Chen, R, Gore F, Nguyen Q-A, Ramakrishnan C, Patel S, Kim SH, Raffiee M, Kim YS, Hsueh B, Krook-Magnusson E, Soltesz I, Deisseroth K. Deep brain optogenetics without intracranial surgery. Nature Biotechnology. 2020. PMID: 33020604 DOI: 10.1038/s41587-020-0679-9 [PDF]

Fenno LE, Ramakrishnan C, Kim YS, Evans KE, Lo M, Vesuna S, Inoue M, Cheung KYM, Yuen E, Pichamoorthy N, Hong ASO, Deisseroth K. Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals. Neuron. 2020. PMID: 32574559 DOI: 10.1016/j.neuron.2020.06.003 [PDF]

Lovett-Barron M, Chen R, Bradbury S, Andalman AS, Wagle M, Guo S, Deisseroth K. Multiple convergent hypothalamus-brainstem circuits drive defensive behavior. Nature Neuroscience. 2020. PMID: 32572237 DOI: 10.1038/s41593-020-0655-1 [PDF]

Kauvar IV, Machado TA, Yuen E, Kochalka J, Choi M, Allen WE, Wetzstein G, Deisseroth K. Cortical Observation by Synchronous Multifocal Optical Sampling Reveals Widespread Population Encoding of Actions. Neuron. 2020. PMID: 32433908 DOI: 10.1016/j.neuron.2020.04.023 [PDF]

Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert L-M, Jiang Y, Wang H, Fenno LE, Tok JB-H, Paşca, Shen K, Bao Z, Deisseroth K. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science. 2020. PMID: 32193327 DOI: 10.1126/science.aay4866 [PDF]

Vesuna S, Kauvar IV, Richman E, Gore F, Oskotsky T, Sava-Segal C, Luo L, Malenka RC, Henderson JM, Nuyujukian P, Parvizi J, Deisseroth K. (2020) Deep posteromedial cortical rhythm in dissociation. Nature 586:87-94. doi: 10.1038/s41586-020-2731-9. PMID: 32939091 [PDF]

Marshel JH, Kim YS, Machado TA, Quirin S, Benson B, Kadmon J, Raja C, Chibukhchyan A, Ramakrishnan C, Inoue M, Shane JC, McKnight DJ, Yoshizawa, S, Kato HE, Ganguli S, Deisseroth K. Cortical layer-specific critical dynamics triggering perception. Science. 2019. PMID: 31320556. doi: 10.1126/science.aaw5202 [PDF]

Allen, WE, Chen, MZ, Pichamoorthy, N, Tien, RH, Pachitariu, M, Luo, L, Deisseroth, K. Thirst regulates motivated behavior through modulation of brainwide neural population dynamics. Science. 2019 PMID: 30948440. doi: 10.1126/science.aav3932 [PDF]

Jennings, J. H., Kim, C. K., Marshel, J. H., Raffiee, M., Ye, L., Quirin, S., Pak, S., Ramakrishnan, C., Deisseroth, K. (2019). Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour. Nature. [ PDF ]

Kim YS, Kato HE, Yamashita K, Ito S, Inoue K, Ramakrishnan C, Fenno LE, Evans KE, Paggi JM, Dror RO, Kandori H, Kobilka BK, Deisseroth K. Crystal structure of the natural anion-conducting channelrhodopsin GtACR1. Nature. 2018. PMID: 30158696 [  PDF  ]

Kato HE, Kim YS, Paggi JM, Evans KE, Allen WE, Richardson C, Inoue K, Ito S, Ramakrishnan C, Fenno LE, Yamashita K, Hilger D, Lee SY, Berndt A, Shen K, Kandori H, Dror RO, Kobilka BK, Deisseroth K. Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature. 2018. PMID: 30158697 [  PDF  ]

Wang Xiao, Allen WE, Wright MA, Sylwestrak EL, Samusik N, Vesuna S, Evans K, Liu C, Ramakrishnan C, Liu J, Nolan GP, Bava FA, Deisseroth K. Three-dimensional intact-tissue sequencing of single-cell transcriptional states. Science. 2018. PMID: 29930089 [  PDF | Supplement | Perspective  ]

