Bio

Clinical Focus


  • Peripheral Nerve
  • Neurosurgery
  • Traumatic Brain Injury

Academic Appointments


Administrative Appointments


  • Director, Brain Injury, Department of Neurosurgery (2009 - Present)
  • Associate Chief of Staff, Polytrauma, PAVAHCS (2009 - Present)
  • Director, Defense Veterans Brain Injury Center (2009 - Present)

Professional Education


  • Residency:Stanford Hospital and Clinics-Room HC 435 (2003) CA
  • Medical Education:Stanford University School of Medicine - Stem Cell Institute Dr Weissman's Laboratory (1996) CA
  • Fellowship:Louisiana State University - New Orleans (06/2007) LA
  • MPH, UC Berkeley, Public Health, Epidemiology (2001)
  • Board Certification: Neurosurgery, American Board of Neurological Surgery (2008)
  • Fellowship:Van Wagenen Fellowship / University Hospital of the West Indies (2004) West Indies
  • Fellowship, LSU, Peripheral Nerve (2007)

Community and International Work


  • Neurosurgery Training and Education, Kingston, Jamaica

    Topic

    Neurosurgery

    Partnering Organization(s)

    University Hospital of the West Indies

    Location

    International

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    No

Research & Scholarship

Current Research and Scholarly Interests


Traumatic brain injury with a focus on epidemiology and outcomes.

Teaching

2013-14 Courses


Publications

Journal Articles


  • A Systematic Review of an Emerging Consciousness Population: Focus on Program Evolution JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE Gray, M., Lai, S., Wells, R., Chung, J., Teraoka, J., Howe, L., Harris, O. A. 2011; 71 (5): 1465-1474

    View details for DOI 10.1097/TA.0b013e31821f82f5

    View details for Web of Science ID 000297118600072

    View details for PubMedID 22071939

  • Hospital costs, incidence, and inhospital mortality rates of traumatic subdural hematoma in the United States Clinical article JOURNAL OF NEUROSURGERY Kalanithi, P., Schubert, R. D., Lad, S. P., Harris, O. A., Boakye, M. 2011; 115 (5): 1013-1018

    Abstract

    This study provides the first US national data regarding frequency, cost, and mortality rate of traumatic subdural hematoma (SDH), and identifies demographic factors affecting morbidity and death in patients with traumatic SDH undergoing surgical drainage.A retrospective analysis was conducted by querying the Nationwide Inpatient Sample, the largest all-payer database of nonfederal community hospitals. All cases of traumatic SDH were identified using ICD-9 codes. The study consisted of 2 parts: 1) trends data, which were abstracted from the years 1993-2006, and 2) univariate analysis and multivariate logistic regression of demographic variables on inhospital complications and deaths for the years 1993-2002.Admissions for traumatic SDH increased 154% from 17,328 in 1993 to 43,996 in 2006. Inhospital deaths decreased from 16.4% to 11.6% for traumatic SDH. Average costs increased 67% to $47,315 per admission. For the multivariate regression analysis, between 1993 and 2002, 67,864 patients with traumatic SDH underwent operative treatment. The inhospital mortality rate was 14.9% for traumatic SDH drainage, with an 18% inhospital complication rate. Factors affecting inhospital deaths included presence of coma (OR = 2.45) and more than 2 comorbidities (OR = 1.60). Increased age did not worsen the inhospital mortality rate.Nationally, frequency and cost of traumatic SDH cases are increasing rapidly.

    View details for DOI 10.3171/2011.6.JNS101989

    View details for Web of Science ID 000296377800026

    View details for PubMedID 21819196

  • The role of hypothermia in the management of severe brain injury. A meta-analysis ARCHIVES OF NEUROLOGY Harris, O. A., Colford, J. M., Good, M. C., Matz, P. G. 2002; 59 (7): 1077-1083

