Identification of a new driver and therapeutic target for a highly aggressive subtype of prostate cancer
January 28, 2020
Exciting new results from our lab identifying a new driver and therapeutic target for highly aggressive metastatic prostate cancer with neuroendocrine features are published in PNAS. Congratulations En-Chi!
Jordan Lee, undergraduate student at Stanford, joins the lab. Welcome Jordan!
New review article on prostate cancer therapies published
August 28, 2019
Stoyanova Lab publishes a review article discussing second-generation anti-androgen therapies for prostate cancer. Congratulations Meghan!
Michelle Shen, undergraduate student at Stanford, joins the lab. Welcome Michelle!
Stoyanova lab launches it's first manuscript
April 26, 2019
Excellent work by Stoyanova Lab, showing that loss of Notch1 activity inhibits prostate cancer growth and metastasis and sensitizes prostate cancer cells to anti-androgen therapies.
Dr. Ali Ghoochani, PhD, Postdoctoral Fellow in Stoyanova Lab awarded Department of Defense, Prostate Cancer Research Program, Early Investigator Award for his project title:
"Ferroptosis Induction is a Novel Therapeutic Strategy for Advanced Prostate Cancer"
The overall goal of the proposed research is to develop novel therapeutic strategies that improve outcomes for men with lethal prostate cancer. In the proposed research, we aim to assess the therapeutic potential of ferroptosis induction (Iron-dependent cell death) by erastin treatment in advanced prostate cancer. We will also evaluate the therapeutic potential of ferroptosis induction in combination with FDA approved second-generation anti-androgens Enzalutamide and Abiraterone. Additionally, we will investigate the molecular mechanisms through which ferroptosis induction affects prostate cancer. Completion of the proposed research will lead to the development of novel therapeutic strategies for advanced prostate cancer and thus significantly reduce mortalities associated with lethal prostate cancer.
Congratulations Dr. Ghoochani!
Welcome Dr. Shiqin Liu
The Stoyanova lab is excited to announce the addition of Postdoctoral Fellow, Dr. Shiqin Liu, to the team.
Stoyanova Lab awarded NCI Small Grants Program for Cancer Research award for the project titled:
"Elucidating novel mechanisms underlying prostate cancer development"
The major goals of the proposed project are to define novel mechanisms through which Trop2 contributes to the development of advanced prostate cancer. The study will also develop new the therapeutic strategies to target Trop2 activity. Completion of the proposed research will give us insights into new mechanisms underlying the development of aggressive prostate cancer and open novel avenues for therapeutic intervention.
2018 Canary Challenge Fundraiser
Thank you to everyone who came out to support the important cause of cancer early detection. Together, the Canary Center Team raised over $30,000 this year at the 2018 Canary Challenge. We are overjoyed at this achievement and are grateful for everyone's committment.
Thank you and Congratulations to all participants and volunteers!
Please visit www.canarychallenge.com to obtain more information.
Stoyanova Lab awarded Department of Defense, Prostate Cancer Research Program, Idea Development Award for project title:
"Trop2 as a novel driver and therapeutic target for castration-resistant prostate cancer"
The proposed research aims to define new drives and therapeutic targets for advanced prostate cancer. We have recently demonstrated that cell surface protein, Trop2, represents a new promising therapeutic target for advanced prostate cancer. The proposed project will evaluate novel strategies to target Trop2 in aggressive prostate cancer. Identifying new therapeutic strategies and pathways and mechanisms that contribute to the development of aggressive prostate cancer will significantly advance the field of prostate cancer research.
Dr. Meghan Rice, PhD, Postdoctoral Fellow in Stoyanova Lab awarded Department of Defense, Prostate Cancer Research Program, Early Investigator Research Award for her project title:
"Defining the Role and Therapeutic Potential of Notch Signaling in Aggressive Prostate Cancer"
The overall goal of this proposal is to understand the mechanisms causing aggressive prostate cancer. The proposed project will investigate the role of Notch signaling pathway in prostate cancer to understand the mechanism through which Notch can drive the aggressive disease and determine the requirement of Notch for tumor maintenance. Additionally, we will test new treatment strategies involving two types of Notch inhibitors alone, and in combination with current standard of care treatments for castration resistant disease. This study will facilitate our understanding of fundamental molecular mechanisms underlying the development of aggressive prostate cancer and direct novel strategies regarding new combination therapies for the advanced disease.
