Search Pubmed for Monte Winslow


Xue B, Chuang CH, Prosser HM, Fuziwara CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B, He L. miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts. BioRxiv. 2020 Sept 3. doi: 10.1101/2020.09.02.276550

Foggetti G, Li C, Cai, H, Hellyer JA, Lin WY, Ayeni D, Hastings K, Choi J, Wurtz A, Andrejka L, Maghini D, Rashleigh N, Levy S, Homer R, Gettinger S, Diehn M, Wakelee HA, Petrov DA, Winslow MM, Politi. Genetic determinates of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo. BioRxiv. 2020 Aug 31. doi: 10.1101/2020.04.13.036921

Li C, Lin WY, Rizvi H, Cai H, McFarland CD, Rogers ZN, Yousefi M, Winters IP, Rudin, CM, Petrov DA, and Winslow MM. Quantitative in vivo analyses reveal a complex pharmacogenic landscape in lung adenocarcinomaBioRxiv. 2020 Jan 29. doi: 10.1101/2020.01.28.923912 *pre-print


Tang R, Murray CW, Linde I, Kramer NJ, Lyu Z, Tsai MK, Chen LC, Cai H, Gitler AD, Engleman E, Lee W, and Winslow MM. A versatile system to record cell-cell interactions. eLife. 2020 Oct 7. doi: 10.7554/eLife.61080

Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Sipkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, and Bassik MC. CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities. Nature. 2020 Mar 11. doi: 10.1038/s41586-020-2099-x


Yang D, Qu F, Cai H, Chuang CH, Lim JS, Jahchan N, Grüner BM, S Kuo C, Kong C, Oudin MJ, Winslow MM**, and Sage J**. Axon-like protrusions promote small cell lung cancer migration and metastasis. eLife. 2019 Dec 13. doi: 10.7554/eLife.50616. **Co-senior authors.

Murray CW, Brady JJ, Tsai MK, Li C, Winters IP, Tang R, Andrejka L, Ma RK, Kunder CA, Chu P, and Winslow MM. An Lkb1-Sik axis suppresses lung tumor growth and controls differentiation. Cancer Discovery. 2019 July 26. doi: 10.1158/2159-8290.CD-18-1237 


Winters IP*, Murray CW*, and Winslow MM. Towards quantitative and multiplexed in vivo functional cancer genomics. Nature Reviews Genetics. 2018 Sep 28. doi: 10.1038/s41576-018-0053-7. [Epub ahead of print] *Co-first authors.

Chiou S-H, Dorsch M, Kusch E, Naranjo S, Kozak MM, Koong AC, Winslow MM**, and Grüner BM**. Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance. Scientific Reports. 2018;8:14008. **Co-senior authors.

Yang D, Denny SK, Greenside PG, Chaikovsky AC, Brady JJ, Ouadah Y, Granja JM, Jahchan NS, Lim JS, Kwok S, Kong CS, Berghoff AS, Schmitt A, Reinhardt HC, Park KS, Preusser M, Kundaje A, Greenleaf WJ, Sage J**, and Winslow MM**. Intertumoral heterogeneity in SCLC is influenced by the cell type of origin. Cancer Discovery. 2018 Oct;8(10):1316-1331. **Co-senior authors.

Caswell DR, Chuang CH, Ma RK, Winters IP, Snyder EL, and Winslow MM. Tumor suppressor activity of Selenbp1, a direct Nkx2-1 target, in lung adenocarcinoma. Molecular Cancer Research. 2018 Jul 12.

Rogers ZN*, McFarland CD*, Winters IP, Seoane JA, Brady JJ, Yoon S, Curtis C, Petrov DA**, and Winslow MM**. Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice. Nature genetics. 2018;50(4):483-486. doi:10.1038/s41588-018-0083-2. Epub 2018 Apr 2. *Co-first authors. **Co-senior authors.


