Our Initiative
Our primary aim is to study the roles that infection and the immune response play in the symptoms of patients suffering from chronic, unexplained diseases.
Why we believe our initiative is important:
The study of infection-associated chronic diseases is a relatively new field, and more research is needed. Examples of infection-associated chronic diseases include Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). ME/CFS is a multi-system and complex diseases with potentially devastating physical and cognitive symptoms. This disease can significantly impair the lives of patients and result in substantial reductions in previous levels of occupational, educational, social, or personal activities. A broad spectrum, innovative approach to discovery surrounding these debilitating diseases is paramount and a priority at Stanford.
It is common for physicians in the United States to take a skeptical position towards these patients’ symptoms, and this skepticism is unfortunately enhanced because most (if not all) results of conventional laboratory and radiological tests are normal.
The ME/CFS Initiative has taken the approach of exploring whether infection can be a trigger for these patients’ ailments. We postulated that infection, or the body’s immune response to it, can play an etiologic role in ME/CFS and other chronic illnesses. It is important to emphasize, however, that our approach does not work in all patients.
Our Long-term Goal
Patient Care
- Stanford Health Care is devoted to providing the highest quality care to our ME/CFS patients and their families. Our highly experienced, ME/CFS-specialized team includes assistants one physician and 3 advanced practice providers who are dedicated to our ME/CFS patients full-time
- Working in close partnership with our clinicians, researchers at the Stanford University School of Medicine pursue a full range of research efforts in ME/CFS
- For more information, visit Stanford Health Care’s Infectious Disease Clinic page.
Research
& Discovery
- Determine the etiologic role of specific infectious agents in the illness of patients with chronic diseases.
- Discover, define, and establish objective parameters that quantify the degree of physical, cognitive and immunological dysfunction observed in patients with chronic diseases.
- Collaborate with the Stanford Human Immune Monitoring Center (HIMC) and other groups to explore the dynamics of the immune system and gene expression in patients with chronic diseases that may unveil the etiology and pathogenesis of these diseases.
- Determine the role of genetics in predisposing patients to developing chronic diseases.
- Collaborate with the Stanford Blood Center Human Leukocyte Antigen (HLA) laboratory and the HIMC to determine whether patients with specific HLA groups are predisposed to chronic illnesses.
- Collaborate with the Stanford Institute for Immunity Transplantation and Infection (ITI) bioinformatics team and other bioinformatics teams at Stanford to synthesize and analyze patient and research data.
- Engage basic scientists and clinicians in the center’s work by distributing seed grants that can evolve into projects funded by the National Institutes of Health (NIH).
Education
- Create a Stanford-based web site for the “Stanford Initiative for the Study of Infection-Associated Chronic Diseases.”
- Establish a one-day biennial international symposium at Stanford covering the newest discoveries in infection-associated chronic and inflammatory diseases. Our goal is to host the first symposium within the next three years.
- Establish a biennial conference to educate practicing physicians, fellows, residents, and medical students on the clinical care of these patients.
Our Mission
Our mission is to become a center of excellence that improves the health of patients with chronic diseases in which infection or its immune response plays a major etiologic role.
Additonally, our mission is to provide leadership, facilitate multidisciplinary collaboration, make new discoveries, and educate in the field of infection-associated chronic diseases.
Our Long-Term Goal
- Establish and support a clinic that evaluates patients with chronic diseases in which infection or its immune response may play an etiologic role.
- Initiate clinical trials that assess the role of specific antimicrobial interventions off-label anti-inflammatory medications in patients with chronic diseases that are likely to have an infectious etiology.
- Collaborate with faculty from departments that will contribute to designing and implementing these studies.
- Discover, define, and establish objective parameters that quantify the degree of physical, cognitive and immunological dysfunction observed in patients with chronic diseases.