Congratulations Dr. Rice!
Austin You Su, Undergraduate Student in the Stoyanova Lab receives Undergraduate Advising Research (UAR) award
Austin You Su Awarded summer research funding for the design and planning of a series of experiments to assess the role of Aurora A Kinase in prostate cancer progression, under the guidance of his mentor Professor Tanya Stoyanova.
The Office of Undergraduate Advising and Research (UAR) helps students realize the full intellectual richness of undergraduate life at Stanford. Undergraduate Advising and Research (UAR) Student Grants support rigorous, independent projects in all disciplines. Research, arts, and senior synthesis projects in any field (including engineering, fine arts, humanities, natural sciences, and social sciences) can make use of this funding.
Austin also received a perfect score in the MCAT exam.
The Medical College Admission Test® (MCAT®), developed and administered by the AAMC, is a standardized, multiple-choice examination created to help medical school admissions offices assess your problem solving, critical thinking, and knowledge of natural, behavioral, and social science concepts and principles prerequisite to the study of medicine.
The Canary Center at Stanford and Cancer Research UK Cambridge Centre collaborate to fund innovative research to help diagnose cancer earlier. The awards were announced at Cambridge’s third annual early detection symposium on January 15.
Congratulations Dr. Stoyanova and Dr. Gnanapragasam!
Mark Buckup, Undergraduate Student in the Stoyanova Lab receives the Verily Young Scientist Award
Canary Center summer internship student Mark Buckup (mentored by Dr. Meghan Rice) wins the Verily Young Scientist Award for his poster titled: "Elucidating the Role of Legumain in Prostate Cancer".
Congratulations Mark and Dr. Rice!
Photo on left features Mark Buckup, Student Intern and Dr. Stephanie van de Ven, Canary Center Deputy Director Programs
Dr. Meghan Rice receives best Poster Award
Dr. Meghan Rice, PhD, Postdoctoral Fellow in Stoyanova Lab received Best Poster Award at the Canary Foundation Early Detection Symposium for her poster titled: "Role of Notch1 in Early Stratification of Aggressive Prostate Cancer".
Congratulations Dr. Rice!
Austin You Su, Undergraduate Student in the Stoyanova Lab receives Stanford Bio-X Undergraduate Research Fellowship for Summer 2017
Introducing undergraduates to the excitement of interdisciplinary research at the frontiers of knowledge is essential for training a new generation to participate in discovery. The Bio-X Undergraduate Summer Research Program (Bio-X USRP) provides an opportunity for these undergraduate students to conduct hands-on research, build awareness of interdisciplinary areas, and network with Bio-X faculty. This formative experience influences their subsequent graduate work at Stanford and beyond.
Dr. Meghan Rice, PhD, Postdoctoral Fellow in Stoyanova Lab received the Helena Anna Henzl-Gabor Young Women in Science Postdoctoral Travel Grant Award.to present her work on "Therapeutic Inhibition of Notch1 in Metastatic Prostate Cancer" at the 2017 American Association of Cancer Research in Washington, D.C.
The Stoyanova lab has discovered that Notch1 is overexpressed in high grade prostate cancer compared to low grade prostate cancer or benign prostate, and that Notch1 synergizes with several common prostate cancer alterations to drive aggressive disease. Dr. Rice determined that Notch1 is a therapeutically relevant target in prostate cancer and is exploring novel inhibition strategies in prostate cancer.
Congratulations Dr. Rice!
September 27, 2016
Dr. Tanya Stoyanova, an Assistant Professor in the Canary Center at Stanford for Early Cancer Detection, was awarded a 2016 Stanford McCormick-Gabilan Faculty Award.
The McCormick Funds were established to support the advancement of women in medicine and/or medical research directly, or by supporting the mentoring, training and encouragement of women pursuing the study of medicine, in teaching medicine, and engaging in medical research.
Congratulations Dr. Stoyanova!