Thomas Quertermous, MD
Academic Appointments
- Professor, Medicine - Cardiovascular Medicine
- Member, Bio-X
Key Documents
Contact Information
- Academic Offices
Personal Information Tel (650) 723-5013Alternate Contact Celest Landini Administrative Assistant Email Tel Work 650-723-5013
Professional Overview
Postdoctoral Advisees
Ivan Carcamo Oribe, Indumathi Chennamsetty, Clint Miller, Sylvia Nuernberg, Azad Raiesdana, Olga Sazonova, Amy Sherborne
Internet Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
The Quertermous laboratory employs two basic approaches of study to better understand the genetic basis of atherosclerotic heart disease. One approach uses basic molecular biology methodology, primarily working with cellular and genetic mouse models, and is focused on the recently identified apelin-APJ pathway. A second approach employs the power of modern human genetics. Informative cohorts have been collected that allow investigation of risk factors such as hypertension and insulin resistance as well as coronary heart disease. Initial studies have employed the candidate gene approach, and more recently whole genome association studies, to identify allelic variation that is associated with risk factor and disease susceptibility.
Publications
- Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010; (7307): 707-13
- Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet. 2010; (5): 441-7
- Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010; (7317): 832-8
- Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse. Cardiovasc Res. 2010; (1): 156-65
- Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest. 2008; (10): 3343-54
- Network analysis of human in-stent restenosis. Circulation. 2006; (24): 2644-54
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