Publications
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Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.
Nabhan JF,
Hu R, Oh RS, Cohen SN, Lu Q.
Proc Natl Acad Sci U S A.
2012;
109
(11):
4146-51
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Human genetic variation altering anthrax toxin sensitivity.
Martchenko M,
Candille SI, Tang H, Cohen SN.
Proc Natl Acad Sci U S A.
2012;
109
(8):
2972-7
-
Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R.
Wu K,
Koo J, Jiang X, Chen R, Cohen SN, Nathan C.
PLoS One.
2012;
7
(2):
e30512
-
Ribonuclease E modulation of the bacterial SOS response.
Manasherob R,
Miller C, Kim KS, Cohen SN.
PLoS One.
2012;
7
(6):
e38426
-
Second-site suppression of RNase E essentiality by mutation of the deaD RNA helicase in Escherichia coli.
Tamura M,
Kers JA, Cohen SN.
J Bacteriol.
2012;
194
(8):
1919-26
-
Spt4 is selectively required for transcription of extended trinucleotide repeats.
Liu CR,
Chang CR, Chern Y, Wang TH, Hsieh WC, Shen WC, Chang CY, Chu IC, Deng N, Cohen SN, Cheng TH.
Cell.
2012;
148
(4):
690-701
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Upregulation of RNase E activity by mutation of a site that uncompetitively interferes with RNA binding.
Go H,
Moore CJ, Lee M, Shin E, Jeon CO, Cha CJ, Han SH, Kim SJ, Lee SW, Lee Y, Ha NC, Kim YH, Cohen SN, Lee K.
RNA Biol.
2011 Nov-Dec;
8
(6):
1022-34
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Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4.
Chen R,
Liliental JE, Kowalski PE, Lu Q, Cohen SN.
Oncogene.
2011;
30
(22):
2570-80
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Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin.
Martchenko M,
Jeong SY, Cohen SN.
Proc Natl Acad Sci U S A.
2010;
107
(35):
15583-8
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Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.
Lee HN,
Huang J, Im JH, Kim SH, Noh JH, Cohen SN, Kim ES.
Appl Environ Microbiol.
2010;
76
(9):
3039-43
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Regulation of morphological differentiation in S. coelicolor by RNase III (AbsB) cleavage of mRNA encoding the AdpA transcription factor.
Xu W,
Huang J, Lin R, Shi J, Cohen SN.
Mol Microbiol.
2010;
75
(3):
781-91
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A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation.
Zhang YW,
Liu S, Zhang X, Li WB, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P, Liao FF, Li L, Xu H.
Neuron.
2009;
64
(3):
328-40
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Identification of cellular genes affecting the infectivity of foot-and-mouth disease virus.
Piccone ME,
Feng Y, Chang AC, Mosseri R, Lu Q, Kutish GF, Lu Z, Burrage TG, Gooch C, Rock DL, Cohen SN.
J Virol.
2009;
83
(13):
6681-8
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Microbial Drug Resistance: An Old Problem in Need of New Solutions.
Cohen SN,
Microbial Evolution and Co-Adaptation: A Tribute to the Life and Scientific Legacies of Joshua Lederberg. (D.A. Relman, M.A. Hamburg, E.R. Choffnes, and A. Mack, eds). Washington, DC: National Academies Press.
2009:
173-180
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Autoregulation of AbsB (RNase III) expression in Streptomyces coelicolor by endoribonucleolytic cleavage of absB operon transcripts.
Xu W,
Huang J, Cohen SN.
J Bacteriol.
2008;
190
(15):
5526-30
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Genomic expression profiling of TNF-alpha-treated BDC2.5 diabetogenic CD4+ T cells.
Lee LF,
Lih CJ, Huang CJ, Cao T, Cohen SN, McDevitt HO.
Proc Natl Acad Sci U S A.
2008;
105
(29):
10107-12
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Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines.
Demuth T,
Rennert JL, Hoelzinger DB, Reavie LB, Nakada M, Beaudry C, Nakada S, Anderson EM, Henrichs AN, McDonough WS, Holz D, Joy A, Lin R, Pan KH, Lih CJ, Cohen SN, Berens ME.
BMC Genomics.
2008:
9
54
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Identification of amino acid residues in the catalytic domain of RNase E essential for survival of Escherichia coli: functional analysis of DNase I subdomain.
Shin E,
Go H, Yeom JH, Won M, Bae J, Han SH, Han K, Lee Y, Ha NC, Moore CJ, Sohlberg B, Cohen SN, Lee K.
Genetics.
2008;
179
(4):
1871-9
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Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction.
Tavassoli A,
Lu Q, Gam J, Pan H, Benkovic SJ, Cohen SN.
ACS Chem Biol.
2008;
3
(12):
757-64
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Suppression of human tumor cell proliferation by Smurf2-induced senescence.
Zhang H,
Teng Y, Kong Y, Kowalski PE, Cohen SN.
J Cell Physiol.
2008;
215
(3):
613-20
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YmdB: a stress-responsive ribonuclease-binding regulator of E. coli RNase III activity.
Kim KS,
Manasherob R, Cohen SN.
Genes Dev.
