Bevacizumab and Lapatinib in Children With Recurrent or Refractory Ependymoma

Inclusion Criteria:

   1. Age: Patient must be < or = 21 years of age.

   2. Tumor: Patients must have recurrent or refractory intracranial ependymoma (including
   myxopapillary, clear cell, papillary, tanycytic, and anaplastic ependymoma) or
   subependymoma. Patients with primary diagnosis of intracranial ependymoma with spinal
   cord metastases or relapse are eligible. The diagnosis must be confirmed by the CERN
   enrolling site's pathologist on tissue from either the initial presentation or time of
   recurrence prior to registration. For central pathology review and trial biological
   studies, submission of a paraffin block with tumor measuring at least 1 cm x 1 cm in
   area is preferred, but 15 x 5micro m unstained sections on slides may be provided by
   the referring laboratory instead. Tissue must be submitted within 60 days after
   enrollment for central processing and analysis.

   3. Patients must have measureable disease which is defined as at least one measurable
   lesion that can be accurately measured in 2 planes. Diffuse leptomeningeal involvement
   ("sugar coating") that does not allow measurement of at least one lesion in 2 planes
   will not be considered measurable disease.

   4. Patients may have had any number of prior treatment regimens (including biologic)
   before or after radiotherapy. Patients may not have previously been treated with
   Bevacizumab or Lapatinib. Gliadel wafers must be approved by CERN PI (Project Leader,
   Co-Leader and Protocol PI).

   5. Neurological Deficits: Patients with neurological deficits should have deficits that
   are stable or improving for a minimum of 1 week prior to registration.

   6. Performance Score: Karnofsky Performance Scale (KPS for > 16 years of age) or Lansky
   Performance Score (LPS for < or = 16 years of age) > or = 50 assessed within 2 weeks
   prior to registration.

   7. Evidence of recovery from any prior chemotherapy. No myelosuppressive anticancer
   chemotherapy or biological therapy within 3 weeks (6 weeks if a nitrosourea or
   mitomycin C agent) prior to registration.

   8. Prior/Concurrent Therapy: external beam radiation therapy (XRT): Patients must have
   had prior radiation therapy for treatment of their ependymoma. XRT must be > or = 3
   months prior to registration for craniospinal irradiation (> or = 18 Gy); > or = 4
   weeks for local radiation to primary tumor; and > or = 2 weeks prior to registration
   for focal irradiation to symptomatic metastatic sites.

   9. Prior/Concurrent Therapy: Bone Marrow Transplant: > or = 3 months prior to
   registration for autologous bone marrow/stem cell transplant.

10. Prior/Concurrent Therapy: Anti-convulsants: Patients with seizure disorder may be
   enrolled if well controlled. Patients receiving enzyme-inducing anticonvulsants are
   not eligible for this study. Patients must be off EIACD for at least 2 weeks prior to
   registration.

11. Prior/Concurrent Therapy: Corticosteroids: Patients who are receiving corticosteroids
   must be on a stable or decreasing dose for at least 1 week prior to registration.

12. Prior/Concurrent Therapy: Growth Factors: Off all colony forming growth factor(s) > or
   = 2 weeks prior to registration (G-CSF, GM-CSF, Erythropoietin).

13. Patients must not have received: cytochrome P450 3A4 (CYP3A4) inhibitors within seven
   (7) days prior to registration on protocol and for the duration of the study. However,
   amiodarone, another CYP3A4 inhibitor, should have been discontinued 6 months prior to
   registration and for the duration of the study.

14. Patient must not have received: CYP3A4 inducers within fourteen (14) days prior to
   registration and for the duration of the study.

15. Patient must not have received: Cimetidine within 48 hours prior and for the duration
   of the study.

16. The following laboratory values must be assessed within 7 days prior to registration
   and must be repeated if initial labs were done greater than (>seven) (7) calendar days
   prior to the start of therapy. Organ Function: Must have adequate organ function and
   marrow function as defined by the following parameters: Bone Marrow: Absolute
   neutrophil count >or =1000microliter, Platelets > or = 100,000 microliter (transfusion
   independent), Hemoglobin >or =8.0 g/dL. Renal: Serum creatinine    limit of institutional for age or glomerular filtration rate (GFR)>or =
   70ml/min/1.73m2 Hepatic: Total bilirubin < or = 1.5 times upper limit of normal for
   age: serum glutamate pyruvate transaminase (SGPT) (ALT)<2.5x institutional upper limit
   of normal for age and albumin > or = 2g/dL. No overt renal, hepatic, cardiac or
   pulmonary disease.

17. No overt renal, hepatic, cardiac or pulmonary disease.

18. Adequate cardiac function, assessed within 2 weeks prior to registration, defined as:
   shortening fraction of > or = 27% by echocardiogram, or ejection fracture (LVEF) > or
   = 50% by gated radionucleotide study.

19. Adequate pulmonary function, assessed within 2 weeks prior to registration, defined
   as: no evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry >
   94% if there is clinical indication for determination.

20. Signed informed consent according to institutional guidelines must be obtained.

21. Women of child-bearing potential and men must agree to use adequate contraception
   (hormonal or barrier method of birth control; abstinence) prior to study entry and for
   the duration of study participation. Should a woman become pregnant or suspect she is
   pregnant while participating in this study, she should inform her treating physician
   immediately and will be removed from the study.

22. Patient must begin therapy within 7 calendar days of registration.

Exclusion Criteria:

   1. Patients may not have previously been treated with Bevacizumab or Lapatinib.

   2. Patients with any significant medical illnesses that, in the investigator's opinion,
   cannot be adequately controlled with appropriate therapy or would compromise the
   patient's ability to tolerate this therapy.

   3. Patients with any disease that would obscure toxicity or dangerously alter drug
   metabolism.

   4. Patients receiving any other anticancer or experimental drug therapy.

   5. Patients with uncontrolled infection.

   6. Patients on enzyme inducing anticonvulsants.

   7. Patients with > / = Grade 2 uncontrolled hypertension.

   8. History of a stroke, myocardial infarction, or unstable angina in the previous 6
   months.

   9. Evidence of a bleeding diathesis, coagulopathy or PT international normalized ratio
   (INR)>1.5.

10. Patients who require the use of therapeutic anti-coagulation: except as required to
   maintain patency of preexisting permanent vascular catheter.

11. Pre-existing coagulopathy or thrombosis: Patients must not have been previously
   diagnosed with a deep venous or arterial thrombosis (including pulmonary embolism),
   and must not have a known thrombophilic condition.

12. Patients must have recovered from any surgical procedure before enrolling on this
   study.

13. History of an abdominal fistula, GI perforation, or intra-abdominal abscess within
   previous 6 months.

14. A serious, non healing wound, ulcer, or bone fracture.

15. Evidence of a new intracranial or intratumoral hemorrhage that is larger than a
   punctuate size on baseline MRI obtained within 14 days prior to study registration.

16. If there is proteinuria present on dipstick, patients must have a 24 hour urine
   collection. Patients are excluded if they have >500 mg protein on 24 hour urine
   collection.

17. Pregnancy: Females of childbearing potential must have negative serum or urine
   pregnancy test within 7 days prior to study entry. The effects of lapatinib on the
   developing human fetus are unknown. However, bevacizumab is known to be teratogenic
   and detrimental to fetal development and endometrial proliferation, thereby having a
   negative effect on fertility.

18. Breastfeeding: Because there is an unknown but potential risk for adverse events in
   nursing infants secondary to treatment of the mother with lapatinib of bevacizumab,
   breastfeeding should be discontinued if the mother is treated on this study.