    Abstract

    Hypothermia is utilized in the management of severe traumatic brain injury despite the lack of unequivocal evidence supporting its use. Because of its widespread use, the effects of hypothermia are a concern.To determine the effectiveness of hypothermia in the management of severe brain injury.Two investigators working independently abstracted data in a blinded fashion from studies identified using multiple literature databases, including MEDLINE, Ovid, PubMed, the Cochrane Database of Systematic Reviews, EMBASE, and the abstract center for the American Association of Neurological Surgery and the Congress of Neurological Surgery, as well as the bibliographies of these articles. Additionally, experts in the field of hypothermia and neurotrauma provided additional references.Seven studies met predetermined inclusion criteria: (1) the study was a randomized clinical trial comparing the efficacy of hypothermia vs normothermia in patients with posttraumatic head injury, (2) only subjects aged 10 years or older were included in the study, and (3) relative risks (odds ratios [ORs], cumulative incidence, or incidence density measures) and 95% confidence intervals (CIs) or weighted mean differences and 95% CIs could be calculated from the data presented in the article. These criteria were applied in a blinded fashion by 2 independent investigators.No single outcome variable was evaluated in all studies. The following outcome variables were assessed: intracranial pressure, Glasgow Outcome Scale score, pneumonia, cardiac arrhythmia, prothrombin time, and partial thromboplastin time. Either ORs or weighted mean differences (when the data provided did not permit calculation of an OR) comparing the effects of hypothermia vs normothermia were calculated from the data provided.The weighted mean difference (hypothermia - normothermia) for intracranial pressure was -2.98 mm Hg (95% CI, -7.58 to 1.61; P =.2). The OR (hypothermia vs normothermia) for Glasgow Outcome Scale score was 0.61 (95% CI, 0.26-1.46; P =.3). The OR for pneumonia was 2.05 (95% CI, 0.79-5.32; P =.14). The OR for cardiac arrhythmia was 1.27 (95% CI, 0.38-4.25; P =.7). The weighted mean difference for prothrombin time was 0.02 seconds (95% CI, -0.07 to 0.10; P =.7). The weighted mean difference for partial thromboplastin time was 2.22 seconds (95% CI, 1.73-2.71; P<.001).This meta-analysis of randomized controlled trials suggests that hypothermia is not beneficial in the management of severe head injury. However, because hypothermia continues to be used to treat these injuries, additional studies are justified and urgently needed.

    View details for Web of Science ID 000176714500002

    View details for PubMedID 12117354

  • Acquired cerebral arteriovenous malformation induced by an anaplastic astrocytoma: An interesting case NEUROLOGICAL RESEARCH Harris, O. A., Chang, S. D., Harris, B. T., Adler, J. R. 2000; 22 (5): 473-477

    Abstract

    High grade gliomas foster an environment rich in angiogenic factors that promote neovascularity. We report a case of a cerebral arteriovenous malformation, which developed in the setting of a high grade astrocytoma. The patient presented with complaints of confusion and left hemiparesis. An initial cerebral angiogram was normal. Repeat angiography six weeks later demonstrated an extremely vascular lesion with arteriovenous shunting involving the right thalamus and occipital lobe. Histopathologic evaluation of open biopsy and autopsy specimens demonstrated a high grade astrocytoma in association with an arteriovenous malformation. Immunohistochemical staining with VEGF was diffusely positive. A possible role for the hyperangiogenic environment of a high grade astrocytoma resulting in the development of an arteriovenous malformation is discussed.

    View details for Web of Science ID 000088406000007

    View details for PubMedID 10935219

  • Analysis of the proliferative potential of residual tumor after radiosurgery for intraparenchymal brain metastases JOURNAL OF NEUROSURGERY Harris, O. A., Adler, J. R. 1996; 85 (4): 667-671

    Abstract

    A retrospective immunohistochemical study of radiosurgically treated brain metastases was performed to determine whether residual tumor has reduced proliferative potential. The monoclonal antibodies MIB-10 and PC-10 were used as markers for proliferation. The experimental group consisted of pathological specimens obtained from five patients in whom brain metastasis previously had been treated with radiosurgery. Pathological specimens obtained from 10 patients with brain metastases, matched in histology to diseases in the experimental group but untreated by radiosurgery, served as controls. A significant decrease in proliferative indices was observed in metastatic brain cancers after radiosurgery (p < 0.001). These results indicate that the persistent tumor that is present at the site of a metastasis previously treated with radiosurgery is less viable and may not in itself be a significant finding.

    View details for Web of Science ID A1996VJ24700021

    View details for PubMedID 8814172

Conference Proceedings


  • Infratentorial traumatic brain hemorrhage: May outcome be predicted by initial GCS? Harris, O. A., Lane, B., Lewen, A., Matz, P. G. LIPPINCOTT WILLIAMS & WILKINS. 2000: 1076-1082

    Abstract

    Overall prognosis of nonpenetrating traumatic brain hemorrhage may be predicted by neurologic function days after insult. The relationship between immediate function and outcome has not been examined for infratentorial traumatic brain hemmorhage (iTBH) identified on computed tomographic (CT) scan. Given the severity of brain stem injury, it is conceivable that immediate function may be predictive.A retrospective review of 1,500 brain injuries occurring at our institution identified 18 patients (1.2%) with iTBH on CT scan (eight brain stem, five cerebellum, five both). Demographics, supratentorial injuries, and outcome at 6 months (Glasgow Outcome Scale) were recorded.Initial Glasgow Coma Scale (GCS) in 11 patients was less than 5 (group I). Seven patients had GCS scores greater than or equal to 6 (group II). Nine patients in group I either died or were vegetative. In group II, one died; none were vegetative (p < 0.02). Regression analysis demonstrated a strong correlation between initial GCS and Glasgow Outcome Scale scores at 6 months for all patients (p < 0.001).We conclude that initial GCS score may be predictive of long-term outcome in patients with CT scan evidence of iTBH-a relationship to be explored further for prognostic information.

    View details for Web of Science ID 000165909500018

    View details for PubMedID 11130492

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