2008;
22
(24):
3497-508
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Characterization of a large, stable, high-copy-number Streptomyces plasmid that requires stability and transfer functions for heterologous polyketide overproduction.
Fong R,
Vroom JA, Hu Z, Hutchinson CR, Huang J, Cohen SN, Cohen S, Kao CM, Kao C.
Appl Environ Microbiol.
2007;
73
(4):
1296-307
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Human MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops.
Cheng TH,
Cohen SN.
Mol Cell Biol.
2007;
27
(1):
111-9
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Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces.
Kang SH,
Huang J, Lee HN, Hur YA, Cohen SN, Kim ES.
J Bacteriol.
2007;
189
(11):
4315-9
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Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome.
Gao J,
Lee K, Zhao M, Qiu J, Zhan X, Saxena A, Moore CJ, Cohen SN, Georgiou G.
Mol Microbiol.
2006;
61
(2):
394-406
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Phenotype-based identification of host genes required for replication of African swine fever virus.
Chang AC,
Zsak L, Feng Y, Mosseri R, Lu Q, Kowalski P, Zsak A, Burrage TG, Neilan JG, Kutish GF, Lu Z, Laegreid W, Rock DL, Cohen SN.
J Virol.
2006;
80
(17):
8705-17
-
RNase E maintenance of proper FtsZ/FtsA ratio required for nonfilamentous growth of Escherichia coli cells but not for colony-forming ability.
Tamura M,
Lee K, Miller CA, Moore CJ, Shirako Y, Kobayashi M, Cohen SN.
J Bacteriol.
2006;
188
(14):
5145-52
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Retention of core catalytic functions by a conserved minimal ribonuclease E peptide that lacks the domain required for tetramer formation.
Caruthers JM,
Feng Y, McKay DB, Cohen SN.
J Biol Chem.
2006;
281
(37):
27046-51
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The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.
Wei W,
Lu Q, Chaudry GJ, Leppla SH, Cohen SN.
Cell.
2006;
124
(6):
1141-54
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Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes.
Lih CJ,
Wei W, Cohen SN.
Genes Dev.
2006;
20
(15):
2082-95
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rag genes: novel components of the RamR regulon that trigger morphological differentiation in Streptomyces coelicolor.
San Paolo S,
Huang J, Cohen SN, Thompson CJ.
Mol Microbiol.
2006;
61
(5):
1167-86
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An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma.
Patil MA,
Chua MS, Pan KH, Lin R, Lih CJ, Cheung ST, Ho C, Li R, Fan ST, Cohen SN, Chen X, So S.
Oncogene.
2005;
24
(23):
3737-47
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Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor.
Huang J,
Shi J, Molle V, Sohlberg B, Weaver D, Bibb MJ, Karoonuthaisiri N, Lih CJ, Kao CM, Buttner MJ, Cohen SN.
Mol Microbiol.
2005;
58
(5):
1276-87
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Effects of threshold choice on biological conclusions reached during analysis of gene expression by DNA microarrays.
Pan KH,
Lih CJ, Cohen SN.
Proc Natl Acad Sci U S A.
2005;
102
(25):
8961-5
-
Regional organization of gene expression in Streptomyces coelicolor.
Karoonuthaisiri N,
Weaver D, Huang J, Cohen SN, Kao CM.
Gene.
2005;
353
(1):
53-66
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Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions.
Zhang H,
Herbert BS, Pan KH, Shay JW, Cohen SN.
Oncogene.
2004;
23
(37):
6193-8
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EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin.
Lu Q,
Wei W, Kowalski PE, Chang AC, Cohen SN.
Proc Natl Acad Sci U S A.
2004;
101
(49):
17246-51
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Genome plasticity in Streptomyces: identification of 1 Mb TIRs in the S. coelicolor A3(2) chromosome.
Weaver D,
Karoonuthaisiri N, Tsai HH, Huang CH, Ho ML, Gai S, Patel KG, Huang J, Cohen SN, Hopwood DA, Chen CW, Kao CM.
Mol Microbiol.
2004;
51
(6):
1535-50
-
Global analysis of Escherichia coli RNA degradosome function using DNA microarrays.
Bernstein JA,
Lin PH, Cohen SN, Lin-Chao S.
Proc Natl Acad Sci U S A.
2004;
101
(9):
2758-63
-
Reverse transcriptase activity innate to DNA polymerase I and DNA topoisomerase I proteins of Streptomyces telomere complex.
Bao K,
Cohen SN.
Proc Natl Acad Sci U S A.
2004;
101
(40):
14361-6
-
SOS response induction by beta-lactams and bacterial defense against antibiotic lethality.
Miller C,
Thomsen LE, Gaggero C, Mosseri R, Ingmer H, Cohen SN.
Science.
2004;
305
(5690):
1629-31
-
Smurf2 up-regulation activates telomere-dependent senescence.
Zhang H,
Cohen SN.
Genes Dev.
2004;
18
(24):
3028-40
-
A Streptomyces coelicolor functional orthologue of Escherichia coli RNase E shows shuffling of catalytic and PNPase-binding domains.
Lee K,
Cohen SN.
Mol Microbiol.
2003;
48
(2):
349-60
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DpiA binding to the replication origin of Escherichia coli plasmids and chromosomes destabilizes plasmid inheritance and induces the bacterial SOS response.
