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Cyclosporine in Treating Patients With Recurrent or Refractory Angioimmunoblastic T-Cell Lymphoma
Not Recruiting
Trial ID: NCT00070291
Purpose
RATIONALE: Cyclosporine may help the immune system slow the growth of angioimmunoblastic
T-cell lymphoma.
PURPOSE: This phase II trial is studying how well cyclosporine works in treating patients
with recurrent or refractory angioimmunoblastic T-cell lymphoma.
Official Title
A Phase II Study of Cyclosporine in the Treatment of Angioimmunoblastic T-Cell Lymphoma
Stanford Investigator(s)
Harlan Pinto
Associate Professor of Medicine (Oncology) and of Otolaryngology - Head & Neck Surgery
Eligibility
Inclusion Criteria:
- Diagnosis of angioimmunoblastic T-cell lymphoma (recurrent or refractory) based on
histologic examination.
- At least one objective measurable or evaluable disease parameter.
- Have failed at least one type of treatment: chemotherapy, auto-transplant, or steroid
treatment. Patients may not receive concurrent chemotherapy.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
- Adequate renal function as indicated by creatinine <= 1.5 the upper limit of normal
(ULN).
- Adequate liver function as indicated by alkaline phosphatase, Aspartate
Aminotransferase (AST), and Alanine Aminotransferase (ALT) <= 2x the upper limit of
normal.
- Total bilirubin <= 2x the upper limit of normal.
- Age 18 or older.
Exclusion Criteria:
- Prior cyclosporine or Tacrolimus (FK506).
- Prior allogeneic transplant.
- Evidence of active infection.
- Congestive heart failure, kidney failure, liver failure, or other severe
co-morbidities.
- Evidence of active neurological impairment.
- Previous history of hypersensitivity to cyclosporine and/or Cremorphor EL
(polyoxyethylated oil).
- History of other malignancies (other than cured carcinomas in situ of the cervix or
basal cell carcinoma of the skin).
- pregnant or breastfeeding women.
- Human immunodeficiency virus (HIV) positive.
Intervention(s):
drug: cyclosporine
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Cancer Clinical Trials Office
6504987061