An Open-Label, Dose Escalation, Phase 1 Study of MLN4924, a Novel Inhibitor of Nedd8-Activating Enzyme, in Adult Patients With Acute Myelogenous Leukemia,Myelodysplastic Syndrome, and Acute Lymphoblastic Leukemia
An open-label, multicenter, phase 1, dose escalation study of MLN4924 in adult patients with acute myelogenous leukemia (AML), high-grade myelodysplastic syndrome (MDS). The patient population will consist of adults previously diagnosed with AML including high-grade MDS for which standard curative, life-prolonging treatment does not exist or is no longer effective.
Stanford is not currently accepting new patients for this trial. You may want to check clinicaltrials.gov to see if other locations are recruiting.
- drug : Azacitidine
- drug : MLN4924
Phase: Phase 1
Ages Eligible For Study:
- Age greater than or equal to 18 years - Have the following diagnosis: - AML or ALL (for the dose escalation phase only)including leukemia secondary to prior chemotherapy or resulting from an antecedent hematologic disorder, who have failed to achieve complete response (CR) or who have relapsed after prior therapy and are not candidates for potentially curative treatment. - Acute Promyelocytic Leukemia (APL) patients are not eligible - AML or ALL patients who are over age 60 and have not received prior therapy are also eligible if they are not candidates for standard induction chemotherapy - High-grade MDS, defined as > 10% blasts on bone marrow examination - Low-grade MDS, defined as < 10% blasts on bone marrow examination (Schedule B expansion cohort only) - Patients who are willing to refrain from donating blood for at least 90 days after their final dose of MLN4924 and (for male patients) willing to refrain from donating semen for at least 4 months after their final dose of MLN4924 - Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 - Female patients who are postmenopausal, surgically sterile, or agree to practice 2 effective methods of contraception or abstain from heterosexual intercourse - Male patients who agree to practice 2 effective methods of contraception or abstain from heterosexual intercourse - Voluntary written consent - Suitable venous access - Adequate clinical laboratory values during the screening period as specified in the protocol - Patients who are on hydroxyurea may be included in the study and may continue on hydroxyurea while participating in this study.