Miller C,
Ingmer H, Thomsen LE, Skarstad K, Cohen SN.
J Bacteriol.
2003;
185
(20):
6025-31
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Identification and characterization of a pSLA2 plasmid locus required for linear DNA replication and circular plasmid stable inheritance in Streptomyces lividans.
Qin Z,
Shen M, Cohen SN.
J Bacteriol.
2003;
185
(22):
6575-82
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Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere-binding protein essential for linear DNA replication.
Bao K,
Cohen SN.
Genes Dev.
2003;
17
(6):
774-85
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RraA. a protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli.
Lee K,
Zhan X, Gao J, Qiu J, Feng Y, Meganathan R, Cohen SN, Georgiou G.
Cell.
2003;
114
(5):
623-34
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Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci.
Zhang H,
Pan KH, Cohen SN.
Proc Natl Acad Sci U S A.
2003;
100
(6):
3251-6
-
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.
Lu Q,
Hope LW, Brasch M, Reinhard C, Cohen SN.
Proc Natl Acad Sci U S A.
2003;
100
(13):
7626-31
-
The Streptomyces coelicolor polynucleotide phosphorylase homologue, and not the putative poly(A) polymerase, can polyadenylate RNA.
Sohlberg B,
Huang J, Cohen SN.
J Bacteriol.
2003;
185
(24):
7273-8
-
The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor.
Elliot MA,
Karoonuthaisiri N, Huang J, Bibb MJ, Cohen SN, Kao CM, Buttner MJ.
Genes Dev.
2003;
17
(14):
1727-40
-
Tsg101 control of human immunodeficiency virus type 1 Gag trafficking and release.
Goff A,
Ehrlich LS, Cohen SN, Carter CA.
J Virol.
2003;
77
(17):
9173-82
-
Analysis of DNA microarrays using algorithms that employ rule-based expert knowledge.
Pan KH,
Lih CJ, Cohen SN.
Proc Natl Acad Sci U S A.
2002;
99
(4):
2118-23
-
Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays.
Bernstein JA,
Khodursky AB, Lin PH, Lin-Chao S, Cohen SN.
Proc Natl Acad Sci U S A.
2002;
99
(15):
9697-702
-
Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus.
Yeh SD,
Chen YJ, Chang AC, Ray R, She BR, Lee WS, Chiang HS, Cohen SN, Lin-Chao S.
J Biol Chem.
2002;
277
(8):
6311-7
-
Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1).
Oh H,
Mammucari C, Nenci A, Cabodi S, Cohen SN, Dotto GP.
Proc Natl Acad Sci U S A.
2002;
99
(8):
5430-5
-
Polyadenylation can regulate ColE1 type plasmid copy number independently of any effect on RNAI decay by decreasing the interaction of antisense RNAI with its RNAII target.
Xu FF,
Gaggero C, Cohen SN.
Plasmid.
2002;
48
(1):
49-58
-
RNase G complementation of rne null mutation identifies functional interrelationships with RNase E in Escherichia coli.
Lee K,
Bernstein JA, Cohen SN.
Mol Microbiol.
2002;
43
(6):
1445-56
-
Survival mechanisms for Streptomyces linear replicons after telomere damage.
Qin Z,
Cohen SN.
Mol Microbiol.
2002;
45
(3):
785-94
-
The catalytic domain of RNase E shows inherent 3' to 5' directionality in cleavage site selection.
Feng Y,
Vickers TA, Cohen SN.
Proc Natl Acad Sci U S A.
2002;
99
(23):
14746-51
-
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control.
Li L,
Liao J, Ruland J, Mak TW, Cohen SN.
Proc Natl Acad Sci U S A.
2001;
98
(4):
1619-24
-
Effects of 3' terminus modifications on mRNA functional decay during in vitro protein synthesis.
Lee K,
Cohen SN.
J Biol Chem.
2001;
276
(26):
23268-74
-
Escherichia coli poly(A)-binding proteins that interact with components of degradosomes or impede RNA decay mediated by polynucleotide phosphorylase and RNase E.
Feng Y,
Huang H, Liao J, Cohen SN.
J Biol Chem.
2001;
276
(34):
31651-6
-
Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays.
Huang J,
Lih CJ, Pan KH, Cohen SN.
Genes Dev.
2001;
15
(23):
3183-92
-
Modulation of actinorhodin biosynthesis in Streptomyces lividans by glucose repression of afsR2 gene transcription.
Kim ES,
Hong HJ, Choi CY, Cohen SN.
J Bacteriol.
2001;
183
(7):
2198-203
-
RNA degradosomes exist in vivo in Escherichia coli as multicomponent complexes associated with the cytoplasmic membrane via the N-terminal region of ribonuclease E.
Liou GG,
Jane WN, Cohen SN, Lin NS, Lin-Chao S.
Proc Natl Acad Sci U S A.
2001;
98
(1):
63-8
-
Terminal proteins essential for the replication of linear plasmids and chromosomes in Streptomyces.
Bao K,
Cohen SN.
Genes Dev.
2001;
15
(12):
1518-27
-
The RepA protein of plasmid pSC101 controls Escherichia coli cell division through the SOS response.
