ME/CFS in the Department of Medicine
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Stanford Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Initiative

An initiative dedicated to studying infection-associated chronic diseases

Mission Statement

To become a center of excellence that improves the health of patients with chronic diseases in which infection or its immune response plays a major etiologic role.

To provide leadership, facilitate multidisciplinary collaboration, make new discoveries, and educate in the field of infection-associated chronic diseases.

Aim

Our primary aim is to study the roles that infection and the immune response play in the symptoms of patients suffering from chronic, unexplained diseases.

Recent News

On February 23rd 2015, Dr. Montoya presented on the Stanford ME/CFS Initiative: Collaboration, Innovation and Discovery, during the CDC Chronic Fatigue Syndrome (CFS) Patient-Centered Outreach and Communication Activity (PCOCA) Conference Call. Click Here to view the agenda.

Dear Stanford ME/CFS Patients,
Recently, the Institute of Medicine (IOM) was charged with the important task to review over 65 years of clinical and research literature on ME/CFS, 9,112 articles in total. Their final recommendations propose new diagnostic criteria (see below), a new name, Systemic Exertion Intolerance Disease (SEID), and an increase in research funding. In our opinion, these provide the ME/CFS community with a step forward into changing the narrative of the disease and significant progress in ensuring that patients will be properly recognized and supported by their health care providers. We at the Stanford ME/CFS Initiative, echo the message IOM has put forth: this is a complex, multisystemic and crippling illness in much need of multidisciplinary research approach that must always take heed of patients' concerns in order to improve diagnosis and treatment once and for all.
Sincerely,
Jose G. Montoya

Proposed Diagnostic Criteria for ME/CFS
Diagnosis requires that the patient have the following three symptoms:
1) A substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities, that persists for more than 6 months and is accompanied by fatigue, which is often profound, is of new or definite onset (not lifelong), is not the result of ongoing excessive exertion, and is not substantially alleviated by rest, and
2) Post-exertional malaise,* and
3) Unrefreshing sleep*
At least one of the two following manifestations is also required:
1) Cognitive impairment* or
2) Orthostatic intolerance
*Frequency and severity of symptoms should be assessed. The diagnosis of ME/CFS should be questioned if patients do not have these symptoms at least half of the time with moderate, substantial, or severe intensity.
Excerpt from the IOM Report "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" 2015.

On February 10th, 2015, the Institute of Medicine released a new report on ME/CFS. For full access to the report, visit http://www.iom.edu/Reports/2015/ME-CFS.aspx

A Stanford Medicine video of Dr. Montoya featured this week in the Washington Post's article on the IOM Report. Watch the video at http://www.washingtonpost.com/news/to-your-health/wp/2015/02/10/chronic-fatigue-syndrome-is-a-real-condition-not-a-psychological-illness-expert-panel-says/

Dr. Montoya comments on the IOM ME/CFS report in this article

On February 10th, 2015, the Institute of Medicine released a new report on ME/CFS.  For full access to the report, visit http://www.iom.edu/Reports/2015/ME-CFS.aspx

Dr. Montoya and his research was recently featured in an ABC7 News feature about ME/CFS. Check out the video on the ABC7 website.

"An imaging study by Stanford University School of Medicine investigators has found distinct differences between the brains of patients with chronic fatigue syndrome and those of healthy people."

Immune System Disruption: The search for answers

Dear Patients, Researchers and Supporters of the ME/CFS Stanford Research, 

The video capture from the 2014 Stanford Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symposium hosted on March 19, 2014 is now available to the public. Please follow this link to access the video from this event. If you find these materials helpful and would like to make a contribution to our research, please click on the link below.    

Make a Gift

Your donation will help us continue unraveling the mystery of this debilitating illness.