Winters IP, Chiou S-H, Paulk NK, McFarland CD, Lalgudi PV, Ma RK, Lisowski L, Connolly AJ, Petrov DA, Kay MA, and Winslow MM. Multiplex in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. Nature Communication. 2017 Dec 12; 8(1): 2053. 

Chiou S-H, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, and Winslow MM. Blimp1 induces transient metastatic heterogenity in pancreatic cancer. Cancer Discovery. 2017 Oct; Volume 7(10): 1184-99

Gocheva V, Naba A, Bhutkar A, Guardia T, Miller KM, Li CM, Dayton TL, Sanchez-Riera FJ, Kim-Kiselak C, Jaikhni N, Winslow MM, Del Rosario A, Hynes RO, and Jacks T. Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survivial. PNAS. 2017 Jul; 114(28): E5625-E5634

Rogers ZN*, McFarland CD*, Winter IP*, Naranjo S, Chuang C-H, Petrov D, and Winslow MM. A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. Nature Methods. 2017 July; 14(7); 737-742 *Co-first authors.

Chuang C-H, Greenside PG, Rogers ZN, Brady JJ, Yang D, Ma RK, Caswell DR, Chiou S-H, Winters A, Grüner BM, Ramaswami G, Spencley AL, Kopecky KE, Sayles LC, Sweet-Cordero EA, Li JB, Kundaje A, and Winslow MM. Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Jak-Stat axis. Nature Medicine. 2017 Mar; 23(3):291-300


Grüner BM*, Schulze CJ*, Yang D, Ogasawara D, Dix MM, Rogers ZR, Chuang C-H, McFarland CD, Chiou S-H, Brown JM, Cravatt BF, Bogyo M**, and Winslow MM** An in vivo multiplexed small molecule screening platform. Nature Methods. 2016 Oct;13(10):883-9 *Co-first authors. ** Co-senior authors.

Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J. Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, Guerston H, Barkal A, Trapani F, George J, Poirier JT, Gardner EE, Miles LA, de Stanchina E, Lofgren SM, Vogel H, Winslow MMDive C, Thomas RK, Rudin CM, van de Rijn M, Majeti R, Garcia KC, Weissman IL,  and Sage J. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. Journal of Clinical Investigation. 2016 Jul 1; 126(7):2610-20 

Denny SK*, Yang D*, Chuang CH, Brady JJ, Lim JS, Grüner BM, Chiou SH, Schep AN, Baral J, Hamard C, Antoine M, Wislez M, Kong CS, Connolly AJ, Park KS, Sage J**, Greenleaf WJ**, and Winslow MM**. Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility. Cell. 2016 July *Co-first authors. ** Co-senior authors.

Brady JJ, Chuang CH, Greenside PG, Rogers ZN, Murray CW, Caswell DR, Hartmann U, Connolly AJ, Sweet-Cordero EA, Kundaje A, and Winslow MM. An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency. Cancer Cell. 2016 Volume 29(5); 697-710


Chiou S-H*, Winters IP*, Wang J, Naranjo S, Dudgeon C, Tambuini FB, Brady JJ, Yang D, Gruner BM, Chuang C-H, Cawell DR, Zeng H, Chu P, Kim GE, Carpizo DR, Kim SK, and Winslow MM. Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editingGenes and Development. 2015 Volume 29(14);1576-85 *Co-first authors.