Ingmer H,
Miller C, Cohen SN.
Mol Microbiol.
2001;
42
(2):
519-26
-
Unraveling the essential role in conjugation of the Tra protein of Streptomyces lividans plasmid pIJ101.
Pettis GS,
Cohen SN.
Antonie Van Leeuwenhoek.
2001;
79
(3-4):
247-50
-
p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.
Ruland J,
Sirard C, Elia A, MacPherson D, Wakeham A, Li L, de la Pompa JL, Cohen SN, Mak TW.
Proc Natl Acad Sci U S A.
2001;
98
(4):
1859-64
-
Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis.
Liu K,
Li L, Cohen SN.
J Biol Chem.
2000;
275
(40):
31093-8
-
Long palindromes formed in Streptomyces by nonrecombinational intra-strand annealing.
Qin Z,
Cohen SN.
Genes Dev.
2000;
14
(14):
1789-96
-
Mutational analysis of the tra locus of the broad-host-range Streptomyces plasmid pIJ101.
Pettis GS,
Cohen SN.
J Bacteriol.
2000;
182
(16):
4500-4
-
Neoplastic transformation and tumorigenesis associated with sam68 protein deficiency in cultured murine fibroblasts.
Liu K,
Li L, Nisson PE, Gruber C, Jessee J, Cohen SN.
J Biol Chem.
2000;
275
(51):
40195-201
-
TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence.
Feng GH,
Lih CJ, Cohen SN.
Cancer Res.
2000;
60
(6):
1736-41
-
Unpaired terminal nucleotides and 5' monophosphorylation govern 3' polyadenylation by Escherichia coli poly(A) polymerase I.
Feng Y,
Cohen SN.
Proc Natl Acad Sci U S A.
2000;
97
(12):
6415-20
-
Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene.
Chang AC,
Sohlberg B, Trinkle-Mulcahy L, Claverie-Martin F, Cohen P, Cohen SN.
Gene.
1999;
240
(1):
45-55
-
Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors.
Trinkle-Mulcahy L,
Ajuh P, Prescott A, Claverie-Martin F, Cohen S, Lamond AI, Cohen P.
J Cell Sci.
1999:
112 ( Pt 2)
157-68
-
Regulation of transfer functions by the imp locus of the Streptomyces coelicolor plasmidogenic element SLP1.
Hagege JM,
Brasch MA, Cohen SN.
J Bacteriol.
1999;
181
(19):
5976-83
-
Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein.
Liu K,
Li L, Nisson PE, Gruber C, Jessee J, Cohen SN.
Mol Cell Biol.
1999;
19
(5):
3696-703
-
Separate roles of Escherichia coli replication proteins in synthesis and partitioning of pSC101 plasmid DNA.
Miller C,
Cohen SN.
J Bacteriol.
1999;
181
(24):
7552-7
-
Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300.
Sun Z,
Pan J, Hope WX, Cohen SN, Balk SP.
Cancer.
1999;
86
(4):
689-96
-
Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency.
Xie W,
Li L, Cohen SN.
Proc Natl Acad Sci U S A.
1998;
95
(4):
1595-600
-
Destabilized inheritance of pSC101 and other Escherichia coli plasmids by DpiA, a novel two-component system regulator.
Ingmer H,
Miller CA, Cohen SN.
Mol Microbiol.
1998;
29
(1):
49-59
-
Poly(A)- and poly(U)-specific RNA 3' tail shortening by E. coli ribonuclease E.
Huang H,
Liao J, Cohen SN.
Nature.
1998;
391
(6662):
99-102
-
Replication at the telomeres of the Streptomyces linear plasmid pSLA2.
Qin Z,
Cohen SN.
Mol Microbiol.
1998;
28
(5):
893-903
-
gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation.
Ju YT,
Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S.
Proc Natl Acad Sci U S A.
1998;
95
(19):
11423-8
-
A developmentally regulated Streptomyces endoribonuclease resembles ribonuclease E of Escherichia coli.
Hagège JM,
Cohen SN.
Mol Microbiol.
1997;
25
(6):
1077-90
-
ARD-1 cDNA from human cells encodes a site-specific single-strand endoribonuclease that functionally resembles Escherichia coli RNase E.
Claverie-Martin F,
Wang M, Cohen SN.
J Biol Chem.
1997;
272
(21):
13823-8
-
Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours.
Gayther SA,
Barski P, Batley SJ, Li L, de Foy KA, Cohen SN, Ponder BA, Caldas C.
Oncogene.
1997;
15
(17):
2119-26
-
RNase E: still a wonderfully mysterious enzyme.
Cohen SN,
McDowall KJ.
Mol Microbiol.
1997;
23
(6):
1099-106
-
The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer.
Li L,
Li X, Francke U, Cohen SN.
Cell.
1997;
88
(1):
143-54
-
Plasmid transfer and expression of the transfer (tra) gene product of plasmid pIJ101 are temporally regulated during the Streptomyces lividans life cycle.
Pettis GS,
Cohen SN.
Mol Microbiol.
1996;
19
(5):
1127-35
-
Streptomyces linear plasmids that contain a phage-like, centrally located, replication origin.
Chang PC,
Kim ES, Cohen SN.
