Clinical Trials Directory

Weight Loss Diet Study: Low Carbohydrate vs. Low Fat and Genotype Predisposition

The traditional weight loss diet recommended by health professionals has been a low-fat, high-carbohydrate, calorie restricted diet. This recommendation has been challenged by a number of alternative dietary strategies, particularly low-carbohydrate diets. In several recent weight loss studies insulin resistant adults had more success with low- vs. high-carbohydrate diets, in contrast to insulin sensitive adults who had either more success or comparable success with the low-fat diets. The investigators plan to enroll 80 people with a wide range of insulin sensitivity/resistance. After determining their insulin resistance status, the investigators will split them in the middle and randomly assign them to one of four groups: (1) Low-Carbohydrate/Insulin Resistant (LC/IR); (2) Low-Carbohydrate/Insulin Sensitive (LC/IS); (3) Low-Fat/Insulin Resistant (LF/IR); and (4) Low-Fat/Insulin Sensitive (LF/IS) (20 people/group). The purpose of this study is to determine whether weight loss success can be increased if one follows the dietary approach appropriately matched to their insulin resistance status.

Stanford is not currently accepting new patients for this trial. You may want to check clinicaltrials.gov to see if other locations are recruiting.

Investigator(s):

Intervention(s):

  • behavioral : Low-Carbohydrate or Low-Fat Diet

Phase: N/A

Eligibility

Ages Eligible For Study:

18 Years - 50 Years

Inclusion Criteria

- Age: > or = 18 years of age - Women: Pre-menopausal (self-report) and <50 years of age - Men: <50 years of age - Race/Ethnicity: All - BMI (body mass index): 27-40 kg/m2 (need to lose >10% body weight to achieve healthy BMI) - Body weight stable for the last two months, and not actively on a weight loss plan - No plans to move from the area over the next 14 months - Available and able to participate in the evaluations and intervention for the study period - Willing to accept random assignment - To enhance study generalizability, people on medications not noted below as specific exclusions can participate if they have been stable on such medications for at least three months - Ability and willingness to give written informed consent - No known active psychiatric illness

External Links

Contact information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Antonella Dewell
6507368577
Not Recruiting

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