Ofori LO, Withana NP, Prestwood TR, Verdoes M, Brady JJ, Winslow MM, Sorger J, and Bogyo M. Design of protease activated optical contrast agents that exploit a latent lysosomotropic effect for use in fluorescence-guided surgery. ACS Chemical Biology. 2015 Volume 10(9): 1977-88

Valdmanis PN, Roy-Chaudhuri B, Kim HK, Sayles LC, Zheng Y, Chuang CH, Caswell DR, Chu K, Zhang Y, Winslow MM, Sweet-Cordero EA, and Kay MA. Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. Oncogene. 2015 Jan 2;34(1):94-103

Robles-Oteiza C, Taylor S, Yates T, Cicchini M, Lauderback B, Cashman CR, Burds AA, Winslow MM, Jacks T, and Feldser DM. Recombinase-based conditional and reversible gene regulation via XTR alleles. Nature Communications. 2015 Nov 5;6:8783

Madison BB, Jeganathan AN, Mizuno R, Winslow MM, Castells A, Cuatrecasas M, and Rustgi AK. Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2. PLoS Genetics. 2015 Aug 5;11(8)


Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, and Shaw RJ. An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential. Molecular Cell. 2014 Jul 16. pii: S1097-2765(14)00529-2. [Epub ahead of print]

Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, and Kim CF. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. PNAS. 2014; 111(28):10299-304.

Chiou S-H, Kim-Kiselak C, Risca VI, Heimann M, Chuang C-H, Burds AA, Greenleaf WJ, Jacks TE, Feldser DM, and Winslow MM. A conditional system to specifically link disruption of protein coding function with reporter expression in mice.Cell Reports. 2014 Jun 26;7(6):2078-86.

Caswell DR*, Chuang CH*, Yang D, Chiou SH, Cheemalavagu S, Kim-Kiselak C, Connolly A, and Winslow MM. Obligate progression precedes lung adenocarinoma dissemination. Cancer Discovery. 2014 Jul;4(7):781-9. *Contributed equally.


Li CM, Chen G, Dayton TL, Kim-Kiselak C, Hoersch S, Whittaker CA, Bronson RT, Beer DG, Winslow MM, and Jacks T. Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma. Genes and Development. 2013 Jul 15;27(14):1557-67. doi: 10.1101/gad.222745.113.

Rice SJ, Lai SC, Wood LW, Helsley KR, Runkle EA, Winslow MM, and Mu D. (2013) MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1)Journal of Biological Chemistry. 2013 Jun 7;288(23):16348-60. doi: 10.1074/jbc.M113.474643. Epub 2013 Apr 26.

Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang JH, Hecht VC, Winslow MM, Jacks T, Mallick P, and Manalis SR. (2013) Characterizing deformability and surface friction of cancer cells. PNAS. 2013 Apr 22. [Epub ahead of print]


Reticker-Flynn NE, Malta DF, Winslow MM, Lamar JM, Xu MJ, Underhill GH, Hynes RO, Jacks TE, and Bhatia SN. A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications. (2012) 3:1122. doi: 10.1038/ncomms2128.

Runkle EA, Rice SJ, Qi J, Masser D, Antonetti DA, Winslow MM, and Mu D. Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1). Journal of Biological Chemistry. (2012) Aug 17;287(34):28790-801. doi: 10.1074/jbc.M112.367987. Epub 2012 Jul 2.


Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, and Jacks T. Suppression of Lung Adenocarcinoma Progression by Nkx2-1Nature. 2011 Volume 473(7345), 101-104. 

Schroeder A*, Heller DA*, Winslow MM*, Dahlman JE*, Pratt GW, Langer R, Jacks T, and Anderson DG. Treating metastatic cancer with nanotechnology. Nature Reviews Cancer. 2011 Volume 12(1), 39-50. *Contributed Equally 

Xue W, Meylan E, Oliver TO, Feldser DM, Winslow MM, Bronson R, and Jacks T. Response and resistance to NF-kB inhibitors in mouse models of lung adenocarcinomaCancer Discovery. 2011 Volume 1(3), 236-247.

Dooley AL, Winslow MM, Chiang DY, Banerji S, Stransky N, Dayton TL, Snyder E, Senna S, Whittaker CA, Bronson RT, Crowley D, Barretina J, Garraway L, Meyerson M, and Jacks T. Nuclear factor I/B is a proto-oncogene in Small Cell Lung CancerGenes and Development. 2011 Volume 25(14), 1470-1475.