Mol Microbiol.
1996;
22
(5):
789-800
-
The N-terminal domain of the rne gene product has RNase E activity and is non-overlapping with the arginine-rich RNA-binding site.
McDowall KJ,
Cohen SN.
J Mol Biol.
1996;
255
(3):
349-55
-
The platelet-derived growth factor alpha-receptor is encoded by a growth-arrest-specific (gas) gene.
Lih CJ,
Cohen SN, Wang C, Lin-Chao S.
Proc Natl Acad Sci U S A.
1996;
93
(10):
4617-22
-
Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells.
Li L,
Cohen SN.
Cell.
1996;
85
(3):
319-29
-
Boundaries of the pSC101 minimal replicon are conditional.
Miller CA,
Ingmer H, Cohen SN.
J Bacteriol.
1995;
177
(17):
4865-71
-
Disparate replication properties of integrated and extrachromosomal forms of bovine papilloma virus in ID13 cells.
Ten Hagen KG,
Ravnan JB, Cohen SN.
J Mol Biol.
1995;
254
(2):
119-29
-
Effects of the pSC101 partition (par) locus on in vivo DNA supercoiling near the plasmid replication origin.
Conley DL,
Cohen SN.
Nucleic Acids Res.
1995;
23
(4):
701-7
-
Isolation and characterization of plasmid mutations that enable partitioning of pSC101 replicons lacking the partition (par) locus.
Conley DL,
Cohen SN.
J Bacteriol.
1995;
177
(4):
1086-9
-
Monomer-dimer equilibrium of the pSC101 RepA protein.
Ingmer H,
Fong EL, Cohen SN.
J Mol Biol.
1995;
250
(3):
309-14
-
RNA degradation in Escherichia coli regulated by 3' adenylation and 5' phosphorylation.
Xu F,
Cohen SN.
Nature.
1995;
374
(6518):
180-3
-
Sequences essential for replication of plasmid pIJ101 in Streptomyces lividans.
Brasch MA,
Cohen SN.
Plasmid.
1995;
33
(3):
191-7
-
Site-specific RNase E cleavage of oligonucleotides and inhibition by stem-loops.
McDowall KJ,
Kaberdin VR, Wu SW, Cohen SN, Lin-Chao S.
Nature.
1995;
374
(6519):
287-90
-
Surprises at the 3' end of prokaryotic RNA.
Cohen SN,
Cell.
1995;
80
(6):
829-32
-
Transformed mouse cell lines that consist predominantly of cells maintaining bovine papilloma virus at high copy number.
Ravnan JB,
Cohen SN.
Virology.
1995;
213
(2):
526-34
-
A+U content rather than a particular nucleotide order determines the specificity of RNase E cleavage.
McDowall KJ,
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Timing of replication of beta satellite repeats of human chromosomes.
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Identification and analysis of transcriptional regulatory signals for the kil and kor loci of Streptomyces plasmid pIJ101.
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Initiation of pro-opiomelanocortin mRNA from a normally quiescent promoter in a human small cell lung cancer cell line.
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Bovine papilloma virus plasmids replicate randomly in mouse fibroblasts throughout S phase of the cell cycle.
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Effect of premature termination of translation on mRNA stability depends on the site of ribosome release.
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Human homologs of TU transposon sequences: polypurine/polypyrimidine sequence elements that can alter DNA conformation in vitro and in vivo.
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Identification and characterization of recD, a gene affecting plasmid maintenance and recombination in Escherichia coli.
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Sequence of the cDNA encoding porcine pro-opiomelanocortin.
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Structural analysis of plasmid and chromosomal loci involved in site-specific excision and integration of the SLP1 element of Streptomyces coelicolor.
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The stability of E. coli gene transcripts is dependent on determinants localized to specific mRNA segments.
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Differential expression of photosynthesis genes in R. capsulata results from segmental differences in stability within the polycistronic rxcA transcript.
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Hormonally mediated negative regulation of human pro-opiomelanocortin gene expression after transfection into mouse L cells.
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Nucleotide sequences encoding and promoting expression of three antibiotic resistance genes indigenous to Streptomyces.
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Partitioning of the pSC101 plasmid during cell division.
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Effects of alterations in the translation control region on bacterial gene expression: use of cat gene constructs transcribed from the lac promoter as a model system.
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Plasmid formation in Streptomyces: excision and integration of the SLP1 replicon at a specific chromosomal site.
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Structural and functional analysis of the par region of the pSC 10 1 plasmid.
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An unusual transposon with long terminal inverted repeats in the sea urchin Strongylocentrotus purpuratus.
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A DNA polymorphism in close physical linkage with the proopiomelanocortin gene.
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Alignment of genetic and restriction maps of the photosynthesis region of the Rhodopseudomonas capsulata chromosome by a conjugation-mediated marker rescue technique.
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Decay of mRNA in Escherichia coli: investigation of the fate of specific segments of transcripts.
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Proc Natl Acad Sci U S A.
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Hollow-fiber membrane bioreactors using immobilized E. coli for protein synthesis.
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Hybridization of cloned Rhodopseudomonas capsulata photosynthesis genes with DNA from other photosynthetic bacteria.
