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M. Peter Marinkovich

Academic Appointments

Contact Information

  • Clinical Offices
    Medical Dermatology 450 Broadway Street Pavilion B, 4th Floor MC 5338 Redwood City, CA 94063
    Tel Work (650) 723-6316 Fax (650) 721-3476
  • Academic Offices
    Administrative Contact
    Luana Morcom Administrative Assistant Tel Work 650-498-6295
    Not for medical emergencies or patient use

Professional Snapshot

Clinical Focus

  • Dermatology

Administrative Appointments

  • Core Investigator, Program in Epithelial Biology, Stanford University (1999 - present)
  • Director, Bullous Disease Clinic, Department of Dermatology, Stanford University School of Medicine (1995 - present)
  • Staff Physician, Dermatology Service, Palo Alto VA Medical Center (1995 - present)
  • Board Member, Medical Institutional Review Board 4, Stanford University School of Medicine (2005 - present)
  • Member, Cancer Center, Stanford University School of Medicine (2004 - present)

Professional Education

Board Certification: Dermatology, American Board of Dermatology (1995)
Residency: Oregon Health Science University Hospital, OR (1994)
Fellowship: Shriner's Hospital - Portland, OR (1990)
Internship: *UCSF House Staff Office, CA (1989)
Medical Education: St. Louis University School of Medicine, MO (1988)

Graduate & Fellowship Program Affiliations

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities. View Full Information

Consulting: Novo Nordisk

Scientific Focus

Research Interests

The extracellular matrix of epithelial tissues plays a critical role in many important biological processes such as tissue development and differentiation, wound healing, tumor invasion, cell proliferation and cell migration. A highly organized array of these molecules, termed the basement membrane, lies at the interface of epithelial tissues with surrounding stroma. Cell surface receptors termed integrins transmit the informational cues brought about by changes in the extracellular environment, and transmit them, via intracellular signaling, to effect changes in epithelial gene expression. Laminins and collagens are molecules of the extracellular matrix which play particularly crucial roles in epithelial development.

EXTRACELLULAR MATRIX IN CARCINOMA INVASION
Laminin-5 and its cell surface receptor a6b4 integrin are required for development of squamous cell carcinomas. Lack of either of these molecules results in a lack of tumor growth, whereas overexpression of these molecules correlates with increasing tumor invasiveness and a worsening patient prognosis. We have identified that laminin-5 undergoes proteolytic processing of two of its three chains, via mammalian Tolloid, a metalloprotease of the astacin family. Processing of laminin-5 promotes tumor invasion. We are currently studying the mechanisms whereby these processing events influence tumor cell invasion, migration and metastasis. Type VII collagen appears to play a key role in tumor invasion, and appears to operate through association with laminin-5. We are currently studying the mechanism of this association and its role in tumorigenesis. The laminin-5 receptor a6b4 integrin interacts with laminin-5 at one end and with intracellular protein complexes at the other end, through which it transmits important signaling information to the cell. Disruption of laminin-5 binding or binding to the intracellular protein plectin, through site directed mutagenesis results in a lack of tumor growth, indicating...

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