Key Documents
David Feldman
Academic Appointments
- Emeritus (Active) Professor, Medicine - Endocrinology/Gerontology/Metab
- Emeritus Faculty, Acad Council, Medicine - Endocrinology/Gerontology/Metab
- Member, Cancer Center
Professional Snapshot
Web Site Links
Industry Relationships
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| Consulting: | Elsevier, Receptor Therapeutics, BioXell |
Scientific Focus
Current Research Interests
Steroid hormones act by binding to intracellular receptors which regulate the expression of specific genes in target cells. My group is studying a number of aspects that relate molecular and cellular events of hormone action at the receptor level to clinically relevant questions. Some of the current projects are as follows:
1. Elucidation of the molecular basis of hereditary vitamin D resistant rickets, a genetic disease due to mutations in the vitamin D receptor.
2. Analysis of the endocrinologic mechanisms regulating vitamin D receptor expression and thereby modulating target organ sensitivity to the actions of vitamin D and its analogs.
3. Investigation of the role of vitamin D as a differentiating and antiproliferative agent with the potential to affect malignant cells, specifically prostate cancer.
4. Study of genetic variations in the vitamin D receptor gene and inheritance of low bone mass in relation to the development of osteoporosis.
Clinical Trials
Publications
- Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor. Mol Genet Metab. 2010; (1): 72-9
- Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment. Endocr Relat Cancer. 2010; (1): R19-38
- Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy. Endocrinology. 2010; (1): 32-42
- Hereditary vitamin D resistant rickets: identification of a novel splice site mutation in the vitamin D receptor gene and successful treatment with oral calcium therapy. Bone. 2009; (4): 743-6
- Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation. Prostate. 2009; (7): 719-26
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