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Nucleotide sequence of the partition locus of Escherichia coli plasmid pSC101.
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1983;
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Use of synthetic oligonucleotide probes complementary to genes for human HLA-DR alpha and beta as extension primers for the isolation of 5'-specific genomic clones.
Das HK,
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Proc Natl Acad Sci U S A.
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Amino-terminal sequence of the Tn3 transposase protein.
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Characterization of the structural gene and putative 5'-regulatory sequences for human proopiomelanocortin.
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Gene expression in Streptomyces: construction and application of promoter-probe plasmid vectors in Streptomyces lividans.
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Overproduction of the Tn3 transposition protein and its role in DNA transposition.
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Cloning and analysis of strong promoters is made possible by the downstream placement of a RNA termination signal.
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Proc Natl Acad Sci U S A.
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Cloning and expression in streptomyces lividans of antibiotic resistance genes derived from Escherichia coli.
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Construction and characterization of a novel two-plasmid system for accomplishing temperature-regulated, amplified expression of cloned adventitious genes in Escherichia coli.
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A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces.
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Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.
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Initiation of protein synthesis in bacteria at a translational start codon of mamalian cDNA: effects of the preceding nucleotide sequence.
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Proc Natl Acad Sci U S A.
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Partitioning of bacterial plasmids during cell division: a cis-acting locus that accomplishes stable plasmid inheritance.
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Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide.
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Structure and genomic organization of the mouse dihydrofolate reductase gene.
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Cell.
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Studies of cloned DNA encoding the structure for the bovine corticotropin-beta-lipotropin precursor protein.
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The transplantation and manipulation of genes in microorganisms.
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Antimicrobial selection by a computer. A blinded evaluation by infectious diseases experts.
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Cloning and endonuclease mapping of the hepatitis B viral genome.
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Computer-based system for adverse drug reaction detection and prevention.
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Evaluating the performance of a computer-based consultant.
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Filter affinity transfer. A new technique for the in situ identification of proteins in gels.
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Genetic analysis of the inter-relationship between plasmid replication and incompatibility.
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High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA.
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Identification and characterization of a self-regulated repressor of translocation of the Tn3 element.
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Immunological detection and characterization of products translated from cloned DNA fragments.
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Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor.
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Structural and functional analysis of cloned DNA segments containing the replication and incompatibility regions of a miniplasmid derived from a copy number mutant of NR1.
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681-9
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Cloning and characterization of EcoRI and HindIII restriction endonuclease-generated fragments of antibiotic resistance plasmids R6-5 and R6.
Timmis KN,
Cabello F, Cohen SN.
Mol Gen Genet.
1978;
162
(2):
121-37
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Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.
Chang AC,
Cohen SN.
J Bacteriol.
1978;
134
(3):
1141-56
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Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-beta-lipotropin precursor.
Nakanishi S,
Inoue A, Kita T, Numa S, Chang AC, Cohen SN, Nunberg J, Schimke RT.
Proc Natl Acad Sci U S A.
1978;
75
(12):
6021-5
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Instability of plasmid DNA sequences: macro and micro evolution of the antibiotic resistance plasmid R6-5.
Timmis KN,
Cabello F, Andrés I, Nordheim A, Burkhardt HJ, Cohen SN.
Mol Gen Genet.
1978;
167
(1):
11-19
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Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.
Chang AC,
Nunberg JH, Kaufman RJ, Erlich HA, Schimke RT, Cohen SN.
Nature.
1978;
275
(5681):
617-24
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Phenotypically cryptic EcoRI endonuclease activity specified by the ColE1 plasmid.
Miller CA,
Cohen SN.
Proc Natl Acad Sci U S A.
1978;
75
(3):
1265-9
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Genetic recombination through protoplast fusion in Streptomyces.
Hopwood DA,
Wright HM, Bibb MJ, Cohen SN.
Nature.
1977;
268
(5616):
171-4
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In vivo site-specific genetic recombination promoted by the EcoRI restriction endonuclease.
Chang S,
Cohen SN.
Proc Natl Acad Sci U S A.
1977;
74
(11):
4811-5
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Receptivity of physicians in a teaching hospital to computerized drug interaction monitoring and reporting system.
Morrell J,
Podlone M, Cohen SN.
Med Care.
1977;
15
(1):
68-78
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Recombinant DNA: fact and fiction.
Cohen SN,
West J Med.
1977;
126
(5):
415-20
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Recombinant DNA: fact and fiction.
Cohen SN,
Science.
1977;
195
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654-7
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Revised interpretation of the origin of the pSC101 plasmid.
Cohen SN,
Chang AC.
J Bacteriol.
1977;
132
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734-7
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Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element.
Kretschmer PJ,
Cohen SN.
J Bacteriol.
1977;
130
(2):
888-99
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Site-specific DNA deletions occurring adjacent to the termini of a transposable ampicillin resistance element (Tn3).
Nisen PD,
Kopecko DJ, Chou J, Cohen SN.
J Mol Biol.
1977;
117
(4):
975-8
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Computerized consultation system for selection of antimicrobial therapy.
Wraith SM,
Aikins JS, Buchanan BG, Clancey WJ, Davis R, Fagan LM, Hannigan JF, Scott AC, Shortliffe EH, van Melle WJ, Yu VL, Axline SG, Cohen SN.
