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Taia Wang, MD, PhD is an Assistant Professor of Medicine and of Microbiology and Immunology with research aimed at defining mechanisms in human immunity and disease. The Wang laboratory uses in vivo and in vitro systems to study how antibodies can modulate viral infections or anti-viral vaccine responses through signaling interactions with Fc gamma receptors (FcγRs). The overarching goal of projects in the Wang lab is to elucidate FcγR pathways that can be harnessed towards the development of enhanced vaccines and therapeutics. Dr. Wang obtained M.D. and Ph.D. training at Mount Sinai School of Medicine. Her Ph.D. training focused on mechanisms in immunity against influenza viruses (P. Palese). Following this training, she completed postdoctoral research at the Rockefeller University where she studied human IgG and FcγR biology in the Laboratory of Molecular Genetics and Immunology (J. Ravetch). Most recently, Dr. Wang received the Searle Scholar’s Award and was selected to be a Chan Zuckerberg Investigator for her work in the pathogenesis of infectious diseases.SARS-CoV-2, dengue viruses, influenza viruses, disease pathogenesis, influenza virus vaccines
Major goal: To define how IgG Fc glycoforms are regulated in vivo.
Major goal: To define the role of FcγRIIIa in antibody-dependent enhancement of dengue infections.
Major goal: To define Fc-Fc receptor interactions that are essential for immunity against influenza and dengue viruses.
Major goal: This work will define mechanisms for enhancing the durability of passive immunization of neonates
Impact of Initial Influenza Exposure on Immunity in Infants
Major Goals: To define the role of antibodies in broad protection against influenza viruses
Major Goals: PROJECT 3: To determine whether specific forms of IgG antibodies predispose to severe dengue disease during infection.
Major Goals: Defining adaptive and innate immunity, memory and repertoire in vaccination and infection
Laboratory of Mechanisms in Human Immunity and Disease Pathogenesis<br/><br/>Studies in our lab are aimed at defining mechanisms in human immunity and disease. We are particularly interested the hypothesis that diversity in antibody-based signaling that arises from diversity in IgG antibodies and their receptors, is a central driver of heterogeneity in human immune functioning and susceptibility to infectious diseases. We are studying how the Fc domain repertoire of an individual impacts the quality of effector cell responses that can be recruited during immune activation and how selectivity of effector responses contributes to immunity and disease. <br/><br/>SARS-CoV-2, dengue viruses, influenza viruses, disease pathogenesis, influenza vaccines<br/><br/>Current clinical studies:<br/>Recruiting:<br/><br/>An Open Label Study of IgG Fc Glycan Composition in Human Immunity<br/>Principal Investigator: Taia T. Wang, MD, PhD<br/>ClinicalTrials.gov Identifier:<br/>NCT01967238