Lovett-Barron M, Andalman AS, Allen WE, Vesuna S, Kauvar I, Burns VM, Deisseroth K. Ancestral circuits for the coordinated modulation of brain state. Cell. 2017. PMID: 29103613 [  PDF | S1 (mov) | S1 (mp4) | Highlight | Stanford Medicine | NIMH News | Scope Blog  ]

Gradinaru V, Treweek J, Overton K, Deisseroth K. Hydrogel-tissue chemistry: principles and applications. Annu. Rev. Biophys. 2018. PMID: 29792820 [  PDF  ]

Deisseroth K, Hegemann P. The form and function of channelrhodopsin. Science. 2017. PMID: 28912215 [  PDF  ]

Kebschull JM, Richman EB, Ringach N, Friedmann D, Albarran E, Kollulu S, Jones RC, Allen WE, Wang Y, Cho SW, Zhou H, Ding JB, Chang HW, Deisseroth K, Quake SR, Luo L (2020). Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set. Science, 370, eabd5059. DOI: 10.1126/science.abd5059. in press. (will appear in Dec 18 issue)

Wagner MJ, Savall J, Kim TH, Schnitzer MJ, Luo L (2020) Skilled reaching tasks for head-fixed mice using a robotic manipulandum. Nat Protoc. 15(3):1237-1254.

Wall NR, Neumann PA, Beier KT, Mokhtari AK, Luo L, Malenka RC. (2019) Complementary genetic targeting and monosynaptic input mapping reveal recruitment and refinement of distributed corticostriatal ensembles by cocaine. Neuron 104:916-930. doi: 10.1016/j.neuron.2019.10.032. PMID: 31759807.

Wagner MJ, Savall J, Kim TH, Schnitzer MJ, Luo L. (2020) Skilled reaching tasks for head-fixed mice using a robotic manipulandum. Nat Protoc 15:1237-1254. doi: 10.1038/s41596-019-0286-8. PMID: 32034393.

Steinberg EE, Gore F, Heifets BD, Taylor MD, Norville ZC, Beier KT, Földy C, Lerner TN, Luo L, Deisseroth K, Malenka RC (2020) Amygdala-midbrain connections modulate appetitive and aversive learning. Neuron 106:1026-1043. doi: 10.1016/j.neuron.2020.03.016. PMID: 32294466.

Tasaka GI, Feigin L, Maor I, Groysman M, DeNardo LA, Schiavo JK, Froemke RC, Luo L, Mizrahi A. (2020) The temporal association cortex plays a key role in auditory-driven maternal behavior. Neuron 107:566-579. doi: 10.1016/j.neuron.2020.05.004. PMID: 32473095

Ren J, Isakova A, Friedmann D, Zeng J, Grutzner SM, Pun A, Zhao GQ, Kolluru SS, Wang R, Lin R, Li P, Li A, Raymond JL, Luo Q, Luo M, Quake SR, Luo L. Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei. eLife. 2019. PMID: 31647409. DOI: 10.7554/eLife.49424

M.J. Wagner, T.H. Kim, J. Kadmon, N.D. Nguyen, S. Ganguli, M.J. Schnitzer, L. Luo. Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task. Cell. 2019. PMID: 30929901. doi: 10.1016/j.cell.2019.02.019 [PDF]

L. A. DeNardo et al., Temporal evolution of cortical ensembles promoting remote memory retrieval. Nat. Neurosci. (2019) [ PDF ]

Beier KT, Gao XJ, Xie S, DeLoach KE, Malenka RC, Luo L. (2019) Topological Organization of Ventral Tegmental Area Connectivity Revealed by Viral-Genetic Dissection of Input-Output Relations. Cell Rep. 2019 PMID: 30605672. [ PDF ]

Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, DeLoach KE, Ran C, Pun A, Sun Y, Weissbourd B, Neve RL, Huguenard J, Horowitz MA, Luo L. (2018). Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell. 2018. PMID: 30146164 [ PDF | Stanford News ] 

Kohl J, Babayan BM, Rubinstein ND, Autry AE, Marin-Rodriguez B, Kapoor V, Miyamishi K, Zweifel LS, Luo L, Uchida N, Dulac C. (2018) Functional circuit architecture underlying parental behaviour. Nature. 2018 PMID: 29643503 [ PDF ]

Tasaka GI, Guenthner CJ, Shalev A, Gilday O, Luo L, Mizrahi A. Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations. Nat Comm. 2018. PMID: 29491360 [ PDF ]

