Inclusion Criteria:To be considered for participation in the study, subject must meet all
of the following criteria:

1. Meets DSM-IV criteria for Major Depressive Episode without psychotic features.

2. 18-75 years of age and able to provide legal consent. 3. Referred to Stanford ECT
service by treating physician for bilateral electroconvulsive therapy with inpatient
hospitalization.

4. Completed process for consenting to the clinical use of ECT according to California
State law.

5. Females of childbearing potential must be using a double-barrier method of contraception
during the study and for 30 days after the study (modified 6-2003) Exclusion
Criteria:Subjects will be excluded from participation if they meet any of the following
criteria:

   1. Treatment with ECT in the 6 months prior to screening.

   2. Meets criteria for drug or alcohol abuse or dependence in the 6 months prior to
   screening.

   3. Use of alcohol or illegal drugs within seven days of randomization or during study.

   4. Presence of unstable or untreated cardiovascular disease, hypertension, or endocrine
   disorder as determined by investigator.

   5. Use of antipsychotic, antidepressant, or other prescription medications unless dose is
   stable for at least 7 days prior to randomization.

   6. Use of any investigational treatment within 30 days of randomization.

   7. Current pregnancy.

   8. Current lactation.

   9. Previous allergic reaction to mifepristone or drugs of similar chemical structure.
   (added 6-2003)

10. Use of any oral contraceptives or other drugs that may result in adverse
   drug-mifepristone interaction effects. A 30-day wash out period for oral
   contraceptives is required before mifepristone begins.