Inclusion Criteria:

   - Must be between 18-80 years old

   - Histologically confirmed glioblastoma

   - Planned for Carboplatin monotherapy

   - Be willing and able to provided written informed consent/asent

   - Tumor progression after first line chemo radiation

   - Recovered to grade 0 or 1 or pre-treatment baseline from clinically significant toxic
   effects of prior therapy

   - Women of childbearing potential is confirmed not pregnant. Male and Female subjects
   utilize highly effective contraception

   - Able to communicate verbally

Exclusion Criteria:

   - Acute intracranial hemorrhage

   - Ferrous metallic implanted objects in the skull or brain

   - Prior toxicity with carboplatin chemotherapy

   - Women who are pregnant or breastfeeding

   - Cerebellar spinal cord or brain stem tumor

   - Known active Hepatitis B or Hepatitis C or HIV

   - Significant depression not adequately controlled

   - Has previously received anti-VEGF or anti-VEGF agents like Avastin

   - Cardiac disease or unstable hemodynamics

   - Severe hypertension

   - History of a bleeding disorder, coagulopathy or with a history of spontaneous tumor
   hemorrhage

   - Active drug or alcohol use disorder

   - Known sensitivity to gadolinium-based contrast agents

   - Known sensitivity or contraindications to ultrasound contrast agent or perflutren

   - Unable to undergo MRI or contraindications to MRI such as non-MRI compatible implanted
   devices

   - Difficulty lying supine and still or severe claustrophobia which cannot be managed
   with medication

   - Severely impaired renal function

   - Right to left or bi-directional cardiac shunt

   - Cranial or systemic infection requiring antibiotics

   - Known additional malignancy that is progression or require active treatment