Publications

Stefan Heller, PhD

Edward C. and Amy H. Sewall Professor of Otolaryngology — Head & Neck Surgery in the School of Medicine and, by courtesy, Molecular and Cellular Physiology

Hair Cell Degeneration & Regeneration

McGovern MM, Hartman B, Thawani A, Maunsell H, Zhang H, Yousaf R, Heller S, Stone J, Groves AK. “Fbxo2CreERT2:A new model for targeting cells in the neonatal and mature inner ear.” Hearing Research 428, (February 2023): 108686. https://doi.org/10.1016/j.heares.2022.108686.

Alsina B, Heller S, Varela-Nieto I. “Editorial: Inner ear biology: Development, physiopathology, repair and recovery.” Frontiers in Cell and Developmental Biology 10, (October 13, 2022):1049463. https://doi.org/10.3389/fcell.2022.1049463.

Scheibinger M, Janesick A, Benkafadar N, Ellwanger DC, Jan TA, Heller S. “Cell-type identity of the avian utricle.” Cell Reports 40, no. 13 (September 27, 2022):111432. https://doi.org/10.1016/j.celrep.2022.111432.

Janesick AS, Scheibinger M, Benkafadar N, Kirti S, Heller S. “Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells.” Development 149, no. 8 (April 15, 2022):dev200113. https://doi.org/10.1242/dev.200113.

Vaisbuch Y, Hosseini DK, Wagner A, Hirt B, Mueller M, Ponnusamy R, Heller S, Cheng AG, Löwenheim H, Aaron KA. “Surgical Approach for Rapid and Minimally Traumatic Recovery of Human Inner Ear Tissues From Deceased Organ Donors”. Otology & Neurotology 43, no. 4 (April 1, 2022): e519-e525. doi: 10.1097/MAO.0000000000003500.

Benkafadar, Nesrine, Amanda Janesick, Mirko Scheibinger, Angela H. Ling, Taha A. Jan, and Stefan Heller. “Transcriptomic Characterization of Dying Hair Cells in the Avian Cochlea.” Cell Reports 34, no. 12 (March 23, 2021): 108902. https://doi.org/10.1016/j.celrep.2021.108902.

Janesick, Amanda S., and Stefan Heller. “Stem Cells and the Bird Cochlea-Where Is Everybody?” Cold Spring Harbor Perspectives in Medicine 9, no. 4 (April 1, 2019): a033183. https://doi.org/10.1101/cshperspect.a033183.

Roccio, Marta, Pascal Senn, and Stefan Heller. “Novel Insights into Inner Ear Development and Regeneration for Targeted Hearing Loss Therapies.” Hearing Research 397 (November 2020): 107859. https://doi.org/10.1016/j.heares.2019.107859.

Senn, Pascal, Amir Mina, Stefan Volkenstein, Veronika Kranebitter, Kazuo Oshima, and Stefan Heller. “Progenitor Cells from the Adult Human Inner Ear.” Anatomical Record (Hoboken, N.J.: 2007) 303, no. 3 (March 2020): 461–70. https://doi.org/10.1002/ar.24228.

Hair Cell Development

Matern MS, Durruthy-Durruthy R, Birol O, Darmanis S, Scheibinger M, Groves AK, Heller S. "Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle." Cell Reports 42, no. 6 (May 23, 2023):112545.  https://doi.org/10.1016/j.celrep.2023.112545.

Ellwanger, Daniel C., Mirko Scheibinger, Rachel A. Dumont, Peter G. Barr-Gillespie, and Stefan Heller. “Transcriptional Dynamics of Hair-Bundle Morphogenesis Revealed with CellTrails.” Cell Reports 23, no. 10 (June 5, 2018): 2901-2914.e13. https://doi.org/10.1016/j.celrep.2018.05.002.

Janesick, Amanda, Mirko Scheibinger, Nesrine Benkafadar, Sakin Kirti, Daniel C. Ellwanger, and Stefan Heller. “Cell-Type Identity of the Avian Cochlea.” Cell Reports 34, no. 12 (March 23, 2021): 108900. https://doi.org/10.1016/j.celrep.2021.108900.

Kubota, Marie, Mirko Scheibinger, Taha A. Jan, and Stefan Heller. “Greater Epithelial Ridge Cells Are the Principal Organoid-Forming Progenitors of the Mouse Cochlea.” Cell Reports 34, no. 3 (January 19, 2021): 108646. https://doi.org/10.1016/j.celrep.2020.108646.

Human Hair Cell Biology

Vaisbuch Y, Hosseini DK, Wagner A, Hirt B, Mueller M, Ponnusamy R, Heller S, Cheng AG, Löwenheim H, Aaron KA. “Surgical Approach for Rapid and Minimally Traumatic Recovery of Human Inner Ear Tissues From Deceased Organ Donors”. Otology & Neurotology 43, no. 4 (April 1, 2022): e519-e525. https://doi.org/10.1097/MAO.0000000000003500.

Aaron KA, Hosseini DK, Vaisbuch Y, Scheibinger M, Grillet N, Heller S, Wang T, Cheng AG. “Selection Criteria Optimal for Recovery of Inner Ear Tissues From Deceased Organ Donors.” Otology & Neurotology 43, no. 4 (April 1, 2022):e507-e514. https://doi.org/10.1097/MAO.0000000000003496.