Girasole AE, Lum MY, Nathaniel D, Bair-Marshall CJ, Guenthner CJ, Luo L, Kreitzer AC, Nelson AB. A subpopulation of striatal neurons mediates levodopa-induced dyskinesia. Neuron. 2018. PMID: 29398356 [ PDF ]

Li H, Horns F, Wu B, Xie Q, Li J, Li T, Luginbuhl DJ, Quake SR, Luo L. Classifying Drosophila olfactory projection neuron subtypes by single-cell RNA sequencing. Cell. 2017. PMID: 29149607 [ PDF ]

Allen WE, DeNardo LA, Chen MZ, Liu CD, Loh KM, Fenno LE, Ramakrishnan C, Deisseroth K, Luo L. Thirst-associated median preoptic neurons encode an aversive motivational drive. Science. 2017. PMID: 28912243 [ PDF ]

Luo L, Callaway EM, Svoboda K. Genetic dissection of neural circuits: a decade of progress. Neuron. 2018. PMID: 29772206 [ PDF ]

Luo L, Callaway EM, Svoboda K. Genetic dissection of neural circuits: a decade of progress. Neuron. 2018. PMID: 29772206 [ PDF ]

Cho KKA, Davidson TJ, Bouvier G, Marshall JD, Schnitzer MJ, Sohal VS. (2020) Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning. Nat Neurosci. doi: 10.1038/s41593-020-0647-1. Online ahead of print.

Wagner MJ, Savall J, Hernandez O, Mel G, Inan H, Rumyantsev O, Lecoq J, Kim TH, Li JZ, Ramakrishnan C, Deisseroth K, Luo L, Ganguli S, Schnitzer MJ. A neural circuit state change underlying skilled movements. In press.

Rumyantsev OI, Lecoq JA, Hernandez O, Zhang Y, Savall J, Chrapkiewicz R, Li J, Zeng H, Ganguli S, Schnitzer MJ. (2020) Fundamental bounds on the fidelity of sensory cortical coding. Nature. 580(7801):100-105.

Zhang T, Hernandez O, Chrapkiewicz R, Shai A, Wagner MJ, Zhang Y, Wu CH, Li JZ, Inoue M, Gong Y, Ahanonu B, Zeng H, Bito H, Schnitzer MJ. Kilohertz two-photon brain imaging in awake mice. Nature Methods. 2019. PMID: 31659327. doi: 10.1038/s41592-019-0597-2

Gründemann J, Bitterman Y, Lu T, Krabbe S, Grewe BF, Schnitzer MJ, Lüthi A. (2019) Amygdala ensembles encode behavioral states. Science. 364(6437). pii: eaav8736. PMID: 31000636. DOI: 10.1126/science.aav8736

Corder G, Ahanonu B, Grewe BF, Wang D, Schnitzer MJ, Scherrer G. (2019) An amygdalar neural ensemble that encodes the unpleasantness of pain. Science. 363(6424):276-281. PMID: 30655440. DOI: 10.1126/science.aap8586.

Kannan M, Vasan G, Huang C, Haziza S, Li JZ, Inan H, Schnitzer MJ, Pieribone VA (2018) Fast, in vivo voltage imaging using a red fluorescent indicator. Nat Methods. 15(12):1108-1116. PMID: 30420685. DOI: 10.1038/s41592-018-0188-7.

Wang T, Ouzounov DG, Wu C, Horton NG, Zhang B, Wu C-H, Zhang Y, Schnitzer MJ, Xu C. Three-photon imaging of mouse brain structure and function through the intact skull. Nature Methods. 2018. PMID: 30202059 [ PDF ]

Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, Ushiba J, Okano H (2018) Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys. Cell Rep. 24(8):2191-2195.e4. [ PDF ]

Kannan M, Vasan G, Huang C, Haziza S, Li JZ, Inan H, Schnitzer MJ, Pieribone VA (2018) Fast, in vivo voltage imaging using a red fluorescent indicator. Nat Methods. doi: 10.1038/s41592-018-0188-7. [ PDF ]

Huang C, Maxey JR, Sinha S, Savall J, Gong Y, Schnitzer MJ. Long-term optical brain imaging in live adult fruit flies.Nature Communications. 2018. [ PDF ]