Small Animal Imaging Facility
Stanford Center for Innovation in In-Vivo Imaging (SCI3)
The mission of the Stanford Center for Innovation in In vivo Imaging (SCI3) is to provide access to state-of-the-art and first-of-its-kind preclinical imaging instruments to facilitate translation of research from in vitro tests to small animal investigations and clinical practice. This enables assessments of new technologies, novel drugs/tracers, variable phenotypes and novel biological concepts in living murine models. The SCI3 center offers access to imaging equipment at three different locations: The Clark Center houses the primary SCI3 facility, with additional imaging facilities located in the Lokey Stem Cell building, Comparative Medicine Pavilion, The Shriram Center for Bio-Engineering, and the Porter Drive facility off campus. SCI3 center personel offers consultation, dedicated training and supervision for researchers and students on basic concepts and personalized use of imaging modalities available.
The SCI3 facility provides access to the whole spectrum of preclinical imaging modalities, including instruments routinely found in hospitals, but optimized for small animal work (such as ultrasound, MRI, MicroCT, PET and SPECT), instruments developed specifically for small animal work (such as optical imaging systems capable of bioluminescent and fluorescent imaging), as well as new equipment which has just been developed and is being tested (such as photoacoustic imaging and magnetic particle imaging). The facility offers both instruments that are easy to operate for the non-radiologist user as well as the latest imaging technologies and multi-modality imaging combinations for experts in radiology, physics and engineering. All instruments are designed to image living subjects, so repeated studies can be performed, which provide longitudinal data in the same subject and reduce the number of animals required for such studies. The flexibility and rapid analyses of such animal models greatly accelerate the development of molecular imaging strategies, as well as new therapeutic strategies for a variety of diseases. A broad range of imaging and contrasting reagents are available for monitoring disease phenotypes in mouse models, evaluation of novel therapeutic interventions, image data post-processing and quantification, co-clinical trials and clinical drug development, among many others.
The Small Animal Imaging Facility is a Stanford School of Medicine service center, and is supported by the Stanford Cancer Institute, as well as user fees levied on each instrument. It is operated by the Departments of Pediatrics and Radiology. For more information, contact Tim Doyle (Director at the Clark Center Facility), Laura Pisani (Director of Small Animal MRI) and Frezgi Habte (Director of the Porter Drive Facility).
Dr. Daldrup-Link is a Professor of Radiology, and, by courtesy, of Pediatrics (Hematology & Oncology), and is the director of the SCI3.
Dr. Gambhir is the Virginia & D.K. Ludwig Professor of Cancer Research Professor, Chair of the Department of Radiology, Professor by courtesy of Bioengineering and and Material Science Engineering, and co-directs the SCI3.
Dr. Levin is a Professor of Radiology, and, by courtesy, of Physics, of Electrical Engineering and of Bioengineering, and co-directs the SCI3.
Dr. Moseley is a Professor of Radiology and is the Director of Experimental MRI and MRS at the Lucas MR Center. He directs the MR imaging and spectroscopy aspects of the SCI3.
Dr. Doyle is Scientific Director of the Small Animal Imaging Facility, and oversees its day-to-day running, providing training and assistance with the instruments.
SCI3 Research Staff
Director at the Clark Center Facility
Dr. Doyle provides training on the IVIS Imaging Systems (both bioluminescence and fluorescence imaging), MicroCT scanners, MicroSPECT scanners, and the Vevo Ultrasound, and provides regular training sessions on these systems. He can also show users how to use the Leica (Mauna Kea) Cellvizio microscope, cryomicrotome and cryomacrotome systems.
Director of Pre-clinical MRI
Dr Pisani manages the 7T MRI system, providing training and assistance for all users on this system - please coordinate directly with her to arrange for this. She also provides training on the use of radionuclides in the imaging facility, as well as training on the MicroPET systems. Finally, Dr Pisani provides training on the CRI Maestro fluorescence imaging systems.
Director of the Porter Drive Facility
Dr Habte provides image quantification assistance to all users of the imaging facility. He runs regular software training classes focusing on different software applications used within the facility, as well as providing assistance with specific problems as required.