Am J Hosp Pharm.
1976;
33
(12):
1304-8
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Covalently closed circular DNA molecules of low superhelix density as intermediate forms in plasmid replication.
Timmis K,
Cabello F, Cohen SN.
Nature.
1976;
261
(5560):
512-6
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Gene manipulation.
Cohen SN,
N Engl J Med.
1976;
294
(16):
883-9
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Involvement of multiple translocating DNA segments and recombinational hotspots in the structural evolution of bacterial plasmids.
Kopecko DJ,
Brevet J, Cohen SN.
J Mol Biol.
1976;
108
(2):
333-60
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Replication control in a composite plasmid constructed by in vitro linkage of two distinct replicons.
Cabello F,
Timmis K, Cohen SN.
Nature.
1976;
259
(5541):
285-90
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Replication region fragments cloned from Flac+ are identical to EcoRI fragment f5 of F.
Skurray RA,
Guyer MS, Timmis K, Cabello F, Cohen SN, Davidson N, Clark AJ.
J Bacteriol.
1976;
127
(3):
1571-5
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Structural evolution of bacterial plasmids: role of translocating genetic elements and DNA sequence insertions.
Cohen SN,
Kopecko DJ.
Fed Proc.
1976;
35
(9):
2031-6
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Transposable genetic elements and plasmid evolution.
Cohen SN,
Nature.
1976;
263
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731-8
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Uniform nomenclature for bacterial plasmids: a proposal.
Novick RP,
Clowes RC, Cohen SN, Curtiss R, Datta N, Falkow S.
Bacteriol Rev.
1976;
40
(1):
168-89
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Detection and prevention of drug interactions utilizing an on-line computer system.
Tatro DS,
Briggs RL, Chavez-Pardo R, Feinberg LS, Hannigan JF, Moore TN, Cohen SN.
Drug Inf J.
1975 Jan-Apr;
9
(1):
10-7
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Cloning, isolation, and characterization of replication regions of complex plasmid genomes.
Timmis K,
Cabello F, Cohen SN.
Proc Natl Acad Sci U S A.
1975;
72
(6):
2242-6
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Computer-based consultations in clinical therapeutics: explanation and rule acquisition capabilities of the MYCIN system.
Shortliffe EH,
Davis R, Axline SG, Buchanan BG, Green CC, Cohen SN.
Comput Biomed Res.
1975;
8
(4):
303-20
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Indirect selection of bacterial plasmids lacking identifiable phenotypic properties.
Kretschmer FJ,
Chang AC, Cohen SN.
J Bacteriol.
1975;
124
(1):
225-31
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Isolation of histone genes from unfractionated sea urchin DNA by subculture cloning in E. coli.
Kedes LH,
Chang AC, Houseman D, Cohen SN.
Nature.
1975;
255
(5509):
533-8
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Occurrence of insertion sequence (IS) regions on plasmid deoxyribonucleic acid as direct and inverted nucleotide sequence duplications.
Ptashne K,
Cohen SN.
J Bacteriol.
1975;
122
(2):
776-81
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Online drug interaction surveillance.
Tatro DS,
Briggs RL, Chavez-Pardo R, Feinberg LS, Hannigan JF, Moore TN, Cohen SN.
Am J Hosp Pharm.
1975;
32
(4):
417-20
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Site specific recA--independent recombination between bacterial plasmids: involvement of palindromes at the recombinational loci.
Kopecko DJ,
Cohen SN.
Proc Natl Acad Sci U S A.
1975;
72
(4):
1373-7
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Studies of mouse mitochondrial DNA in Escherichia coli: structure and function of the eucaryotic-procaryotic chimeric plasmids.
Chang AC,
Lansman RA, Clayton DA, Cohen SN.
Cell.
1975;
6
(2):
231-44
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The manipulation of genes.
Cohen SN,
Sci Am.
1975;
233
(1):
25-33
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The organization of sea urchin histone genes.
Kedes LH,
Cohn RH, Lowry JC, Chang AC, Cohen SN.
Cell.
1975;
6
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359-69
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alphabeta sequence of F is IS31.
Hu S,
Ptashne K, Cohen SN, Davidson N.
J Bacteriol.
1975;
123
(2):
687-92
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A method for selective cloning of eukaryotic DNA fragments in Escherichia coli by repeated transformation.
Cohen SN,
Chang AC.
Mol Gen Genet.
1974;
134
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133-41
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Aryl hydrocarbon hydroxylase induction in mouse peritoneal macrophages and blood-derived human macrophages.
Ptashne K,
Brothers L, Axline SG, Cohen SN.
Proc Soc Exp Biol Med.
1974;
146
(2):
585-9
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Genome construction between bacterial species in vitro: replication and expression of Staphylococcus plasmid genes in Escherichia coli.
Chang AC,
Cohen SN.
Proc Natl Acad Sci U S A.
1974;
71
(4):
1030-4
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Replication and transcription of eukaryotic DNA in Escherichia coli.
Morrow JF,
Cohen SN, Chang AC, Boyer HW, Goodman HM, Helling RB.
Proc Natl Acad Sci U S A.
1974;
71
(5):
1743-7
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Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid.
