Despite numerous recent advances in pulmonary arterial hypertension (PAH), additional research is warranted to better understand disease pathogenesis, identify and deconstruct novel sources of biological and clinical heterogeneity across patients, and pave a road to new treatment paradigms.

 More The exciting field of precision biology arms researchers with powerful tools to study PAH pathobiology, such as single cell transcriptomics, spatial proteomics, lineage tracing and the use of induced pluripotent stem cells to model disease in a dish. These cutting-edge methods have the potential to transform the way we understand disease pathogenesis, identify specific treatment targets, and develop precise and highly effective PAH therapies.

Precision medicine is a therapeutic strategy that takes into account individual variability in genes, environment, and lifestyle to identify clinical phenotypes that would specifically benefit from targeted therapies.  The importance of precision medicine to the future of US health care has been stressed by president Obama in his Precision Medicine Initiative, which aims to provide clinicians with a way to integrate seemingly disparate data (e.g. genetics, proteomics, epigenetics, metabolomics, medical record data, etc.) into a framework that improves individual clinical outcomes and health care quality. Given the rapid advancement of high-throughput ‘Omics’ platforms, availability of sophisticated machine learning algorithms, and emergence of collaborative PAH biorepositories and phenotyping efforts, the time is ripe to discuss how state-of-the-art technologies can facilitate the translation of scientific discoveries into clinical tools for improved diagnosis and treatment of PAH patients.


Guest Faculty

Evan Brittain, MD
Vanderbilt University

Jane Leopold, MD
Brigham and Womans Hopsital, Boston

Joseph Loscalzo, MD, PhD
Harvard University

Nick Morrell, MD
Cambridge University, UK

Christopher Rhodes, PhD
Imperial College, UK

Stanford Faculty

Vinicio de Jesus Perez, MD (Co-Chair) 
Pulmonary and Critical Care Medicine

Mingxia Gu, MD, MPH
Pediatric Cardiology

Rachel Hopper, MD (Symposium Committee) 
Pediatric Cardiology

Purvesh Khatri, PhD
Biomedical Informatics

Mark Krasnow, MD, PhD

Maya Kumar, PhD
Allergy and Asthma Research

Emma Lundberg, PhD
Genetics (Visiting Associate Professor)

Alison Marsden, PhD
Pediatric Cardiology

Ross Metzger, PhD
Pediatric Cardiology

Mark Nicolls, MD
Pulmonary and Critical Care Medicine

Marlene Rabinovitch, MD
Pediatric Cardiology

Edda Spiekerkoetter, MD (Co-Chair) 
Pulmonary and Critical Care Medicine

Andrew Sweatt, MD (Symposium Committee) 
Pulmonary and Critical Care

Ke Yuan, PhD
Pulmonary and Critical Care Medicine

Roham Zamanian, MD
Pulmonary and Critical Care Medicine


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