Shaw AT, Winslow MM, Magendantz M, Ouyang C, Dowdle J, Subramanian A, Lamb J, Lewis T, Maglathin R, Tolliday N, and Jacks T. Selective Killing of K-ras Mutant Cancer Cells by Novel, Small Molecule Inducers of Oxidative StressPNAS. 2011 Volume 108(21), 8773-8778.

DuPage MJ, Cheung A, Mazumdar C, Winslow MM, Bronson RT, Crowley D, Chen J, and Jacks T. Endogenous T cell responses to lung adenocarcinoma neoantigens delay tumor progressionCancer Cell. 2011 19(1), 72-85.


Feldser DM, Kostova KK, Winslow MM, Sanchez-Rivera F, Whittaker C, Taylor S, Cashman C, Resnick R, Bronson R, Hemann MT, and Jacks T. Stage-specific sensitivity to p53 restoration during lung tumor progressionNature. 2010 Volume 468(7323), 572-575.


Ventura A, Garfinkel AG*, Winslow MM*, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JA, Jaenisch R, Sharp PA, and Jacks T. Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17~92 Family of miRNA ClustersCell. 2008 Volume 132(5), 875-886. *Contributed equally.

Gallo EM, Ho L, Winslow MM, Staton TL, and Crabtree GR. Selective role of calcineurin in haematopoiesis and lymphopoiesisEMBO Reports. 2008 Nov; 9(11):1141-8. doi: 10.1038/embor.2008.174. Epub 2008 Sep 26.


Gallo EM, Winslow MM, Cante-Barrett K, Radermacher AN, Ho L, Neilson JR, McGinnis L, Iritani B, and Crabtree GR. (2007) Calcineurin sets the bandwidth for discrimination of signals during thymocyte developmentNature. 2007 Volume 450(7170), 731-735.

Lessard J*, Wu JI*, Ranish JA, Wang M, Winslow MM, Staahl B, Wu H, Aebersold R, Graef IA, and Crabtree GR. (2007) An essential switch in subunit composition of a chromatin remodeling complex during neural developmentNeuron. 2007 Volume 55(2), 201-15. *Contributed equally.

Cante-Barrett K, Winslow MM, and Crabtree GR. (2007) Selective role of NFATc3 in positive selection of thymocytesThe Journal of Immunology. 2007 Volume 179(1), 103-110.

Pan M, Winslow MM, Chen L, Kuo A, Felsher D, Crabtree GR. Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulationThe Journal of Immunology. 2007 Apr 1;178(7):4315-21.


Winslow MM, Pan M, Starbuck M, Gallo EM, Deng L, Karsenty G, and Crabtree GR. (2006) Calcineurin/NFAT signaling in osteoblasts regulates bone massDevelopmental Cell. 2006 Volume 10(6), 771-782.

Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, and Kim SK. (2006) Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and functionNature. 2006 Volume 443(7109), 345-349.

Arron J*, Winslow MM*, Polleri A*, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim S, Yamasaki N, Miyakawa T, Franke U, Graef IA*, and Crabtree GR. (2006) NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on Chromosome 21Nature. 2006 Volume 441(7093), 595-600. *Contributed equally.

Staton TL, Habtezion A, Winslow MM, Sato T, Love PE, and Butcher EC. (2006) CD8 recent thymic emigrants efficiently home to and populate the small intestine epitheliumNature Immunology. 2006 Volume 7(5), 482-488.

Winslow MM, Gallo EM, Neilson JR, and Crabtree GR. (2006) The Calcineurin Phosphatase Complex Modulates Immunogenic B cell ResponsesImmunity. 2006 Volume 24(2), 141-52.


Neilson JR, Winslow MM, Hur EM, and Crabtree GR. (2004) Calcineurin B1 is essential for positive but not negative selection during thymocyte developmentImmunity. 2004 Volume 20(3), 255-266.