Current Research and Scholarly Interests
Our lab studies human immunity and susceptibility to viral pathogens. Studies are driven by the observation that humans generate unique IgG Fc domain repertoires, or “fingerprints”, defined by serum IgG subclass and Fc glycoform distributions. We have discovered that the Fc domain fingerprint of an individual determines key immune processes such as vaccine responses and susceptibility to infectious diseases (Cell. 2015 Jul 2;162, Science. 2017 Jan 27;355). This is because the repertoire of serum IgG subclass and Fc glycofoms dictates the affinity of immune complexes for various Fc receptors on effector cells. Ultimately, the Fc domain fingerprint of an individual determines the quality of effector cell responses that can be recruited during immune activation. Ongoing projects in the lab are defining the role of the Fc fingerprint in susceptibility to viral diseases (influenza, dengue and Zika) and in the maturation of protective antibody responses. Much of our research revolves around clinical studies that are designed to clarify how the Fc domain fingerprint impacts specific immune functions.
Current clinical studies:
An Open Label Study of IgG Fc Glycan Composition in Human Immunity
Principal Investigator: Taia T. Wang, MD, PhD