Dorsey Bass
Academic Appointments
- Associate Professor - Med Center Line, Pediatrics - Gastroenterology
Contact Information
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Clinical Offices
Medicine Specialties Clinic 730 Welch Rd 2nd Floor Palo Alto, CA 94304 Tel Work (650) 736-7642 Fax (650) 724-3106Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
Professional Snapshot
Clinical Focus
- Gastroenterology/Nutrition/Hepatology, Pediatric
- Pediatric Gastroenterology
Professional Education
| Fellowship: | Massachusetts General Hospital, MA (1986) |
| Board Certification: | Pediatric Gastroenterology, American Board of Pediatrics (1995) |
| Board Certification: | General Pediatrics, American Board of Pediatrics (1987) |
| Fellowship: | SUMC - Graduate Medical Education, CA (1990) |
| Residency: | Boston City Hospital, MA (1982) |
Scientific Focus
Current Research Interests
Viral gastroenteritis is the single most important cause of diarrhea in infancy world-wide and accounts for enormous morbidity and mortality in children in both the developing and developed worlds. Our laboratory is interested in the pathogenesis of viral gastroenteritis, specifically in intestinal factors which are critical to the outcome of rotavirus infection which range from asymptomatic viral shedding to severe clinical disease. Previous observations have shown that rotavirus has both a narrowly defined tissue tropism, essentially mature enterocytes of the intestinal villus tip, and a fairly narrow host range restriction, causing disease mainly in suckling animals and usually only with viral strains derived from the same host species. We believe that local gastrointestinal factors determine the outcome of rotavirus infection. Specific studies include:
1) Cell receptors for rotavirus are being identified and characterized by a variety of biochemical and immunological approaches.
2) Rotavirus penetration of target cell membranes. Work from our lab has shown that this is a critical step in determing host cell susceptibility to the virus.
3) Role of enteric secretions on rotavirus pathogeneis. Rotavirus requires exogenous trypsin for replication. We are studying the effects of gastrointestinal proteases and acid secretion on rotavirus pathogeneis in vitro and in vivo.
4) Role of intestinal mucins as a defense mechanism against rotavirus.
5) Mucosal immunity and protection from enteric viral pathogens.
Publications
- Laboratory evaluation of inflammatory bowel disease. Curr Opin Pediatr. 2008; (5): 566-70
- Use of serologic markers as a screening tool in inflammatory bowel disease compared with elevated erythrocyte sedimentation rate and anemia. Pediatrics. 2007; (1): e193-9
- Gastrointestinal bleeding. Clin Pediatr (Phila). 2005; (7): 641-3
- Noncirrhotic portal hypertension in association with juvenile nephropathic cystinosis: case presentation and review of the literature. J Inherit Metab Dis. 2004; (5): 693-9
- Intestinal imaging of children with acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr. 2004; (3): 270-4
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