Welcome to the Garcia Laboratory

Our laboratory is broadly interested in cell surface receptors and their ligands. Our principal goal is to exploit mechanistic and structural information on receptor-ligand interactions to interrogate and therapeutically impact human disease. We ask how ligand recognition and signaling coordinate with the physiology of the cell using protein engineering to manipulate signaling pathways in order to control cell function and fate. The receptor systems we study play key roles in immunology, stem cell and neurobiology, and have translational relevance to immunotherapy and regenerative medicine.