School of Medicine
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The Ernest and Amelia Gallo Professor in the School of Medicine, Professor of Developmental Biology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
Assistant Professor of Biochemistry
Current Research and Scholarly Interests The Brandman Lab studies how cells ensure protein quality and how they signal stress. To achieve this, we employ an integrated set of techniques including single cell anaysis of stress pathways, structural studies, in vitro translation, and full genome screens in yeast and mammalian cells.
Patrick O. Brown
Professor of Biochemistry, Emeritus
Current Research and Scholarly Interests Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program. The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.
Douglas L. Brutlag
Professor of Biochemistry, Emeritus
Current Research and Scholarly Interests My primary interest is to understand the flow of information from the genome to the phenotype of an organism. This interest includes predicting the structure and function of genes and proteins from their primary sequence, predicting function from structure simulating protein folding and ligand docking, and predicitng disease from genome variations. These goals are the same as the goals of molecular biology, however, we use primarily computational approaches.
Professor of Medicine (Oncology) and of Biochemistry
Current Research and Scholarly Interests Our laboratory seeks to understand how cells repair DNA damage. We currently focus on how non-homologous end joining proteins assemble on DNA ends to juxtapose them for repair of DNA double-strand breaks.
We are collaborating in the development of a point-of-care device to measure ammonia from a drop of blood. The device will facilitate diagnosis and management of urea cycle defects, liver disease, and chemobrain due to elevated ammonia.
Associate Professor of Biochemistry
Current Research and Scholarly Interests Our lab seeks an agile and predictive understanding of how nucleic acids and proteins code for information processing in living systems. We develop new computational & chemical tools to enable the precise modeling, regulation, and design of RNA and RNA/protein machines.
Ronald W. Davis
Professor of Biochemistry and of Genetics
Current Research and Scholarly Interests We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.