Kindest regards,

The Stanford ME/CFS Initiative

Dear Stanford ME/CFS Clinic patients,

Dr. Montoya's Stanford University ME/CFS Initiative is helping to support  the International Association for Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (IACFS/ME) 11th Biennial Conference this year. The meeting will take place March 20-23, 2014 at the Parc 55 Hotel in San Francisco and will feature physicians and researchers from around the US and the world.  Dr. Montoya will be welcoming patient attendees as well as speaking on antivirals during part of the conference. If you would like to attend, please visit www.iacfsme.org for more details and/or see the attached announcement. If you have any questions, please e-mail Admin@iacfsme.org.  You can register up to and even on the first day of the Conference but register before January 31 for the lowest fee. I hope to see you there!
Sincerely,

Lily Chu, MD, MS
Board member, IACFS/ME
Advisory board member, Stanford ME/CFS Initiative

The Stanford ME/CFS Initiative is pleased to host the 2014 Stanford Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome Symposium: Advances in Clinical Care and Translational Research for health care providers. We invite all interested health care providers and allied health to attend. This CME eligible conference will take place on March 19, 2014 at the Li Ka Shing Center for Learning and Knowledge, Stanford, California. The goal is to bring awareness about ME/CFS to the Medical Community. For questions on the event, please contact Yolanda Cervantes.

ENROLLMENT COMPLETED for Synergy Trial. Thank you very much for your interest and/or participation. The Synergy Trial: A Clinical Trial investigating a Combination of a CFS Nutrient Formula plus a Currently Available Medication to treat Chronic Fatigue Syndrome

Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome. (please note this link will direct you to a webpage unaffiliated with Stanford University)

Persistent human herpesvirus-6 infection in patients with an inherited form of the virus. (please note this link will direct you to a webpage unaffiliated with Stanford University)

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology.(please note this link will direct you to a webpage unaffiliated with Stanford University)

Please see our 2013 Newsletter of all the progress from our ME/CFS research team!

We would like to introduce two new physician assistants, Jane Norris and Aimee Jadav, respectively, to our clincal care team. Please learn more about Jane and Aimee here!

Stanford has a ME/CFS Biobank of stored research samples

Response to valganciclovir in Chronic Fatigue Syndrome patients with human herpesvirus 6 and Epstein-Barr viru IgG antibdy titers. (please note this link will direct you to a webpage unaffiliated with Stanford University)

We have recently added a new physician assistant, Amity Hall, to our ME/CFS clinical care team. Please learn more about Amity Hall here!

A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus of polytropic murine leukemia virus. (please note this link will direct you to a webpage unaffiliated with Stanford University)

We have recently launched a new web page specifically designed for ME/CFS patients. On this page you will find information on how to navigate our website, tips on managing your health, and clinical updates.

Dr. A. Martin Lerner has released a diagnostic and treatment resource guide for ME/CFS. In addition to this resource guide, Dr. Lerner has a video presentation available online which details his diagnostic and treatment protocol. (Please see August 20, 2011, Part 1 and Part 2 for this information)

Benefit from B-Lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study. (please note this link will direct you to a webpage unaffiliated with Stanford University)

The Stanford ME/CFS Team
  • Jose G. Montoya, MD
    Professor of Medicine in the Division of Infectious Diseases
  • Tyson H. Holmes, PhD
    Sr Research Engineer, Sleep Sciences and Medicine, Biostatistician
  • Jane Norris, PA-C
    Study Coordinator
  • Amity Hall, PA-C
    Physician Assistant
  • Aimee Jadav, PA-C
    Physician Assistant
  • Luciana Mendiola, MA
    Research and Grant Writing Assistant
Make A Gift
If you would like to make a contribution to our research, please click on the link below.
Make a Gift
Your donation will help us continue unraveling the mystery of this debilitating illness.
Current Areas of Study
Infection-associated chronic diseases that our group studies include Myalgic Encephalomyelitis/Chronic Fatigue Syndrome/ Systemic Exertion Intolerance Disease, Epilepsy, Multiple Sclerosis, and other unexplained chronic illnesses. In addition, infectious agents such as human herpesvirus-6 (HHV-6), parasites such as Toxoplasma gondii, and fungi such as Coccidiodes immitis, may play an etiologic role in these diseases. We are also interested in unveiling the pathogenesis of Chronic Lyme Disease, keeping an open mind to possible etiologies, including the bacteria Borrelia burgdorferi.
 

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