospital of Los Angeles, CA (1992) |
| Internship: | Children's Hospital of Los Angeles, CA (1990) |
| Medical Education: | UCLA Medical Center, CA (1989) |
Graduate & Fellowship Program Affiliations
Community & International Work
Web Site Links
Scientific Focus
Current Research Interests
I have participated in multiple clinical studies and have contributed to the development of therapeutic interventions designed specifically for the treatment of lung disease in children and adults with CF. Initially, my research interests concentrated on gene therapy for CF. Over time, the emphasis of my research led to investigator-initiated clinical research studies which have produced the description of novel mechanisms that drive the inflammatory milieu of the CF airway. With support from the CF Research Center resources at Stanford University, the CF Foundation, and the Food and Drug Administration, I have successfully completed Phase I and Phase IIa clinical research studies to assess the efficacy of N-acetylcysteine (NAC) in a novel approach to reduce inflammation in the lungs of CF patients. Building upon the foundation of these initial trials, and with CFF support, I am continuing studies as the Principal Investigator for a 3-year, Phase IIb, multi-center trial for NAC in CF that began in November of 2008.
As the pulmonary division has grown over the years, my clinical and academic interests have broadened to include pediatric lung transplantation. In 2002, I subsumed the role of program director for the pediatric pulmonary lung and heart-lung transplant program at LPCH. As a result, we are the 5th largest pediatric lung and heart-lung transplant program in the United States (the 2nd largest pediatric heart-lung transplant program). At least 60 infants and children have been evaluated at the center for pediatric lung and heart-lung transplantation at LPCH and 19 children have received transplants in this period of time. My career plans are to foster further growth of the center with the goal to create a translational pediatric research center for lung and heart-lung transplantation at LPCH.
This nascent field of medicine is one in which little is known of the cellular and molecular mechanisms within transplantation dynamics and where the possibilities...
Clinical Trials
- NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients Recruiting
- #5902 Rare Genetic Disorders Study Recruiting
- Cystic Fibrosis Registry Recruiting
- GSK study #2110399 in 2010 (Study Drug: SB-656933) Recruiting
- Gilead FTI Study Recruiting
Publications
- Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Proc Natl Acad Sci U S A. 2008; (11): 4335-9
- Increased mortality after pulmonary fungal infection within the first year after pediatric lung transplantation. J Heart Lung Transplant. 2008; (6): 655-61
- Novel tobramycin inhalation powder in cystic fibrosis subjects: pharmacokinetics and safety. Pediatr Pulmonol. 2007; (4): 307-13
- American Society of Transplantation executive summary on pediatric lung transplantation. Am J Transplant. 2007; (2): 285-92
- Risk factors for small bowel bacterial overgrowth in cystic fibrosis. J Pediatr Gastroenterol Nutr. 2007; (2): 212-8
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