Lederberg EM,
Cohen SN.
J Bacteriol.
1974;
119
(3):
1072-4
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Utilization of two distinct modes of replication by a hybrid plasmid constructed in vitro from separate replicons.
Timmis K,
Cabello F, Cohen SN.
Proc Natl Acad Sci U S A.
1974;
71
(11):
4556-60
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An artificial intelligence program to advise physicians regarding antimicrobial therapy.
Shortliffe EH,
Axline SG, Buchanan BG, Merigan TC, Cohen SN.
Comput Biomed Res.
1973;
6
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544-60
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Construction of biologically functional bacterial plasmids in vitro.
Cohen SN,
Chang AC, Boyer HW, Helling RB.
Proc Natl Acad Sci U S A.
1973;
70
(11):
3240-4
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Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors.
Sharp PA,
Cohen SN, Davidson N.
J Mol Biol.
1973;
75
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235-55
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Lack of specific inhibition of Vaccinia plaque formation by bacteriophage lambda products.
Brown A,
Cohen SN.
Infect Immun.
1973;
7
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862-4
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Molecular and genetic studies of an R factor system consisting of independent transfer and drug resistance plasmids.
van Embden J,
Cohen SN.
J Bacteriol.
1973;
116
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699-709
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Recircularization and autonomous replication of a sheared R-factor DNA segment in Escherichia coli transformants.
Cohen SN,
Chang AC.
Proc Natl Acad Sci U S A.
1973;
70
(5):
1293-7
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Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA.
Cohen SN,
Chang AC, Hsu L.
Proc Natl Acad Sci U S A.
1972;
69
(8):
2110-4
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Further studies on the synthesis of RNA in vitro by enzyme--template complexes isolated from induced lambda lysogens.
Cohen SN,
Hurwitz J.
J Mol Biol.
1971;
58
(2):
635-9
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Genetic expression in bacteriophage lambda. 3. Inhibition of Escherichia coli nucleic acid and protein synthesis during lambda development.
Cohen SN,
Chang AC.
J Mol Biol.
1970;
49
(3):
557-75
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Non-chromosomal antibiotic resistance in bacteria. 3. Isolation of the discrete transfer unit of the R-factor R1.
Cohen SN,
Miller CA.
Proc Natl Acad Sci U S A.
1970;
67
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510-6
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Non-chromosomal antibiotic resistance in bacteria. II. Molecular nature of R-factors isolated from Proteus mirabilis and Escherichia coli.
Cohen SN,
Miller CA.
J Mol Biol.
1970;
50
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671-87
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Multiple molecular species of circular R-factor DNA isolated from Escherichia coli.
Cohen SN,
Miller CA.
Nature.
1969;
224
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1273-7
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Genetic transcription in bacteriophage lambda: studies of lambda m RNA synthesis in vivo.
Cohen SN,
Hurwitz J.
J Mol Biol.
1968;
37
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387-406
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Role of DNA in RNA synthesis. XI. Selective transcription of gamma DNA segments in vitro by RNA polymerase of Escherichia coli.
Cohen SN,
Maitra U, Hurwitz J.
J Mol Biol.
1967;
26
(1):
19-38
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Specificity of in vitro initiation and synthesis of RNA.
Maitra U,
Cohen SN, Hurwitz J.
Proc Can Cancer Conf.
1967:
7
113-32
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Transcription of complementary strands of phage lambda-DNA in vivo and in vitro.
Cohen SN,
Hurwitz J.
Proc Natl Acad Sci U S A.
1967;
57
(6):
1759-66
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Investigations of the possible relation of ferrihemic acid to drug resistance in Plasmodium berghei.
Phifer KO,
Yielding KL, Cohen SN.
Exp Parasitol.
1966;
19
(1):
101-9
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Specificity of initiation and synthesis of RNA from DNA templates.
Maitra U,
Cohen SN, Hurwitz J.
Cold Spring Harb Symp Quant Biol.
1966:
31
113-22
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Inhibition of DNA and RNA polymerase reactions by chloroquine.
Cohen SN,
Yielding KL.
Proc Natl Acad Sci U S A.
1965;
54
(2):
521-7
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SPECTROPHOTOMETRIC STUDIES OF THE INTERACTION OF CHLOROQUINE WITH DEOXYRIBONUCLEIC ACID.
COHEN SN,
YIELDING KL.
J Biol Chem.
1965:
240
3123-31
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COMPLEX FORMATION BETWEEN CHLOROQUINE AND FERRIHAEMIC ACID IN VITRO, AND ITS EFFECT ON THE ANTIMALARIAL ACTION OF CHLOROQUINE.
COHEN SN,
PHIFER KO, YIELDING KL.
Nature.
1964:
202
805-6
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OBSERVATIONS ON THE HISTONE/DNA RATIO OF THE IMMATURE RABBIT UTERUS FOLLOWING ADMINISTRATION OF ESTROGEN.
COHEN SN,
SPICER SS, YIELDING KL.
Biochim Biophys Acta.
1964:
87
511-4
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Comparison of autologous, homologous, and heterologous normal skin grafts in the hamster cheek pouch.
COHEN SN,
Proc Soc Exp Biol Med.
1961:
106
677-80
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